Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

• Adaikalavan Ramasamy ,

  Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

  Affiliations Respiratory Epidemiology and Public Health, Imperial College London, London, United Kingdom, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, Department of Medical and Molecular Genetics, King’s College London, London, United Kingdom

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• Mikko Kuokkanen ,

  Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

  Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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• Sailaja Vedantam ,

  Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

  Affiliations Divisions of Genetics and Endocrinology, Children’s Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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• Zofia K. Gajdos ,

  Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

  Affiliations Divisions of Genetics and Endocrinology, Children’s Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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• Alexessander Couto Alves,

  Affiliation Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

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• Helen N. Lyon,

  Affiliations Divisions of Genetics and Endocrinology, Children’s Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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• Manuel A. R. Ferreira,

  Affiliation The Queensland Institute of Medical Research, Brisbane, Australia

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• David P. Strachan,

  Affiliation Division of Community Health Sciences, St George’s, University of London, London, United Kingdom

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• Jing Hua Zhao,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom

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• Michael J. Abramson,

  Affiliation Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia,

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• Matthew A. Brown,

  Affiliation University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia

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• Lachlan Coin,

  Affiliation Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

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• Shyamali C. Dharmage,

  Affiliation Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia

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• David L. Duffy,

  Affiliation The Queensland Institute of Medical Research, Brisbane, Australia

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• Tari Haahtela,

  Affiliation Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland

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• Andrew C. Heath,

  Affiliation Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Christer Janson,

  Affiliation Department of Medical Sciences: Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden

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• Mika Kähönen,

  Affiliation Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland

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• Kay-Tee Khaw,

  Affiliation Clinical Gerontology Unit, Addenbrooke’s Hospital, Cambridge, United Kingdom

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• Jaana Laitinen,

  Affiliation Finnish Institute of Occupational Health, Oulu, Finland

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• Peter Le Souef,

  Affiliation School of Paediatrics and Child Health, Princess Margaret Hospital for Children, Perth, Australia

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• Terho Lehtimäki,

  Affiliation Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland

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• Australian Asthma Genetics Consortium collaborators ,

  ¶Collaborators of the Asthma Genetics Consortium are listed in Supplementary Methods S1.

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• Pamela A. F. Madden,

  Affiliation Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Guy B. Marks,

  Affiliation Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia

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• Nicholas G. Martin,

  Affiliation The Queensland Institute of Medical Research, Brisbane, Australia

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• Melanie C. Matheson,

  Affiliation Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia

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• Cameron D. Palmer,

  Affiliations Divisions of Genetics and Endocrinology, Children’s Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

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• Aarno Palotie,

  Affiliations Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland, Medical and Population Genetics and Genetic Analysis Platform, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

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• Anneli Pouta,

  Affiliations Department of Children, Young People and Families, National Institute for Health and Welfare, Helsinki, Finland, Institute of Clinical Medicine/Obstetrics and Gynecology, University of Oulu, Oulu, Finland

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• Colin F. Robertson,

  Affiliation Respiratory Medicine, Murdoch Children’s Research Institute, Melbourne, Australia

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• Jorma Viikari,

  Affiliation Department of Medicine, University of Turku, Turku, Finland

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• Elisabeth Widen,

  Affiliation Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

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• Matthias Wjst,

  Affiliation Helmholtz Zentrum Munchen German Research Center for Environmental Health, Munich-Neuherberg, Germany

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• Deborah L. Jarvis,

  Affiliations Respiratory Epidemiology and Public Health, Imperial College London, London, United Kingdom, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, United Kingdom

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• Grant W. Montgomery,

  Affiliation The Queensland Institute of Medical Research, Brisbane, Australia

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• Philip J. Thompson,

  Affiliation Lung Institute of Western Australia and Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, Australia

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• Nick Wareham,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom

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• Johan Eriksson,

  Affiliations National Institute for Health and Welfare, Helsinki, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland, Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Folkhälsan Research Center, Helsinki, Finland

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• Pekka Jousilahti,

  Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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• Tarja Laitinen,

  Affiliations Department of Pulmonary Diseases and Clinical Allergology, Turku University Hospital, Turku, Finland, University of Turku, Turku, Finland

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• Juha Pekkanen,

  Affiliations Department of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

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• Olli T. Raitakari,

  Affiliations Research Centre of Applied and Preventive Medicine, University of Turku, Turku, Finland, Department of Clinical Physiology, Turku University Hospital, Turku, Finland

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• George T. O'Connor,

  Affiliations Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, The National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America

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• Veikko Salomaa ,

  Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

  * E-mail: joelh@broadinstitute.org (JNH); m.jarvelin@imperial.ac.uk (M-RJ); veikko.salomaa@thl.fi (VS)

  Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

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• Marjo-Riitta Jarvelin ,

  Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

  * E-mail: joelh@broadinstitute.org (JNH); m.jarvelin@imperial.ac.uk (M-RJ); veikko.salomaa@thl.fi (VS)

  Affiliations Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom, MRC Health Protection Agency (HPA) Centre for Environment and Health, Imperial College London, London, United Kingdom, National Institute for Health and Welfare, Helsinki, Finland, Institute of Health Sciences, University of Oulu, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland

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•  [ ... ],
• Joel N. Hirschhorn

  Contributed equally to this work with: Adaikalavan Ramasamy, Mikko Kuokkanen, Sailaja Vedantam, Zofia K. Gajdos, Veikko Salomaa, Marjo-Riitta Jarvelin, Joel N. Hirschhorn

  * E-mail: joelh@broadinstitute.org (JNH); m.jarvelin@imperial.ac.uk (M-RJ); veikko.salomaa@thl.fi (VS)

  Affiliations Divisions of Genetics and Endocrinology, Children’s Hospital, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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