Scoping Review of the Zika Virus Literature

Lisa A. Waddell; Judy D. Greig

doi:10.1371/journal.pone.0156376

Abstract

The global primary literature on Zika virus (ZIKV) (n = 233 studies and reports, up to March 1, 2016) has been compiled using a scoping review methodology to systematically identify and characterise the literature underpinning this broad topic using methods that are documented, updateable and reproducible. Our results indicate that more than half the primary literature on ZIKV has been published since 2011. The articles mainly covered three topic categories: epidemiology of ZIKV (surveillance and outbreak investigations) 56.6% (132/233), pathogenesis of ZIKV (case symptoms/ outcomes and diagnosis) 38.2% (89/233) and ZIKV studies (molecular characterisation and in vitro evaluation of the virus) 18.5% (43/233). There has been little reported in the primary literature on ZIKV vectors (12/233), surveillance for ZIKV (13/233), diagnostic tests (12/233) and transmission (10/233). Three papers reported on ZIKV prevention/control strategies, one investigated knowledge and attitudes of health professionals and two vector mapping studies were reported. The majority of studies used observational study designs, 89.7% (209/233), of which 62/233 were case studies or case series, while fewer (24/233) used experimental study designs. Several knowledge gaps were identified by this review with respect to ZIKV epidemiology, the importance of potential non-human primates and other hosts in the transmission cycle, the burden of disease in humans, and complications related to human infection with ZIKV. Historically there has been little research on ZIKV; however, given its current spread through Australasia and the Americas, research resources are now being allocated to close many of the knowledge gaps identified in this scoping review. Future updates of this project will probably demonstrate enhanced evidence and understanding of ZIKV and its impact on public health.

Citation: Waddell LA, Greig JD (2016) Scoping Review of the Zika Virus Literature. PLoS ONE 11(5): e0156376. https://doi.org/10.1371/journal.pone.0156376

Editor: Caroline Quach, McGill University Health Centre, CANADA

Received: April 4, 2016; Accepted: May 13, 2016; Published: May 31, 2016

Copyright: © 2016 Waddell, Greig. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Availability: All relevant data are within the paper and its Supporting Information files. All relevant studies are listed in the reference list; references are publicly available.

Funding: This study was funded through the Public Health Agency of Canada (http://www.phac-aspc.gc.ca). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests: The authors have declared that no competing interests exist.

Introduction

Zika virus (ZIKV) was first identified in rhesus monkeys in the Zika forest of Uganda in 1947 and has circulated in Africa and Asia relatively unnoticed for sixty years [1]. It is a Flavivirus transmitted by Aedes spp. mosquitoes, particularly Aedes aegypti, and infection is frequently asymptomatic. Clinical manifestations include rash, mild fever, arthralgia, conjunctivitis, myalgia, retro-orbital pain, headache and cutaneous maculopapular rash [2]. The epidemiology of ZIKV changed in 2007 when an outbreak occurred on Yap Island of the Federated States of Micronesia; this was the first report of infection outside of Africa or Asia. In 2013–2014 outbreaks occurred in New Caledonia, French Polynesia, the Cook Islands, Easter Island, Vanuatu, Samoa, Brazil (2015) and currently (March 2016) 31 countries in the Americas have reported autochthonous transmission [3]. With the geographic spread, a previously unreported clinical pattern began to emerge with an increase in cases of Guillain-Barré syndrome (French Polynesia) and a rise in infants born with microcephaly in Brazil [4].

A systematic summary of the global scientific knowledge regarding ZIKV and effective prevention and control measures is required to support evidence-informed decision making concerning this emerging public health issue. Scoping reviews are a synthesis method designed to address broad, often policy-driven research questions [5–7] by identifying all the relevant evidence concerning the issue and producing summaries of the findings [5,6,8]. Scoping reviews, similar to systematic reviews, follow a structured protocol for the identification and characterisation of the literature in a manner that is both reproducible and updateable [5,6,9]. Unlike a systematic review, a scoping review is well-suited to the identification of evidence on a broad topic, but does not include a quality assessment or in depth data extraction stage that would be required for meta-analysis of studies. Systematic reviews may be prioritized as a next step based on the results of a scoping review if adequate research exists on specific questions of interest [9,10]. Another important output of a scoping review is the identification of where evidence is lacking or non-existent to help direct future research and use of resources.

Objective

In response to the current ZIKV outbreaks and changes in its epidemiology, a scoping review was conducted to capture all published literature addressing the following aspects of ZIKV: 1) ZIKV infection in humans, any host or vector—pathogenesis, epidemiology, diagnosis, conditions for virus transmission, and surveillance for ZIKV, 2) studies on ZIKV—pathogenesis, transmission and molecular mechanisms, 3) prevention strategies to prevent ZIKV infections and/or control of ZIKV harbouring vectors, and 4) societal knowledge, perception and attitudes towards ZIKV.

Methods

Review protocol, team and expertise

To ensure the scoping review methods were reproducible, transparent and consistent, a scoping review protocol was developed a priori. The protocol, list of definitions, search algorithms, abstract screening form and data characterization and utility form (DCU) are available upon request. The location of the repository of relevant articles and the dataset resulting from this review is available upon request.

The review team consisted of individuals with multi-disciplinary expertise in epidemiology, microbiology, veterinary public health, knowledge synthesis and information science.

Review question and scope

This scoping review was conducted to answer the following question: What is the current state of the evidence on ZIKV pathogenesis, epidemiology, risk factors, diagnosis, surveillance methods, prevention and control strategies and, knowledge, societal attitudes and perceptions towards infections in humans, mosquito vectors and animal reservoirs?

Search strategy

To ensure the search was comprehensive the term “zika” was implemented in the following bibliographic databases on January 27 2016 and updated March 1, 2016: Scopus, PubMed/MEDLINE, Embase, CINAHL (Cumulative Index to Nursing & Allied Health), CAB, LILACS (South American), Agricola and the COCHRANE library for any relevant trials in the trial registry. No limits were placed on the search and it was pretested in Scopus.

The capacity of the electronic search to identify all relevant primary research was verified by hand searching the reference lists of three ZIKV risk assessments, 19 literature reviews. Reference lists of the 3 risk assessments [11–13] and 19 selected relevant literature reviews were evaluated for additional research that had been omitted by the bibliographic database search [14–29]. From this exercise 34 grey literature reports with primary information and peer-reviewed primary literature articles were identified and added to the scoping review process.

Additional grey literature was identified by hand-searching the websites of the World Health Organisation (http://www.who.int/csr/disease/zika/en/), Pan American Health Organisation (http://www.paho.org/hq/index.php?option=com_content&view=article&id=11585&Itemid=41688&lang=en), Center for Disease Control and Prevention (http://www.cdc.gov/zika/index.html), Morbidity and Mortality Weekly Report (http://www.cdc.gov/mmwr/zika_reports.html), European Center for Disease Control (http://ecdc.europa.eu/en/healthtopics/zika_virus_infection/Pages/index.aspx) and ProMed-mail (http://www.promedmail.org/) for primary research reports, guidelines, epidemiological alerts, situation reports, surveillance bulletins and referenced publications that were not already captured. One hundred and eleven additional references were added to the project, many of these were guidelines / government reports and new articles that have not been indexed in the bibliographic databases yet.

Relevance screening and inclusion criteria

A screening form was developed a priori to screen abstracts, titles and keywords of identified citations. Primary peer-reviewed articles were considered relevant if they addressed one or more aspects of the research question, conducted anywhere and anytime. Presently only articles in English and French are included but articles in Spanish and Portuguese are identified and can be included when resources are available. Primary research was defined as original research where authors generated and reported their own data.

Study Characterisation and extraction

Complete articles of potentially relevant citations were reviewed using a data characterization and utility (DCU) form consisting of potentially 52 questions designed a priori to confirm article relevance, data utility and extraction of the main characteristics including reported information, study methodology, populations, intervention strategies, sampling, laboratory tests and outcome characteristics.

Scoping review management, data charting and analysis

All potentially relevant citations identified by the literature search were imported into reference management software (RefWorks 2.0, ProQuest LLC, Bethesda, Maryland, USA), where duplicates were manually removed; the list of unique citations was then imported into a web-based electronic systematic review management platform (DistillerSR, Evidence Partners, Ottawa, Canada). All stages of the scoping review from relevance screening to data extraction were conducted within this software. Two reviewers independently completed all steps of the scoping review.

Data collected in the DCU form were exported into Excel spreadsheets (Microsoft Corporation, Redmond, WA), formatted, and analyzed descriptively (frequencies and percentages) to facilitate categorization, charting and discussion.

Results

Scoping review descriptive statistics

Of the 820 abstracts and titles screened for relevance, 270 were considered potentially relevant primary research/data and the full article was obtained, data was extracted and categorized for 233 relevant primary research articles in English or French, Fig 1. Research was scarce and sporadic after the virus was first isolated in 1947, until the outbreak on Yap Island, Micronesia in 2007; the majority of primary research on ZIKV has been published since 2011, 73.0% (170/233), Fig 2.

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Fig 1. Flow of citations and articles through the scoping review process last updated March 1, 2016.

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Fig 2. Number of primary literature publications on ZIKV by year of publication since its discovery in 1947 to search date March 1, 2016.

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The general characteristics of the included articles are described in Table 1. Most included articles were peer-reviewed 63.9% (149/233) and in English 91.0% (212/233). Fifteen articles were in languages other than French and English (Spanish (7), Portuguese (3), Chinese (3), Russian (1), and German (1)) and Fig 1. The largest body of research is now from the Americas 34.87% (81/233), followed by Australasia 24.9% (58/233) and Africa, 24.0% (56/233), the remaining research was fairly evenly distributed over the other continents. The articles mainly covered three topic categories: epidemiology of ZIKV (surveillance and outbreak investigations) 56.6% (132/233), pathogenesis of ZIKV (case symptoms/ outcomes and diagnosis) 38.2% (89/233) and ZIKV studies (molecular characterisation and in vitro evaluation of the virus) 18.5% (43/233). There has been little reported in the primary literature on ZIKV vectors (12/233), ZIKV surveillance (13/233), diagnostic tests (12/233) and transmission (10/233). Three papers reported on ZIKV prevention/control strategies [30–32], one investigated knowledge and attitudes of health professionals [33] two vector mapping studies [34,35] and one ZIKV transmission model were reported [36]. The majority of studies used observational study designs, 89.7% (209/233) of which 62/233 were case studies or case series, while fewer (24/233) used experimental study designs.

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Table 1. General characteristics of 233 included primary research publications.

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In the 233 included articles, human populations were the most frequently reported (191/233) with 15 studies focusing solely on pediatric populations (<16 years old), Table 2. Blood was the most common sample (179/191) used to evaluate ZIKV infection or seropositivity in humans, Table 2. Monkeys were the most frequently studied non-human hosts (7/13) followed by three recent studies (4 citations) on bats from which none report ZIKV isolation, Table 2. Mice were used for the majority of animal model experiments (13/15) while monkeys were used in 4/15 studies, Table 2.

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Table 2. Human and non-human host populations studied in 233 included articles.

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ZIKV virus studies

A small number of studies examined the attributes of ZIKV, Table 3. Early reports describe a 40 mμ, spherical shaped virus [37] that infects the nucleus of cells [27]. Others examined the antigenic relatedness of various Flaviviruses [26,38]. The virus growth, replication and survival in human cell lines [39] and in vivo (mice) was investigated [40] and the pathogenesis in mice has also been described [38,41,42]. The evaluation of a mouse model for virus propagation is described in three studies [42–44]; the mouse model was also used in 13 studies to identify and propagate ZIKV. In one report, researchers describe the use of chick embryos and inoculation of the yolk sac for virus propagation as being comparable to intracerebral inoculation of mice [45]. Earlier studies were identified that examined the cross neutralization tests and cross complement fixation tests on a number of new and known viruses to examine their relatedness [45] and used a monkey model to show there was no cross-immunity with yellow-fever and ZIKV [46].

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Table 3. 45 studies examined the ZIKV characteristics: genotype, molecular characterisation, pathogenic attributes and virus propagation in mice.

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ZIKV genotype was provided in 17.6% (41/233) of studies, 36 observational studies and 5 experimental studies, Table 3 [21,32,39,46–81]. One study failed to report the genotype even though sequencing was done [82]. Due to the outbreaks in Australasia since 2007 and more recently in the Americas, many of the studies reporting genotype reported the Asian type (33/41), Table 3. With respect to studies that lend evidence to the molecular characterisation of the virus, authors frequently reported the virus had been partially sequenced, provided a gene bank number or provided a phylogenic tree in the paper [21,47,50–55,57–63,66–81,83]. A number of studies discussed ZIKV genetic relatedness other Flaviviruses and the evolution of ZIKV [47,50–54,57–59,63,68,70,83]. In a few studies the evolution of the virus (12/41) was discussed or proportions of nucleotide identities across strains (5/41) were provided in the paper. A recent paper examined codon adaptation and fitness [51] and concluded that across studies no particular mutations or evidence of adaptation to a new vector would explain the recent spread through the Pacific Islands to the Americas.

Zika Vectors

Known ZIKV vectors are all mosquitos; no evidence was identified for any other type of vector. Table 4 reports on the 26 mosquito vector studies that tested 45 different mosquito species for either a natural infection with ZIKV or evaluated the mosquito species for vector competence to transmit ZIKV. Eighteen species of mosquitos were found to be positive for ZIKV during epidemiological sampling in Africa and Asia from 1956 to 2015 and eight were evaluated experimentally for vector competence, Table 4. Ae. aegypti 15/26, and Ae. africanus 10/26 were investigated most often. Ae. albopictus, a species of particular interest as a possible vector for ZIKV in North America, was evaluated for vector competence in one study and as a naturally infected vector of ZIKV in two studies.

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Table 4. Vector species evaluated in 26 studies for carriage of ZIKV or vector competence to transmit ZIKV.

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Experimental studies examining vector competence and feeding activity under laboratory conditions (24–29 C and 75–95% relative humidity) mainly focused on Ae. aegypti and provided data on infection rates, dissemination rates, transmission rates, minimum infection rate, entomologic inoculation rate or mean biting rate, Table 5. Studies on Ae. aegypti demonstrated that individual mosquitos held under laboratory conditions transmitted ZIKV 33–100% of the time and transmission of the virus occurred irrespective of whether the mosquito was engorged with a blood meal [90]. In one experiment infected Ae. aegypti transmitted ZIKV to a rhesus monkey 72 days post mosquito infection [89]. Mitigation by biological control was investigated in one experiment where the researcher examined the transferability of mosquito resistance to ZIKV between species (Ae. aegypti and Ae. formosus), however they concluded the resistance gene is complex and not easily manipulated [31].

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Table 5. Summary of eight studies on vector competence and behaviour.

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Active mosquito surveillance programs were reported in three studies in Uganda, Senegal and Burkina Faso between 1946 and 1986, where routine samples were collected [35,94,97]. Studies that conducted surveillance activities or prevalence surveys of mosquitos for ZIKV were identified from Africa and Asia and several species were implicated as possible vectors including Ae. aegypti (5 studies) and Ae. albopictus (1 study), Table 6. The results of the studies in Table 6 were not necessarily conducted when ZIKV was actively circulating.

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Table 6. Twelve studies from Africa and Asia between 1956 and 2011 that sampled mosquitos for ZIKV.

Studies were conducted as prevalence surveys or part of entomological surveillance for arboviruses.

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Several epidemiological studies examining risk factors for mosquito abundance, human exposure to mosquitos and conditions for ZIKV infected mosquitos were identified by the scoping review. Observations include some mosquito species such as Ae. aegypti are well suited to urban environments, are often trapped within homes [87] and are able to reproduce in water containers which are frequently found in homes. For example, on Yap Island during the 2007 outbreak 87% of the homes were found to have mosquito infested water containers [85,100]. Biting behaviour of mosquitos was shown to increase in the two months following rainfall and decreased at temperatures less than 13°C [97]. A study conducted in Senegal found the forest canopy and forest ground areas were more likely to yield ZIKV positive mosquitoes [91]. From 13 species of mosquitos examined, Ae. furcifer showed significant temporal variation and Ae. luteocephalus and Ae. taylori showed a significant correlation between biting and infection rates with a one month lag time [91].

A vector mapping model based on mosquito data collected in Senegal between 1972 and 2008 demonstrated ZIKV was not correlated with the incidence of other viruses, the abundance of mosquitos, mean temperature or humidity [35]. However, ZIKV was shown to increase 12% (95% CI = 5%-21%) for each additional inch of rain above the baseline, was positively correlated with Chikungunya virus at a 6 year lag time, and was correlated with Ae. fuciferi and Ae. taylori at a 13 year lag time [35]. The minimum infection rate for Ae. furcifer and Ae. taylori was 80% (95% CI = 41%-94%) lower than for Ae. luteocephalus [35].

Non-human hosts of ZIKV

Zika virus was first isolated in 1947 in a rhesus sentinel monkey used for yellow fever surveillance [1]. Subsequent studies in Africa to evaluate potential hosts of ZIKV examined a number of small mammals in the Zika forest and bats in Uganda, but failed to identify ZIKV or seroreactivity to ZIKV in any sample, Table 7 [98,101]. Surveys of various monkeys in Uganda, Gabon and Burkina Faso showed a range of seroprevalence for ZIKV from 0% to >50% in some species, Table 7 [97,102–104]. Surveys from Indonesia (1978) and Pakistan (1983) sampled a number of rodents, bats, wild birds and domestic livestock; they reported some ZIKV seropositivity in rodents, bats, ducks, horses and large domestic livestock [28,105]. One study, published in two papers, on the orangutans in the Sabah region of Malaysia reported a higher seroprevalence among free-ranging orangutans compared to the semi-captive group and higher seroprevalence among humans than orangutans [22,23]. They hypothesize that ZIKV among orangutans may be incidental infections from mosquitos that had contact with viremic humans or another sylvatic cycle [22,23]. At this time it has been experimentally demonstrated that infected mosquitos can transmit ZIKV to mice and monkeys under controlled laboratory conditions [89]. However, no studies were identified that examined the relative importance of non-human primates or other potential hosts compared to humans in the transmission cycle of ZIKV.

