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Research Article

Transcriptional Regulation of PIK3CA Oncogene by NF-κB in Ovarian Cancer Microenvironment

  • Nuo Yang,

    Affiliation: Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Jia Huang,

    Affiliation: Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Joel Greshock,

    Affiliations: Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Translational Medicine and Genetics at GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America

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  • Shun Liang,

    Affiliation: Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Andrea Barchetti,

    Affiliation: Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Kosei Hasegawa,

    Affiliation: Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Sarah Kim,

    Affiliation: Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Antonis Giannakakis,

    Affiliations: Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Laboratory of Gene Expression, Modern Diagnostic and Therapeutic Methods, Democritus University of Thrace, Alexandroupolis, Greece

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  • Chunsheng Li,

    Affiliation: Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Anne O'Brien-Jenkins,

    Affiliation: Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Dionyssios Katsaros,

    Affiliation: Departments of Obstetrics and Gynecology, University of Turin, Turin, Italy

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  • Ralf Bützow,

    Affiliations: Department of Obstetrics, University of Helsinki, Helsinki, Finland, Department of Gynecology, University of Helsinki, Helsinki, Finland

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  • George Coukos,

    Affiliations: Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Lin Zhang mail

    To whom correspondence should be addressed. E-mail: linzhang@mail.med.upenn.edu

    Affiliations: Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Published: March 12, 2008
  • DOI: 10.1371/journal.pone.0001758

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