Inhibition of Ceramide Metabolism Sensitizes Human Leukemia Cells to Inhibition of BCL2-Like Proteins

• Lavona Casson,

  Affiliation Division of Hematology and Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America

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• Lauren Howell,

  Affiliation Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy at the Medical School of South Carolina, Charleston, South Carolina, United States of America

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• Lesley A. Mathews,

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

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• Marc Ferrer,

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

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• Noel Southall,

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

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• Rajarshi Guha,

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

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• Jonathan M. Keller,

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

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• Craig Thomas,

  Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

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• Leah J. Siskind ,

  Contributed equally to this work with: Leah J. Siskind, Levi J. Beverly

  * E-mail: Levi.Beverly@Louisville.edu (LJB); Siskind@MUSC.edu (LJS)

  Affiliations Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy at the Medical School of South Carolina, Charleston, South Carolina, United States of America, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina, United States of America

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• Levi J. Beverly

  Contributed equally to this work with: Leah J. Siskind, Levi J. Beverly

  * E-mail: Levi.Beverly@Louisville.edu (LJB); Siskind@MUSC.edu (LJS)

  Previous address: Cancer Biology and Genetics Section, Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  Affiliation Division of Hematology and Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America

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