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Table 7. Potential host populations sampled for ZIKV in nine studies conducted between 1952 and 2016.

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Pathogenesis of ZIKV infection in rhesus monkeys has been described for two animals; the initial sentinel monkey developed fever and was viremic on day 3 of the fever. The second monkey who was subcutaneously challenged with ZIKV showed no signs of disease, but was viremic on days 4–5 and tested seropositive 30 days after exposure [1,44]. Mice were primarily used across 13 laboratory studies published between 1952 and 1976 to study pathogenesis, transmission and to propagate ZIKV, Table 8 [1,38,42,44]. Pathogenesis of ZIKV infection in mice mainly consists of degeneration of nerve cells, wide-spread softening of the brain and often porencephaly [38,42], with little effect on other major organs [38]. In one experiment challenged rats, guinea pigs and rabbits did not show signs of illness, however, the rabbits became seropositive while the guinea pigs died [38]. No ZIKV could be identified in the guinea pigs to indicate the virus had a role in the deaths [38].

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Table 8. List of studies that used an animal model to propagate ZIKV or investigate the pathology and transmission of ZIKV in mice, monkeys or other laboratory animals.

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ZIKV in humans

Epidemiology.

Studies investigating the epidemiology of ZIKV in humans (120/233) provided prevalence estimates (46) or summarized an outbreak situation (74) from 1952–2016 and included the following healthy populations: general and pediatric populations, blood donors and military personnel and acute viral fever patients as indicated in Table 9. The majority of the prevalence surveys and outbreak reports were from the Americas (44), Asia/Australasia (42) and Africa (30); some reported for more than one region. Risk factors for testing ZIKV positive were examined in three studies. On Yap Island, a study found men 77% [95% CI, 72% to 83%] were more likely to have IgM antibodies against ZIKV virus compared to women 68% [95% CI, 62% to 74%], which was a relative risk of 1.1 [95% CI, 1.0 to 1.2] [100]. Higher density housing was significantly associated with increased risk of arbovirus infections in Kenya (1970) [109]. A recent study from Zambia found that indoor residual spraying had an adjusted odds ratio of 0.81, 95% CI [0.66, 0.99] and having an iron sheet roof on the home was protective against being ZIKV seropositive. However, increasing age, farming and having a grass roof significantly increased the risk of being ZIKV seropositive [110].

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Table 9. One hundred and twenty prevalence studies and outbreak reports that report ZIKV infection in human populations published between 1952 and 2016.

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Clinical Symptoms, Complications and Pathogenesis.

Clinical symptoms associated with ZIKV illness in humans is reported in 72 studies and described in Table 10, including the first experimentally challenged human case recorded in Nigeria (1956) [88] to present cases in South America and the Caribbean region. Thirty four studies report travel related cases in individuals returning from various affected countries. Thirty five studies report on complications with ZIKV, Table 11. Publications that described the clinical features of ZIKV infection in humans were mainly case reports/case series (57/78), epidemiological surveys (12/78), outbreak investigations (11/78), and one human challenge experiment (some studies fell into multiple categories). For most studies (58/78) the total number of cases was <6 while other results summarized the clinical features of up to 13,786 cases. The majority of studies have been published in the past decade and are based on ZIKV acquired infections in South-Central America and Caribbean region (54/75) and Asia/Australasia (48/75) with a number of publications reporting on both regions. A wide range of clinical symptoms are reported for ZIKV infection, most common are mild fever and a maculopapular rash followed by joint pain, headache and more recently bilateral conjunctivitis; see the summary at the bottom of Table 10 for averages across studies. In a recent study, researchers found an association with more severe symptoms in patients that were co-infected with malaria [131]. Six studies reported co-infections with dengue and/or chikungunya [74,116,117,144,146,199], one study reported co-infection with Influenza B and another with Human Immunodeficiency Virus [81,189]. Some of these studies provide evidence for the viremic period, suggested which samples and diagnostic tests to use at various stages of infection and the possible range of incubation periods, however, only one study investigated the immune response in humans [200]. Tappe (2015), investigated the role of cytokines and chemokines in the pathogenesis of ZIKV infected patients from the acute stage (≤ 10 days after symptom onset) to convalescent stage (> 10 days after disease onset) [200].

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Table 10. Pathogenesis: Studies (n = 72) reporting on clinical symptoms in humans from the first experimentally challenged human in Nigeria (1956) to present (March 1, 2016) cases in the South America and Caribbean region divided by studies with n>6 (25.4%) and n<6 (74.6%).

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Table 11. Complications reported to be associated with ZIKV infection in 35 case reports/ case series and outbreak reports.

20 reports on birth defects and microcephaly in pregnant women (2013–2016) and 24 on Guillain-Barré syndrome following ZIKV infection (probable and confirmed) during outbreaks in the Pacific Islands and the Americas (2011–2016).

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Complications associated with ZIKV infection in humans are reported in Table 11. The research and attention concentrated on all potential complications of ZIKV has increased significantly in the last few months; we identified that many official reports and papers published the same information multiple times. A number of small case series or case studies investigating complications with ZIKV have demonstrated a chronological association between ZIKV infection in pregnant women and development of microcephaly in the fetus, ZIKV infection in fetuses and newborns from mothers exposed to ZIKV at various points during pregnancy, and ZIKV preceding neurological conditions, mainly Guillain-Barre syndrome in adults, Table 11. A significant increase in microcephaly has been reported in Brazil and a good deal of research and scrutiny of the existing data is on-going to determine the degree that ZIKV is contributing to microcephaly cases. Two studies discuss the criteria used to categorize infants as positive for microcephaly and the potential impact on the numbers reported in Brazil [247,248]; one study shows evidence of an increase in microcephaly in Brazil starting in 2012 prior to ZIKV arriving in the Americas [248]. Other birth defects have also been noted including a number of ocular abnormalities and hydrops fetalis [48,201]. Hopefully on-going cohort studies will provide better evidence for the role ZIKV plays in birth defects and fetal death. Outside of Brazil, no other country has noted the increase in microcephaly at the time of writing (March 1, 2016), however several countries in the Americas and Australasia have noted an increase in Guillain-Barré Syndrome coinciding with a ZIKV outbreak, Table 11 [146,242,246].

Transmission.

ZIKV is known to be transmitted by mosquitos; however there is also increasing evidence that intrauterine transmission and sexual transmission via semen may occur, Table 12. It has also been suggested that transmission by blood transfusion is possible, although no cases have been reported [71]. Two studies examined the efficacy of amotosalen combined with UVA light treatment of plasma and recommended that it was effective to deactivate ZIKV [30,32].

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Table 12. Studies reporting various modes of human to human transmission and one human to mosquito transmission study.

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Testing for ZIKV infection.

Serum samples were most commonly used to diagnose ZIKV infection, but other samples including saliva, nasopharyngeal swabs, urine, semen, amniotic fluid and breast milk have also been used to detect ZIKV infection with RT-PCR, Table 13. There were very few studies (9) that evaluated a diagnostic test for ZIKV and of those only 33% reported data on test performance and none reported on a commercial test, Table 14. Of note, several studies captured in this review discuss potential cross-reactivity of some dengue serology tests during the acute phases of ZIKV infection, therefore laboratories and physicians need to follow readily available guidelines [249] so appropriate samples are taken for accurate diagnosis [208,211,212,227].

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Table 13. Non-serum samples for ZIKV rtPCR testing reported in 29 studies 2013–2015.

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Table 14. Nine studies evaluated the performance of diagnostic tests for ZIKV—none were reported to be commercially available and in most studies evaluation was not on clinical samples.

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From the studies (n = 76) where details of cases and diagnosis were reported, RT-PCR was most frequently used (68.4%) followed by serology (40.8%) and virus isolation (3.9%); one study conducted a serum cytokine analysis [200]. Among the studies that used serology (n = 31), IgM was used in 80.6% of studies, IgG in 41.9% and plaque reduction neutralization tests (PRNT) in 67.7%. Four studies published before 1982 used hemagglutination-inhibition tests, complement fixation tests and neutralization tests [127,204,232,233].

Discussion

In this scoping study we identified 233 primary research papers, reports, theses and conference proceedings on ZIKV published between 1952 and March 1, 2016. There is evidence that the Asian lineage of ZIKV, which had been historically shown to be circulating in Malaysia, Philippines, Pakistan, Thailand and Cambodia, caused an outbreak on Yap Island in 2007 and continued to spread, affecting a number of the Polynesian islands from 2012 to present. In 2014 the virus traveled to South America where autochthonous circulation was recognised in Brazil in early 2015. At this time (March 2016), 31 countries in South-Central America and the Caribbean are reporting local transmission [3].

Historically ZIKV was not known to cause severe illness in humans and for the first 60 years since its initial identification in Uganda (1947) there were only a few accounts of illness caused by ZIKV. These were mainly in laboratory workers who inadvertently became exposed to the virus. Epidemiological studies in this time period were mainly conducted in Africa and evaluated populations for seropositivity to ZIKV, but not active infection. In most countries where the population was tested for ZIKV, researchers found a proportion of the population had been exposed. This proportion varied widely and was likely affected by the types of samples and tests used, a variety of climatic factors, vectors present and their abundance, and other competing viruses circulating in the area. ZIKV can circulate at the same time as other viruses e.g. dengue and Chikungunya, sharing the same vector, however there is no evidence that exposure, infection or immunity to one virus impacts the outcome of a ZIKV infection or provides protection.

During the recent outbreaks from 2007 to present, reporting of data concerning clinical characteristics of ZIKV has significantly increased. Based on the Yap Island outbreak, 18% of exposed individuals are likely to experience symptoms, thus there is likely substantial under-reporting of ZIKV infections as 80% of infected individuals may be asymptomatic [100]. Symptoms are usually mild and very similar to other co-circulating viruses (dengue and chikungunya), which makes diagnosis based on clinical symptoms challenging [173]. The World Health Organization released its interim case definition for ZIKV as a person presenting with clinical symptoms: rash or fever and one or more of arthralgia, arthritis or conjunctivitis and a positive IgM with epidemiological link (probable case) or a sample positive for ZIKV RNA or IgM with a positive PRNT for ZIKV vs. other flaviviruses [256]. However clinical identification of ZIKV is difficult due to similarities with other co-circulating viruses (e.g. dengue and chikungunya) and testing is currently the responsibility of specialized laboratories [257].

Potential complications reported following ZIKV infection are of great concern to the public health community. Associations with birth defects and neurological complications have been reported relatively recently causing the World Health Organization to issue an alert for precautionary measures and intense investigation to close the knowledge gaps associated with ZIKV potential to cause birth defects; mainly microcephaly [4,258–260]. Reports of increased incidence of GBS and other neurological complications were noted in the French Polynesian and New Caledonia outbreaks [137,223,246] and have since been noted in several countries in South and Central America [117,173]. Currently Brazil, El Salvador, Venezuela, Colombia and Suriname have reported an increased incidence and Puerto Rico and Martinique have reported ZIKV associated cases of GBS [117,237,261]. A number of studies are underway to try to understand who is at high risk of developing GBS and other neurological symptoms following ZIKV infection [245]. Although birth defects such as microcephaly linked to ZIKV have been reported in Brazil and possibly from French Polynesia [148], it is not known why microcephaly has not been reported by other affected countries. This may be a matter of population size, a lag time between ZIKV spread and the birth of affected infants, and a lack of awareness that ZIKV may impact fetal development. Hopefully the retrospective and prospective studies underway in Brazil and other ZIKV affected countries will improve our understanding of the role of ZIKV in causing microcephaly, other birth defects and negative pregnancy outcomes as this is a current knowledge gap.

Guidelines have been developed for the diagnosis of ZIKV infection in humans and based on the studies captured in this review RT-PCR is most common on serum samples and is recommended for samples collected within the first 7 days of symptoms. Many studies were identified that used other samples (saliva, nasopharyngeal swabs, urine, cerebral spinal fluid, semen, amniotic fluid and breast milk) and RT-PCR to identify ZIKV RNA which would be indicative of ZIKV infection. Studies on some of these other sample types may offer a longer or later window of sampling for identification of the virus RNA with RT-PCR, but none have been widely used within primary research studies to date. The identification of ZIKV RNA in various types of bodily fluids raises questions of human to human transmission via saliva, semen and breast milk. At this time only sexual transmission via semen has been reported. ZIKV has been identified in semen up to 72 days post symptoms; however, this is based on a small number of observations and further research is needed to confirm and better understand this finding. Given the potential for ZIKV survival in semen for a long period of time, current guidelines suggest precautions are taken for up to 6 months following possible exposure to ZIKV to try to prevent some of the growing number of sexually transmitted cases reported from Europe and North America [215,221,227,262–264]. Intrauterine transmission has also been shown to be highly plausible. The first case study was from French Polynesia in women who were already infected at time of delivery and infection was confirmed in both mothers and newborns; the newborns recovered from ZIKV infection without complications [222]. Studies from Brazil and other countries have now provided further evidence for the impact of ZIKV on fetuses in utero as several studies have reported ZIKV in amniotic fluid and deceased fetuses and infants with severe birth defects [55,80,172,214,222,240,251]. The implications of ZIKV infection during gestation and variability in the severity of birth defects depending on when maternal ZIKV exposure occurs during pregnancy are current knowledge gaps that are the focus of research progressing in the Americas [48,52,55,234,240,259]. Based on the first few case series of women exposed to ZIKV during pregnancy with documented fetal/infant outcomes, the data suggest ZIKV infection up to 20 weeks of gestation may be the highest risk for negative outcomes such as fetal death or birth defects [48,52,55,234,240,259]. Transmission by blood transfusion is also possible, although there are currently no documented cases of this type of transmission. There are studies from French Polynesia indicating the possible risk of transfusion due to subclinical viremic blood donors. Two studies demonstrated the efficacy of photochemical treatment of plasma to prevent plasma transfusion-transmitted ZIKV and potentially other arboviruses [30,32,71].

Only 56 publications on ZIKV preceded the 2007 Yap Island outbreak, which was the first time that wide spread illness due to ZIKV was documented. This research was primarily published in Africa and focused on vectors, hosts, and understanding the virus rather than on the burden of illness in humans. These articles provide evidence for the vector competence of several mosquito species to be infected with ZIKV and their ability to transmit ZIKV. They also suggest that non-human primates can be infected with ZIKV and may have a role in its transmission cycle. However, there is not enough evidence to conclude whether non-human primates are a reservoir or incidental host of ZIKV [23]. Very few surveys have been conducted on other animal species and the literature doesn’t suggest other potential reservoirs including bats. Thus, identification of the reservoirs or potential spectrum of hosts for ZIKV remains a knowledge gap.

Molecular evaluation of ZIKV through time has been carried out in a few studies and suggest that ZIKV emerged in Uganda around the 1920s and demonstrated little preference for host or vector during its spread through west and central Africa and Asia [68,83]. They demonstrated that the ZIKV cycle may be 1–2 years compared to 5–8 year cycles seen by other viruses [68]. To date a significant change in the ZIKV genome that lead to increased pathogenesis in humans, increased virulence or spread to new competent vectors has not been described in the literature. Although given the range of vectors shown to be competent for ZIKV transmission, it is possible that ZIKV recently started cycling in a vector species it historically had not. Further research on the evolution of ZIKV and competent vectors may explain this knowledge gap.

Mitigation strategies to prevent or control ZIKV were the topic of one experimental study examining the complexity of a resistance gene in Ae. aegypti formosus and concluded that the resistance to ZIKV in this mosquito was complex and not easily transferred to other mosquito species [31]. Although general mosquito mitigation is outside the scope of this review, it is relevant to the prevention of ZIKV and other mosquito transmitted diseases.

This scoping review identified and characterized the global literature on ZIKV (up to March 1^st, 2016) and identified several knowledge gaps with respect to its epidemiology, the burden of disease in humans and complications related to ZIKV infection. Historically there has been little research on this virus, however, given the current spread of ZIKV through Australasia and the Americas, significant research resources have been allocated to closing many of the knowledge gaps identified in this scoping review. Future updates of this review will likely demonstrate enhanced evidence and understanding of ZIKV and its impact on public health.

Supporting Information

S1 File. Protocol for the Scoping Study of Zika Virus literature

https://doi.org/10.1371/journal.pone.0156376.s001

(DOCX)

S2 File. Dataset for the Scoping Study of Zika Virus literature.

https://doi.org/10.1371/journal.pone.0156376.s002

(XLSX)

Acknowledgments

We would like to thank Janet Harris and the NML library staff for their help with article procurement.

Author Contributions

Conceived and designed the experiments: LW JG. Performed the experiments: LW JG. Analyzed the data: LW. Contributed reagents/materials/analysis tools: LW JG. Wrote the paper: LW JG.

