Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

• A. David Smith ,

  Contributed equally to this work with: A. David Smith, Helga Refsum

  * E-mail: david.smith@pharm.ox.ac.uk

  Affiliations Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom, University Department of Pharmacology and Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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• Stephen M. Smith,

  Affiliation Department of Clinical Neurology, Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom

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• Celeste A. de Jager,

  Affiliation Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

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• Philippa Whitbread,

  Affiliation Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

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• Carole Johnston,

  Affiliations Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom, University Department of Pharmacology and Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

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• Grzegorz Agacinski,

  Affiliation Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

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• Abderrahim Oulhaj,

  Affiliation Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom

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• Kevin M. Bradley,

  Affiliation Department of Radiology and Nuclear Medicine, Oxford Radcliffe Hospitals NHS Trust, Oxford, United Kingdom

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• Robin Jacoby,

  Affiliation University Department of Psychiatry, University of Oxford, Oxford, United Kingdom

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• Helga Refsum

  Contributed equally to this work with: A. David Smith, Helga Refsum

  Affiliations Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, Oxford, United Kingdom, University Department of Pharmacology and Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

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