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Research Article

Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold Optimization

  • Matthew D. Smith,

    Affiliations: Center for BioOptical Nanotechnology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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  • Matthew A. Rosenow,

    Affiliations: Center for BioOptical Nanotechnology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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  • Meitian Wang,

    Affiliation: Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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  • James P. Allen,

    Affiliation: Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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  • Jack W. Szostak,

    Affiliation: Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • John C. Chaput mail

    To whom correspondence should be addressed. E-mail: john.chaput@asu.edu

    Affiliations: Center for BioOptical Nanotechnology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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  • Published: May 23, 2007
  • DOI: 10.1371/journal.pone.0000467

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