Advertisement
Research Article

Adaptor SKAP-55 Binds p21ras Activating Exchange Factor RasGRP1 and Negatively Regulates the p21ras-ERK Pathway in T-Cells

  • Helga Schneider equal contributor,

    equal contributor Contributed equally to this work with: Helga Schneider, Hongyan Wang

    Affiliations: Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

    X
  • Hongyan Wang equal contributor,

    equal contributor Contributed equally to this work with: Helga Schneider, Hongyan Wang

    Affiliations: Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom, Cambridge Institute for Medical Research, Cambridge, United Kingdom

    X
  • Monika Raab,

    Affiliations: Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom, Department of Gynecology and Obstetrics, Medical School, Johann Wolfgang Goethe-University, Frankfurt, Germany

    X
  • Elke Valk,

    Affiliations: Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

    X
  • Xin Smith,

    Affiliation: Cambridge Institute for Medical Research, Cambridge, United Kingdom

    X
  • Matt Lovatt,

    Affiliation: Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

    X
  • Zhonglin Wu,

    Affiliations: Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

    X
  • Braudel Maqueira-Iglesias,

    Affiliation: Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom

    X
  • Klaus Strebhardt,

    Affiliation: Department of Gynecology and Obstetrics, Medical School, Johann Wolfgang Goethe-University, Frankfurt, Germany

    X
  • Christopher E. Rudd mail

    To whom correspondence should be addressed. E-mail: cer51@cam.ac.uk

    Affiliations: Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom, Cambridge Institute for Medical Research, Cambridge, United Kingdom

    X
  • Published: March 05, 2008
  • DOI: 10.1371/journal.pone.0001718

Viewed info

Cited info

Saved info

Discussed info

Questions or concerns about usage data? Please let us know.