TY - JOUR T1 - Mathematical Analysis of Copy Number Variation in a DNA Sample Using Digital PCR on a Nanofluidic Device A1 - Dube, Simant A1 - Qin, Jian A1 - Ramakrishnan, Ramesh Y1 - 2008/08/06 N2 - Copy Number Variations (CNVs) of regions of the human genome have been associated with multiple diseases. We present an algorithm which is mathematically sound and computationally efficient to accurately analyze CNV in a DNA sample utilizing a nanofluidic device, known as the digital array. This numerical algorithm is utilized to compute copy number variation and the associated statistical confidence interval and is based on results from probability theory and statistics. We also provide formulas which can be used as close approximations. JF - PLOS ONE JA - PLOS ONE VL - 3 IS - 8 UR - https://doi.org/10.1371/journal.pone.0002876 SP - e2876 EP - PB - Public Library of Science M3 - doi:10.1371/journal.pone.0002876 ER -