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Open Access

Peer-reviewed

Research Article

Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

  • Katerina V. Savelieva ,

    *ksavelieva@lexpharma.com

    Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

    ⨯
  • Shulei Zhao ,

    Contributed equally to this work with: Shulei Zhao, Vladimir M. Pogorelov

    Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

    ⨯
  • Vladimir M. Pogorelov ,

    Contributed equally to this work with: Shulei Zhao, Vladimir M. Pogorelov

    Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

    ⨯
  • Indrani Rajan,

    Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

    ⨯
  • Qi Yang,

    Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

    ⨯
  • Emily Cullinan,

    Current address: Baylor College of Medicine, Houston, Texas, United States of America

    Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

    ⨯
  • Thomas H. Lanthorn

    Affiliation Lexicon Pharmaceuticals Incorporated, The Woodlands, Texas, United States of America

    ⨯

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