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Research Article

Deletion of Genes Implicated in Protecting the Integrity of Male Germ Cells Has Differential Effects on the Incidence of DNA Breaks and Germ Cell Loss

  • Catriona Paul,

    Affiliation: Medical Research Council Human Reproductive Sciences Unit, Queen's Medical Research Institute, Edinburgh, United Kingdom

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  • Joanne E. Povey,

    Affiliation: Sir Alastair Currie Cancer Research United Kingdom Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Nicola J. Lawrence,

    Affiliation: Sir Alastair Currie Cancer Research United Kingdom Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Jim Selfridge,

    Affiliation: Sir Alastair Currie Cancer Research United Kingdom Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • David W. Melton,

    Affiliation: Sir Alastair Currie Cancer Research United Kingdom Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

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  • Philippa T. K. Saunders mail

    To whom correspondence should be addressed. E-mail: p.saunders@ed.ac.uk

    Affiliation: Medical Research Council Human Reproductive Sciences Unit, Queen's Medical Research Institute, Edinburgh, United Kingdom

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  • Published: October 03, 2007
  • DOI: 10.1371/journal.pone.0000989

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