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Research Article

Critical Role of Methylglyoxal and AGE in Mycobacteria-Induced Macrophage Apoptosis and Activation

  • Helmy Rachman,

    Affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

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  • Nayoung Kim,

    Affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

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  • Timo Ulrichs,

    Affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

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  • Sven Baumann,

    Affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

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  • Lydia Pradl,

    Affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

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  • Ali Nasser Eddine,

    Affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

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  • Matthias Bild,

    Affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

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  • Marion Rother,

    Affiliation: Max Planck Institute for Infection Biology, Department of Molecular Biology, Berlin, Germany

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  • Ralf-Jürgen Kuban,

    Affiliation: Laboratory of Functional Genomics, Charité, Universitätsmedizin Berlin, Berlin, Germany

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  • Jong Seok Lee,

    Affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

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  • Robert Hurwitz,

    Affiliation: Max Planck Institute for Infection Biology, Core Facility, Berlin, Germany

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  • Volker Brinkmann,

    Affiliation: Max Planck Institute for Infection Biology, Core Facility, Berlin, Germany

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  • George A. Kosmiadi,

    Affiliation: Central Tuberculosis Research Institute, Department of Immunology 2, Moscow, Russian Federation

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  • Stefan H.E. Kaufmann mail

    To whom correspondence should be addressed. E-mail: kaufmann@mpiib-berlin.mpg.de

    Affiliation: Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

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  • Published: December 20, 2006
  • DOI: 10.1371/journal.pone.0000029

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