Population Transregulator ID SNP Gene Accession p-value GO cohesion score weighted GO cohesion score Adjusted Cohesion Score Number of GO Terms Number of Edges Number of Possible Edges Number of Paths Ave. Number of Paths per GO Term Max Number of Paths for Term ID of GO Term with Maximum Number of Paths GO Term YRI T00891 rs10084927 NM_000458 0.00000038 0.0128310128310128 0.164755758099377 0.000714635862513785 297 564 43956 11844 39.8787878787879 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T09837 rs1009031 MIMAT0000682 0.000000966 0.019774011299435 0.23788226053724 0.0329688712248229 177 308 15576 1650 9.32203389830508 137 GO:0051898 negative regulation of protein kinase B signaling cascade YRI T00910 rs10099342 NM_004559 0.000000533 0.0350495049504951 0.439750211486058 0.0365077673031071 101 177 5050 983 9.73267326732673 125 GO:0006355 regulation of transcription, DNA-dependent YRI T09810 rs10138520 MI0000443 0.000000809 0.0290322580645161 0.353732021325739 0.0365123886587262 125 225 7750 1211 9.688 125 GO:0006355 regulation of transcription, DNA-dependent YRI T09810 rs10138520 MI0000444 0.000000809 0.0290322580645161 0.353732021325739 0.0365123886587262 125 225 7750 1211 9.688 125 GO:0006355 regulation of transcription, DNA-dependent YRI T09810 rs10138520 MI0000445 0.000000809 0.0290322580645161 0.353732021325739 0.0365123886587262 125 225 7750 1211 9.688 125 GO:0006355 regulation of transcription, DNA-dependent YRI T08520 rs1017829 NM_003194 0.000000733 0.0308857808857809 0.378962108792564 0.00648459200865031 144 318 10296 3189 22.1458333333333 380 GO:0045741 positive regulation of epidermal growth factor receptor activity YRI T09807 rs10503848 MIMAT0000417 0.000000618 0.00858355767239594 0.106590817025292 0.0120958372465456 440 829 96580 5416 12.3090909090909 315 GO:0033138 positive regulation of peptidyl-serine phosphorylation YRI T15206 rs10736433 NM_005378 0.0000000401 0.0260713215462991 0.385691602985942 0.0397487707129274 142 261 10011 1322 9.30985915492958 148 GO:0006357 regulation of transcription from RNA polymerase II promoter YRI T00558 rs10753989 NM_198055 0.000000546 0.0289256198347107 0.362311169430304 0.102913973141958 121 210 7260 758 6.26446280991736 68 GO:0050927 positive regulation of positive chemotaxis YRI T10359 rs10754981 NM_003111 0.000000482 0.0207788045510389 0.262517461901083 0.000667634581887173 194 389 18721 10033 51.7164948453608 1475 GO:0007191 activation of adenylate cyclase activity by dopamine receptor signaling pathway YRI T10359 rs10754981 NM_138473 0.000000482 0.0217831813576494 0.275206663987568 0.000546165071623116 189 387 17766 12203 64.5661375661376 1475 GO:0007191 activation of adenylate cyclase activity by dopamine receptor signaling pathway YRI T01814 rs10755971 NM_001621 0.000000922 0.0358547305112191 0.432785892776631 0.000406881786271392 132 310 8646 10794 81.7727272727273 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T00498 rs10777021 NM_001428 0.000000286 0.0526610644257703 0.689189459816101 0.00248618146299698 85 188 3570 2774 32.6352941176471 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T14942 rs10797531 MI0000270 0.000000597 0.147619047619048 1.83756948319038 3.14096179103471 21 31 210 43 2.04761904761905 6 GO:0007268 synaptic transmission YRI T14942 rs10797531 MI0000683 0.000000597 0.147619047619048 1.83756948319038 3.14096179103471 21 31 210 43 2.04761904761905 6 GO:0007268 synaptic transmission YRI T00151 rs10883446 NM_005653 0.000000588 0.0540792540792541 0.67389485331018 0.0289552769877603 66 116 2145 685 10.3787878787879 148 GO:0006357 regulation of transcription from RNA polymerase II promoter YRI T00899 rs10958671 NM_024426 0.000000718 0.00732065264308941 0.08995435765214 0.00276664717265538 590 1272 173755 15676 26.5694915254237 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T05065 rs10982127 BC050260 0.000000928 0.0799396681749623 0.964464426124888 0.0246576070367484 52 106 1326 641 12.3269230769231 165 GO:0045084 positive regulation of interleukin-12 biosynthetic process YRI T08972 rs11119554 NM_005234 0.000000551 0.0196078431372549 0.245445035339146 0.00374064397056921 187 341 17391 3178 16.9946524064171 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T00910 rs11120212 NM_004559 0.000000861 0.0350495049504951 0.425150274135724 0.0352956903068852 101 177 5050 983 9.73267326732673 125 GO:0006355 regulation of transcription, DNA-dependent YRI T08972 rs11201443 NM_005234 0.000000769 0.0196078431372549 0.239767594517591 0.00365411834682593 187 341 17391 3178 16.9946524064171 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T02223 