Module1 Ingenuity Canonical Pathways -log(p-value) Ratio Molecules PI3K Signaling in B Lymphocytes 8.74E+00 4.58E-02 "CD79B,CD19,DAPP1,BTK,CD79A,BLNK" B Cell Receptor Signaling 8.43E+00 4.05E-02 "CD79B,CD19,DAPP1,BTK,CD79A,BLNK" FcŒ_RIIB Signaling in B Lymphocytes 7.13E+00 8.16E-02 "CD79B,BTK,CD79A,BLNK" Primary Immunodeficiency Signaling 6.93E+00 7.27E-02 "CD19,BTK,CD79A,BLNK" B Cell Development 5.49E+00 1.00E-01 "CD79B,CD19,CD79A" p70S6K Signaling 5.27E+00 3.28E-02 "CD79B,CD19,BTK,CD79A" Role of NFAT in Regulation of the Immune Response 4.67E+00 2.16E-02 "CD79B,BTK,CD79A,BLNK" Phospholipase C Signaling 4.16E+00 1.65E-02 "CD79B,BTK,CD79A,BLNK" Systemic Lupus Erythematosus Signaling 3.54E+00 1.99E-02 "CD79B,CD72,CD79A" Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 2.51E+00 2.33E-02 "CD79B,CD79A" Module2 Ingenuity Canonical Pathways -log(p-value) Ratio Molecules Protein Ubiquitination Pathway 7.31E+01 1.67E-01 "PSMB6,PSMA4,PSMC2,PSMD6,PSMB1,PSMD12,PSMC3,CDC23,PSMD7,PSMB4,ANAPC5,UBE2C,UBE2D1,PSMD1,PSMB2,PSMD2,PSMD13,PSMD10,PSME1,PSMD5,PSMC6,PSMC1,PSMC5,PSMA6,PSME2,PSMA5,PSMB9,ANAPC10,PSMD3,PSMB10,PSMD14,PSMA2,PSMA7,PSMD4,UBE2E1,PSMA1,ANAPC1,PSMD8,PSMB5,PSMC4,PSMB7,PSMD9,PSMB8,ANAPC2,PSMB3" Mitotic Roles of Polo-Like Kinase 9.00E+00 1.19E-01 "CDC23,CDC27,ANAPC5,ANAPC10,ANAPC2,ANAPC1,CDC16" Antigen Presentation Pathway 4.95E+00 9.30E-02 "PSMB6,PSMB5,PSMB9,PSMB8" Polyamine Regulation in Colon Cancer 4.22E+00 1.25E-01 "PSME1,PSME2,PSMF1" Protein Kinase A Signaling 4.13E+00 2.30E-02 "CDC23,CDC27,ANAPC5,ANAPC10,ANAPC2,ANAPC1,CDC16" Purine Metabolism 4.07E+00 2.31E-02 "PSMC6,PSMC3,PSMC5,PSMC1,PSMC4,PSMC2,PSMD6" Hypoxia Signaling in the Cardiovascular System 2.81E+00 4.55E-02 "UBE2C,UBE2D1,UBE2E1" DNA Double-Strand Break Repair by Homologous Recombination 1.32E+00 6.25E-02 BRCA2 Module3 Ingenuity Canonical Pathways -log(p-value) Ratio Molecules Molecular Mechanisms of Cancer 5.16E+00 1.39E-02 "RALA,RRAS2,RALBP1,RALGDS,ARHGEF2" Tight Junction Signaling 5.11E+00 2.55E-02 "MLLT4,TJP1,CLDN4,ARHGEF2" Phospholipase C Signaling 4.43E+00 1.65E-02 "RALA,RRAS2,RALGDS,ARHGEF2" Pancreatic Adenocarcinoma Signaling 4.00E+00 2.63E-02 "RALA,RALBP1,RALGDS" Germ Cell-Sertoli Cell Junction Signaling 3.49E+00 1.89E-02 "MLLT4,TJP1,RRAS2" Notch Signaling 3.31E+00 4.88E-02 "JAG1,MFNG" PAK Signaling 2.56E+00 1.92E-02 "RRAS2,EPHB3" Cdc42 Signaling 2.25E+00 1.41E-02 "RALA,EXOC7" Ephrin Receptor Signaling 2.00E+00 1.03E-02 "RRAS2,EPHB3" Leukocyte Extravasation Signaling 1.93E+00 1.06E-02 "MLLT4,CLDN4" Thrombin Signaling 1.93E+00 1.03E-02 "RRAS2,ARHGEF2" Breast Cancer Regulation by Stathmin1 1.91E+00 1.02E-02 "RRAS2,ARHGEF2" Integrin Signaling 1.90E+00 9.76E-03 "RALA,RRAS2" Colorectal Cancer Metastasis Signaling 1.75E+00 8.23E-03 "RRAS2,RALGDS" Oncostatin M Signaling 1.52E+00 2.94E-02 RRAS2 FcŒ_RIIB Signaling in B Lymphocytes 1.44E+00 2.04E-02 RRAS2 Melanoma Signaling 1.43E+00 2.27E-02 RRAS2 Thyroid Cancer Signaling 1.41E+00 2.22E-02 RRAS2 CNTF Signaling 1.37E+00 1.92E-02 RRAS2 Axonal Guidance Signaling 1.34E+00 4.77E-03 "RRAS2,EPHB3" Module4 Ingenuity Canonical Pathways -log(p-value) Ratio Molecules GABA Receptor Signaling 2.19E+00 2.13E-02 GABARAP Virus Entry via Endocytic Pathways 1.91E+00 1.09E-02 TFRC Clathrin-mediated Endocytosis Signaling 1.67E+00 6.02E-03 TFRC Module5 Ingenuity Canonical Pathways -log(p-value) Ratio Molecules Lysine Degradation 1.81E+00 1.79E-02 SETDB1 TR/RXR Activation 1.63E+00 1.12E-02 GPS2 Acute