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Research Article

Safety and Immunogenicity of an AMA-1 Malaria Vaccine in Malian Adults: Results of a Phase 1 Randomized Controlled Trial

  • Mahamadou A. Thera,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Ogobara K. Doumbo,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Drissa Coulibaly,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Dapa A. Diallo,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Abdoulaye K. Kone,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Ando B. Guindo,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Karim Traore,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Alassane Dicko,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Issaka Sagara,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Mahamadou S. Sissoko,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Mounirou Baby,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Mady Sissoko,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Issa Diarra,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Amadou Niangaly,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Amagana Dolo,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Modibo Daou,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • Sory I. Diawara,

    Affiliation: Malaria Research and Training Center, University of Bamako, Bamako, Mali

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  • D. Gray Heppner,

    Affiliation: Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • V. Ann Stewart,

    Affiliation: Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Evelina Angov,

    Affiliation: Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Elke S. Bergmann-Leitner,

    Affiliation: Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • David E. Lanar,

    Affiliation: Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Sheetij Dutta,

    Affiliation: Division of Malaria Vaccine Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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  • Lorraine Soisson,

    Affiliation: Malaria Vaccine Development Program, U.S. Agency for International Development, Washington, D. C., United States of America

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  • Carter L. Diggs,

    Affiliation: Malaria Vaccine Development Program, U.S. Agency for International Development, Washington, D. C., United States of America

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  • Amanda Leach,

    Affiliation: World Wide Clinical Development – Malaria Vaccines, GlaxoSmithKline Biologicals, Rixensart, Belgium

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  • Alex Owusu,

    Affiliation: World Wide Clinical Development – Malaria Vaccines, GlaxoSmithKline Biologicals, Rixensart, Belgium

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  • Marie-Claude Dubois,

    Affiliation: World Wide Clinical Development – Malaria Vaccines, GlaxoSmithKline Biologicals, Rixensart, Belgium

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  • Joe Cohen,

    Affiliation: World Wide Clinical Development – Malaria Vaccines, GlaxoSmithKline Biologicals, Rixensart, Belgium

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  • Jason N. Nixon,

    Affiliation: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    Current address: Department of Radiology, University of Washington, Seattle, Washington, United States of America,

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  • Aric Gregson,

    Affiliation: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    Current address: Division of Infectious Diseases, Department of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America

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  • Shannon L. Takala,

    Affiliation: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Kirsten E. Lyke,

    Affiliation: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Christopher V. Plowe mail

    To whom correspondence should be addressed. E-mail: cplowe@medicine.umaryland.edu

    Affiliation: Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Published: January 23, 2008
  • DOI: 10.1371/journal.pone.0001465

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