rs1121529 NM_004350 0.000000933 0.10752688172043 1.29679964650613 0.0958929255380417 31 50 465 228 7.35483870967742 57 GO:0006917 induction of apoptosis YRI T10359 rs11247942 NM_003111 0.000000596 0.0145924651833768 0.18166900445967 0.000842777630754093 269 526 36046 10575 39.3122676579926 1475 GO:0007191 activation of adenylate cyclase activity by dopamine receptor signaling pathway YRI T10359 rs11247942 NM_138473 0.000000596 0.0151501857213887 0.188612350469688 0.000689474441042286 262 518 34191 12731 48.5916030534351 1475 GO:0007191 activation of adenylate cyclase activity by dopamine receptor signaling pathway YRI T08618 rs11720056 NM_002957 0.000000031 0.0216803760282021 0.325580203874871 0.000624499384052955 185 369 17020 10392 56.172972972973 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T08618 rs11720056 NM_138712 0.000000031 0.0141394441735739 0.212335944299177 0.000818348336884056 294 609 43071 13062 44.4285714285714 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T00910 rs11782220 NM_004559 0.000000844 0.0350495049504951 0.425757380969212 0.0353460919085813 101 177 5050 983 9.73267326732673 125 GO:0006355 regulation of transcription, DNA-dependent YRI T15206 rs1181164 NM_005378 0.000000377 0.0251117991056072 0.322619251073256 0.00253120489509238 171 365 14535 5162 30.187134502924 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T10747 rs11849440 NM_005955 0.000000739 0.4 4.90508444928414 24.5254222464207 5 4 10 5 1 1 GO:0008150 biological_process YRI T04964 rs11909819 NM_001300 0.000000866 0.0475444096133751 0.57647426523137 0.00259413704092816 88 182 3828 2527 28.7159090909091 681 GO:0045944 positive regulation of transcription from RNA polymerase II promoter YRI T05111 rs11930882 NM_021141 0.000000839 0.0161477791614778 0.196235499978218 0.0189123065996267 220 389 24090 1714 7.79090909090909 293 GO:0016481 negative regulation of transcription YRI T09837 rs11963108 MIMAT0000682 0.000000966 0.019774011299435 0.23788226053724 0.0329688712248229 177 308 15576 1650 9.32203389830508 137 GO:0051898 negative regulation of protein kinase B signaling cascade YRI T09819 rs12258622 MIMAT0000443 0.000000777 0.0114107711015975 0.139430014563188 0.00939986485458914 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T01313 rs12258754 NM_001030287 0.000000331 0.112554112554113 1.45874001871715 5.51586069577426 22 26 231 32 1.45454545454545 4 GO:0014829 vascular smooth muscle contraction YRI T02322 rs12266092 NM_001706 0.0000000879 0.0141505141505142 0.199692370538908 0.00216111546267603 297 622 43956 9832 33.1043771043771 829 GO:0032319 regulation of Rho GTPase activity YRI T00498 rs12358485 NM_001428 0.000000143 0.0526610644257703 0.720894579807601 0.00260055448551244 85 188 3570 2774 32.6352941176471 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T00151 rs12475949 NM_005653 0.000000538 0.0540792540792541 0.678069236384801 0.0291346379334404 66 116 2145 685 10.3787878787879 148 GO:0006357 regulation of transcription from RNA polymerase II promoter YRI T04870 rs12691592 NM_002359 0.000000787 0.0329444063143445 0.402186977140377 0.113610106458196 94 144 4371 460 4.8936170212766 68 GO:0006750 glutathione biosynthetic process YRI T10747 rs12691592 NM_005955 0.00000071 0.123809523809524 1.52254555174575 3.27532969912136 21 26 210 41 1.95238095238095 5 GO:0006898 receptor-mediated endocytosis YRI T09811 rs12712421 MI0000446 0.000000676 0.012312730249693 0.151940403918195 0.000695880802923955 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09811 rs12712421 MI0000470 0.000000676 0.012312730249693 0.151940403918195 0.000695880802923955 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09819 rs12712421 MIMAT0000443 0.000000497 0.0114107711015975 0.143858868708423 0.00969844210537919 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T08972 rs12745898 NM_005234 0.000000551 0.0196078431372549 0.245445035339146 0.00374064397056921 187 341 17391 3178 16.9946524064171 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T08520 rs12876586 NM_003194 0.000000526 0.0308857808857809 0.387864516969524 0.00663692514059849 144 318 10296 3189 22.1458333333333 380 GO:0045741 positive regulation of epidermal growth factor receptor activity YRI T09819 rs13387395 MIMAT0000443 0.000000501 0.0114107711015975 0.143779419226098 0.00969308591002224 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T00910 rs1341147 NM_004559 0.000000773 0.0350495049504951 0.428432566168894 0.035568183987702 101 177 5050 983 9.73267326732673 125 GO:0006355 regulation of transcription, DNA-dependent YRI T10331 rs1347038 