References

1. Dick GWA, Kitchen SF, Haddow AJ. Zika Virus (I). Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952;46: 509–520. pmid:12995440
- View Article
- PubMed/NCBI
- Google Scholar
2. Marano G, Pupella S, Vaglio S, Liumbruno GM, Grazzini G. Zika virus and the never-ending story of emerging pathogens and transfusion medicine. Blood Transfus. 2015: 1–6.
- View Article
- Google Scholar
3. Center for Disease Control and Prevention. Zika Webpage. 2016.
4. World Health Organization. Epidemiological alert: neurological syndrome, congenital malformations, and Zika virus infection. Implications for public health in the Americas. WHO. 2015, December 1.
5. Pham MT, Rajic A, Greig JD, Sargeant JM, Papadopoulos A, McEwen SA. A scoping review of scoping reviews: advancing the approach and enhancing the consistency. 2014: n/a-n/a. 10.1002/jrsm.1123.
6. Colquhoun HL, Levac D, O'Brien KK, Straus S, Tricco AC, Perrier L, et al. Scoping reviews: time for clarity in definition, methods, and reporting. J Clin Epidemiol. 2014;67: 1291–1294. pmid:25034198
- View Article
- PubMed/NCBI
- Google Scholar
7. Arksey H, O'Malley L. Scoping studies: towards a methodological framework. International Journal of Social Research Methodology. 2005;8: 19–32.
- View Article
- Google Scholar
8. Levac D, Colquhoun H, O'Brien KK. Scoping studies: Advancing the methodology. Implementation Science. 2010;5.
- View Article
- Google Scholar
9. Young I, Waddell L, Sanchez J, Wilhelm B, McEwen SA, Rajic A. The application of knowledge synthesis methods in agri-food public health: recent advancements, challenges and opportunities. Prev Vet Med. 2014;113: 339–355. pmid:24485274
- View Article
- PubMed/NCBI
- Google Scholar
10. Tusevljak N, Rajic A, Waddell L, Dutil L, Cernicchiaro N, Greig J, et al. Prevalence of zoonotic bacteria in wild and farmed aquatic species and seafood: a scoping study, systematic review, and meta-analysis of published research. Foodborne Pathog Dis. 2012;9: 487–497. pmid:22571642
- View Article
- PubMed/NCBI
- Google Scholar
11. European Centre for Disease Prevention and Control. Rapid risk assessment: Zika virus infection outbreak, French Polynesia. ECDC. 2014, February 14.
12. European Centre for Disease Prevention and Control. Rapid risk assessment: Zika virus infection outbreak, Brazil and the Pacific region– 25 May 2015. ECDC. 2015, May 25.
13. European Centre for Disease Prevention and Control. Zika virus epidemic in the Americas: potential association with microcephaly and Guillain-Barré syndrome (first update) 21 January 2016. ECDC. 2016, January 21.
14. Nhan T, Musso D. Emergence of the Zika virus. Virologie. 2015;19: 225–235.
- View Article
- Google Scholar
15. Yasri S, Wiwanitkit V. New human pathogenic dengue like virus infections (Zika, Alkhumraand Mayaro viruses): A short review. Asian Pac J Trop Dis. 2015;5: S31–S32.
- View Article
- Google Scholar
16. Musso D, Cao-Lormeau VM, Gubler DJ. Zika virus: Following the path of dengue and chikungunya? Lancet. 2015;386: 243–244. pmid:26194519
- View Article
- PubMed/NCBI
- Google Scholar
17. Rodríguez-Morales AJ. Zika: The new arbovirus threat for latin america. J Infect Dev Ctries. 2015;9: 684–685. pmid:26142684
- View Article
- PubMed/NCBI
- Google Scholar
18. Salim Mattar V, Marco Gonzalez T. Now is the time for the Zika virus. Rev MVZ Cordoba. 2015;20: 4511–4512.
- View Article
- Google Scholar
19. Joob B, Wiwanitkit V. Zika virus infection and dengue: A new problem in diagnosis in a dengue-endemic area. Ann Trop Med Public Health. 2015;8: 145–146.
- View Article
- Google Scholar
20. Derraik JG, Slaney D. Notes on Zika virus—An emerging pathogen now present in the South Pacific. Aust New Zealand J Public Health. 2015;39: 5–7.
- View Article
- Google Scholar
21. Kuno G, Chang G-J. Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses. Arch Virol. 2007;152: 687–696. pmid:17195954
- View Article
- PubMed/NCBI
- Google Scholar
22. Kilbourn AM, Karesh WB, Wolfe ND, Bosi EJ, Cook RA, Andau M. Health evaluation of free-ranging and semi-captive orangutans (Pongo pygmaeus pygmaeus) in Sabah, Malaysia. J Wildl Dis. 2003;39: 73–83. pmid:12685070
- View Article
- PubMed/NCBI
- Google Scholar
23. Wolfe ND, Kilbourn AM, Karesh WB, Rahman HA, Bosi EJ, Cropp BC, et al. Sylvatic transmission of arboviruses among Bornean orangutans. Am J Trop Med Hyg. 2001;64: 310–316. pmid:11463123
- View Article
- PubMed/NCBI
- Google Scholar
24. Pierre V, Drouet M, Deubel V. Identification of mosquito-borne flavivirus sequences using universal primers and reverse transcription/polymerase chain reaction. Res Virol. 1994;145: 93–104. pmid:7520190
- View Article
- PubMed/NCBI
- Google Scholar
25. Martinez-Pulgarin DF, Acevedo-Mendoza WF, Cardona-Ospina JA, Rodríguez-Morales AJ, Paniz-Mondolfi AE. A bibliometric analysis of global Zika research. Travel Med Infect Dis. 2015.
- View Article
- Google Scholar
26. Baba SS, Fagbami AH, Olaleye OD. Antigenic relatedness of selected flaviviruses: Study with homologous and heterologous immune mouse ascitic fluids. Rev Inst Med Trop Sao Paulo. 1998;40: 343–349. pmid:10436653
- View Article
- PubMed/NCBI
- Google Scholar
27. Buckley A, Gould EA. Detection of virus-specific antigen in the nuclei or nucleoli of cells infected with Zika or Langat virus. J Gen Virol. 1988;69: 1913–1920. pmid:2841406
- View Article
- PubMed/NCBI
- Google Scholar
28. Olson JG, Ksiazek TG, Gubler DJ, Lubis SI, Simanjuntak G, Lee VH, et al. A survey for arboviral antibodies in sera of humans and animals in Lombok, Republic of Indonesia. Ann Trop Med Parasitol. 1983;77: 131–137. pmid:6309104
- View Article
- PubMed/NCBI
- Google Scholar
29. Pan American Health Organization. Epidemiological Alert Zika virus infection 7 May 2015. PAHO. 2015.
30. Aubry M, Richard V, Musso D. Amotosalen and ultraviolet a light inactivate zika virus in plasma. Vox Sang. 2015;109: 189–190.
- View Article
- Google Scholar
31. Miller BR, Mitchell CJ. Genetic selection of a flavivirus-refractory strain of the yellow fever mosquito Aedes aegypti. Am J Trop Med Hyg. 1991;45: 399–407. pmid:1659238
- View Article
- PubMed/NCBI
- Google Scholar
32. Aubry M, Richard V, Green J, Broult J, Musso D. Inactivation of Zika virus in plasma with amotosalen and ultraviolet A illumination. Transfusion. 2016;56: 33–40. pmid:26283013
- View Article
- PubMed/NCBI
- Google Scholar
33. Sabogal-Roman JA, Murillo-García DR, Yepes-Echeverri MC, Restrepo-Mejia JD, Granados-Álvarez S, Paniz-Mondolfi AE, et al. Healthcare students and workers' knowledge about transmission, epidemiology and symptoms of Zika fever in four cities of Colombia. Travel Med Infect Dis. 2015.
- View Article
- Google Scholar
34. Bogoch II, Brady OJ, Kraemer MUG, German M, Creatore MI, Kulkarni MA, et al. Anticipating the international spread of Zika virus from Brazil. The Lancet. 2016;387: 335–336.
- View Article
- Google Scholar
35. Althouse BM, Hanley KA, Diallo M, Sall AA, Ba Y, Faye O, et al. Impact of climate and mosquito vector abundance on sylvatic arbovirus circulation dynamics in senegal. Am J Trop Med Hyg. 2015;92: 88–97. pmid:25404071
- View Article
- PubMed/NCBI
- Google Scholar
36. Kucharski AJ, Funk S, Eggo RM, Mallet HP, Edmunds WJ, Nilles EJ. Transmission dynamics of Zika virus in island populations: a modelling analysis of the 2013{14 French Polynesia outbreak. bioRxiv. EPUB: Feb. 7, 2016.
- View Article
- Google Scholar
37. Reagan RL, Brueckner AL. Comparison by electron microscopy of the Ntaya and Zika viruses. Tex Rep Biol Med. 1953;11: 347–351. pmid:13077401
- View Article
- PubMed/NCBI
- Google Scholar
38. Weinbren MP, Williams MC. Zika virus: Further isolations in the zika area, and some studies on the strains isolated. Trans R Soc Trop Med Hyg. 1958;52: 263–268. pmid:13556872
- View Article
- PubMed/NCBI
- Google Scholar
39. Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, et al. Biology of Zika virus infection in human skin cells. J Virol. 2015;89: 8880–8896. pmid:26085147
- View Article
- PubMed/NCBI
- Google Scholar
40. Way HJ, Bowen ETW, Platt GS. Comparative studies of some African arboviruses in cell culture and in mice. J Gen Virol. 1976;30: 123–130. pmid:1245842
- View Article
- PubMed/NCBI
- Google Scholar
41. Reagan RL, Chang SC, Brueckner AL. Electron micrographs of erythrocytes from Swiss albino mice infected with Zika virus. Tex Rep Biol Med. 1955;13: 934–938. pmid:13281796
- View Article
- PubMed/NCBI
- Google Scholar
42. Bell TM, Field EJ, Narang HK. Zika virus infection of the central nervous system of mice. Archiv f Virusforschung. 1971;35: 183–193.
- View Article
- Google Scholar
43. MacNamara FN. Zika virus: A report on three cases of human infection during an epidemic of jaundice in Nigeria. Trans R Soc Trop Med Hyg. 1954;48: 139–145. pmid:13157159
- View Article
- PubMed/NCBI
- Google Scholar
44. Dick GWA. Zika virus (II). Pathogenicity and physical properties. Trans R Soc Trop Med Hyg. 1952;46: 521–534. pmid:12995441
- View Article
- PubMed/NCBI
- Google Scholar
45. Rockefeller Foundation. Rockefeller Foundation Annual Report. Zika pages 131–140. Rockefeller Foundation, NY, USA. 1951.
46. Henerson B, Cheshire P, Kirya G, Lule M. Immunologic Studies with Yellow Fever and Selected African Group B Arboviruses in Rhesus and Vervet Monkeys. The American Journal of Tropical Medicine and Hygiene. 1970;19: 110. pmid:4984581
- View Article
- PubMed/NCBI
- Google Scholar
47. Lanciotti RS, Lambert AJ, Holodniy M, Saavedra S, del Carmen Castillo Signor L. Phylogeny of Zika virus inWestern Hemisphere,2015 [letter]. Emerg Infect Dis. 2016 May.
- View Article
- Google Scholar
48. Sarno M, Sacramento GA, Khouri R, do Rosario MS, Costa F, Archanjo G, et al. Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. PLoS Negl Trop Dis. 2016;10.
- View Article
- Google Scholar
49. de M Campos R, Cirne-Santos C, Meira GL, Santos LL, de Meneses MD, Friedrich J, et al. Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil. J Clin Virol. 2016;77: 69–70. S1386-6532(16)30001-4 [pii]. pmid:26921737
- View Article
- PubMed/NCBI
- Google Scholar
50. Kuno G, Chang GJ, Tsuchiya KR, Karabatsos N, Cropp CB. Phylogeny of the genus Flavivirus. J Virol. 1998;72: 73–83. pmid:9420202
- View Article
- PubMed/NCBI
- Google Scholar
51. Freire CCM, lamarino A, Neto DF, Sall AA, Zanotto PMA. Spread of the pandemic Zika virus lineage is associated with NS1 codon usage adaptation in humans. bioRxiv. 2015.
- View Article
- Google Scholar
52. Calvet G, Aguiar RS, Melo AS, Sampaio SA, de Filippis I, Fabri A, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016. S1473-3099(16)00095-5 [pii].
- View Article
- Google Scholar
53. Perkasa A, Yudhaputri F, Haryanto S, Hayati RF, Chairin NM, Antonjaya U, et al. Isolation of Zika Virus from Febrile Patient, Indonesia. Emerg Infect Dis. 2016;22.
- View Article
- Google Scholar
54. Camacho E, Paternina-Gomez M, Blanco PJ, Osorio JE, Aliota MT. Detection of Autochthonous Zika Virus Transmission in Sincelejo, Colombia. Emerging Infectious Disease journal. 2016;22.
- View Article
- Google Scholar
55. Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, et al. Zika Virus Associated with Microcephaly. N Engl J Med. 2016.
- View Article
- Google Scholar
56. Martines RB, Bhatnagar J, Keating MK, Silva-Flannery L, Muehlenbachs A, Gary J, et al. Notes from the Field: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses—Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65: 159–160. pmid:26890059
- View Article
- PubMed/NCBI
- Google Scholar
57. Pyke AT, Daly MT, Cameron JN, Moore PR, Taylor CT, Hewitson GR, et al. Imported zika virus infection from the cook islands into australia, 2014. PLoS Curr. 2014;6.
- View Article
- Google Scholar
58. Korhonen EM, Huhtamo E, Smura T, Kallio-Kokko H, Raassina M, Vapalahti O. Zika virus infection in a traveller returning from the Maldives, June 2015. Euro Surveill. 2016;21.
- View Article
- Google Scholar
59. Baronti C, Piorkowski G, Charrel RN, Boubis L, LeparcGoffart I, Lamballerie X. Complete coding sequence of Zika virus from a French Polynesia outbreak in 2013. Genome Announcements. 2014;2: e00500–14. pmid:24903869
- View Article
- PubMed/NCBI
- Google Scholar
60. Fonseca K, Meatherall B, Zarra D, Drebot M, MacDonald J, Pabbaraju K, et al. First case of Zika virus infection in a returning Canadian traveler. Am J Trop Med Hyg. 2014;91: 1035–1038. http://dx.doi.org/10.4269/ajtmh.14-0151. pmid:25294619
- View Article
- PubMed/NCBI
- Google Scholar
61. Enfissi A, Codrington J, Roosblad J, Kazanji M, Rousset D. Zika virus genome from the Americas. Lancet. 2016;387: 227–228. http://dx.doi.org/10.1016/S0140-6736(16)00003-9. pmid:26775124
- View Article
- PubMed/NCBI
- Google Scholar
62. Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008;14: 1232–1239. pmid:18680646
- View Article
- PubMed/NCBI
- Google Scholar
63. Haddow AD, Schuh AJ, Yasuda CY, Kasper MR, Heang V, Huy R, et al. Genetic characterization of zika virus strains: Geographic expansion of the asian lineage. PLoS Negl Trop Dis. 2012;6.
- View Article
- Google Scholar
64. Li MI, Wong PSJ, Ng LC, Tan CH. Oral Susceptibility of Singapore Aedes (Stegomyia) aegypti (Linnaeus) to Zika Virus. PLoS Negl Trop Dis. 2012;6.
- View Article
- Google Scholar
65. Wong P-J, Li M-I, Chong C, Ng L, Tan C. Aedes (Stegomyia) albopictus (Skuse): A Potential Vector of Zika Virus in Singapore. PLoS Negl Trop Dis. 2013;7.
- View Article
- Google Scholar
66. Kwong JC, Druce JD, Leder K. Case report: Zika virus infection acquired during brief travel to indonesia. Am J Trop Med Hyg. 2013;89: 516–517. pmid:23878182
- View Article
- PubMed/NCBI
- Google Scholar
67. Wæhre T, Maagard A, Tappe D, Cadar D, Schmidt-Chanasit J. Zika virus infection after travel to Tahiti, December 2013. Emerg Infect Dis. 2014;20: 1412–1414. pmid:25062427
- View Article
- PubMed/NCBI
- Google Scholar
68. Faye O, Freire CCM, Iamarino A, Faye O, de Oliveira JVC, Diallo M, et al. Molecular Evolution of Zika Virus during Its Emergence in the 20th Century. PLoS Negl Trop Dis. 2014;8: 36.
- View Article
- Google Scholar
69. Kutsuna S, Kato Y, Takasaki T, Moi ML, Kotaki A, Uemura H, et al. Two cases of zika fever imported from french polynesia to Japan, December to January 2013. Eurosurveillance. 2014;19.
- View Article
- Google Scholar
70. Berthet N, Nakouné E, Kamgang B, Selekon B, Descorps-Declère S, Gessain A, et al. Molecular characterization of three zika flaviviruses obtained from sylvatic mosquitoes in the Central African Republic. Vector Borne Zoonotic Dis. 2014;14: 862–865. pmid:25514122
- View Article
- PubMed/NCBI
- Google Scholar
71. Musso D, Nhan T, Robin E, Roche C, Bierlaire D, Zisou K, et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Eurosurveillance. 2014;19.
- View Article
- Google Scholar
72. Cao-Lormeau V. : Zika virus, French Polynesia, South Pacific, 2013. Emerg Infect Dis. 2014;20: 1960. pmid:24856001
- View Article
- PubMed/NCBI
- Google Scholar
73. Campos GS, Bandeira AC, Sardi SI. Zika virus outbreak, Bahia, Brazil. Emerg Infect Dis. 2015;21: 1885–1886. pmid:26401719
- View Article
- PubMed/NCBI
- Google Scholar
74. Dupont-Rouzeyrol M, O’Connor O, Calvez E, Daures M, John M, Grangeon J, et al. Co-infection with zika and dengue viruses in 2 patients, New Caledonia, 2014. Emerg Infect Dis. 2015;21: 381–382. pmid:25625687
- View Article
- PubMed/NCBI
- Google Scholar
75. Alera MT, Hermann L, Tac-An IA, Klungthong C, Rutvisuttinunt W, Manasatienkij W, et al. Zika virus infection, philippines, 2012. Emerg Infect Dis. 2015;21: 722–724. pmid:25811410
- View Article
- PubMed/NCBI
- Google Scholar
76. Zanluca C, De Melo VCA, Mosimann ALP, Dos Santos GIV, dos Santos CND, Luz K. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz. 2015;110: 569–572. pmid:26061233
- View Article
- PubMed/NCBI
- Google Scholar
77. Buathong R, Hermann L, Thaisomboonsuk B, Rutvisuttinunt W, Klungthong C, Chinnawirotpisan P, et al. Detection of zika virus infection in Thailand, 2012–2014. Am J Trop Med Hyg. 2015;93: 380–383. pmid:26101272
- View Article
- PubMed/NCBI
- Google Scholar
78. Leung GH, Baird RW, Druce J, Anstey NM. Zika Virus Infection in Australia Following a Monkey Bite in Indonesia. Southeast Asian J Trop Med Public Health. 2015;46: 460–464. pmid:26521519
- View Article
- PubMed/NCBI
- Google Scholar
79. Tognarelli J, Ulloa S, Villagra E, Lagos J, Aguayo C, Fasce R, et al. A report on the outbreak of Zika virus on Easter Island, South Pacific, 2014. Arch Virol. 2015: 1–4.
- View Article
- Google Scholar
80. Oliveira Melo AS, Malinger G, Ximenes R, Szejnfeld PO, Alves Sampaio S, Bispo De Filippis AM. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: Tip of the iceberg? Ultrasound Obstet Gynecol. 2016;47: 6–7. pmid:26731034
- View Article
- PubMed/NCBI
- Google Scholar
81. Calvet GA, Filippis AMB, Mendonça MCL, Sequeira PC, Siqueira AM, Veloso VG, et al. First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil. J Clin Virol. 2016;74: 1–3. pmid:26615388
