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Research Article

The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae

  • Maninder K. Sohi,

    Affiliation: Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

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  • Dennis A. Veselkov,

    Affiliation: Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

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  • Ivan Laponogov,

    Affiliation: Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

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  • Xiao-Su Pan,

    Affiliation: Molecular Genetics Group, Molecular and Metabolic Signalling Centre, Division of Basic Medical Sciences, St. George's, University of London, London, United Kingdom

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  • L. Mark Fisher mail,

    lfisher@sgul.ac.uk (LMF); mark.sanderson@kcl.ac.uk (MRS)

    Affiliation: Molecular Genetics Group, Molecular and Metabolic Signalling Centre, Division of Basic Medical Sciences, St. George's, University of London, London, United Kingdom

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  • Mark R. Sanderson mail

    lfisher@sgul.ac.uk (LMF); mark.sanderson@kcl.ac.uk (MRS)

    Affiliation: Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

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  • Published: September 12, 2008
  • DOI: 10.1371/journal.pone.0003201

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