NM_005011 0.000000619 0.0225091984705288 0.279488134695292 0.0288357327403778 167 312 13861 1609 9.63473053892216 168 GO:0043558 regulation of translational initiation in response to stress YRI T00899 rs1350460 NM_024426 0.000000763 0.0227332804652392 0.278140570835781 0.00204503815700152 195 430 18915 7163 36.7333333333333 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T05694 rs1371087 NM_003150 0.000000294 0.0106752520545624 0.139454077161411 0.00112544994277659 407 882 82621 15015 36.8918918918919 1367 GO:0007253 cytoplasmic sequestering of NF-kappaB YRI T05694 rs1461397 NM_003150 0.0000000442 0.0106349665173195 0.156431375828991 0.00126850591256256 408 883 83028 15017 36.8063725490196 1367 GO:0007253 cytoplasmic sequestering of NF-kappaB YRI T08520 rs1480462 NM_003194 0.0000000904 0.0308857808857809 0.435108476905368 0.00744533790258432 144 318 10296 3189 22.1458333333333 380 GO:0045741 positive regulation of epidermal growth factor receptor activity YRI T06135 rs1558560 NM_003722 0.000000521 0.0119441034840903 0.150093480880485 0.000903254511298882 357 759 63546 12953 36.2829131652661 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T06135 rs1558561 NM_003722 0.000000819 0.0119441034840903 0.145400733911303 0.000875013811933179 357 759 63546 12953 36.2829131652661 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T10852 rs1591684 NM_001430 0.000000122 0.0302462192225972 0.418222952375131 0.00311585806028757 127 242 8001 3179 25.0314960629921 681 GO:0045944 positive regulation of transcription from RNA polymerase II promoter YRI T10852 rs1591684 NM_001668 0.000000122 0.0244568590937306 0.338171846891887 0.00357611450835857 180 394 16110 4825 26.8055555555556 635 GO:0043193 positive regulation of gene-specific transcription YRI T08482 rs16845045 NM_001017535 0.000000674 0.0110034097169488 0.135811567322118 0.000944807924709708 367 739 67161 11276 30.724795640327 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T04959 rs16848653 NM_002097 0.000000858 0.0197034628836018 0.239062616113543 0.00383652836711926 202 400 20301 4573 22.6386138613861 556 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest YRI T09811 rs16909324 MI0000446 0.000000794 0.012312730249693 0.150219729256646 0.000688000183719503 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09811 rs16909324 MI0000470 0.000000794 0.012312730249693 0.150219729256646 0.000688000183719503 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09819 rs16909324 MIMAT0000443 0.00000000727 0.0114107711015975 0.185732335911831 0.0125213990844644 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T01556 rs16952932 NM_004176 0.000000549 0.013132894874204 0.164435076535793 0.00278063765443615 310 629 47895 8345 26.9193548387097 681 GO:0045944 positive regulation of transcription from RNA polymerase II promoter YRI T08482 rs16979211 NM_001017535 0.0000000162 0.0105113636363636 0.163777241171547 0.00122252874085384 385 777 73920 11565 30.038961038961 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T00899 rs17027844 NM_024426 0.000000801 0.0227332804652392 0.277180863662044 0.00203798187684813 195 430 18915 7163 36.7333333333333 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T09815 rs17030632 MI0000455 0.000000906 0.019387089763095 0.23430739611703 0.000573247330060193 215 446 23005 11004 51.1813953488372 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T09815 rs17030632 MI0000476 0.000000906 0.019387089763095 0.23430739611703 0.000573247330060193 215 446 23005 11004 51.1813953488372 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T10744 rs17030632 NM_003367 0.000000443 0.0167158308751229 0.212411281522533 0.000419130622144484 226 425 25425 11945 52.853982300885 2167 GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose YRI T10747 rs17044072 NM_005955 0.000000335 0.4 5.17996415437052 25.8998207718526 5 4 10 5 1 1 GO:0008150 biological_process YRI T00368 rs17048287 NM_000545 0.000000437 0.0116096824751843 0.147663982423627 0.00122391247480283 322 600 51681 7651 23.7608695652174 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09837 rs17059418 MIMAT0000682 0.000000966 0.019774011299435 0.23788226053724 0.0329688712248229 177 308 15576 1650 9.32203389830508 137 GO:0051898 negative regulation of protein kinase B signaling cascade YRI T00910 rs17075347 NM_004559 0.000000386 0.0311220311220311 0.39919685900487 0.0390357499984048 111 190 6105 1008 9.08108108108108 125 GO:0006355 regulation of transcription, DNA-dependent YRI T10095 rs17084388 NM_016655 0.0000000908 0.0195354560836794 0.275134009302514 0.00101557238711903 198 381 19503 