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Repeatability of and Relationship between Potential COPD Biomarkers in Bronchoalveolar Lavage, Bronchial Biopsies, Serum, and Induced Sputum

  • Stefan Röpcke ,

    Contributed equally to this work with: Stefan Röpcke, Olaf Holz

    Affiliation Department of Biomarker Development, Nycomed GmbH, Konstanz, Germany

  • Olaf Holz ,

    Contributed equally to this work with: Stefan Röpcke, Olaf Holz

    olaf.holz@item.fraunhofer.de

    Affiliations Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany

  • Gereon Lauer,

    Affiliation Department of Biomarker Development, Nycomed GmbH, Konstanz, Germany

  • Meike Müller,

    Affiliation Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany

  • Susanne Rittinghausen,

    Affiliation Department of Toxicology and Environmental Hygiene, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany

  • Peter Ernst,

    Affiliation GeneData AG, Basel, Switzerland

  • Gezim Lahu,

    Affiliation Department of Biomarker Development, Nycomed GmbH, Konstanz, Germany

  • Martin Elmlinger,

    Affiliation Department of Biomarker Development, Nycomed GmbH, Konstanz, Germany

  • Norbert Krug,

    Affiliations Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany

  • Jens M. Hohlfeld

    Affiliations Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany

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