The author noted multiple errors in the original reference section. Here are the updated, correct reference section: Corrected references: 1. Vu, T. K., Hung, D. T., Wheaton, V. I., & Coughlin, S. R. (1991) Cell 64, 1057-1068 2. Coughlin, S. R. (2000) Nature 407, 258-264 3. Rickles FR, Edwards RL (1983) Activation of blood coagulation in cancer: Trousseau's syndrome revisited. Blood 62: 14-31. 4. Camerer E, Duong DN, Hamilton JR, Coughlin SR (2004) Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency. Blood 103: 152-154. 5. Palumbo JS, Kombrinck KW, Drew AF, Grimes TS, Kiser JH, et al. (2000) Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood 96: 3302-3309. 6. Boire A, Covic L, Agarwal A, Jacques S, Sherifi S, et al. (2005) PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120: 303-313. 7. Even-Ram S, Uziely B, Cohen P, Grisaru-Granovsky S, Maoz M, et al. (1998) Thrombin receptor overexpression in malignant and physiological invasion processes. Nat Med 4: 909-914. 8. Grisaru-Granovsky S, Salah Z, Maoz M, Pruss D, Beller U, et al. (2005) Differential expression of protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples. Int J Cancer 113: 372-378. 9. Even-Ram SC, Grisaru-Granovsky S, Pruss D, Maoz M, Salah Z, et al. (2003) The pattern of expression of protease-activated receptors (PARs) during early trophoblast development. J Pathol 200: 47-52. 10. Trejo J, Coughlin SR (1999) The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem 274: 2216-2224. 11. Hein L, Ishii K, Coughlin SR, Kobilka BK (1994) Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. J Biol Chem 269: 27719-27726. 12. Booden MA, Eckert LB, Der CJ, Trejo J (2004) Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol 24: 1990-1999. 13. Shapiro MJ, Trejo J, Zeng D, Coughlin SR (1996) Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. J Biol Chem 271: 32874-32880. 14. Hammes SR, Coughlin SR (1999) Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand. Biochemistry 38: 2486-2493. 15. Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin SR (2001) A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 293: 1666-1670. 16. Connolly AJ, Ishihara H, Kahn ML, Farese RV, Jr., Coughlin SR (1996) Role of the thrombin receptor in development and evidence for a second receptor. Nature 381: 516-519. 17. Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, et al. (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70: 93-104. 18. Pronk GJ, McGlade J, Pelicci G, Pawson T, Bos JL (1993) Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins. J Biol Chem 268: 5748-5753. 19. Kuruppu D, Christophi C, Maeda H, O'Brien PE (2002) Changes in the microvascular architecture of colorectal liver metastases following the administration of SMANCS/lipiodol. J Surg Res 103: 47-54. 20. Qiu Y, Kung HJ (2000) Signaling network of the Btk family kinases. Oncogene 19: 5651-5661. 21. Qiu Y, Robinson D, Pretlow TG, Kung HJ (1998) Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. Proc Natl Acad Sci U S A 95: 3644-3649. 22. Tsai YT, Su YH, Fang SS, Huang TN, Qiu Y, et al. (2000) Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. Mol Cell Biol 20: 2043-2054. 23. Yin YJ, Salah Z, Grisaru-Granovsky S, Cohen I, Even-Ram SC, et al. (2003) Human protease-activated receptor 1 expression in malignant epithelia: a role in invasiveness. Arterioscler Thromb Vasc Biol. pp. 940-944. 24. Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003 Jul;30(3):256-68 25. Karpatkin, S. (2007). Growth regulated oncogene is pivotal in thrombin-induced angiogenesis. Thromb Res 120 Suppl 2, S71-74 26. Yin YJ, Salah Z, Maoz M, Ram SC, Ochayon S, Neufeld G, et al. Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activation. Faseb J 2003; 17: 163-74 27. Salah Z, Maoz M, Pokroy E, Lotem M, Bar-Shavit R, et al. (2007) Protease-activated receptor-1 (hPar1), a survival factor eliciting tumor progression. Mol Cancer Res 5: 229-240. 