Violacein Induces Death of Resistant Leukaemia Cells via Kinome Reprogramming, Endoplasmic Reticulum Stress and Golgi Apparatus Collapse

• Karla C. S. Queiroz,

  Affiliations Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Biochemistry, Institute of Biology, University of Campinas, Brazil (UNICAMP), Campinas, São Paulo, Brazil

  ⨯
• Renato Milani,

  Affiliation Department of Biochemistry, Institute of Biology, University of Campinas, Brazil (UNICAMP), Campinas, São Paulo, Brazil

  ⨯
• Roberta R. Ruela-de-Sousa,

  Affiliations Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Biochemistry, Institute of Biology, University of Campinas, Brazil (UNICAMP), Campinas, São Paulo, Brazil

  ⨯
• Gwenny M. Fuhler,

  Affiliation Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands

  ⨯
• Giselle Z. Justo,

  Affiliation Department of Cell Biology and Department of Biochemistry, Federal University of São Paulo (UNIFESP), São Paulo, São Paulo, Brazil

  ⨯
• Willian F. Zambuzzi,

  Affiliations Multidisciplinary Lab in Dental Research, Heath Sciences School, University of Grande Rio (UNIGRANRIO), Rio de Janeiro, Brazil, Biotechnology Lab, Bioengineering Sector, National Institute of Metrology, Quality and Technology (Inmetro), Duque de Caxias, Rio de Janeiro, Brazil

  ⨯
• Nelson Duran,

  Affiliation Biological Chemistry Laboratory, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

  ⨯
• Sander H. Diks,

  Affiliation Beatrix Children's Hospital, Department of Pediatric Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

  ⨯
• C. Arnold Spek,

  Affiliation Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  ⨯
• Carmen V. Ferreira,

  Affiliation Department of Biochemistry, Institute of Biology, University of Campinas, Brazil (UNICAMP), Campinas, São Paulo, Brazil

  ⨯
• Maikel P. Peppelenbosch

  * E-mail: M.Peppelenbosch@erasmusmc.nl

  Affiliation Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands

  ⨯