- View Article
- PubMed/NCBI
- Google Scholar
82. Heang V, Yasuda CY, Sovann L, Haddow AD, da Rosa APT, Tesh RB, et al. Zika virus infection, Cambodia, 2010. Emerg Infect Dis. 2012;18: 349–351. pmid:22305269
- View Article
- PubMed/NCBI
- Google Scholar
83. Grard G, Caron M, Mombo IM, Nkoghe D, Mboui Ondo S, Jiolle D, et al. Zika Virus in Gabon (Central Africa) - 2007: A New Threat from Aedes albopictus? PLoS Negl Trop Dis. 2014;8.
- View Article
- Google Scholar
84. Diagne CT, Diallo D, Faye O, Ba Y, Faye O, Gaye A, et al. Potential of selected Senegalese Aedes spp. mosquitoes (Diptera: Culicidae) to transmit Zika virus. BMC Infect Dis. 2015;15.
- View Article
- Google Scholar
85. Ledermann JP, Guillaumot L, Yug L, Saweyog SC, Tided M, Machieng P, et al. Aedes hensilli as a Potential Vector of Chikungunya and Zika Viruses. PLoS Negl Trop Dis. 2014;8.
- View Article
- Google Scholar
86. Monlun E, Zeller H, Le Guenno B, Traoré-Lamizana M, Hervy JP, Adam F, et al. Surveillance of the circulation of arbovirus of medical interest in the region of eastern Senegal. Bull Soc Pathol Exot. 1993;86: 21–28. pmid:8099299
- View Article
- PubMed/NCBI
- Google Scholar
87. Marchette NJ, Garcia R, Rudnick A. Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. Am J Trop Med Hyg. 1969;18: 411–415. pmid:4976739
- View Article
- PubMed/NCBI
- Google Scholar
88. Bearcroft WGC. Zika virus infection experimentally induced in a human volunteer. Trans R Soc Trop Med Hyg. 1956;50: 438–441.
- View Article
- Google Scholar
89. Boorman JPT, Porterfield JS. A simple technique for infection of mosquitoes with viruses transmission of zika virus. Trans R Soc Trop Med Hyg. 1956;50: 238–242. pmid:13337908
- View Article
- PubMed/NCBI
- Google Scholar
90. Cornet M, Robin Y, Adam C, Valade M, Calvo MA. Comparison between experimental transmission of yellow fever and Zika viruses in Aedes aegypti. Cahiers O R S T O M Serie entomologie medicale et parasitologie. 1979;17: 47–53.
- View Article
- Google Scholar
91. Diallo D, Sall AA, Diagne CT, Faye O, Faye O, Ba Y, et al. Zika virus emergence in mosquitoes in Southeastern Senegal, 2011. 2014;9: e10; 44 ref. http://dx.doi.org/10.1371/journal.pone.0109442.
- View Article
- Google Scholar
92. AkouaKoffi C, Diarrassouba S, Benie VB, Ngbichi JM, Bozoua T, Bosson A, et al. Inquiry into a fatal case of yellow fever in Cote d'Ivoire in 1999. Bulletin de la Societe de Pathologie Exotique. 2001;94: 227–230.
- View Article
- Google Scholar
93. Traore Lamizana M, Zeller H, Monlun E, Mondo M, Hervy JP, Adam F, et al. Dengue 2 outbreak in southeastern Senegal during 1990: virus isolations from mosquitoes (Diptera: Culicidae). J Med Entomol. 1994;31: 623–627. pmid:7932611
- View Article
- PubMed/NCBI
- Google Scholar
94. Robert V, Lhuillier M, Meunier D. Yellow fever virus, dengue 2 virus and other arboviruses isolated from mosquitoes in Burkina Faso during 1983–86. Entomological and epidemiological considerations. Bull Soc Pathol Exot. 1993;86: 90–100. pmid:8102567
- View Article
- PubMed/NCBI
- Google Scholar
95. Lee VH, Moore DL. Vectors of the 1969 yellow fever epidemic on the Jos Plateau, Nigeria. Bull World Health Organ. 1972;46: 669–673. pmid:4403105
- View Article
- PubMed/NCBI
- Google Scholar
96. Faye O, Faye O, Diallo D, Diallo M, Weidmann M, Sall AA. Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes. Virol J. 2013;10.
- View Article
- Google Scholar
97. McCrae AWR, Kirya BG. Yellow fever and Zika virus epizootics and enzootics in Uganda. Trans R Soc Trop Med Hyg. 1982;76: 552–562. pmid:6304948
- View Article
- PubMed/NCBI
- Google Scholar
98. Haddow AJ, Williams MC, Woodall JP, Simpson DI, Goma LK. Twelve Isolations of Zika Virus from Aedes (Stegomyia) Africanus (Theobald) Taken in and Above a Uganda Forest. Bull World Health Organ. 1964;31: 57–69. pmid:14230895
- View Article
- PubMed/NCBI
- Google Scholar
99. Cornet M, Robin Y, Chateau R, Heme G, Adam C, Valade M, et al. Isolations of arboviruses in eastern Senegal from mosquitoes (1972–1977) and notes on the epidemiology of viruses transmitted by Aedes spp., especially yellow fever. Cahiers ORSTOM, Entomologie Medicale et Parasitologie. 1979;17: 149–163.
- View Article
- Google Scholar
100. Duffy MR, Chen T, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. New Engl J Med. 2009;360: 2536–2543. pmid:19516034
- View Article
- PubMed/NCBI
- Google Scholar
101. Kading Mossel, Borland Ledermann, Panella Crabtree, et al. Arbovirus surveillance in bats in Uganda. American Journal of Tropical Medicine and Hygiene Conference. 2014;91: 260.
- View Article
- Google Scholar
102. Kirya BG, Okia NO. A yellow fever epizootic in Zika Forest, Uganda, during 1972: Part 2: Monkey serology. Trans R Soc Trop Med Hyg. 1977;71: 300–303. pmid:413216
- View Article
- PubMed/NCBI
- Google Scholar
103. Saluzzo JF, Ivanoff B, Languillat G, Georges AJ. Serological survey for arbovirus antibodies in the human and simian populations of the South East of Gabon. Bull Soc Pathol Exot Fil. 1982;75: 262–266.
- View Article
- Google Scholar
104. Saluzzo JF, Sarthou JL, Cornet M. Specific ELISA-IgM antibodies for diagnosis and epidemiological surveillance of flaviviruses in Africa. Ann Inst Pasteur Virol. 1986;137: 155–170.
- View Article
- Google Scholar
105. Darwish MA, Hoogstraal H, Roberts TJ, Ahmed IP, Omar F. A sero-epidemiological survey for certain arboviruses (Togaviridae) in Pakistan. Trans R Soc Trop Med Hyg. 1983;77: 442–445. pmid:6314612
- View Article
- PubMed/NCBI
- Google Scholar
106. Crockett Ledermann, Borland Powers, Panella Crabtree, Miller. Arbovirus surveillance and virus isolations from bats in Uganda, Kenya, and the democratic republic of the Congo. American Journal of Tropical Medicine and Hygiene Conference. 2012;87: 170.
- View Article
- Google Scholar
107. Crockett Crabtree, Ledermann Borland, Powers Mutebi, et al. Investigations into mosquito blood feeding patterns on wildlife and a potential role for bats in arbovirus transmission cycles in Uganda. American Journal of Tropical Medicine and Hygiene Conference. 2011;85: 374–375.
- View Article
- Google Scholar
108. Pond WL. Arthropod-borne virus antibodies in sera from residents of South-East Asia. Trans R Soc Trop Med Hyg. 1963;57: 364–371. pmid:14062273
- View Article
- PubMed/NCBI
- Google Scholar
109. Geser A, Henderson BE, Christensen S. A multipurpose serological survey in Kenya. 2. Results of arbovirus serological tests. Bull World Health Organ. 1970;43: 539–552. pmid:5313066
- View Article
- PubMed/NCBI
- Google Scholar
110. Babaniyi OA, Mwaba P, Songolo P, Mazaba-Liwewe ML, Mweene-Ndumba I, Masaninga F, et al. Seroprevalence of Zika virus infection specific IgG in Western and North-Western Provinces of Zambia. International Journal of Public Health and Epidemiology. 2015, January;4: 110–114.
- View Article
- Google Scholar
111. Kokernot RH, Casaca VMR, Weinbren MP, McIntosh BM. Survey for antibodies against arthropod-borne viruses in the sera of indigenous residents of Angola. Trans R Soc Trop Med Hyg. 1965;59: 563–570. pmid:5893149
- View Article
- PubMed/NCBI
- Google Scholar
112. Rodhain F, Carterton B, Laroche R, Hannoun C. Human arbovirus infections in Burundi: results of a seroepidemiological survey, 1980–1982. Bull Soc Pathol Exot Filiales. 1987;80: 155–161. pmid:3038355
- View Article
- PubMed/NCBI
- Google Scholar
113. Fokam EB, Levai LD, Guzman H, Amelia PA, Titanji VP, Tesh RB, et al. Silent circulation of arboviruses in Cameroon. East Afr Med J. 2010;87: 262–268. pmid:23057269
- View Article
- PubMed/NCBI
- Google Scholar
114. Boche R, Jan C, Le Noc P, Ravisse P. Immunologic survey on the incidence of arboviruses in the Pygmy population in Eastern Cameroon (Djoum area). Bull Soc Pathol Exot Fil. 1974;67: 126–140.
- View Article
- Google Scholar
115. World Health Organization. Zika virus infection–Cape Verde. Disease Outbreak News. 21 December 2015. WHO. 2015.
116. World Health Organization. Neurological Syndrome and Congenital Anomalies. Situration Report. 5 February 2016. WHO. 2016.
117. World Health Organization. Zika Virus Microcephaly and Gullian-Barre Syndrome: Situation Report. 19 February 2016. WHO. 2016.
118. Saluzzo JF, Gonzalez JP, Herve JP, Georges AJ. Serological survey for the prevalence of certain arboviruses in the human population of the south-east area of Central African Republic. Bull Soc Pathol Exot Fil. 1981;74: 490–499.
- View Article
- Google Scholar
119. Tsegaye . Virological and serological investigation of the first dengue fever outbreak in Ethiopia. American Journal of Tropical Medicine and Hygiene Conference. 2014;91: 53.
- View Article
- Google Scholar
120. Jan Ch., Languillat G, Renaudet J, Robin Y. A serologic survey on arboviruses in Gabon. Bull Soc Pathol Exot Fil. 1978;71: 140–146.
- View Article
- Google Scholar
121. De Araujo LJ, Bausch D.G., Mores C.N. Serological evidence of co-circulating dengue virus serotypes, an underreported arboviral disease in Guinea. Am J Trop Med Hyg. 2010;83: 314.
- View Article
- Google Scholar
122. Ofula Wurapa. Evidence of circulation of selected arboviruses in ijara and marigat districts, Kenya. American Journal of Tropical Medicine and Hygiene Conference. 2013;89: 278.
- View Article
- Google Scholar
123. Ofula Wurapa. Seroprevalence of selected arboviruses in ijara and marigat districts,Kenya. American Journal of Tropical Medicine and Hygiene Conference. 2012;87: 126.
- View Article
- Google Scholar
124. Bowen ETW, Simpson DIH, Platt GS, Way H, Bright WF, Day J, et al. Large scale irrigation and arbovirus epidemiology, Kano plain, Kenya II. Preliminary serological survey. Trans R Soc Trop Med Hyg. 1973;67: 702–709. pmid:4779116
- View Article
- PubMed/NCBI
- Google Scholar
125. Adekolu-John EO, Fagbami AH. Arthropod-borne virus antibodies in sera of residents of Kainji Lake Basin, Nigeria 1980. Trans R Soc Trop Med Hyg. 1983;77: 149–151. pmid:6306872
- View Article
- PubMed/NCBI
- Google Scholar
126. Fagbami A. Epidemiological investigations on arbovirus infections at Igbo-Ora, Nigeria. Trop Geogr Med. 1977;29: 187–191. pmid:906078
- View Article
- PubMed/NCBI
- Google Scholar
127. Fagbami AH. Zika virus infections in Nigeria: Virological and seroepidemiological investigations in Oyo State. J Hyg. 1979;83: 213–219. pmid:489960
- View Article
- PubMed/NCBI
- Google Scholar
128. Monath TP, Wilson DC, Casals J. The 1970 yellow fever epidemic in Okwoga District, Benue Plateau State, Nigeria. 3. Serological responses in persons with and without pre-existing heterologous group B immunity. BULL WHO. 1973;49: 235–244. pmid:4546521
- View Article
- PubMed/NCBI
- Google Scholar
129. Moore DL, Causey OR, Carey DE, Reddy S, Cooke AR, Akinkugbe FM, et al. Arthropod borne viral infections of man in Nigeria, 1964–1970. Ann Trop Med Parasitol. 1975;69: 49–64. pmid:1124969
- View Article
- PubMed/NCBI
- Google Scholar
130. Macnamara FN, Horn DW, Porterfield JS. Yellow fever and other arthropod-borne viruses. A consideration of two serological surveys made in South Western Nigeria. Trans R Soc Trop Med Hyg. 1959;53: 202–212. pmid:13647627
- View Article
- PubMed/NCBI
- Google Scholar
131. Sow A, Loucoubar C, Diallo D, Faye O, Ndiaye Y, Senghor CS, et al. Concurrent malaria and arbovirus infections in Kedougou, southeastern Senegal. Malar J. 2016;15: 47-016-1100-5.
- View Article
- Google Scholar
132. Renaudet J, Jan C, Ridet J, Adam C, Robin Y. A serological survey of arboviruses in the human population of Senegal. Bull Soc Pathol Exot Filiales. 1978;71: 131–140. pmid:33772
- View Article
- PubMed/NCBI
- Google Scholar
133. Robin Y, Mouchet J. Serological and entomological survey of yellow fever in Sierra Leone. Bull Soc Pathol Exot. 1975;68: 249–258.
- View Article
- Google Scholar
134. Direction de la santé Bureau de veille sanitaire. Surveillance et veille sanitaire en Polynésie française. Données du 01 au 07 Février 2016 (Semaine 05). Direction de la santé Bureau de veille sanitaire. 2016.
135. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 6, ending 14 Feb, 2016. WHO. 2016.
136. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 7, ending 21 Feb, 2016. WHO. 2016.
137. Roth A, Mercier A, Lepers C, Hoy D, Duituturaga S, Benyon E, et al. Concurrent outbreaks of dengue, chikungunya and zika virus infections–An unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012–2014. Eurosurveillance. 2014;19.
- View Article
- Google Scholar
138. Institut de Veille Sanitaire. Bulletin Hebdomadaire International N°442, 05 au 11 mars 2014. Institut de Veille Sanitaire. 2014.
139. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 17, ending 27 Apr, 2014. WHO. 2014.
140. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 20, ending 17 May, 2015. WHO. 2015.
141. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 20, ending 18 May, 2014. WHO. 2014.
142. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 21, ending 25 May, 2014. WHO. 2014.
143. World Health Organization. Pacific syndromic surveillance report. Week 33, ending 16 August, 2015. WHO. 2015.
144. Mallet HP. Emergence du virus Zika en Polynésie française [presentation]. Conference: 15es JNI, Bordeaux du 11 au 13 juin 2014. 2014.
145. Agence Regionale de Sante. Emergence des maladies infectieuses. Bulletin de veille sanitaire. no2 Jun-Aug 2014. Agence Regionale de Sante. 2014.
146. Mallet HP, Vial AL, Musso D. Bilan de l'Epidemie a Virus Zika en Polynesie Francaise, 2013–2014. Bulletin d'Information Sanitaires, Epidemiologiques et Statistiques. 2015.
- View Article
- Google Scholar
147. Institut de Veille Sanitaire. Virus Zika Polynesie 2013–2014, Isle de yap, Micronesia 2007 (janvier 2014). Institut de Veille Sanitaire. 2014.
148. Jouannic JM, Friszer S, Leparc-Goffart I, Garel C, Eyrolle-Guignot D. Zika virus infection in French Polynesia. Lancet. 2016. S0140-6736(16)00625-5 [pii].
- View Article
- Google Scholar
149. Aubry M, Finke J, Teissier A, Roche C, Broult J, Paulous S, et al. Seroprevalence of arboviruses among blood donors in French Polynesia, 2011–2013. Int J Infect Dis. 2015;41: 11–12. pmid:26482390
- View Article
- PubMed/NCBI
- Google Scholar
150. Antonjaya . Study of arboviruses in archived specimens from acute febrile illness studies in bandung,Indonesia. American Journal of Tropical Medicine and Hygiene Conference. 2012;87: 122.
- View Article
- Google Scholar
151. Van Peenen PFD, Joseph SW, Casals J. Arbovirus antibodies in Indonesians at Malili, South Sulawesi (Celebes) and Balikpapan, E. Kalimantan (Borneo). Ann Trop Med Parasitol. 1975;69: 475–482.
- View Article
- Google Scholar
152. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 24, ending 15 Jun, 2014. WHO. 2014.
153. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 30, ending 27 Jul, 2014. WHO. 2014.
154. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 49, ending 6 Dec, 2015. WHO. 2015.
155. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 37, ending 13 Sep, 2015. WHO. 2015.
156. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 46, ending 15 Nov, 2015. WHO. 2015.
157. World Health Organization. Pacific syndromic surveillance report. Week 17, ending 26 April, 2015. WHO. 2015.
158. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 22, ending 31 May, 2015. WHO. 2015.
159. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 12, ending 22 Mar, 2015. WHO. 2015.
160. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 14, ending 5 Apr, 2015. WHO. 2015.
161. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 16, ending 19 Apr, 2015. WHO. 2015.
162. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 17, ending 22 Apr, 2015. WHO. 2015.
163. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 18, ending 3 May, 2015. WHO. 2015.
164. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 19, ending 10 May, 2015. WHO. 2015.
165. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 21, ending 24 May, 2015. WHO. 2015.
166. Wikan N, Suputtamongkol Y, Yoksan S, Smith DR, Auewarakul P. Immunological evidence of Zika virus transmission in Thailand. Asian Pac J Trop Med. 2016;9: 141–144. pmid:26919943
- View Article
- PubMed/NCBI
- Google Scholar
167. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 4, ending 31 Jan, 2016. WHO. 2016.
168. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 5, ending 7 Feb, 2016. WHO. 2016.
169. World Health Organization. Zika virus infection–Guyana, Barbados and Ecuador. Disease Outbreak News. 20 January 2016. WHO. 2016.
170. World Health Organization. Zika and Potential Complications. Situation Report. 12 February 2016. WHO. 2016.
171. World Health Organization. Zika virus infection–Brazil and Colombia. Disease Outbreak News. 21 October 2015. WHO. 2015.
172. Pan American Health Organization. Epidemiological Alert Neurological syndrome, congenital malformations, and Zika virus infection. Implications for public health in the Americas 1 December 2015. PAHO. 2015.
