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Research Article

HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization

  • John P. Norman,

    Affiliations: Center for Neural Development and Disease, the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, Department of Neurology (Child Neurology Division), the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Seth W. Perry,

    Affiliations: Center for Neural Development and Disease, the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, Department of Neurology (Child Neurology Division), the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Holly M. Reynolds,

    Affiliations: Center for Neural Development and Disease, the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, Department of Neurology (Child Neurology Division), the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Michelle Kiebala,

    Affiliation: Department of Microbiology and Immunology, the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Karen L. De Mesy Bentley,

    Affiliation: Department of Laboratory Medicine and Pathology, the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Margarita Trejo,

    Affiliation: Department of Neurosciences and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • David J. Volsky,

    Affiliation: Molecular Virology Division, St. Lukes-Roosevelt Hospital Center, Columbia University, New York, New York, United States of America

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  • Sanjay B. Maggirwar,

    Affiliation: Department of Microbiology and Immunology, the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Stephen Dewhurst,

    Affiliation: Department of Microbiology and Immunology, the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Eliezer Masliah,

    Affiliation: Department of Neurosciences and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, United States of America

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  • Harris A. Gelbard mail

    harris_gelbard@urmc.rochester.edu

    Affiliations: Center for Neural Development and Disease, the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, Department of Neurology (Child Neurology Division), the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, Department of Microbiology and Immunology, the University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

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  • Published: November 14, 2008
  • DOI: 10.1371/journal.pone.0003731

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