Breast Tumor Cells with PI3K Mutation or HER2 Amplification Are Selectively Addicted to Akt Signaling

Qing-Bai She; Sarat Chandarlapaty; Qing Ye; Jose Lobo; Kathleen M. Haskell; Karen R. Leander; Deborah DeFeo-Jones; Hans E. Huber; Neal Rosen

doi:10.1371/journal.pone.0003065

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Peer-reviewed

Research Article

Breast Tumor Cells with PI3K Mutation or HER2 Amplification Are Selectively Addicted to Akt Signaling

Qing-Bai She,

Affiliation Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Sarat Chandarlapaty ,

Contributed equally to this work with: Sarat Chandarlapaty, Qing Ye

Affiliation Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Qing Ye ,

Contributed equally to this work with: Sarat Chandarlapaty, Qing Ye

Affiliation Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Jose Lobo,

Affiliation Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Kathleen M. Haskell,

Affiliation Department of Cancer Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America
⨯
Karen R. Leander,

Affiliation Department of Cancer Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America
⨯
Deborah DeFeo-Jones,

Affiliation Department of Cancer Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America
⨯
Hans E. Huber,

Affiliation Department of Cancer Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America
⨯
Neal Rosen

* E-mail: rosenn@mskcc.org

Affiliation Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯

Breast Tumor Cells with PI3K Mutation or HER2 Amplification Are Selectively Addicted to Akt Signaling

Qing-Bai She,
Sarat Chandarlapaty,
Qing Ye,
Jose Lobo,
Kathleen M. Haskell,
Karen R. Leander,
Deborah DeFeo-Jones,
Hans E. Huber,
Neal Rosen

x

Published: August 26, 2008
https://doi.org/10.1371/journal.pone.0003065

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Breast cancer
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Cancer treatment
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Signal inhibition
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Signal amplification
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Apoptosis
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