173. Cardoso CW, Paploski IA, Kikuti M, Rodrigues MS, Silva MM, Campos GS, et al. Outbreak of Exanthematous Illness associated with Zika, Chikungunya, and Dengue viruses, Salvador, Brazil. Emerg Infect Dis. 2015;21: 2274–2276. pmid:26584464
- View Article
- PubMed/NCBI
- Google Scholar
174. World Health Organization. Zika virus infection–Bolivia. Disease Outbreak News. 20 January 2016. WHO. 2016.
175. World Health Organization. Guillain-Barré syndrome–Colombia and Venezuela. Disease Outbreak News. 12 February 2016. WHO. 2016.
176. Arzuza-Ortega L, Polo A, Pérez-Tatis G, López-García H, Parra E, Pardo-Herrera LC. Fatal Zika virus infection in girl with sickle cell disease, Colombia [letter]. Emerg Infect Dis. 2016 May.
- View Article
- Google Scholar
177. World Health Organization. Zika virus infection–Dominican Republic. Disease Outbreak News. 27 January 2016. WHO. 2016.
178. World Health Organization. Guillain-Barré syndrome–El Salvador. Disease Outbreak News. 21 January 2016. WHO. 2016.
179. World Health Organization. Zika virus infection–France—French Guiana and Martinique. Disease Outbreak News. 8 January 2016. WHO. 2016.
180. World Health Organization. Zika virus infection–Guatemala. Disease Outbreak News. 27 November 2015. WHO. 2015.
181. Agence Regionale de Sante. Emergence du virus Zika aux Antilles Guyane. Situation épidémiologique Point épidémiologique du 21 janvier—N°3 / 2016. Agence Regionale de Sante. 2016.
182. World Health Organization. Zika virus infection–France—Saint Martin and Guadeloupe. Disease Outbreak News, 21 January 2016. WHO. 2016.
183. World Health Organization. Zika virus infection–Haiti. Disease Outbreak News. 21 January 2016. WHO. 2016.
184. World Health Organization. Zika virus infection–Honduras. Disease Outbreak News. 21 December 2015. WHO. 2015.
185. World Health Organization. Zika virus infection–Mexico. Disease Outbreak News. 3 December 2015. WHO. 2015.
186. World Health Organization. Zika virus infection–Panama. Disease Outbreak News. 22 December 2015. WHO. 2015.
187. World Health Organization. Zika virus infection–Panama. Disease Outbreak News. 5 December 2015. WHO. 2015.
188. World Health Organization. Zika virus infection–Paraguay. Disease Outbreak News. 3 December 2015. WHO. 2015.
189. Thomas DL, Sharp TM, Torres J, Armstrong PA, Munoz-Jordan J, Ryff KR, et al. Local Transmission of Zika Virus—Puerto Rico, November 23, 2015-January 28, 2016. MMWR Morb Mortal Wkly Rep. 2016;65: 154–158. pmid:26890470
- View Article
- PubMed/NCBI
- Google Scholar
190. World Health Organization. Zika virus infection–United States of America—Puerto Rico. Disease Outbreak News. 8 January 2016. WHO. 2016.
191. World Health Organization. Zika virus infection–Suriname. Disease Outbreak News. 13 November 2015. WHO. 2015.
192. World Health Organization. Zika virus infection–Suriname. Disease Outbreak News. 11 November 2015. WHO. 2015.
193. Downs WG, Anderson CR, Theiler M. Neutralizing antibodies against certain viruses in the sera of residents of Trinidad, B.W.I. Carib Med J. 1965;27: 39–53.
- View Article
- Google Scholar
194. World Health Organization. Zika virus infection–Venezuela. Disease Outbreak News. 3 December 2015. WHO. 2015.
195. World Health Organization. Zika virus infection–United States of America. — United States Virgin Islands. Disease Outbreak News. 29 January 2016. WHO. 2016.
196. New Zealand Public Health. An outbreak of mumps-like illness. New Zealand Public Health Surveill Rep. 2015;13.
- View Article
- Google Scholar
197. New Zealand Public Health. A summary of the key trends in notifiable diseases for 2014. New Zealand Public Health Surveill Rep. 2015;13.
- View Article
- Google Scholar
198. UK government. Health Protection Report: volume 10, issue 8, News February 26th. Zika epidemiological update. Public Health England. 2016.
199. Villamil-Gomez WE, Gonzalez-Camargo O, Rodriguez-Ayubi J, Zapata-Serpa D, Rodriguez-Morales AJ. Dengue, chikungunya and Zika co-infection in a patient from Colombia. J Infect Public Health. 2016. S1876-0341(15)00221-X [pii].
- View Article
- Google Scholar
200. Tappe D, Pérez-Girón JV, Zammarchi L, Rissland J, Ferreira DF, Jaenisch T, et al. Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase. Med Microbiol Immunol. 2015: 1–5.
- View Article
- Google Scholar
201. Freitas B, Oliveira Dias J, Prazeres J. Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil. JAMA Ophthalmol. 2016;Published online February 9, 2016.
- View Article
- Google Scholar
202. Ventura CV, Maia M, Ventura BV, Linden VV, Araujo EB, Ramos RC, et al. Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol. 2016;79: 1–3. pmid:26840156
- View Article
- PubMed/NCBI
- Google Scholar
203. Gourinat A, O’Connor O, Calvez E, Goarant C, Dupont-Rouzeyrol M. Detection of zika virus in urine. Emerg Infect Dis. 2015;21: 84–86. pmid:25530324
- View Article
- PubMed/NCBI
- Google Scholar
204. Olson JG, Ksiazek TG, , . Zika virus, a cause of fever in Central Java, Indonesia. Trans R Soc Trop Med Hyg. 1981;75: 389–393. pmid:6275577
- View Article
- PubMed/NCBI
- Google Scholar
205. Fontes BM. Zika virus-related hypertensive iridocyclitis. Arq Bras Oftalmol. 2016;79: 63–2749.20160020. pmid:26840174
- View Article
- PubMed/NCBI
- Google Scholar
206. Ventura CV, Maia M, Bravo-Filho V, Góis AL, Belfort R Jr. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet. 2016;387: 228.
- View Article
- Google Scholar
207. Zammarchi L, Tappe D, Fortuna C, Remoli ME, Günther S, Venturi G, et al. Zika virus infection in a traveller returning to europe from Brazil, march 2015. Eurosurveillance. 2015;20.
- View Article
- Google Scholar
208. Gyurech D, Schilling J, Schmidt-Chanasit J, Cassinotti P, Kaeppeli F, Dobec M. False positive dengue NS1 antigen test in a traveller with an acute Zika virus infection imported into Switzerland. Swiss Med Wkly. 2016;146: w14296. pmid:26859285
- View Article
- PubMed/NCBI
- Google Scholar
209. Weitzel T, Cortes CP. Zika Virus Infection Presenting with Postauricular Lymphadenopathy. Am J Trop Med Hyg. 2016. 16–0096 [pii].
- View Article
- Google Scholar
210. World Health Organization. Zika virus infection–Region of the Americas. Disease Outbreak News. 8 February 2016. WHO. 2016.
211. Chen LH. Zika Virus Infection in a Massachusetts Resident After Travel to Costa Rica: A Case Report. Ann Intern Med. 2016.
- View Article
- Google Scholar
212. Maria AT, Maquart M, Makinson A, Flusin O, Segondy M, Leparc-Goffart I, et al. Zika virus infections in three travellers returning from South America and the Caribbean respectively, to Montpellier, France, December 2015 to January 2016. Euro Surveill. 2016; 21.
- View Article
- Google Scholar
213. Goorhuis A. Zika Virus- Netherlands ex Suriname. ProMED-mail. 2015.
214. Karimi O, Goorhuis A, Schinkel J, Codrington J, Vreden SG, Vermaat JS, et al. Thrombocytopenia and subcutaneous bleedings in a patient with Zika virus infection. Lancet. 2016. S0140-6736(16)00502-X [pii].
- View Article
- Google Scholar
215. World Health Organization. Zika virus infection–United States of America. Disease Outbreak News. 12 February 2016. WHO. 2016.
216. Macesic N, Abbott IJ, Johnson DF. Fever and rash in a husband and wife returning from the Cook Islands. Clin Infect Dis. 2015;61: 1445 and 1485–1486. pmid:26453655
- View Article
- PubMed/NCBI
- Google Scholar
217. Hearn Brooks. Identification of the first case of imported Zika Fever to the UK: A novel sample type for diagnostic purposes and support for a potential non-vectorborne route of transmission. American Journal of Tropical Medicine and Hygiene Conference. 2014;91: 62–63.
- View Article
- Google Scholar
218. Zammarchi L, Stella G, Mantella A, Bartolozzi D, Tappe D, Günther S, et al. Zika virus infections imported to Italy: Clinical, immunological and virological findings, and public health implications. J Clin Virol. 2015;63: 32–35. pmid:25600600
- View Article
- PubMed/NCBI
- Google Scholar
219. Brust KB, Prince WS, Fader RC. Trouble in paradise. IDCases. 2014;1: 95–96. pmid:26839785
- View Article
- PubMed/NCBI
- Google Scholar
220. Musso D, Roche C, Nhan T, Robin E, Teissier A, Cao-Lormeau V. Detection of Zika virus in saliva. J Clin Virol. 2015;68: 53–55. pmid:26071336
- View Article
- PubMed/NCBI
- Google Scholar
221. Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau V. Potential sexual transmission of zika virus. Emerg Infect Dis. 2015;21: 359–361. pmid:25625872
- View Article
- PubMed/NCBI
- Google Scholar
222. Besnard M, Lastère S, Teissier A, Cao-Lormeau VM, Musso D. Evidence of perinatal transmission of zika virus, French Polynesia, December 2013 and February 2014. Eurosurveillance. 2014;19.
- View Article
- Google Scholar
223. Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastãre S, Valour F, et al. Zika virus infection complicated by guillain-barré syndrome a case report, French Polynesia, December 2013. Eurosurveillance. 2014;19.
- View Article
- Google Scholar
224. Summers DJ, Acosta RW, Acosta AM. Zika Virus in an American Recreational Traveler. J Travel Med. 2015;22: 338–340. pmid:25996909
- View Article
- PubMed/NCBI
- Google Scholar
225. Tappe D, Nachtigall S, Kapaun A, Schnitzler P, Günther S, Schmidt-Chanasit J. Acute Zika virus infection after travel to Malaysian Borneo, September 2014. Emerg Infect Dis. 2015;21: 911–913. pmid:25898277
- View Article
- PubMed/NCBI
- Google Scholar
226. Dupont-Rouzeyrol M, Biron A, O'Connor O, Huguon E, Descloux E. Infectious Zika viral particles in breastmilk. Lancet. 2016. S0140-6736(16)00624-3 [pii].
- View Article
- Google Scholar
227. Venturi G, Zammarchi L, Fortuna C, Remoli ME, benedetti E, Florentini C, et al. An Autochthonous case of zika due to possible sexual transmission, Florence, Italy, 2014. Euro Surveill. 2016;21.
- View Article
- Google Scholar
228. Center for Disease Control, ROC (Taiwan). As first imported case of Zika virus infection identified in Taiwan, Taiwan CDC to list Zika virus infection as Category II Notifiable Infectious Disease and raises travel notice level for Central and South America and six countries in Southeast Asia: 2016-01-19. Center for Disease Control, ROC (Taiwan);. 2016.
229. Shinohara K, Kutsuna S, Takasaki T, Moi ML, Ikeda M, Kotaki A, et al. Zika fever imported from Thailand to Japan, and diagnosed by PCR in the urines. J Travel Med. 2016;23: Print 2016 Jan. 10.1093/jtm/tav011.
- View Article
- Google Scholar
230. Tappe D, Rissland J, Gabriel M, Emmerich P, Günther S, Held G, et al. First case of laboratory-confirmed zika virus infection imported into Europe, November 2013. Eurosurveillance. 2014;19.
- View Article
- Google Scholar
231. Foy BD, Kobylinski KC, Foy JLC, Blitvich BJ, da Rosa AT, Haddow AD, et al. Probable Non-Vector-borne Transmission of Zika Virus, Colorado, USA. Emerg Infect Dis. 2011;17: 880–882. pmid:21529401
- View Article
- PubMed/NCBI
- Google Scholar
232. Simpson DI. Zika Virus Infection in Man. Trans R Soc Trop Med Hyg. 1964;58: 335–338. pmid:14175744
- View Article
- PubMed/NCBI
- Google Scholar
233. Filipe AR, Martins CMV, Rocha H. Laboratory infection with Zika virus after vaccination against yellow fever. Arch Ges Virusforsch. 1973;43: 315–319. pmid:4799154
- View Article
- PubMed/NCBI
- Google Scholar
234. Schuler-Faccini L, Ribeiro EM, Feitosa IM, Horovitz DD, Cavalcanti DP, Pessoa A, et al. Possible Association Between Zika Virus Infection and Microcephaly—Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65: 59–62. pmid:26820244
- View Article
- PubMed/NCBI
- Google Scholar
235. World Health Organization. Microcephaly–Brazil. Disease Outbreak News. 27 November 2015. WHO. 2015.
236. World Health Organization. Microcephaly–Brazil. Disease Outbreak News. 15 December 2015. WHO. 2015.
237. Pan American Health Organization. Reported increase of congenital microcephaly and other central nervous system symptoms—10 February 2016. PAHO. 2016.
238. Pan American Health Organization. Zika Epidemiological Update—17 February 2016. PAHO. 2016.
239. World Health Organization. Microcephaly–United States of America. Disease Outbreak News. 12 February 2016. WHO. 2016.
240. Meaney-Delman D, Hills Sl, Williams C, Galang RR, Iyengar P, Hennenfent AK, et al. Zika Virus Infection Among U.S. Pregnant Travelers: August 2015 –February 2016. MMWR Morb Mortal Wkly Rep. 2016;65.
- View Article
- Google Scholar
241. World Health Organization. Guillain-Barré syndrome–Brazil. Disease Outbreak News. 8 February 2016. WHO. 2016.
242. Pan American Health Organization. Epidemiological Update Neurological syndrome, congenital anomalies, and Zika virus infection 17 January 2016. PAHO. 2016.
243. World Health Organization. Zika virus infection–El Salvador. Disease Outbreak News. 27 November 2015. WHO. 2015.
244. Direction de la Santé - Bureau de Veille sanitaire. Surveillance de la dengue et du zika en Polynésie française. Données actualisées au 14 février 2014. Direction de la Santé - Bureau de Veille sanitaire. 2014.
245. Cao-Lormeau VM, Blake A, Mons S, Lastere S, Roche C, Vanhomwegen J, et al. Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet. 2016. S0140-6736(16)00562-6 [pii].
- View Article
- Google Scholar
246. Millon P. Epidemiologie des syndromes de Gullain-Barre en Nouvelle-Caledonie entre 2011 et 2014: influence des arboviroses. Medecine humaine et pathologie. 2015;1153577.
- View Article
- Google Scholar
247. Victora CG, Schuler-Faccini L, Matijasevich A, Ribeiro E, Pessoa A, Barros FC. Microcephaly in Brazil: how to interpret reported numbers? 2016;387: 621–624. pmid:26864961
- View Article
- PubMed/NCBI
- Google Scholar
248. Araújo J, Regis CT, Gomes RG, Tavares TR, Santos CR, Assunção PM, et al. Microcephaly in northeastern Brazil: a review of 16 208 births between 2012 and 2015. Bull World Health Organ. E-pub: 4 Feb 2016.
- View Article
- Google Scholar
249. Center for Disease Control and Prevention. Subject: Revised diagnostic testing for Zika, chikungunya, and dengue viruses in US Public Health Laboratories. CDC. 2016.
250. Cao-Lormeau , Roche , Teissier , Musso . Epidemiological and molecular features of dengue, Zika and Chikungunya concurrent outbreaks in the pacific, 2014. American Journal of Tropical Medicine and Hygiene Conference. 2014;91: 588.
- View Article
- Google Scholar
251. World Health Organization. Guillain-Barré syndrome–France—Martinique. Disease Outbreak News. 8 February 2016. WHO. 2016.
252. Balm MN, Lee CK, Lee HK, Chiu L, Koay ES, Tang JW. A diagnostic polymerase chain reaction assay for Zika virus. J Med Virol. 2012;84: 1501–1505. pmid:22825831
- View Article
- PubMed/NCBI
- Google Scholar
253. Faye O, Faye O, Dupressoir A, Weidmann M, Ndiaye M, Alpha Sall A. One-step RT-PCR for detection of Zika virus. J Clin Virol. 2008;43: 96–101. pmid:18674965
- View Article
- PubMed/NCBI
- Google Scholar
254. De Madrid AT, Porterfield JS. The flaviviruses (group B arboviruses): a cross-neutralization study. J Gen Virol. 1974;23: 91–96. pmid:4833603
- View Article
- PubMed/NCBI
- Google Scholar
255. De Madrid AT, Porterfield JS. A simple micro-culture method for the study of group B arboviruses. Bull World Health Organ. 1969;40: 113–121. pmid:4183812
- View Article
- PubMed/NCBI
- Google Scholar
256. World Health Organization. Zika virus disease: Interim case definitions. 12 February 2016. WHO. 2016.
257. Center for Disease Control and Prevention. New CDC Laboratory Test for Zika Virus Authorized for Emergency Use by FDA. Media Release. Friday, March 18, 2016. Available: http://www.cdc.gov/media/releases/2016/s0318-zika-lab-test.html. Accessed March 22, 2016.
- View Article
- Google Scholar
258. World Health Organization. WHO statement on the first meeting of the International Health Regulations (2005) (IHR 2005) Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations. WHO. 2016, February 1.
259. Vouga M, Musso D, Van Mieghem T, Baud D. CDC guidelines for pregnant women during the Zika virus outbreak. Lancet. 2016. S0140-6736(16)00383-4 [pii].
- View Article
- Google Scholar
260. Heymann DL, Hodgson A, Sall AA, Freedman DO, Staples JE, Althabe F, et al. Zika virus and microcephaly: why is this situation a PHEIC? Lancet. 2016;387: 719–721. pmid:26876373
- View Article
- PubMed/NCBI
- Google Scholar
261. World Health Organization. Zika situation report (February 16, 2016): Zika virus, Microcephaly and Guillain-Barré syndrome. WHO. 2016.
262. Oster AM, Brooks JT, Stryker JE, Kachur RE, Mead P, Pesik NT, et al. Interim Guidelines for Prevention of Sexual Transmission of Zika Virus—United States, 2016. MMWR Morb Mortal Wkly Rep. 2016;65: 120–121 2p. pmid:26866485
- View Article
- PubMed/NCBI
- Google Scholar
263. [Anonymous]. CDC investigating 14 new reports of possible sexual transmission of Zika virus. American Health Line. First Look. 2016: n/a.
- View Article
- Google Scholar
264. World Health Organization. Prevention of potential sexual transmission of Zika virus. Interim guidance. 18 February 2016. WHO. 2016;WHO/ZIKV/MOC/16.1.

