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Research Article

Experimental Rugged Fitness Landscape in Protein Sequence Space

  • Yuuki Hayashi,

    Affiliation: Department of Bioinformatic Engineering, Osaka University, Suita, Osaka, Japan

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  • Takuyo Aita,

    Affiliations: Rational Evolutionary Design of Advanced Biomolecules (REDS) Group/JST, Saitama Small Enterprise Promotion Corporation SKIP City, Kawaguchi, Saitama, Japan, Department of Functional Materials Science, Saitama University, Saitama, Japan

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  • Hitoshi Toyota,

    Affiliation: Department of Biotechnology, Osaka University, Suita, Osaka, Japan

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  • Yuzuru Husimi,

    Affiliation: Department of Functional Materials Science, Saitama University, Saitama, Japan

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  • Itaru Urabe,

    Affiliation: Department of Biotechnology, Osaka University, Suita, Osaka, Japan

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  • Tetsuya Yomo mail

    To whom correspondence should be addressed. E-mail: yomo@ist.osaka-u.ac.jp

    Affiliations: Department of Bioinformatic Engineering, Osaka University, Suita, Osaka, Japan, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan, Expoloratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), Suita, Osaka, Japan

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  • Published: December 20, 2006
  • DOI: 10.1371/journal.pone.0000096

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