Binding of sFRP-3 to EGF in the Extra-Cellular Space Affects Proliferation, Differentiation and Morphogenetic Events Regulated by the Two Molecules

• Raffaella Scardigli ,

  Contributed equally to this work with: Raffaella Scardigli, Cesare Gargioli

  Current address: European Brain Research Institute, Rome, Italy

  Affiliations Department of Developmental Biology, Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park of Rome, Rome, Italy, Department of Histology and Medical Embryology, II° Medical School, University of Rome “La Sapienza”, Rome, Italy

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• Cesare Gargioli ,

  Contributed equally to this work with: Raffaella Scardigli, Cesare Gargioli

  Affiliations Department of Developmental Biology, Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park of Rome, Rome, Italy, Department of Histology and Medical Embryology, II° Medical School, University of Rome “La Sapienza”, Rome, Italy

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• Daniela Tosoni,

  Current address: Department of Experimental Oncology, European Institute of Oncology, Milan, Italy

  Affiliation Department of Histology and Medical Embryology, II° Medical School, University of Rome “La Sapienza”, Rome, Italy

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• Ugo Borello,

  Current address: Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, California, United States of America

  Affiliations Department of Histology and Medical Embryology, II° Medical School, University of Rome “La Sapienza”, Rome, Italy, Stem Cell Research Institute, H. “S. Raffaele”, Milan, Italy

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• Maurilio Sampaolesi,

  Affiliations Department of Experimental Medicine, University of Pavia, Pavia, Italy, Interdepartemental Stem Cell Research Institute, University Hospital Gasthuisberg, Leuven, Belgium

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• Clara Sciorati,

  Affiliation Stem Cell Research Institute, H. “S. Raffaele”, Milan, Italy

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• Stefano Cannata,

  Affiliation Department of Biology, University of Tor Vergata, Rome, Italy

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• Emilio Clementi,

  Affiliations Stem Cell Research Institute, H. “S. Raffaele”, Milan, Italy, Department of Preclinical Sciences, University of Milan, and E. Medea Scientific Institute, Milan, Italy

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• Silvia Brunelli,

  Affiliations Stem Cell Research Institute, H. “S. Raffaele”, Milan, Italy, Department of Experimental Medicine, University of Milan-Bicocca, Monza (Milan), Italy

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• Giulio Cossu

  * E-mail: cossu.giulio@hsr.it

  Affiliations Department of Developmental Biology, Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park of Rome, Rome, Italy, Stem Cell Research Institute, H. “S. Raffaele”, Milan, Italy, Department of Biology, University of Milan, Milan, Italy

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