[ref1] 1. Dick GWA, Kitchen SF, Haddow AJ. Zika Virus (I). Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952;46: 509–520. pmid:12995440
View Article
PubMed/NCBI
Google Scholar

[2] View Article

[3] PubMed/NCBI

[4] Google Scholar

[ref2] 2. Marano G, Pupella S, Vaglio S, Liumbruno GM, Grazzini G. Zika virus and the never-ending story of emerging pathogens and transfusion medicine. Blood Transfus. 2015: 1–6.
View Article
Google Scholar

[6] View Article

[7] Google Scholar

[ref3] 3. Center for Disease Control and Prevention. Zika Webpage. 2016.

[ref4] 4. World Health Organization. Epidemiological alert: neurological syndrome, congenital malformations, and Zika virus infection. Implications for public health in the Americas. WHO. 2015, December 1.

[ref5] 5. Pham MT, Rajic A, Greig JD, Sargeant JM, Papadopoulos A, McEwen SA. A scoping review of scoping reviews: advancing the approach and enhancing the consistency. 2014: n/a-n/a. 10.1002/jrsm.1123.

[ref6] 6. Colquhoun HL, Levac D, O'Brien KK, Straus S, Tricco AC, Perrier L, et al. Scoping reviews: time for clarity in definition, methods, and reporting. J Clin Epidemiol. 2014;67: 1291–1294. pmid:25034198
View Article
PubMed/NCBI
Google Scholar

[12] View Article

[13] PubMed/NCBI

[14] Google Scholar

[ref7] 7. Arksey H, O'Malley L. Scoping studies: towards a methodological framework. International Journal of Social Research Methodology. 2005;8: 19–32.
View Article
Google Scholar

[16] View Article

[17] Google Scholar

[ref8] 8. Levac D, Colquhoun H, O'Brien KK. Scoping studies: Advancing the methodology. Implementation Science. 2010;5.
View Article
Google Scholar

[19] View Article

[20] Google Scholar

[ref9] 9. Young I, Waddell L, Sanchez J, Wilhelm B, McEwen SA, Rajic A. The application of knowledge synthesis methods in agri-food public health: recent advancements, challenges and opportunities. Prev Vet Med. 2014;113: 339–355. pmid:24485274
View Article
PubMed/NCBI
Google Scholar

[22] View Article

[23] PubMed/NCBI

[24] Google Scholar

[ref10] 10. Tusevljak N, Rajic A, Waddell L, Dutil L, Cernicchiaro N, Greig J, et al. Prevalence of zoonotic bacteria in wild and farmed aquatic species and seafood: a scoping study, systematic review, and meta-analysis of published research. Foodborne Pathog Dis. 2012;9: 487–497. pmid:22571642
View Article
PubMed/NCBI
Google Scholar

[26] View Article

[27] PubMed/NCBI

[28] Google Scholar

[ref11] 11. European Centre for Disease Prevention and Control. Rapid risk assessment: Zika virus infection outbreak, French Polynesia. ECDC. 2014, February 14.

[ref12] 12. European Centre for Disease Prevention and Control. Rapid risk assessment: Zika virus infection outbreak, Brazil and the Pacific region– 25 May 2015. ECDC. 2015, May 25.

[ref13] 13. European Centre for Disease Prevention and Control. Zika virus epidemic in the Americas: potential association with microcephaly and Guillain-Barré syndrome (first update) 21 January 2016. ECDC. 2016, January 21.

[ref14] 14. Nhan T, Musso D. Emergence of the Zika virus. Virologie. 2015;19: 225–235.
View Article
Google Scholar

[33] View Article

[34] Google Scholar

[ref15] 15. Yasri S, Wiwanitkit V. New human pathogenic dengue like virus infections (Zika, Alkhumraand Mayaro viruses): A short review. Asian Pac J Trop Dis. 2015;5: S31–S32.
View Article
Google Scholar

[36] View Article

[37] Google Scholar

[ref16] 16. Musso D, Cao-Lormeau VM, Gubler DJ. Zika virus: Following the path of dengue and chikungunya? Lancet. 2015;386: 243–244. pmid:26194519
View Article
PubMed/NCBI
Google Scholar

[39] View Article

[40] PubMed/NCBI

[41] Google Scholar

[ref17] 17. Rodríguez-Morales AJ. Zika: The new arbovirus threat for latin america. J Infect Dev Ctries. 2015;9: 684–685. pmid:26142684
View Article
PubMed/NCBI
Google Scholar

[43] View Article

[44] PubMed/NCBI

[45] Google Scholar

[ref18] 18. Salim Mattar V, Marco Gonzalez T. Now is the time for the Zika virus. Rev MVZ Cordoba. 2015;20: 4511–4512.
View Article
Google Scholar

[47] View Article

[48] Google Scholar

[ref19] 19. Joob B, Wiwanitkit V. Zika virus infection and dengue: A new problem in diagnosis in a dengue-endemic area. Ann Trop Med Public Health. 2015;8: 145–146.
View Article
Google Scholar

[50] View Article

[51] Google Scholar

[ref20] 20. Derraik JG, Slaney D. Notes on Zika virus—An emerging pathogen now present in the South Pacific. Aust New Zealand J Public Health. 2015;39: 5–7.
View Article
Google Scholar

[53] View Article

[54] Google Scholar

[ref21] 21. Kuno G, Chang G-J. Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses. Arch Virol. 2007;152: 687–696. pmid:17195954
View Article
PubMed/NCBI
Google Scholar

[56] View Article

[57] PubMed/NCBI

[58] Google Scholar

[ref22] 22. Kilbourn AM, Karesh WB, Wolfe ND, Bosi EJ, Cook RA, Andau M. Health evaluation of free-ranging and semi-captive orangutans (Pongo pygmaeus pygmaeus) in Sabah, Malaysia. J Wildl Dis. 2003;39: 73–83. pmid:12685070
View Article
PubMed/NCBI
Google Scholar

[60] View Article

[61] PubMed/NCBI

[62] Google Scholar

[ref23] 23. Wolfe ND, Kilbourn AM, Karesh WB, Rahman HA, Bosi EJ, Cropp BC, et al. Sylvatic transmission of arboviruses among Bornean orangutans. Am J Trop Med Hyg. 2001;64: 310–316. pmid:11463123
View Article
PubMed/NCBI
Google Scholar

[64] View Article

[65] PubMed/NCBI

[66] Google Scholar

[ref24] 24. Pierre V, Drouet M, Deubel V. Identification of mosquito-borne flavivirus sequences using universal primers and reverse transcription/polymerase chain reaction. Res Virol. 1994;145: 93–104. pmid:7520190
View Article
PubMed/NCBI
Google Scholar

[68] View Article

[69] PubMed/NCBI

[70] Google Scholar

[ref25] 25. Martinez-Pulgarin DF, Acevedo-Mendoza WF, Cardona-Ospina JA, Rodríguez-Morales AJ, Paniz-Mondolfi AE. A bibliometric analysis of global Zika research. Travel Med Infect Dis. 2015.
View Article
Google Scholar

[72] View Article

[73] Google Scholar

[ref26] 26. Baba SS, Fagbami AH, Olaleye OD. Antigenic relatedness of selected flaviviruses: Study with homologous and heterologous immune mouse ascitic fluids. Rev Inst Med Trop Sao Paulo. 1998;40: 343–349. pmid:10436653
View Article
PubMed/NCBI
Google Scholar

[75] View Article

[76] PubMed/NCBI

[77] Google Scholar

[ref27] 27. Buckley A, Gould EA. Detection of virus-specific antigen in the nuclei or nucleoli of cells infected with Zika or Langat virus. J Gen Virol. 1988;69: 1913–1920. pmid:2841406
View Article
PubMed/NCBI
Google Scholar

[79] View Article

[80] PubMed/NCBI

[81] Google Scholar

[ref28] 28. Olson JG, Ksiazek TG, Gubler DJ, Lubis SI, Simanjuntak G, Lee VH, et al. A survey for arboviral antibodies in sera of humans and animals in Lombok, Republic of Indonesia. Ann Trop Med Parasitol. 1983;77: 131–137. pmid:6309104
View Article
PubMed/NCBI
Google Scholar

[83] View Article

[84] PubMed/NCBI

[85] Google Scholar

[ref29] 29. Pan American Health Organization. Epidemiological Alert Zika virus infection 7 May 2015. PAHO. 2015.

[ref30] 30. Aubry M, Richard V, Musso D. Amotosalen and ultraviolet a light inactivate zika virus in plasma. Vox Sang. 2015;109: 189–190.
View Article
Google Scholar

[88] View Article

[89] Google Scholar

[ref31] 31. Miller BR, Mitchell CJ. Genetic selection of a flavivirus-refractory strain of the yellow fever mosquito Aedes aegypti. Am J Trop Med Hyg. 1991;45: 399–407. pmid:1659238
View Article
PubMed/NCBI
Google Scholar

[91] View Article

[92] PubMed/NCBI

[93] Google Scholar

[ref32] 32. Aubry M, Richard V, Green J, Broult J, Musso D. Inactivation of Zika virus in plasma with amotosalen and ultraviolet A illumination. Transfusion. 2016;56: 33–40. pmid:26283013
View Article
PubMed/NCBI
Google Scholar

[95] View Article

[96] PubMed/NCBI

[97] Google Scholar

[ref33] 33. Sabogal-Roman JA, Murillo-García DR, Yepes-Echeverri MC, Restrepo-Mejia JD, Granados-Álvarez S, Paniz-Mondolfi AE, et al. Healthcare students and workers' knowledge about transmission, epidemiology and symptoms of Zika fever in four cities of Colombia. Travel Med Infect Dis. 2015.
View Article
Google Scholar

[99] View Article

[100] Google Scholar

[ref34] 34. Bogoch II, Brady OJ, Kraemer MUG, German M, Creatore MI, Kulkarni MA, et al. Anticipating the international spread of Zika virus from Brazil. The Lancet. 2016;387: 335–336.
View Article
Google Scholar

[102] View Article

[103] Google Scholar

[ref35] 35. Althouse BM, Hanley KA, Diallo M, Sall AA, Ba Y, Faye O, et al. Impact of climate and mosquito vector abundance on sylvatic arbovirus circulation dynamics in senegal. Am J Trop Med Hyg. 2015;92: 88–97. pmid:25404071
View Article
PubMed/NCBI
Google Scholar

[105] View Article

[106] PubMed/NCBI

[107] Google Scholar

[ref36] 36. Kucharski AJ, Funk S, Eggo RM, Mallet HP, Edmunds WJ, Nilles EJ. Transmission dynamics of Zika virus in island populations: a modelling analysis of the 2013{14 French Polynesia outbreak. bioRxiv. EPUB: Feb. 7, 2016.
View Article
Google Scholar

[109] View Article

[110] Google Scholar

[ref37] 37. Reagan RL, Brueckner AL. Comparison by electron microscopy of the Ntaya and Zika viruses. Tex Rep Biol Med. 1953;11: 347–351. pmid:13077401
View Article
PubMed/NCBI
Google Scholar

[112] View Article

[113] PubMed/NCBI

[114] Google Scholar

[ref38] 38. Weinbren MP, Williams MC. Zika virus: Further isolations in the zika area, and some studies on the strains isolated. Trans R Soc Trop Med Hyg. 1958;52: 263–268. pmid:13556872
View Article
PubMed/NCBI
Google Scholar

[116] View Article

[117] PubMed/NCBI

[118] Google Scholar

[ref39] 39. Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, et al. Biology of Zika virus infection in human skin cells. J Virol. 2015;89: 8880–8896. pmid:26085147
View Article
PubMed/NCBI
Google Scholar

[120] View Article

[121] PubMed/NCBI

[122] Google Scholar

[ref40] 40. Way HJ, Bowen ETW, Platt GS. Comparative studies of some African arboviruses in cell culture and in mice. J Gen Virol. 1976;30: 123–130. pmid:1245842
View Article
PubMed/NCBI
Google Scholar

[124] View Article

[125] PubMed/NCBI

[126] Google Scholar

[ref41] 41. Reagan RL, Chang SC, Brueckner AL. Electron micrographs of erythrocytes from Swiss albino mice infected with Zika virus. Tex Rep Biol Med. 1955;13: 934–938. pmid:13281796
View Article
PubMed/NCBI
Google Scholar

[128] View Article

[129] PubMed/NCBI

[130] Google Scholar

[ref42] 42. Bell TM, Field EJ, Narang HK. Zika virus infection of the central nervous system of mice. Archiv f Virusforschung. 1971;35: 183–193.
View Article
Google Scholar

[132] View Article

[133] Google Scholar

[ref43] 43. MacNamara FN. Zika virus: A report on three cases of human infection during an epidemic of jaundice in Nigeria. Trans R Soc Trop Med Hyg. 1954;48: 139–145. pmid:13157159
View Article
PubMed/NCBI
Google Scholar

[135] View Article

[136] PubMed/NCBI

[137] Google Scholar

[ref44] 44. Dick GWA. Zika virus (II). Pathogenicity and physical properties. Trans R Soc Trop Med Hyg. 1952;46: 521–534. pmid:12995441
View Article
PubMed/NCBI
Google Scholar

[139] View Article

[140] PubMed/NCBI

[141] Google Scholar

[ref45] 45. Rockefeller Foundation. Rockefeller Foundation Annual Report. Zika pages 131–140. Rockefeller Foundation, NY, USA. 1951.

