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Research Article

Imaging Mass Spectrometry Technology and Application on Ganglioside Study; Visualization of Age-Dependent Accumulation of C20-Ganglioside Molecular Species in the Mouse Hippocampus

  • Yuki Sugiura,

    Affiliations: Department of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan, Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan

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  • Shuichi Shimma,

    Affiliation: National Institute for Physiological Sciences, Okazaki, Aichi, Japan

    Current address: Renovation Center of Instruments for Science Education and Technology, Osaka University, Toyonaka, Osaka, Japan

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  • Yoshiyuki Konishi,

    Affiliation: Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan

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  • Maki K. Yamada,

    Affiliation: Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan

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  • Mitsutoshi Setou mail

    setou@hama-med.ac.jp

    Affiliations: Department of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan, Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan, National Institute for Physiological Sciences, Okazaki, Aichi, Japan, Hamamatsu Medical School, Department of Molecular Anatomy, Hamamatsu, Shizuoka, Japan

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  • Published: September 18, 2008
  • DOI: 10.1371/journal.pone.0003232

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