Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold Optimization

• Matthew D. Smith,

  Affiliations Center for BioOptical Nanotechnology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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• Matthew A. Rosenow,

  Affiliations Center for BioOptical Nanotechnology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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• Meitian Wang,

  Affiliation Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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• James P. Allen,

  Affiliation Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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• Jack W. Szostak,

  Affiliation Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• John C. Chaput

  *To whom correspondence should be addressed. E-mail: john.chaput@asu.edu

  Affiliations Center for BioOptical Nanotechnology, The Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, United States of America

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