[ref46] 46. Henerson B, Cheshire P, Kirya G, Lule M. Immunologic Studies with Yellow Fever and Selected African Group B Arboviruses in Rhesus and Vervet Monkeys. The American Journal of Tropical Medicine and Hygiene. 1970;19: 110. pmid:4984581
View Article
PubMed/NCBI
Google Scholar

[144] View Article

[145] PubMed/NCBI

[146] Google Scholar

[ref47] 47. Lanciotti RS, Lambert AJ, Holodniy M, Saavedra S, del Carmen Castillo Signor L. Phylogeny of Zika virus inWestern Hemisphere,2015 [letter]. Emerg Infect Dis. 2016 May.
View Article
Google Scholar

[148] View Article

[149] Google Scholar

[ref48] 48. Sarno M, Sacramento GA, Khouri R, do Rosario MS, Costa F, Archanjo G, et al. Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise. PLoS Negl Trop Dis. 2016;10.
View Article
Google Scholar

[151] View Article

[152] Google Scholar

[ref49] 49. de M Campos R, Cirne-Santos C, Meira GL, Santos LL, de Meneses MD, Friedrich J, et al. Prolonged detection of Zika virus RNA in urine samples during the ongoing Zika virus epidemic in Brazil. J Clin Virol. 2016;77: 69–70. S1386-6532(16)30001-4 [pii]. pmid:26921737
View Article
PubMed/NCBI
Google Scholar

[154] View Article

[155] PubMed/NCBI

[156] Google Scholar

[ref50] 50. Kuno G, Chang GJ, Tsuchiya KR, Karabatsos N, Cropp CB. Phylogeny of the genus Flavivirus. J Virol. 1998;72: 73–83. pmid:9420202
View Article
PubMed/NCBI
Google Scholar

[158] View Article

[159] PubMed/NCBI

[160] Google Scholar

[ref51] 51. Freire CCM, lamarino A, Neto DF, Sall AA, Zanotto PMA. Spread of the pandemic Zika virus lineage is associated with NS1 codon usage adaptation in humans. bioRxiv. 2015.
View Article
Google Scholar

[162] View Article

[163] Google Scholar

[ref52] 52. Calvet G, Aguiar RS, Melo AS, Sampaio SA, de Filippis I, Fabri A, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016. S1473-3099(16)00095-5 [pii].
View Article
Google Scholar

[165] View Article

[166] Google Scholar

[ref53] 53. Perkasa A, Yudhaputri F, Haryanto S, Hayati RF, Chairin NM, Antonjaya U, et al. Isolation of Zika Virus from Febrile Patient, Indonesia. Emerg Infect Dis. 2016;22.
View Article
Google Scholar

[168] View Article

[169] Google Scholar

[ref54] 54. Camacho E, Paternina-Gomez M, Blanco PJ, Osorio JE, Aliota MT. Detection of Autochthonous Zika Virus Transmission in Sincelejo, Colombia. Emerging Infectious Disease journal. 2016;22.
View Article
Google Scholar

[171] View Article

[172] Google Scholar

[ref55] 55. Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, et al. Zika Virus Associated with Microcephaly. N Engl J Med. 2016.
View Article
Google Scholar

[174] View Article

[175] Google Scholar

[ref56] 56. Martines RB, Bhatnagar J, Keating MK, Silva-Flannery L, Muehlenbachs A, Gary J, et al. Notes from the Field: Evidence of Zika Virus Infection in Brain and Placental Tissues from Two Congenitally Infected Newborns and Two Fetal Losses—Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016;65: 159–160. pmid:26890059
View Article
PubMed/NCBI
Google Scholar

[177] View Article

[178] PubMed/NCBI

[179] Google Scholar

[ref57] 57. Pyke AT, Daly MT, Cameron JN, Moore PR, Taylor CT, Hewitson GR, et al. Imported zika virus infection from the cook islands into australia, 2014. PLoS Curr. 2014;6.
View Article
Google Scholar

[181] View Article

[182] Google Scholar

[ref58] 58. Korhonen EM, Huhtamo E, Smura T, Kallio-Kokko H, Raassina M, Vapalahti O. Zika virus infection in a traveller returning from the Maldives, June 2015. Euro Surveill. 2016;21.
View Article
Google Scholar

[184] View Article

[185] Google Scholar

[ref59] 59. Baronti C, Piorkowski G, Charrel RN, Boubis L, LeparcGoffart I, Lamballerie X. Complete coding sequence of Zika virus from a French Polynesia outbreak in 2013. Genome Announcements. 2014;2: e00500–14. pmid:24903869
View Article
PubMed/NCBI
Google Scholar

[187] View Article

[188] PubMed/NCBI

[189] Google Scholar

[ref60] 60. Fonseca K, Meatherall B, Zarra D, Drebot M, MacDonald J, Pabbaraju K, et al. First case of Zika virus infection in a returning Canadian traveler. Am J Trop Med Hyg. 2014;91: 1035–1038. http://dx.doi.org/10.4269/ajtmh.14-0151. pmid:25294619
View Article
PubMed/NCBI
Google Scholar

[191] View Article

[192] PubMed/NCBI

[193] Google Scholar

[ref61] 61. Enfissi A, Codrington J, Roosblad J, Kazanji M, Rousset D. Zika virus genome from the Americas. Lancet. 2016;387: 227–228. http://dx.doi.org/10.1016/S0140-6736(16)00003-9. pmid:26775124
View Article
PubMed/NCBI
Google Scholar

[195] View Article

[196] PubMed/NCBI

[197] Google Scholar

[ref62] 62. Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008;14: 1232–1239. pmid:18680646
View Article
PubMed/NCBI
Google Scholar

[199] View Article

[200] PubMed/NCBI

[201] Google Scholar

[ref63] 63. Haddow AD, Schuh AJ, Yasuda CY, Kasper MR, Heang V, Huy R, et al. Genetic characterization of zika virus strains: Geographic expansion of the asian lineage. PLoS Negl Trop Dis. 2012;6.
View Article
Google Scholar

[203] View Article

[204] Google Scholar

[ref64] 64. Li MI, Wong PSJ, Ng LC, Tan CH. Oral Susceptibility of Singapore Aedes (Stegomyia) aegypti (Linnaeus) to Zika Virus. PLoS Negl Trop Dis. 2012;6.
View Article
Google Scholar

[206] View Article

[207] Google Scholar

[ref65] 65. Wong P-J, Li M-I, Chong C, Ng L, Tan C. Aedes (Stegomyia) albopictus (Skuse): A Potential Vector of Zika Virus in Singapore. PLoS Negl Trop Dis. 2013;7.
View Article
Google Scholar

[209] View Article

[210] Google Scholar

[ref66] 66. Kwong JC, Druce JD, Leder K. Case report: Zika virus infection acquired during brief travel to indonesia. Am J Trop Med Hyg. 2013;89: 516–517. pmid:23878182
View Article
PubMed/NCBI
Google Scholar

[212] View Article

[213] PubMed/NCBI

[214] Google Scholar

[ref67] 67. Wæhre T, Maagard A, Tappe D, Cadar D, Schmidt-Chanasit J. Zika virus infection after travel to Tahiti, December 2013. Emerg Infect Dis. 2014;20: 1412–1414. pmid:25062427
View Article
PubMed/NCBI
Google Scholar

[216] View Article

[217] PubMed/NCBI

[218] Google Scholar

[ref68] 68. Faye O, Freire CCM, Iamarino A, Faye O, de Oliveira JVC, Diallo M, et al. Molecular Evolution of Zika Virus during Its Emergence in the 20th Century. PLoS Negl Trop Dis. 2014;8: 36.
View Article
Google Scholar

[220] View Article

[221] Google Scholar

[ref69] 69. Kutsuna S, Kato Y, Takasaki T, Moi ML, Kotaki A, Uemura H, et al. Two cases of zika fever imported from french polynesia to Japan, December to January 2013. Eurosurveillance. 2014;19.
View Article
Google Scholar

[223] View Article

[224] Google Scholar

[ref70] 70. Berthet N, Nakouné E, Kamgang B, Selekon B, Descorps-Declère S, Gessain A, et al. Molecular characterization of three zika flaviviruses obtained from sylvatic mosquitoes in the Central African Republic. Vector Borne Zoonotic Dis. 2014;14: 862–865. pmid:25514122
View Article
PubMed/NCBI
Google Scholar

[226] View Article

[227] PubMed/NCBI

[228] Google Scholar

[ref71] 71. Musso D, Nhan T, Robin E, Roche C, Bierlaire D, Zisou K, et al. Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Eurosurveillance. 2014;19.
View Article
Google Scholar

[230] View Article

[231] Google Scholar

[ref72] 72. Cao-Lormeau V. : Zika virus, French Polynesia, South Pacific, 2013. Emerg Infect Dis. 2014;20: 1960. pmid:24856001
View Article
PubMed/NCBI
Google Scholar

[233] View Article

[234] PubMed/NCBI

[235] Google Scholar

[ref73] 73. Campos GS, Bandeira AC, Sardi SI. Zika virus outbreak, Bahia, Brazil. Emerg Infect Dis. 2015;21: 1885–1886. pmid:26401719
View Article
PubMed/NCBI
Google Scholar

[237] View Article

[238] PubMed/NCBI

[239] Google Scholar

[ref74] 74. Dupont-Rouzeyrol M, O’Connor O, Calvez E, Daures M, John M, Grangeon J, et al. Co-infection with zika and dengue viruses in 2 patients, New Caledonia, 2014. Emerg Infect Dis. 2015;21: 381–382. pmid:25625687
View Article
PubMed/NCBI
Google Scholar

[241] View Article

[242] PubMed/NCBI

[243] Google Scholar

[ref75] 75. Alera MT, Hermann L, Tac-An IA, Klungthong C, Rutvisuttinunt W, Manasatienkij W, et al. Zika virus infection, philippines, 2012. Emerg Infect Dis. 2015;21: 722–724. pmid:25811410
View Article
PubMed/NCBI
Google Scholar

[245] View Article

[246] PubMed/NCBI

[247] Google Scholar

[ref76] 76. Zanluca C, De Melo VCA, Mosimann ALP, Dos Santos GIV, dos Santos CND, Luz K. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz. 2015;110: 569–572. pmid:26061233
View Article
PubMed/NCBI
Google Scholar

[249] View Article

[250] PubMed/NCBI

[251] Google Scholar

[ref77] 77. Buathong R, Hermann L, Thaisomboonsuk B, Rutvisuttinunt W, Klungthong C, Chinnawirotpisan P, et al. Detection of zika virus infection in Thailand, 2012–2014. Am J Trop Med Hyg. 2015;93: 380–383. pmid:26101272
View Article
PubMed/NCBI
Google Scholar

[253] View Article

[254] PubMed/NCBI

[255] Google Scholar

[ref78] 78. Leung GH, Baird RW, Druce J, Anstey NM. Zika Virus Infection in Australia Following a Monkey Bite in Indonesia. Southeast Asian J Trop Med Public Health. 2015;46: 460–464. pmid:26521519
View Article
PubMed/NCBI
Google Scholar

[257] View Article

[258] PubMed/NCBI

[259] Google Scholar

[ref79] 79. Tognarelli J, Ulloa S, Villagra E, Lagos J, Aguayo C, Fasce R, et al. A report on the outbreak of Zika virus on Easter Island, South Pacific, 2014. Arch Virol. 2015: 1–4.
View Article
Google Scholar

[261] View Article

[262] Google Scholar

[ref80] 80. Oliveira Melo AS, Malinger G, Ximenes R, Szejnfeld PO, Alves Sampaio S, Bispo De Filippis AM. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: Tip of the iceberg? Ultrasound Obstet Gynecol. 2016;47: 6–7. pmid:26731034
View Article
PubMed/NCBI
Google Scholar

[264] View Article

[265] PubMed/NCBI

[266] Google Scholar

[ref81] 81. Calvet GA, Filippis AMB, Mendonça MCL, Sequeira PC, Siqueira AM, Veloso VG, et al. First detection of autochthonous Zika virus transmission in a HIV-infected patient in Rio de Janeiro, Brazil. J Clin Virol. 2016;74: 1–3. pmid:26615388
View Article
PubMed/NCBI
Google Scholar

[268] View Article

[269] PubMed/NCBI

[270] Google Scholar

[ref82] 82. Heang V, Yasuda CY, Sovann L, Haddow AD, da Rosa APT, Tesh RB, et al. Zika virus infection, Cambodia, 2010. Emerg Infect Dis. 2012;18: 349–351. pmid:22305269
View Article
PubMed/NCBI
Google Scholar

[272] View Article

[273] PubMed/NCBI

[274] Google Scholar

[ref83] 83. Grard G, Caron M, Mombo IM, Nkoghe D, Mboui Ondo S, Jiolle D, et al. Zika Virus in Gabon (Central Africa) - 2007: A New Threat from Aedes albopictus? PLoS Negl Trop Dis. 2014;8.
View Article
Google Scholar

[276] View Article

[277] Google Scholar

[ref84] 84. Diagne CT, Diallo D, Faye O, Ba Y, Faye O, Gaye A, et al. Potential of selected Senegalese Aedes spp. mosquitoes (Diptera: Culicidae) to transmit Zika virus. BMC Infect Dis. 2015;15.
View Article
Google Scholar

[279] View Article

[280] Google Scholar

[ref85] 85. Ledermann JP, Guillaumot L, Yug L, Saweyog SC, Tided M, Machieng P, et al. Aedes hensilli as a Potential Vector of Chikungunya and Zika Viruses. PLoS Negl Trop Dis. 2014;8.
View Article
Google Scholar

[282] View Article

[283] Google Scholar

[ref86] 86. Monlun E, Zeller H, Le Guenno B, Traoré-Lamizana M, Hervy JP, Adam F, et al. Surveillance of the circulation of arbovirus of medical interest in the region of eastern Senegal. Bull Soc Pathol Exot. 1993;86: 21–28. pmid:8099299
View Article
PubMed/NCBI
Google Scholar

[285] View Article

[286] PubMed/NCBI

[287] Google Scholar

[ref87] 87. Marchette NJ, Garcia R, Rudnick A. Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. Am J Trop Med Hyg. 1969;18: 411–415. pmid:4976739
View Article
PubMed/NCBI
Google Scholar

[289] View Article

[290] PubMed/NCBI

[291] Google Scholar

[ref88] 88. Bearcroft WGC. Zika virus infection experimentally induced in a human volunteer. Trans R Soc Trop Med Hyg. 1956;50: 438–441.
View Article
Google Scholar

[293] View Article

[294] Google Scholar

[ref89] 89. Boorman JPT, Porterfield JS. A simple technique for infection of mosquitoes with viruses transmission of zika virus. Trans R Soc Trop Med Hyg. 1956;50: 238–242. pmid:13337908
View Article
PubMed/NCBI
Google Scholar

[296] View Article

[297] PubMed/NCBI

[298] Google Scholar

[ref90] 90. Cornet M, Robin Y, Adam C, Valade M, Calvo MA. Comparison between experimental transmission of yellow fever and Zika viruses in Aedes aegypti. Cahiers O R S T O M Serie entomologie medicale et parasitologie. 1979;17: 47–53.
View Article
Google Scholar

[300] View Article

[301] Google Scholar

[ref91] 91. Diallo D, Sall AA, Diagne CT, Faye O, Faye O, Ba Y, et al. Zika virus emergence in mosquitoes in Southeastern Senegal, 2011. 2014;9: e10; 44 ref. http://dx.doi.org/10.1371/journal.pone.0109442.
View Article
Google Scholar

[303] View Article

[304] Google Scholar

[ref92] 92. AkouaKoffi C, Diarrassouba S, Benie VB, Ngbichi JM, Bozoua T, Bosson A, et al. Inquiry into a fatal case of yellow fever in Cote d'Ivoire in 1999. Bulletin de la Societe de Pathologie Exotique. 2001;94: 227–230.
View Article
Google Scholar

[306] View Article

[307] Google Scholar

[ref93] 93. Traore Lamizana M, Zeller H, Monlun E, Mondo M, Hervy JP, Adam F, et al. Dengue 2 outbreak in southeastern Senegal during 1990: virus isolations from mosquitoes (Diptera: Culicidae). J Med Entomol. 1994;31: 623–627. pmid:7932611
View Article
PubMed/NCBI
Google Scholar

[309] View Article

[310] PubMed/NCBI

[311] Google Scholar

[ref94] 94. Robert V, Lhuillier M, Meunier D. Yellow fever virus, dengue 2 virus and other arboviruses isolated from mosquitoes in Burkina Faso during 1983–86. Entomological and epidemiological considerations. Bull Soc Pathol Exot. 1993;86: 90–100. pmid:8102567
View Article
PubMed/NCBI
Google Scholar

[313] View Article

[314] PubMed/NCBI

[315] Google Scholar

[ref95] 95. Lee VH, Moore DL. Vectors of the 1969 yellow fever epidemic on the Jos Plateau, Nigeria. Bull World Health Organ. 1972;46: 669–673. pmid:4403105
View Article
PubMed/NCBI
Google Scholar

[317] View Article

[318] PubMed/NCBI

[319] Google Scholar

[ref96] 96. Faye O, Faye O, Diallo D, Diallo M, Weidmann M, Sall AA. Quantitative real-time PCR detection of Zika virus and evaluation with field-caught Mosquitoes. Virol J. 2013;10.
View Article
Google Scholar

[321] View Article

[322] Google Scholar

[ref97] 97. McCrae AWR, Kirya BG. Yellow fever and Zika virus epizootics and enzootics in Uganda. Trans R Soc Trop Med Hyg. 1982;76: 552–562. pmid:6304948
View Article
PubMed/NCBI
Google Scholar

[324] View Article

[325] PubMed/NCBI

[326] Google Scholar

[ref98] 98. Haddow AJ, Williams MC, Woodall JP, Simpson DI, Goma LK. Twelve Isolations of Zika Virus from Aedes (Stegomyia) Africanus (Theobald) Taken in and Above a Uganda Forest. Bull World Health Organ. 1964;31: 57–69. pmid:14230895
View Article
PubMed/NCBI
Google Scholar

[328] View Article

[329] PubMed/NCBI

[330] Google Scholar

[ref99] 99. Cornet M, Robin Y, Chateau R, Heme G, Adam C, Valade M, et al. Isolations of arboviruses in eastern Senegal from mosquitoes (1972–1977) and notes on the epidemiology of viruses transmitted by Aedes spp., especially yellow fever. Cahiers ORSTOM, Entomologie Medicale et Parasitologie. 1979;17: 149–163.
View Article
Google Scholar

[332] View Article

[333] Google Scholar

[ref100] 100. Duffy MR, Chen T, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. New Engl J Med. 2009;360: 2536–2543. pmid:19516034
View Article
PubMed/NCBI
Google Scholar

