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Open Access

Peer-reviewed

Research Article

Age-Dependent Changes in the Sphingolipid Composition of Mouse CD4+ T Cell Membranes and Immune Synapses Implicate Glucosylceramides in Age-Related T Cell Dysfunction

  • Alberto Molano,

    Affiliation Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

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  • Zhaofeng Huang,

    Current address: Zhongshan Medical School, Sun Yat-Sen University, Guangzhou, Guangdong, China

    Affiliation Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

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  • Melissa G. Marko,

    Affiliation Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

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  • Angelo Azzi,

    Affiliation Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

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  • Dayong Wu,

    Affiliation Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

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  • Elaine Wang,

    Affiliation The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Samuel L. Kelly,

    Affiliation The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Alfred H. Merrill Jr,

    Affiliation The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America

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  • Stephen C. Bunnell ,

    stephen.bunnell@tufts.edu (SCB); simin.meydani@tufts.edu (SNM)

    Affiliation Department of Pathology, Sackler Graduate School of Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America

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  • Simin Nikbin Meydani

    stephen.bunnell@tufts.edu (SCB); simin.meydani@tufts.edu (SNM)

    Affiliations Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America, Department of Pathology, Sackler Graduate School of Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America

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