Progression to AIDS in South Africa Is Associated with both Reverting and Compensatory Viral Mutations

• Kuan-Hsiang Gary Huang ,

  Contributed equally to this work with: Kuan-Hsiang Gary Huang, Dominique Goedhals

  Affiliations Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom, The James Martin 21st Century School, Oxford, United Kingdom

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• Dominique Goedhals ,

  Contributed equally to this work with: Kuan-Hsiang Gary Huang, Dominique Goedhals

  Affiliations University of Free State, Bloemfontein, South Africa, National Health Laboratory Services (NHLS), Johannesburg, South Africa

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• Jonathan M. Carlson,

  Affiliation eScience Group, Microsoft Research, Los Angeles, California, United States of America

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• Mark A. Brockman,

  Affiliations Simon Fraser University, Burnaby, British Columbia, Canada, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada, Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology (MIT), Boston, Massachusetts, United States of America

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• Swati Mishra,

  Affiliation Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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• Zabrina L. Brumme,

  Affiliations Simon Fraser University, Burnaby, British Columbia, Canada, British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada, Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology (MIT), Boston, Massachusetts, United States of America

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• Stephen Hickling,

  Affiliation Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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• Christopher S. W. Tang,

  Affiliation Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

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• Toshiyuki Miura,

  Affiliations Ragon Institute of Massachusetts General Hospital, Harvard University and Massachusetts Institute of Technology (MIT), Boston, Massachusetts, United States of America, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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• Chris Seebregts,

  Affiliation Biomedical Informatics Research Division, Medical Research Council, Cape Town, South Africa

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• David Heckerman,

  Affiliation eScience Group, Microsoft Research, Los Angeles, California, United States of America

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• Thumbi Ndung'u,

  Affiliation HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa

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• Bruce Walker,

  Affiliations HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa, Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of AIDS, Harvard University, Boston, Massachusetts, United States of America

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• Paul Klenerman,

  Affiliations Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom

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• Dewald Steyn,

  Affiliation University of Free State, Bloemfontein, South Africa

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• Philip Goulder,

  Affiliation Department of Paediatrics, University of Oxford, Oxford, United Kingdom

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• Rodney Phillips,

  Affiliations Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom, The James Martin 21st Century School, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom

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• Bloemfontein-Oxford Collaborative Group,
• Cloete van Vuuren,

  Affiliation University of Free State, Bloemfontein, South Africa

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•  [ ... ],
• John Frater

  * E-mail: john.frater@ndm.ox.ac.uk

  Affiliations Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom

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