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Research Article

Site-Directed Mutations in the C-Terminal Extension of Human αB-Crystallin Affect Chaperone Function and Block Amyloid Fibril Formation

  • Teresa M. Treweek,

    Affiliations: Department of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia, Graduate School of Medicine, University of Wollongong, Wollongong, New South Wales, Australia

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  • Heath Ecroyd,

    Affiliation: School of Chemistry and Physics, The University of Adelaide, Adelaide, South Australia, Australia

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  • Danielle M. Williams,

    Affiliation: School of Chemistry and Physics, The University of Adelaide, Adelaide, South Australia, Australia

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  • Sarah Meehan,

    Affiliation: The University Chemical Laboratory, University of Cambridge, Cambridge, United Kingdom

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  • John A. Carver,

    Affiliation: School of Chemistry and Physics, The University of Adelaide, Adelaide, South Australia, Australia

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  • Mark J. Walker mail

    To whom correspondence should be addressed. E-mail: mwalker@uow.edu.au

    Affiliation: School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia

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  • Published: October 17, 2007
  • DOI: 10.1371/journal.pone.0001046

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