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Research Article

Multivalent HA DNA Vaccination Protects against Highly Pathogenic H5N1 Avian Influenza Infection in Chickens and Mice

  • Srinivas Rao,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Wing-Pui Kong,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Chih-Jen Wei,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Zhi-Yong Yang,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Martha Nason,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Darrel Styles,

    Affiliation: United States Department of Agriculture, Animal and Plant Health Inspection Service, Riverdale, Maryland, United States of America

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  • Louis J. DeTolla,

    Affiliation: Comparative Medicine, University of Maryland Baltimore, Baltimore, Maryland, United States of America

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  • Erin M. Sorrell,

    Affiliation: College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Haichen Song,

    Affiliation: College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Hongquan Wan,

    Affiliation: College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Gloria C. Ramirez-Nieto,

    Affiliation: College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Daniel Perez,

    Affiliation: College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Gary J. Nabel mail

    gnabel@nih.gov

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: June 18, 2008
  • DOI: 10.1371/journal.pone.0002432

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