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Adaptor SKAP-55 Binds p21ras Activating Exchange Factor RasGRP1 and Negatively Regulates the p21ras-ERK Pathway in T-Cells

  • Helga Schneider ,

    Contributed equally to this work with: Helga Schneider, Hongyan Wang

    Affiliations Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

  • Hongyan Wang ,

    Contributed equally to this work with: Helga Schneider, Hongyan Wang

    Affiliations Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom, Cambridge Institute for Medical Research, Cambridge, United Kingdom

  • Monika Raab,

    Affiliations Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom, Department of Gynecology and Obstetrics, Medical School, Johann Wolfgang Goethe-University, Frankfurt, Germany

  • Elke Valk,

    Affiliations Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

  • Xin Smith,

    Affiliation Cambridge Institute for Medical Research, Cambridge, United Kingdom

  • Matt Lovatt,

    Affiliation Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

  • Zhonglin Wu,

    Affiliations Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom

  • Braudel Maqueira-Iglesias,

    Affiliation Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom

  • Klaus Strebhardt,

    Affiliation Department of Gynecology and Obstetrics, Medical School, Johann Wolfgang Goethe-University, Frankfurt, Germany

  • Christopher E. Rudd

    To whom correspondence should be addressed. E-mail: cer51@cam.ac.uk

    Affiliations Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom, Molecular Immunology Section, Division of Investigative Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom, Cambridge Institute for Medical Research, Cambridge, United Kingdom

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