Functional Inactivation of EBV-Specific T-Lymphocytes in Nasopharyngeal Carcinoma: Implications for Tumor Immunotherapy

• Jiang Li,

  Affiliations State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China

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• Xue-hui Zeng,

  Affiliation Institute of Molecular Immunology, School of Biotechnology, Technology University of Southern China, Guangzhou, China

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• Hao-yuan Mo,

  Affiliations Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China

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• Ulrika Rolén,

  Affiliation Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden

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• Yan-fang Gao,

  Affiliations Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China

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• Xiao-shi Zhang,

  Affiliations Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China

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• Qiu-yan Chen,

  Affiliations Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China

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• Li Zhang,

  Affiliations Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China

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• Mu-sheng Zeng,

  Affiliations State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China

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• Man-zhi Li,

  Affiliations State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China

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• Wen-lin Huang,

  Affiliations State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China

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• Xiao-ning Wang,

  Affiliation Institute of Molecular Immunology, School of Biotechnology, Technology University of Southern China, Guangzhou, China

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• Yi-Xin Zeng ,

  *To whom correspondence should be addressed. E-mail: maria.masucci@ki.se (MM); zengyxi@mail.sysu.edu.cn (YZ)

  Affiliations State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-sen University, Guangzhou, China, Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, China

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• Maria G. Masucci

  *To whom correspondence should be addressed. E-mail: maria.masucci@ki.se (MM); zengyxi@mail.sysu.edu.cn (YZ)

  Affiliation Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden

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