6496 32.8080808080808 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T01664 rs17238405 NM_003297 0.000000713 0.0145183492195413 0.178485985653731 0.00169865661592283 278 559 38503 8548 30.7482014388489 950 GO:0010768 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage YRI T15913 rs17238405 NM_000964 0.000000214 0.0109548482605477 0.146128610147198 0.00115107381080543 386 814 74305 15855 41.0751295336788 1193 GO:0045630 positive regulation of T-helper 2 cell differentiation YRI T15913 rs17238405 NM_002957 0.000000214 0.0130710713234985 0.174357274533552 0.000718159315351652 309 622 47586 13501 43.6925566343042 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T09725 rs17483163 MI0000103 0.000000533 0.0142327650111193 0.178572034969147 0.00669404071496367 285 576 40470 4690 16.4561403508772 462 GO:0031394 positive regulation of prostaglandin biosynthetic process YRI T09725 rs17483163 MI0000739 0.000000533 0.0142327650111193 0.178572034969147 0.00669404071496367 285 576 40470 4690 16.4561403508772 462 GO:0031394 positive regulation of prostaglandin biosynthetic process YRI T08618 rs17717846 NM_002957 0.000000701 0.0233825944170772 0.287806159028423 0.000494977264862391 175 356 15225 10371 59.2628571428571 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T08618 rs17717846 NM_138712 0.000000701 0.0146195268146488 0.179945380922492 0.000661693437128867 287 600 41041 13046 45.4564459930314 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T15206 rs1817371 NM_005378 0.0000000401 0.0260713215462991 0.385691602985942 0.0397487707129274 142 261 10011 1322 9.30985915492958 148 GO:0006357 regulation of transcription from RNA polymerase II promoter YRI T00910 rs1841544 NM_004559 0.00000046 0.0350495049504951 0.444234401501925 0.0368800417474762 101 177 5050 983 9.73267326732673 125 GO:0006355 regulation of transcription, DNA-dependent YRI T14316 rs1983343 NM_002228 0.000000776 0.0140868690256582 0.172145435322593 0.0085189674215465 268 504 35778 4790 17.8731343283582 303 GO:0031953 negative regulation of protein autophosphorylation YRI T14316 rs1983343 NM_005252 0.000000776 0.0180949129395698 0.221124840405132 0.0104057708670265 203 371 20503 3475 17.1182266009852 252 GO:0045941 positive regulation of transcription YRI T15206 rs2000952 NM_005378 0.0000000401 0.0260713215462991 0.385691602985942 0.0397487707129274 142 261 10011 1322 9.30985915492958 148 GO:0006357 regulation of transcription from RNA polymerase II promoter YRI T14524 rs2072547 NM_012482 0.000000308 0.0781420765027322 1.01763633610977 0.00195841400157249 61 143 1830 2678 43.9016393442623 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T00711 rs2125904 NM_198055 0.000000256 0.0244713708719411 0.322618809015386 0.000913007862635244 184 412 16836 7317 39.7663043478261 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T00712 rs2125904 NM_198055 0.000000256 0.0244713708719411 0.322618809015386 0.000913007862635244 184 412 16836 7317 39.7663043478261 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T02284 rs2425882 NM_006565 0.000000977 0.0120516645196284 0.144863548891313 0.000844183098268178 344 711 58996 12420 36.1046511627907 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T02284 rs2425883 NM_006565 0.000000644 0.0120516645196284 0.14922646105862 0.000869607690852421 344 711 58996 12420 36.1046511627907 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T14524 rs2573572 NM_012482 0.000000438 0.0447928331466965 0.56963277845428 0.00241124609911226 95 200 4465 2953 31.0842105263158 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T00625 rs2588116 NM_198055 0.0000000908 0.0174539935496111 0.245819048353656 0.00259217073690224 252 552 31626 7623 30.25 790 GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein YRI T10852 rs2647876 NM_001430 0.000000744 0.0302462192225972 0.370723496962354 0.00276197609334468 127 242 8001 3179 25.0314960629921 681 GO:0045944 positive regulation of transcription from RNA polymerase II promoter YRI T10852 rs2647876 NM_001668 0.000000744 0.0244568590937306 0.299764154363119 0.00316995915347886 180 394 16110 4825 26.8055555555556 635 GO:0043193 positive regulation of gene-specific transcription YRI T04673 rs267062 NM_001571 0.00000079 0.0371216447744146 0.453060238796255 0.0229427974863459 103 195 5253 1676 16.2718446601942 125 GO:0006355 regulation of transcription, DNA-dependent YRI T04673 rs267063 NM_001571 0.00000079 0.0371216447744146 0.453060238796255 0.0229427974863459 103 195 5253 1676 16.2718446601942 125 GO:0006355 regulation of transcription, DNA-dependent YRI T04673 rs267064 NM_001571 