The following reference was omitted from the article: Wen R, Cheng T, Li Y, Cao W, Steinberg RH. Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage. J Neurosci. 1996 Oct 1;16(19):5986-92. Our findings were supported by the work of Wen et al. who showed a protection of light induced photoreceptor degeneration after multiple injections of xylazine (4 to 7 injections). The protective mechanism by xylazine, an a2-agonist has been traced back to the expression of bFGF. However these findings were shown for a different light damage paradigm (7 days of light exposure) compared to the one used in this present study (single exposure for 2h). Additionally, our study investigated the effect of a single application, rather than multiple injections, of xylazine/ketamine, thus mimicking the widely used paradigm for procedural anesthesia in rodents.
Citation: Arango-Gonzalez B, Schatz A, Bolz S, Eslava-Schmalbach J, Willmann G, Zhour A, et al. (2012) Correction: Effects of Combined Ketamine/Xylazine Anesthesia on Light Induced Retinal Degeneration in Rats. PLoS ONE 7(8): 10.1371/annotation/d52a610e-6a56-4158-90bf-45e37f053567. https://doi.org/10.1371/annotation/d52a610e-6a56-4158-90bf-45e37f053567
Published: August 06, 2012
Copyright: © 2012 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing interests: No competing interests declared.