Limitations of Ab Initio Predictions of Peptide Binding to MHC Class II Molecules

Hao Zhang; Peng Wang; Nikitas Papangelopoulos; Ying Xu; Alessandro Sette; Philip E. Bourne; Ole Lund; Julia Ponomarenko; Morten Nielsen; Bjoern Peters

doi:10.1371/journal.pone.0009272

Loading metrics

Open Access

Peer-reviewed

Research Article

Limitations of Ab Initio Predictions of Peptide Binding to MHC Class II Molecules

Hao Zhang ,

Contributed equally to this work with: Hao Zhang, Peng Wang, Nikitas Papangelopoulos

Affiliation Center for Biological Sequence Analysis, Department for Systems Biology, Technical University of Denmark, Lyngby, Denmark
⨯
Peng Wang ,

Contributed equally to this work with: Hao Zhang, Peng Wang, Nikitas Papangelopoulos

Affiliation La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
⨯
Nikitas Papangelopoulos ,

Contributed equally to this work with: Hao Zhang, Peng Wang, Nikitas Papangelopoulos

Affiliation San Diego Supercomputer Center and Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America
⨯
Ying Xu,

Affiliation Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America
⨯
Alessandro Sette,

Affiliation La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
⨯
Philip E. Bourne,

Affiliation San Diego Supercomputer Center and Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America
⨯
Ole Lund,

Affiliation Center for Biological Sequence Analysis, Department for Systems Biology, Technical University of Denmark, Lyngby, Denmark
⨯
Julia Ponomarenko,

Affiliation San Diego Supercomputer Center and Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America
⨯
Morten Nielsen,

Affiliation Center for Biological Sequence Analysis, Department for Systems Biology, Technical University of Denmark, Lyngby, Denmark
⨯
Bjoern Peters

* E-mail: bpeters@liai.org

Affiliation La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
⨯

Limitations of Ab Initio Predictions of Peptide Binding to MHC Class II Molecules

Hao Zhang,
Peng Wang,
Nikitas Papangelopoulos,
Ying Xu,
Alessandro Sette,
Philip E. Bourne,
Ole Lund,
Julia Ponomarenko,
Morten Nielsen,
Bjoern Peters

x

Published: February 17, 2010
https://doi.org/10.1371/journal.pone.0009272

Viewed

Cited

Saved

Discussed

Powered by Altmetric

Questions or concerns about usage data? Please let us know.

Print

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Major histocompatibility complex
Is the Subject Area "Major histocompatibility complex" applicable to this article?

Thanks for your feedback.
Free energy
Is the Subject Area "Free energy" applicable to this article?

Thanks for your feedback.
Forecasting
Is the Subject Area "Forecasting" applicable to this article?

Thanks for your feedback.
Biochemical simulations
Is the Subject Area "Biochemical simulations" applicable to this article?

Thanks for your feedback.
Molecular dynamics
Is the Subject Area "Molecular dynamics" applicable to this article?

Thanks for your feedback.
Molecular structure
Is the Subject Area "Molecular structure" applicable to this article?

Thanks for your feedback.
Protein structure
Is the Subject Area "Protein structure" applicable to this article?

Thanks for your feedback.
Protein structure prediction
Is the Subject Area "Protein structure prediction" applicable to this article?

Thanks for your feedback.