0.00000079 0.0371216447744146 0.453060238796255 0.0229427974863459 103 195 5253 1676 16.2718446601942 125 GO:0006355 regulation of transcription, DNA-dependent YRI T04673 rs267069 NM_001571 0.00000079 0.0371216447744146 0.453060238796255 0.0229427974863459 103 195 5253 1676 16.2718446601942 125 GO:0006355 regulation of transcription, DNA-dependent YRI T15206 rs2852907 NM_005378 0.0000000401 0.0260713215462991 0.385691602985942 0.0397487707129274 142 261 10011 1322 9.30985915492958 148 GO:0006357 regulation of transcription from RNA polymerase II promoter YRI T10852 rs28740902 NM_001430 0.000000171 0.0234535911235134 0.317421084716174 0.000727003474994612 174 353 15051 8085 46.4655172413793 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T10852 rs28740902 NM_001668 0.000000171 0.0199016715830875 0.269349378024902 0.000871671390650046 226 506 25425 9653 42.712389380531 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T01931 rs289838 NM_006509 0.000000389 0.0217378668991572 0.278681644766543 0.000800000181083511 186 374 17205 7371 39.6290322580645 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T01814 rs2915499 NM_001621 0.00000064 0.0358547305112191 0.444155495735599 0.000417570869345384 132 310 8646 10794 81.7727272727273 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T02689 rs2937889 NM_005257 0.000000836 0.0230917608156517 0.280693917856495 0.00056241866166056 191 419 18145 10604 55.5183246073298 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T15241 rs2938158 NM_006917 0.000000773 0.0653377630121816 0.798665359598713 1.519271862035 43 59 903 108 2.51162790697674 9 GO:0051017 actin filament bundle assembly YRI T09819 rs294960 MIMAT0000443 0.000000325 0.00933078213214277 0.121078405613273 0.0101360107525291 412 790 84666 6437 15.623786407767 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T10852 rs34929677 NM_001430 0.000000122 0.0302462192225972 0.418222952375131 0.00311585806028757 127 242 8001 3179 25.0314960629921 681 GO:0045944 positive regulation of transcription from RNA polymerase II promoter YRI T10852 rs34929677 NM_001668 0.000000122 0.0244568590937306 0.338171846891887 0.00357611450835857 180 394 16110 4825 26.8055555555556 635 GO:0043193 positive regulation of gene-specific transcription YRI T11264 rs3819726 NM_005653 0.000000131 0.0183054393305439 0.251982745451933 0.00301981999474262 240 525 28680 7569 31.5375 635 GO:0043193 positive regulation of gene-specific transcription YRI T05394 rs3902877 NM_001621 0.000000317 0.0334382376081825 0.43462624918292 0.00101887295862366 124 255 7626 5185 41.8145161290323 1265 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly YRI T05394 rs3902877 NM_001668 0.000000317 0.0244568590937306 0.317887355764892 0.00336160918013381 180 394 16110 4825 26.8055555555556 635 GO:0043193 positive regulation of gene-specific transcription YRI T08618 rs3902877 NM_002957 0.000000527 0.0233825944170772 0.293600712116169 0.000504942903013273 175 356 15225 10371 59.2628571428571 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T08618 rs3902877 NM_138712 0.000000527 0.0146195268146488 0.183568316116687 0.000675015659843627 287 600 41041 13046 45.4564459930314 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T08618 rs4076478 NM_002957 0.000000031 0.0216803760282021 0.325580203874871 0.000624499384052955 185 369 17020 10392 56.172972972973 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T08618 rs4076478 NM_138712 0.000000031 0.0141394441735739 0.212335944299177 0.000818348336884056 294 609 43071 13062 44.4285714285714 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T09811 rs4261361 MI0000446 0.000000638 0.012312730249693 0.152559143662765 0.000698714605514633 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09811 rs4261361 MI0000470 0.000000638 0.012312730249693 0.152559143662765 0.000698714605514633 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09819 rs4261361 MIMAT0000443 0.000000195 0.0114107711015975 0.153131758298768 0.0103235866213132 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T09811 rs4281551 MI0000446 0.000000638 0.012312730249693 0.152559143662765 0.000698714605514633 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09811 rs4281551 MI0000470 0.000000638 0.012312730249693 0.152559143662765 0.000698714605514633 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09819 rs4281551 MIMAT0000443 0.000000195 0.0114107711015975 0.153131758298768 0.0103235866213132 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T08618 rs4437076 NM_002957 0.000000031 0.0216803760282021 0.325580203874871 0.000624499384052955 185 