Phase Response Signaling 1.34E+00 5.81E-03 HMOX2 Module6 Ingenuity Canonical Pathways -log(p-value) Ratio Molecules Pantothenate and CoA Biosynthesis 2.22E+00 4.55E-02 CRMP1 Galactose Metabolism 1.87E+00 2.04E-02 GNE Œ_-alanine Metabolism 1.86E+00 2.00E-02 CRMP1 Fructose and Mannose Metabolism 1.85E+00 1.96E-02 GNE Semaphorin Signaling in Neurons 1.85E+00 1.92E-02 CRMP1 Ubiquinone Biosynthesis 1.71E+00 1.41E-02 NDUFV2 Aminosugars Metabolism 1.70E+00 1.37E-02 GNE Starch and Sucrose Metabolism 1.66E+00 1.27E-02 GNE Glycolysis/Gluconeogenesis 1.59E+00 1.08E-02 GNE Mitochondrial Dysfunction 1.44E+00 7.52E-03 NDUFV2 Oxidative Phosphorylation 1.42E+00 7.14E-03 NDUFV2 Pyrimidine Metabolism 1.39E+00 6.62E-03 CRMP1 Module7 Ingenuity Canonical Pathways -log(p-value) Ratio Molecules Germ Cell-Sertoli Cell Junction Signaling 3.46E+00 1.26E-02 "ITGA3,LAMC3" Agrin Interactions at Neuromuscular Junction 1.86E+00 1.49E-02 ITGA3 Caveolar-mediated Endocytosis Signaling 1.83E+00 1.23E-02 ITGA3 NF-Œ_B Activation by Viruses 1.82E+00 1.27E-02 ITGA3 Reelin Signaling in Neurons 1.79E+00 1.22E-02 ITGA3 Neuregulin Signaling 1.75E+00 1.05E-02 ITGA3 FAK Signaling 1.75E+00 1.02E-02 ITGA3 CDK5 Signaling 1.75E+00 1.12E-02 ITGA3 PAK Signaling 1.74E+00 9.62E-03 ITGA3 Virus Entry via Endocytic Pathways 1.74E+00 1.09E-02 ITGA3 Rac Signaling 1.67E+00 8.47E-03 ITGA3 Regulation of eIF4 and p70S6K Signaling 1.67E+00 8.26E-03 ITGA3 Role of Tissue Factor in Cancer 1.66E+00 9.26E-03 ITGA3 PTEN Signaling 1.66E+00 8.33E-03 ITGA3 PI3K/AKT Signaling 1.63E+00 7.75E-03 ITGA3 Cdc42 Signaling 1.58E+00 7.04E-03 ITGA3 Ephrin Receptor Signaling 1.46E+00 5.15E-03 ITGA3 ERK/MAPK Signaling 1.42E+00 5.05E-03 ITGA3 Integrin Signaling 1.40E+00 4.88E-03 ITGA3 Actin Cytoskeleton Signaling 1.38E+00 4.42E-03 ITGA3 "Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis" 1.35E+00 4.41E-03 ITGA3 Phospholipase C Signaling 1.34E+00 4.12E-03 ITGA3 Module8 Ingenuity Canonical Pathways -log(p-value) Ratio Molecules B Cell Development 2.22E+00 3.33E-02 CD40 IL-17A Signaling in Fibroblasts 2.14E+00 2.56E-02 TRAF3IP2 Role of IL-17F in Allergic Inflammatory Airway Diseases 2.08E+00 2.38E-02 TRAF3IP2 Autoimmune Thyroid Disease Signaling 2.06E+00 1.89E-02 CD40 Primary Immunodeficiency Signaling 2.02E+00 1.82E-02 CD40 Allograft Rejection Signaling 2.00E+00 1.69E-02 CD40 TREM1 Signaling 1.98E+00 1.89E-02 CD40 Activation of IRF by Cytosolic Pattern Recognition Receptors 1.91E+00 1.59E-02 CD40 CD40 Signaling 1.89E+00 1.47E-02 CD40 IL-17A Signaling in Airway Cells 1.89E+00 1.45E-02 TRAF3IP2 T Helper Cell Differentiation 1.86E+00 1.45E-02 CD40 IL-17 Signaling 1.83E+00 1.35E-02 TRAF3IP2 Ceramide Signaling 1.79E+00 1.22E-02 NSMAF Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 1.78E+00 1.16E-02 CD40 Communication between Innate and Adaptive Immune Cells 1.77E+00 1.08E-02 CD40 Crosstalk between Dendritic Cells and Natural Killer Cells 1.73E+00 1.09E-02 CD40 Atherosclerosis Signaling 1.69E+00 9.09E-03 CD40 iCOS-iCOSL Signaling in T Helper Cells 1.67E+00 8.93E-03 CD40 IL-12 Signaling and Production in Macrophages 1.66E+00 8.85E-03 CD40 Type II Diabetes Mellitus Signaling 1.63E+00 8.00E-03 NSMAF PI3K Signaling in B Lymphocytes 1.59E+00 7.63E-03 CD40 Systemic Lupus Erythematosus Signaling 1.58E+00 6.62E-03 CD40 Hepatic Fibrosis / Hepatic Stellate Cell Activation 1.55E+00 7.14E-03 CD40 Dendritic Cell Maturation 1.51E+00 5.81E-03 CD40 NF-Œ_B Signaling 1.48E+00 5.88E-03 CD40