Single Cell Genome Amplification Accelerates Identification of the Apratoxin Biosynthetic Pathway from a Complex Microbial Assemblage

• Rashel V. Grindberg,

  Affiliation Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Thomas Ishoey,

  Affiliation J. Craig Venter Institute, San Diego, California, United States of America

  ⨯
• Dumitru Brinza,

  Affiliation Department of Computer Science and Engineering, Center for Algorithmic and Systems Biology, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Eduardo Esquenazi,

  Affiliations Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

  ⨯
• R. Cameron Coates,

  Affiliation Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Wei-ting Liu,

  Affiliation Departments of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Lena Gerwick,

  Affiliation Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Pieter C. Dorrestein,

  Affiliations Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America, Departments of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Pavel Pevzner,

  Affiliation Department of Computer Science and Engineering, Center for Algorithmic and Systems Biology, University of California San Diego, La Jolla, California, United States of America

  ⨯
• Roger Lasken,

  Affiliation J. Craig Venter Institute, San Diego, California, United States of America

  ⨯
• William H. Gerwick

  * E-mail: wgerwick@ucsd.edu

  Affiliations Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, United States of America, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America

  ⨯