369 17020 10392 56.172972972973 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T08618 rs4437076 NM_138712 0.000000031 0.0141394441735739 0.212335944299177 0.000818348336884056 294 609 43071 13062 44.4285714285714 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T08618 rs4596085 NM_002957 0.000000517 0.0216803760282021 0.272587777861144 0.000522853961477561 185 369 17020 10392 56.172972972973 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T08618 rs4596085 NM_138712 0.000000517 0.0141394441735739 0.177775499025135 0.000685151468095155 294 609 43071 13062 44.4285714285714 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T10359 rs4659356 NM_003111 0.00000027 0.0145924651833768 0.191705191147554 0.000889336336042196 269 526 36046 10575 39.3122676579926 1475 GO:0007191 activation of adenylate cyclase activity by dopamine receptor signaling pathway YRI T10359 rs4659356 NM_138473 0.00000027 0.0151501857213887 0.199032117818469 0.000727564010737491 262 518 34191 12731 48.5916030534351 1475 GO:0007191 activation of adenylate cyclase activity by dopamine receptor signaling pathway YRI T10095 rs4662739 NM_016655 0.000000902 0.076679005817028 0.927017506141109 0.000425431067734517 62 145 1891 5123 82.6290322580645 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T15206 rs4754167 NM_005378 0.0000000401 0.0260713215462991 0.385691602985942 0.0397487707129274 142 261 10011 1322 9.30985915492958 148 GO:0006357 regulation of transcription from RNA polymerase II promoter YRI T09811 rs4759567 MI0000446 0.000000638 0.012312730249693 0.152559143662765 0.000698714605514633 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09811 rs4759567 MI0000470 0.000000638 0.012312730249693 0.152559143662765 0.000698714605514633 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09819 rs4759567 MIMAT0000443 0.000000195 0.0114107711015975 0.153131758298768 0.0103235866213132 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T09819 rs4759925 MIMAT0000443 0.000000204 0.0114107711015975 0.152684557489073 0.010293437967975 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T09837 rs5758938 MIMAT0000682 0.00000033 0.019774011299435 0.256329957179971 0.0355255971178558 177 308 15576 1650 9.32203389830508 137 GO:0051898 negative regulation of protein kinase B signaling cascade YRI T02284 rs597619 NM_006565 0.000000355 0.0122789868120938 0.158393321987706 0.000911224803865484 342 716 58311 12435 36.359649122807 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T04870 rs6016268 NM_002359 0.000000752 0.0399221032132425 0.488948526846626 0.105589195711066 79 123 3081 425 5.37974683544304 68 GO:0006750 glutathione biosynthetic process YRI T15206 rs6069855 NM_005378 0.000000831 0.0260713215462991 0.317048073677424 0.0326744764159115 142 261 10011 1322 9.30985915492958 148 GO:0006357 regulation of transcription from RNA polymerase II promoter YRI T00902 rs6111734 NM_005080 0.000000199 0.128571428571429 1.72315206606608 3.61861933873876 21 27 210 42 2 5 GO:0015031 protein transport YRI T01313 rs6507245 NM_001030287 0.000000782 NA NA NA NA NA NA NA NA NA NA NA YRI T04996 rs6549604 BC050260 0.0000000549 0.0557074504442926 0.808919827651835 0.00246485266043496 77 163 2926 2695 35 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T08465 rs6570819 NM_004364 0.000000607 0.00852609141864688 0.10601020310474 0.00102593184266366 478 972 114003 14440 30.2092050209205 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T10911 rs6681714 NR_027329 0.000000703 0.100985221674877 1.24273316095659 1.97942914462971 29 41 406 66 2.27586206896552 8 GO:0006468 protein phosphorylation YRI T10744 rs6802871 NM_003367 0.000000974 0.0167158308751229 0.200972463585179 0.000396559509893217 226 425 25425 11945 52.853982300885 2167 GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose YRI T10273 rs6808294 NM_002040 0.000000953 0.00880323578396384 0.106006929658045 0.000982336012407731 468 962 109278 14456 30.8888888888889 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T10273 rs6808294 NM_016654 0.000000953 0.00884412005660237 0.106499250472808 0.00107297392444792 464 950 107416 13070 28.1681034482759 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T00255 rs6864839 NM_005229 0.000000716 0.0506493506493507 0.622489330207776 0.987918289236633 56 78 1540 152 2.71428571428571 13 GO:0071392 cellular response to estradiol stimulus YRI T00529 rs6915007 NM_198055 0.000000954 0.107936507936508 1.29965304927023 0.0976265201329748 36 68 630 243 6.75 71 GO:0045449 regulation of transcription YRI T09837 rs6917584 MIMAT0000682 0.000000966 0.019774011299435 