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Research Article

A Critical Role for FBXW8 and MAPK in Cyclin D1 Degradation and Cancer Cell Proliferation

  • Hiroshi Okabe,

    Affiliations: Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, California, United States of America, UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Sang-Hyun Lee,

    Affiliations: Cancer Research Institute, School of Medicine, University of California San Francisco, San Francisco, California, United States of America, UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Janyaporn Phuchareon,

    Affiliations: Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, California, United States of America, UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Donna G. Albertson,

    Affiliations: Cancer Research Institute, School of Medicine, University of California San Francisco, San Francisco, California, United States of America, UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Frank McCormick,

    Affiliations: Cancer Research Institute, School of Medicine, University of California San Francisco, San Francisco, California, United States of America, UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Osamu Tetsu mail

    To whom correspondence should be addressed. E-mail: tetsu@cc.ucsf.edu

    Affiliations: Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, California, United States of America, UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, San Francisco, California, United States of America

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  • Published: December 27, 2006
  • DOI: 10.1371/journal.pone.0000128

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