Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

Tiago Fleming Outeiro; Preeti Putcha; Julie E. Tetzlaff; Robert Spoelgen; Mirjam Koker; Filipe Carvalho; Bradley T. Hyman; Pamela J. McLean

doi:10.1371/journal.pone.0001867

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Peer-reviewed

Research Article

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

Tiago Fleming Outeiro ,

* E-mail: touteiro@fm.ul.pt (TO); pmclean@partners.org (PM)

Affiliations Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America, Instituto de Medicina Molecular, Cell and Molecular Neuroscience Unit, Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
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Preeti Putcha,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Julie E. Tetzlaff,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Robert Spoelgen,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Mirjam Koker,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Filipe Carvalho,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Bradley T. Hyman,

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
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Pamela J. McLean

* E-mail: touteiro@fm.ul.pt (TO); pmclean@partners.org (PM)

Affiliation Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
⨯

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

Tiago Fleming Outeiro,
Preeti Putcha,
Julie E. Tetzlaff,
Robert Spoelgen,
Mirjam Koker,
Filipe Carvalho,
Bradley T. Hyman,
Pamela J. McLean

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Published: April 2, 2008
https://doi.org/10.1371/journal.pone.0001867

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Oligomers
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Transfection
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Complement system
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Immunoblotting
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Dimers
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Parkinson disease
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Toxicity
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