28. Chen Y, Grall D, Salcini AE, Pelicci PG, Pouysségur J, Van Obberghen-Schilling E. Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor. EMBO J. 1996 Mar 1;15(5):1037-44 29. Obreztchikova M, Elouardighi H, Ho M, Wilson BA, Gertsberg Z, et al. (2006) Distinct signaling functions for Shc isoforms in the heart. J Biol Chem 281: 20197-20204. 30. Collins LR, Ricketts WA, Olefsky JM, Brown JH (1997) The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain. Oncogene 15: 595-600. 31. Desgrosellier JS, Barnes LA, Shields DJ, Huang M, Lau SK, et al. (2009) An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression. Nat Med 15: 1163-1169. 32. Chen R, Kim O, Li M, Xiong X, Guan JL, et al. (2001) Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat Cell Biol 3: 439-444. 33. Even-Ram SC, Maoz M, Pokroy E, Reich R, Katz BZ, et al. (2001) Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin. J Biol Chem 276: 10952-10962. 34. Abassi YA, Rehn M, Ekman N, Alitalo K, Vuori K (2003) p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration. J Biol Chem 278: 35636-35643. 35. Kim O, Yang J, Qiu Y (2002) Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain. J Biol Chem 277: 30066-30071. 36. Staal SP (1987) Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A 84: 5034-5037. 37. Paavonen K, Ekman N, Wirzenius M, Rajantie I, Poutanen M, et al. (2004) Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing. Mol Biol Cell 15: 4226-4233. 38. Lee LF, Guan J, Qiu Y, Kung HJ (2001) Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases Etk/Bmx, Src, and focal adhesion kinase. Mol Cell Biol 21: 8385-8397. 39. Mao J, Xie W, Yuan H, Simon MI, Mano H, et al. (1998) Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha12/13. Embo J 17: 5638-5646. 40. Jiang Y, Ma W, Wan Y, Kozasa T, Hattori S, et al. (1998) The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. Nature 395: 808-813. 41. Ma YC, Huang XY (1998) Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase. Proc Natl Acad Sci U S A 95: 12197-12201. 42. Bagheri-Yarmand R, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, et al. (2001) Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells. J Biol Chem 276: 29403-29409. 43. Swift S, Leger AJ, Talavera J, Zhang L, Bohm A, et al. (2006) Role of the PAR1 receptor 8th helix in signaling: the 7-8-1 receptor activation mechanism. J Biol Chem 281: 4109-4116. 44. Pan S, An P, Zhang R, He X, Yin G, et al. (2002) Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis. Mol Cell Biol 22: 7512-7523. 45. Arora P, Cuevas BD, Russo A, Johnson GL, Trejo J (2008) Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion. Oncogene 27: 4434-4445. 46. Groeger AM, Esposito V, De Luca A, Cassandro R, Tonini G, et al. (2004) Prognostic value of immunohistochemical expression of p53, bax, Bcl-2 and Bcl-xL in resected non-small-cell lung cancers. Histopathology 44: 54-63. 47. . Nakazato Y, Minami Y, Kobayashi H, Satomi K, Anami Y, et al. Nuclear grading of primary pulmonary adenocarcinomas: correlation between nuclear size and prognosis. Cancer 116: 2011-2019. 48. Dor Y, Djonov V, Abramovitch R, Itin A, Fishman GI, et al. (2002) Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. Embo J 21: 1939-1947. 49. Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson SA, et al. (1987) A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 47: 3239-3245.
Citation: Cohen I, Maoz M, Turm H, Grisaru-Granovsky S, Maly B, Uziely B, et al. (2010) Correction: Etk/Bmx Regulates Proteinase-Activated-Receptor1 (PAR1) in Breast Cancer Invasion: Signaling Partners, Hierarchy and Physiological Significance. PLoS ONE 5(12): 10.1371/annotation/7ed84180-ec3d-46c0-8c10-f7b830999f8d. https://doi.org/10.1371/annotation/7ed84180-ec3d-46c0-8c10-f7b830999f8d
Published: December 29, 2010
Copyright: © 2010 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Competing interests: No competing interests declared.