0.23788226053724 0.0329688712248229 177 308 15576 1650 9.32203389830508 137 GO:0051898 negative regulation of protein kinase B signaling cascade YRI T09159 rs6966461 NM_005234 0.000000611 0.0376259798432251 0.46761257634009 0.0384094826935336 95 168 4465 802 8.4421052631579 137 GO:0046427 positive regulation of JAK-STAT cascade YRI T09707 rs7015085 MIMAT0000063 0.000000595 NA NA NA NA NA NA NA NA NA NA NA YRI T14492 rs7017222 NM_030767 0.0000000555 0.19047619047619 2.76407886357231 2.7277094048411 15 20 105 38 2.53333333333333 6 GO:0007276 gamete generation YRI T10852 rs703572 NM_001430 0.000000744 0.00970806302131603 0.118990312326519 0.00116389314864194 416 838 86320 10821 26.0120192307692 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T10852 rs703572 NM_001668 0.000000744 0.00990212614597317 0.121368915737242 0.00114193244994966 418 863 87153 11358 27.1722488038278 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T05324 rs7072859 NM_002957 0.000000786 0.00565725355086501 0.0690702849558981 0.000828547175886205 773 1688 298378 29011 37.5304010349289 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T05324 rs7072859 NM_005693 0.000000786 0.005484927080233 0.0669663243812166 0.000875150991189371 812 1806 329266 30858 38.0024630541872 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09819 rs7090975 MIMAT0000443 0.000000328 0.0114107711015975 0.147977758726575 0.00997612270121672 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T08972 rs7231541 NM_005234 0.000000868 0.0196078431372549 0.237705108816608 0.00362268554684647 187 341 17391 3178 16.9946524064171 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T09819 rs7342102 MIMAT0000443 0.000000679 0.0114107711015975 0.14076624426106 0.00948994860459115 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T00559 rs7380817 NM_198055 0.000000364 NA NA NA NA NA NA NA NA NA NA NA YRI T05271 rs745637 NM_005359 0.000000598 0.00849801610231519 0.105771387095971 0.000819412615467681 510 1103 129795 19554 38.3411764705882 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T05271 rs745637 NM_005902 0.000000598 0.00654735095413062 0.0814922428817068 0.000902867729137134 650 1381 210925 22210 34.1692307692308 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T08520 rs7464518 NM_003194 0.000000709 0.0308857808857809 0.379855185938575 0.0064998738555415 144 318 10296 3189 22.1458333333333 380 GO:0045741 positive regulation of epidermal growth factor receptor activity YRI T09819 rs7485704 MIMAT0000443 0.00000075 0.0114107711015975 0.13978054786949 0.00942349653616498 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T01795 rs7563844 NM_001621 0.000000857 0.0150752114808597 0.182923194335879 0.00152790157366711 247 458 30381 5774 23.3765182186235 1265 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly YRI T02284 rs761215 NM_006565 0.000000977 0.0120516645196284 0.144863548891313 0.000844183098268178 344 711 58996 12420 36.1046511627907 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T00529 rs7753608 NM_198055 0.000000954 0.107936507936508 1.29965304927023 0.0976265201329748 36 68 630 243 6.75 71 GO:0045449 regulation of transcription YRI T04953 rs7755681 NM_002097 0.000000896 0.0126371054720091 0.152850643088249 0.0136331959555148 314 621 49141 4684 14.9171974522293 236 GO:0001933 negative regulation of protein phosphorylation YRI T00529 rs7758202 NM_198055 0.000000532 0.107936507936508 1.35440637779028 0.101739446218988 36 68 630 243 6.75 71 GO:0045449 regulation of transcription YRI T05694 rs7758739 NM_003150 0.000000292 0.0106752520545624 0.139517370281708 0.001125960743465 407 882 82621 15015 36.8918918918919 1367 GO:0007253 cytoplasmic sequestering of NF-kappaB YRI T00151 rs7893985 NM_005653 0.000000588 0.0540792540792541 0.67389485331018 0.0289552769877603 66 116 2145 685 10.3787878787879 148 GO:0006357 regulation of transcription from RNA polymerase II promoter YRI T09819 rs7920842 MIMAT0000443 0.000000192 0.0114107711015975 0.15328542447529 0.0103339462364689 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T09159 rs7932205 NM_005234 0.00000000228 0.0323359073359073 0.558898035956534 0.052647990170307 112 201 6216 972 8.67857142857143 137 GO:0046427 positive regulation of JAK-STAT cascade YRI T09159 rs7943864 NM_005234 0.00000000228 0.0323359073359073 0.558898035956534 0.052647990170307 112 201 6216 972 8.67857142857143 137 GO:0046427 positive regulation of JAK-STAT cascade YRI T01556 rs8041328 NM_004176 0.000000549 0.013132894874204 0.164435076535793 0.00278063765443615 310 629 47895 8345 26.9193548387097 681 GO:0045944 positive