[335] View Article

[336] PubMed/NCBI

[337] Google Scholar

[ref101] 101. Kading Mossel, Borland Ledermann, Panella Crabtree, et al. Arbovirus surveillance in bats in Uganda. American Journal of Tropical Medicine and Hygiene Conference. 2014;91: 260.
View Article
Google Scholar

[339] View Article

[340] Google Scholar

[ref102] 102. Kirya BG, Okia NO. A yellow fever epizootic in Zika Forest, Uganda, during 1972: Part 2: Monkey serology. Trans R Soc Trop Med Hyg. 1977;71: 300–303. pmid:413216
View Article
PubMed/NCBI
Google Scholar

[342] View Article

[343] PubMed/NCBI

[344] Google Scholar

[ref103] 103. Saluzzo JF, Ivanoff B, Languillat G, Georges AJ. Serological survey for arbovirus antibodies in the human and simian populations of the South East of Gabon. Bull Soc Pathol Exot Fil. 1982;75: 262–266.
View Article
Google Scholar

[346] View Article

[347] Google Scholar

[ref104] 104. Saluzzo JF, Sarthou JL, Cornet M. Specific ELISA-IgM antibodies for diagnosis and epidemiological surveillance of flaviviruses in Africa. Ann Inst Pasteur Virol. 1986;137: 155–170.
View Article
Google Scholar

[349] View Article

[350] Google Scholar

[ref105] 105. Darwish MA, Hoogstraal H, Roberts TJ, Ahmed IP, Omar F. A sero-epidemiological survey for certain arboviruses (Togaviridae) in Pakistan. Trans R Soc Trop Med Hyg. 1983;77: 442–445. pmid:6314612
View Article
PubMed/NCBI
Google Scholar

[352] View Article

[353] PubMed/NCBI

[354] Google Scholar

[ref106] 106. Crockett Ledermann, Borland Powers, Panella Crabtree, Miller. Arbovirus surveillance and virus isolations from bats in Uganda, Kenya, and the democratic republic of the Congo. American Journal of Tropical Medicine and Hygiene Conference. 2012;87: 170.
View Article
Google Scholar

[356] View Article

[357] Google Scholar

[ref107] 107. Crockett Crabtree, Ledermann Borland, Powers Mutebi, et al. Investigations into mosquito blood feeding patterns on wildlife and a potential role for bats in arbovirus transmission cycles in Uganda. American Journal of Tropical Medicine and Hygiene Conference. 2011;85: 374–375.
View Article
Google Scholar

[359] View Article

[360] Google Scholar

[ref108] 108. Pond WL. Arthropod-borne virus antibodies in sera from residents of South-East Asia. Trans R Soc Trop Med Hyg. 1963;57: 364–371. pmid:14062273
View Article
PubMed/NCBI
Google Scholar

[362] View Article

[363] PubMed/NCBI

[364] Google Scholar

[ref109] 109. Geser A, Henderson BE, Christensen S. A multipurpose serological survey in Kenya. 2. Results of arbovirus serological tests. Bull World Health Organ. 1970;43: 539–552. pmid:5313066
View Article
PubMed/NCBI
Google Scholar

[366] View Article

[367] PubMed/NCBI

[368] Google Scholar

[ref110] 110. Babaniyi OA, Mwaba P, Songolo P, Mazaba-Liwewe ML, Mweene-Ndumba I, Masaninga F, et al. Seroprevalence of Zika virus infection specific IgG in Western and North-Western Provinces of Zambia. International Journal of Public Health and Epidemiology. 2015, January;4: 110–114.
View Article
Google Scholar

[370] View Article

[371] Google Scholar

[ref111] 111. Kokernot RH, Casaca VMR, Weinbren MP, McIntosh BM. Survey for antibodies against arthropod-borne viruses in the sera of indigenous residents of Angola. Trans R Soc Trop Med Hyg. 1965;59: 563–570. pmid:5893149
View Article
PubMed/NCBI
Google Scholar

[373] View Article

[374] PubMed/NCBI

[375] Google Scholar

[ref112] 112. Rodhain F, Carterton B, Laroche R, Hannoun C. Human arbovirus infections in Burundi: results of a seroepidemiological survey, 1980–1982. Bull Soc Pathol Exot Filiales. 1987;80: 155–161. pmid:3038355
View Article
PubMed/NCBI
Google Scholar

[377] View Article

[378] PubMed/NCBI

[379] Google Scholar

[ref113] 113. Fokam EB, Levai LD, Guzman H, Amelia PA, Titanji VP, Tesh RB, et al. Silent circulation of arboviruses in Cameroon. East Afr Med J. 2010;87: 262–268. pmid:23057269
View Article
PubMed/NCBI
Google Scholar

[381] View Article

[382] PubMed/NCBI

[383] Google Scholar

[ref114] 114. Boche R, Jan C, Le Noc P, Ravisse P. Immunologic survey on the incidence of arboviruses in the Pygmy population in Eastern Cameroon (Djoum area). Bull Soc Pathol Exot Fil. 1974;67: 126–140.
View Article
Google Scholar

[385] View Article

[386] Google Scholar

[ref115] 115. World Health Organization. Zika virus infection–Cape Verde. Disease Outbreak News. 21 December 2015. WHO. 2015.

[ref116] 116. World Health Organization. Neurological Syndrome and Congenital Anomalies. Situration Report. 5 February 2016. WHO. 2016.

[ref117] 117. World Health Organization. Zika Virus Microcephaly and Gullian-Barre Syndrome: Situation Report. 19 February 2016. WHO. 2016.

[ref118] 118. Saluzzo JF, Gonzalez JP, Herve JP, Georges AJ. Serological survey for the prevalence of certain arboviruses in the human population of the south-east area of Central African Republic. Bull Soc Pathol Exot Fil. 1981;74: 490–499.
View Article
Google Scholar

[391] View Article

[392] Google Scholar

[ref119] 119. Tsegaye . Virological and serological investigation of the first dengue fever outbreak in Ethiopia. American Journal of Tropical Medicine and Hygiene Conference. 2014;91: 53.
View Article
Google Scholar

[394] View Article

[395] Google Scholar

[ref120] 120. Jan Ch., Languillat G, Renaudet J, Robin Y. A serologic survey on arboviruses in Gabon. Bull Soc Pathol Exot Fil. 1978;71: 140–146.
View Article
Google Scholar

[397] View Article

[398] Google Scholar

[ref121] 121. De Araujo LJ, Bausch D.G., Mores C.N. Serological evidence of co-circulating dengue virus serotypes, an underreported arboviral disease in Guinea. Am J Trop Med Hyg. 2010;83: 314.
View Article
Google Scholar

[400] View Article

[401] Google Scholar

[ref122] 122. Ofula Wurapa. Evidence of circulation of selected arboviruses in ijara and marigat districts, Kenya. American Journal of Tropical Medicine and Hygiene Conference. 2013;89: 278.
View Article
Google Scholar

[403] View Article

[404] Google Scholar

[ref123] 123. Ofula Wurapa. Seroprevalence of selected arboviruses in ijara and marigat districts,Kenya. American Journal of Tropical Medicine and Hygiene Conference. 2012;87: 126.
View Article
Google Scholar

[406] View Article

[407] Google Scholar

[ref124] 124. Bowen ETW, Simpson DIH, Platt GS, Way H, Bright WF, Day J, et al. Large scale irrigation and arbovirus epidemiology, Kano plain, Kenya II. Preliminary serological survey. Trans R Soc Trop Med Hyg. 1973;67: 702–709. pmid:4779116
View Article
PubMed/NCBI
Google Scholar

[409] View Article

[410] PubMed/NCBI

[411] Google Scholar

[ref125] 125. Adekolu-John EO, Fagbami AH. Arthropod-borne virus antibodies in sera of residents of Kainji Lake Basin, Nigeria 1980. Trans R Soc Trop Med Hyg. 1983;77: 149–151. pmid:6306872
View Article
PubMed/NCBI
Google Scholar

[413] View Article

[414] PubMed/NCBI

[415] Google Scholar

[ref126] 126. Fagbami A. Epidemiological investigations on arbovirus infections at Igbo-Ora, Nigeria. Trop Geogr Med. 1977;29: 187–191. pmid:906078
View Article
PubMed/NCBI
Google Scholar

[417] View Article

[418] PubMed/NCBI

[419] Google Scholar

[ref127] 127. Fagbami AH. Zika virus infections in Nigeria: Virological and seroepidemiological investigations in Oyo State. J Hyg. 1979;83: 213–219. pmid:489960
View Article
PubMed/NCBI
Google Scholar

[421] View Article

[422] PubMed/NCBI

[423] Google Scholar

[ref128] 128. Monath TP, Wilson DC, Casals J. The 1970 yellow fever epidemic in Okwoga District, Benue Plateau State, Nigeria. 3. Serological responses in persons with and without pre-existing heterologous group B immunity. BULL WHO. 1973;49: 235–244. pmid:4546521
View Article
PubMed/NCBI
Google Scholar

[425] View Article

[426] PubMed/NCBI

[427] Google Scholar

[ref129] 129. Moore DL, Causey OR, Carey DE, Reddy S, Cooke AR, Akinkugbe FM, et al. Arthropod borne viral infections of man in Nigeria, 1964–1970. Ann Trop Med Parasitol. 1975;69: 49–64. pmid:1124969
View Article
PubMed/NCBI
Google Scholar

[429] View Article

[430] PubMed/NCBI

[431] Google Scholar

[ref130] 130. Macnamara FN, Horn DW, Porterfield JS. Yellow fever and other arthropod-borne viruses. A consideration of two serological surveys made in South Western Nigeria. Trans R Soc Trop Med Hyg. 1959;53: 202–212. pmid:13647627
View Article
PubMed/NCBI
Google Scholar

[433] View Article

[434] PubMed/NCBI

[435] Google Scholar

[ref131] 131. Sow A, Loucoubar C, Diallo D, Faye O, Ndiaye Y, Senghor CS, et al. Concurrent malaria and arbovirus infections in Kedougou, southeastern Senegal. Malar J. 2016;15: 47-016-1100-5.
View Article
Google Scholar

[437] View Article

[438] Google Scholar

[ref132] 132. Renaudet J, Jan C, Ridet J, Adam C, Robin Y. A serological survey of arboviruses in the human population of Senegal. Bull Soc Pathol Exot Filiales. 1978;71: 131–140. pmid:33772
View Article
PubMed/NCBI
Google Scholar

[440] View Article

[441] PubMed/NCBI

[442] Google Scholar

[ref133] 133. Robin Y, Mouchet J. Serological and entomological survey of yellow fever in Sierra Leone. Bull Soc Pathol Exot. 1975;68: 249–258.
View Article
Google Scholar

[444] View Article

[445] Google Scholar

[ref134] 134. Direction de la santé Bureau de veille sanitaire. Surveillance et veille sanitaire en Polynésie française. Données du 01 au 07 Février 2016 (Semaine 05). Direction de la santé Bureau de veille sanitaire. 2016.

[ref135] 135. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 6, ending 14 Feb, 2016. WHO. 2016.

[ref136] 136. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 7, ending 21 Feb, 2016. WHO. 2016.

[ref137] 137. Roth A, Mercier A, Lepers C, Hoy D, Duituturaga S, Benyon E, et al. Concurrent outbreaks of dengue, chikungunya and zika virus infections–An unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012–2014. Eurosurveillance. 2014;19.
View Article
Google Scholar

[450] View Article

[451] Google Scholar

[ref138] 138. Institut de Veille Sanitaire. Bulletin Hebdomadaire International N°442, 05 au 11 mars 2014. Institut de Veille Sanitaire. 2014.

[ref139] 139. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 17, ending 27 Apr, 2014. WHO. 2014.

[ref140] 140. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 20, ending 17 May, 2015. WHO. 2015.

[ref141] 141. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 20, ending 18 May, 2014. WHO. 2014.

[ref142] 142. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 21, ending 25 May, 2014. WHO. 2014.

[ref143] 143. World Health Organization. Pacific syndromic surveillance report. Week 33, ending 16 August, 2015. WHO. 2015.

[ref144] 144. Mallet HP. Emergence du virus Zika en Polynésie française [presentation]. Conference: 15es JNI, Bordeaux du 11 au 13 juin 2014. 2014.

[ref145] 145. Agence Regionale de Sante. Emergence des maladies infectieuses. Bulletin de veille sanitaire. no2 Jun-Aug 2014. Agence Regionale de Sante. 2014.

[ref146] 146. Mallet HP, Vial AL, Musso D. Bilan de l'Epidemie a Virus Zika en Polynesie Francaise, 2013–2014. Bulletin d'Information Sanitaires, Epidemiologiques et Statistiques. 2015.
View Article
Google Scholar

[461] View Article

[462] Google Scholar

[ref147] 147. Institut de Veille Sanitaire. Virus Zika Polynesie 2013–2014, Isle de yap, Micronesia 2007 (janvier 2014). Institut de Veille Sanitaire. 2014.

[ref148] 148. Jouannic JM, Friszer S, Leparc-Goffart I, Garel C, Eyrolle-Guignot D. Zika virus infection in French Polynesia. Lancet. 2016. S0140-6736(16)00625-5 [pii].
View Article
Google Scholar

[465] View Article

[466] Google Scholar

[ref149] 149. Aubry M, Finke J, Teissier A, Roche C, Broult J, Paulous S, et al. Seroprevalence of arboviruses among blood donors in French Polynesia, 2011–2013. Int J Infect Dis. 2015;41: 11–12. pmid:26482390
View Article
PubMed/NCBI
Google Scholar

[468] View Article

[469] PubMed/NCBI

[470] Google Scholar

[ref150] 150. Antonjaya . Study of arboviruses in archived specimens from acute febrile illness studies in bandung,Indonesia. American Journal of Tropical Medicine and Hygiene Conference. 2012;87: 122.
View Article
Google Scholar

[472] View Article

[473] Google Scholar

[ref151] 151. Van Peenen PFD, Joseph SW, Casals J. Arbovirus antibodies in Indonesians at Malili, South Sulawesi (Celebes) and Balikpapan, E. Kalimantan (Borneo). Ann Trop Med Parasitol. 1975;69: 475–482.
View Article
Google Scholar

[475] View Article

[476] Google Scholar

[ref152] 152. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 24, ending 15 Jun, 2014. WHO. 2014.

[ref153] 153. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 30, ending 27 Jul, 2014. WHO. 2014.

[ref154] 154. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 49, ending 6 Dec, 2015. WHO. 2015.

[ref155] 155. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 37, ending 13 Sep, 2015. WHO. 2015.

[ref156] 156. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 46, ending 15 Nov, 2015. WHO. 2015.

[ref157] 157. World Health Organization. Pacific syndromic surveillance report. Week 17, ending 26 April, 2015. WHO. 2015.

[ref158] 158. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 22, ending 31 May, 2015. WHO. 2015.

[ref159] 159. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 12, ending 22 Mar, 2015. WHO. 2015.

[ref160] 160. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 14, ending 5 Apr, 2015. WHO. 2015.

[ref161] 161. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 16, ending 19 Apr, 2015. WHO. 2015.

[ref162] 162. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 17, ending 22 Apr, 2015. WHO. 2015.

[ref163] 163. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 18, ending 3 May, 2015. WHO. 2015.

[ref164] 164. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 19, ending 10 May, 2015. WHO. 2015.

[ref165] 165. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 21, ending 24 May, 2015. WHO. 2015.

[ref166] 166. Wikan N, Suputtamongkol Y, Yoksan S, Smith DR, Auewarakul P. Immunological evidence of Zika virus transmission in Thailand. Asian Pac J Trop Med. 2016;9: 141–144. pmid:26919943
View Article
PubMed/NCBI
Google Scholar

[492] View Article

[493] PubMed/NCBI

[494] Google Scholar

[ref167] 167. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 4, ending 31 Jan, 2016. WHO. 2016.

[ref168] 168. World Health Organization, Western Pacific Region, Division of Pacific Technical Support. Pacific Syndromic Surveillance: Week 5, ending 7 Feb, 2016. WHO. 2016.

[ref169] 169. World Health Organization. Zika virus infection–Guyana, Barbados and Ecuador. Disease Outbreak News. 20 January 2016. WHO. 2016.

[ref170] 170. World Health Organization. Zika and Potential Complications. Situation Report. 12 February 2016. WHO. 2016.

[ref171] 171. World Health Organization. Zika virus infection–Brazil and Colombia. Disease Outbreak News. 21 October 2015. WHO. 2015.

[ref172] 172. Pan American Health Organization. Epidemiological Alert Neurological syndrome, congenital malformations, and Zika virus infection. Implications for public health in the Americas 1 December 2015. PAHO. 2015.

[ref173] 173. Cardoso CW, Paploski IA, Kikuti M, Rodrigues MS, Silva MM, Campos GS, et al. Outbreak of Exanthematous Illness associated with Zika, Chikungunya, and Dengue viruses, Salvador, Brazil. Emerg Infect Dis. 2015;21: 2274–2276. pmid:26584464
View Article
PubMed/NCBI
Google Scholar

Figures

Abstract

Introduction

Objective

Methods

Review protocol, team and expertise

Review question and scope

Search strategy

Relevance screening and inclusion criteria

Study Characterisation and extraction

Scoping review management, data charting and analysis

Results

Scoping review descriptive statistics

ZIKV virus studies

Zika Vectors

Non-human hosts of ZIKV

ZIKV in humans

Epidemiology.

Clinical Symptoms, Complications and Pathogenesis.

Transmission.

Testing for ZIKV infection.

Discussion

Supporting Information

S1 File. Protocol for the Scoping Study of Zika Virus literature

S2 File. Dataset for the Scoping Study of Zika Virus literature.

Acknowledgments

Author Contributions

References