regulation of transcription from RNA polymerase II promoter YRI T13796 rs870181 NM_004960 0.00000034 0.0237250554323725 0.306932042517285 0.00335718771081116 165 321 13530 3655 22.1515151515152 681 GO:0045944 positive regulation of transcription from RNA polymerase II promoter YRI T10744 rs873028 NM_003367 0.000000951 0.0167158308751229 0.201319432078788 0.000397244149237929 226 425 25425 11945 52.853982300885 2167 GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose YRI T09837 rs9321491 MIMAT0000682 0.000000966 0.019774011299435 0.23788226053724 0.0329688712248229 177 308 15576 1650 9.32203389830508 137 GO:0051898 negative regulation of protein kinase B signaling cascade YRI T05694 rs9350024 NM_003150 0.000000292 0.0106752520545624 0.139517370281708 0.001125960743465 407 882 82621 15015 36.8918918918919 1367 GO:0007253 cytoplasmic sequestering of NF-kappaB YRI T05694 rs9370948 NM_003150 0.000000292 0.0106752520545624 0.139517370281708 0.001125960743465 407 882 82621 15015 36.8918918918919 1367 GO:0007253 cytoplasmic sequestering of NF-kappaB YRI T05694 rs9370949 NM_003150 0.000000292 0.0106752520545624 0.139517370281708 0.001125960743465 407 882 82621 15015 36.8918918918919 1367 GO:0007253 cytoplasmic sequestering of NF-kappaB YRI T05694 rs9383227 NM_003150 0.0000000585 0.0106752520545624 0.154424868401872 0.00124627019047286 407 882 82621 15015 36.8918918918919 1367 GO:0007253 cytoplasmic sequestering of NF-kappaB YRI T00910 rs9392612 NM_004559 0.000000123 0.0350495049504951 0.484390810009991 0.0402137998202394 101 177 5050 983 9.73267326732673 125 GO:0006355 regulation of transcription, DNA-dependent YRI T05694 rs9396736 NM_003150 0.000000292 0.0106752520545624 0.139517370281708 0.001125960743465 407 882 82621 15015 36.8918918918919 1367 GO:0007253 cytoplasmic sequestering of NF-kappaB YRI T09837 rs9399142 MIMAT0000682 0.000000966 0.019774011299435 0.23788226053724 0.0329688712248229 177 308 15576 1650 9.32203389830508 137 GO:0051898 negative regulation of protein kinase B signaling cascade YRI T09837 rs9402695 MIMAT0000682 0.000000966 0.019774011299435 0.23788226053724 0.0329688712248229 177 308 15576 1650 9.32203389830508 137 GO:0051898 negative regulation of protein kinase B signaling cascade YRI T05111 rs949345 NM_021141 0.000000631 0.0153846153846154 0.190768327407873 0.0161166511613424 235 423 27495 2231 9.4936170212766 293 GO:0016481 negative regulation of transcription YRI T00899 rs9536561 NM_024426 0.000000763 0.0227332804652392 0.278140570835781 0.00204503815700152 195 430 18915 7163 36.7333333333333 722 GO:0000122 negative regulation of transcription from RNA polymerase II promoter YRI T09807 rs9644152 MIMAT0000417 0.000000618 0.00858355767239594 0.106590817025292 0.0120958372465456 440 829 96580 5416 12.3090909090909 315 GO:0033138 positive regulation of peptidyl-serine phosphorylation YRI T00250 rs965676 NM_005229 0.000000526 0.0365186615186615 0.4586023925602 0.00213859306391388 112 227 6216 3950 35.2678571428571 681 GO:0045944 positive regulation of transcription from RNA polymerase II promoter YRI T09159 rs9666783 NM_005234 0.00000000228 0.0323359073359073 0.558898035956534 0.052647990170307 112 201 6216 972 8.67857142857143 137 GO:0046427 positive regulation of JAK-STAT cascade YRI T09811 rs9808234 MI0000446 0.000000676 0.012312730249693 0.151940403918195 0.000695880802923955 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09811 rs9808234 MI0000470 0.000000676 0.012312730249693 0.151940403918195 0.000695880802923955 350 752 61075 16359 46.74 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter YRI T09819 rs9808234 MIMAT0000443 0.000000497 0.0114107711015975 0.143858868708423 0.00969844210537919 347 685 60031 5670 16.3400576368876 315 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation YRI T01462 rs9853360 NM_005438 0.000000721 0.0264180264180264 0.324522456875741 0.000771810854464906 144 272 10296 5487 38.1041666666667 1589 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis YRI T08520 rs988862 NM_003194 0.000000709 0.0308857808857809 0.379855185938575 0.0064998738555415 144 318 10296 3189 22.1458333333333 380 GO:0045741 positive regulation of epidermal growth factor receptor activity YRI T08482 rs9956949 NM_001017535 0.000000186 0.0115902615902616 0.156016211212768 0.00100236908577347 352 716 61776 11232 31.9090909090909 1717 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter YRI T10095 rs9985648 NM_016655 0.000000708 0.0195354560836794 0.240284810420981 0.000886937311480709 198 381 19503 6496 32.8080808080808 1635 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter