[MDH & LDH, Parabasalia, Figure 5D] [Shehre-Banoo Malik, Cynthia D. Brochu, Ivana Bilic, Jing Yuan, Michael Hess, John M. Logsdon Jr., and Jane M. Carlton] [Phylogeny of parasitic Parabasalia and free-living relatives inferred from conventional markers vs. Rpb1, a single-copy gene. PLOS One (2011) doi 10.1371/journal.pone.0020774. sbmalik@dal.ca] >9965352MonocercomonasATCC50210cytMDH -------------------------------------LNLLEITPVLPALNGVVMELTDC AFPALAKIIPTDDPAVAFKDCDYAFLVGSFPRKDGMDRSQLLEKNGGIFKVQGEALSNHA KKTVKVLVVGNPANTNALIALHFA-KNLGPQNFSAMTRLDHNRMLGELAAQKNVTPGKVH RCIIWGNHSNTQVPDVEFAEIELPEGT-KKVTECFEKSYYEGDFIAKISTRGGAVIKARG ASSAASAANAALCQMFS-WIHGTQFGDWVSMAIPVPESKPYGIEPGVIYSFPVTVDEQGK VHIVEGLNVNSFIQEKMQVSLKELQTEKATAWEVLKL--- >9965350MonocercomonascolubrorumcytMDH ----------------GYALAFRIAKGDLLGCCQKVVLHLLEITPALGALNGVCMELQDC AFPTLAGVVATDDPAVAFKDVDVAFLVGSFPRKDGMDRSQLLEKNGGIFKVQGEALSNYA KKTVKVLVVGNPANTNALIALQYA-KNLGPQNFCAMTRLDHNRMIGDIAERLHLTPDCVR KVTVWGNHSNTQVPDVSNAEYDTPEGV-KLVKDALPAELLRGEFVTKISTRGGAVIKARG ASSAASAANAALCRMRN-WCLGTTGDNWVSMAIPVPENKPYGIEPGVVFSFPCRVDQKGN VHVVEGLEVDEWLRGKLDATRQELQTERDTAFKVLNLQ-- >12044147TrichomitusbatrachorumcytMDH2 -------------------------KGDLFGPNQKVILNLLEITPALPALNGVVMELNDC AFPTLEKVNVTDVPNVAFKDADCAFLIGSFPRKDGMDRSQLLEKNGGIFKVQGEALGKNA KKTVKVLVVGNPANTNCLICQHYA-VGLKPENFSAMTRLDHNRMIGEIAARCNTTAGEVK KVTVWGNHSNTQVPDVT---FTTVQG--KPAYDLLKKEDMQGEFIKKIATRGGAVIKARG ASSAASAANAALCQMRD-WCLGTPADDWVSMAIPVPENEPYGIKKGVVYSFPVTV-KDGA VKVVEGLQLDPFVVEKMKVTEEELVTEKNTAFKVLNIQ-- >12044145TrichomitusbatrachorumcytMDH1 -------------------------KGDLFGPNQKVFLNLLEITPVLPALNGVVMELQDC AFPTLAGVQVTDDPNVAFKDIDAAFLIGSFPRKDGMDRSQLLEKNGGIFKVQGEAPGKNA KKTVRVLVVGNPANTNCLICQHYA-VGLKPENFSAMTRLDHNRMIGEIAARCNTTAGEVK KVTVWGNHSNTQVPDVT---FTTVQG--KPAYDLLKKEDMQGEFIKKIATRGGAVIKARG ASSAASAANAALCQMRDWWCLGTPADDWVSMAIPVPENEPYGIKKGVVYSFPVTA-KDGA VKVVEGLQLDPFVVEKMKVTEEELVTEKNTAFTVLNIQ-- >11127931TritrichomonasfoetuscytMDH2 ----------------GYVLAFRIANGDLYP-NRKVRLHLLEITPVLPKLEGVKMELQDC AFPKLAGVEATDDPNVAFKDADVVFLVGSFPRKDGMDRADLLSKNGGIFKEQGLALNN-A RPTVKVIVVGNPANTNCAIALHFA-NKLGPQNFCAMTRLDHNRMKGELAEKAGVPYSNVH RVTVWGNHSNTQVPDCSNAVYDSPEGP-KKVSQLLPDEALKGEFVQKIATRGGAVIKARG ASSAASAANAALAHMRD-WCLGTKAGSWVSMAIPVPEDEPYGIKKGTVFSFPCEVDANGN VHVVKGLEVTGWLRQKLEATEAELISERTTAFEKLNIQ-- >11127929TritrichomonasfoetuscytMDH1 ----------------GYVLAFRIANGDLYP-NRKVRLHLLEITPVLPKLEGVKMELQDC AFPKLAGVEATDDPNVAFKDADVVFLVGSFPRKDGMDRADLLFKNGGIFKEQGLALNN-A RQTVKVIVVGNPANTNCAIALHFA-NKLGPQNFCAMTRLDHNRMKGELAEKAGVPYSNVH RVTVWGNHSNTQVPDCSNAVYDSPEGP-KKVSQLLPDEALKGEFVQKIATRGGAVIKARG ASSAASAANAALAHMRD-WCLGTKAGSWVSMAIPVPEDEPYGIKKGTVFSFPCEVDANGN VHVVKGLEVTGWLRQKLEATEAELISERTTAFEKLNIQ-- >9965342PentatrichomonashominiscytMDH ----------------GYALSFRIAKGDLAG-DRKVVLHLLEIPFGMKALEGCVMELQDC AFPTLAGVVWTDNVEEAFKGVDVAFLVGAFPRKDGMDRADLLEKNGGIFTVQGKALSDFA NPNVKVIVVGNPANTNCAIALASA-PKLGPKNFSAMTRLDHNRCKGAIASKLGVTPEKVH KVTIWGNHSNTQVVDCSQATVELPEGT-VKVSEKIPIAELEGDFCKMIATRGGAVIKMRG ASSAACAANAALTHMRS-WLYGTEEGDWVSMAIPVPDNEPYGVKKGVIYSFPVTIDKEGN VKVVEGLQLDAWTKEKMVETEKELQGEKETAWKVLGL--- >123431031TrichomonasvaginalisG3MDH -MEPIHILITGAAGQIGYALTFRIAKGDLCG-DRKVVLHLLEITPGMKALEGCVMELQDC AFPNVAGIVWTDKVEEAFKDVDVAFLVGSFPRKDGMDRSDLLAKNGGIFTVQGKALNDYA KPTVKVLVVGNPANTNCLIAQASA-PKLQKKNWCAMTRLDHNRMVGALAAKFGVTPEHIH KVCVWGNHSNTQVPDTTHATVDLPEGT-VKVADKLPKEYLEGEFAQMIATRGGAVIKMRG ASSAASAANAALTCVHD-WLYGTKEGDFVSMAIPVPDNEPYGIKQGIIFSFPVTVSKDGE VHVVEGLELNDCVKGKLEATEKELIGEKETAWKVLGL--- >154416576TrichomonasvaginalisG3MDH -MEPVHVLITGAAGQIGYVLTFRIAAGDLFG-DRKVVLHLLEIPQGMQALQGCCMELQDC AFPAVAGIVATDKIEEAFKDVDVAFLVGAFPRKDGMDRADLLGKNGGIFTVQGKTLSDYA KPDVKVLVVGNPANTNALIALASA-PKLGPKNFCAMTRLDHNRMLGELSVKLGVPTNEIH KVTIWGNHSNTQVPDVSHAVYGKEN---KKVSEALQAEYYQGEFVTKISTRGGAVIKMRG ASSAASAANAALEHMRS-WCFGTPADDWVSMAIPVPENEPYGIKKGVIYSFPCTVDKEG- IHVVEGLAINDWVRGKMEATEKELVGEKETAWKVLGL--- >154412413TrichomonasvaginalisG3MDH -MEPIHILITGAAGQIGYALTFRIAKGDLCG-DRKVVLHLLEIPFGMKALEGCVMELQDC AFPNVAGIVWTDKVEEAFKGVDVAFLVGSFPRKDGMDRSDLLAKNGGIFTVQGKALNDYA KPTVKVLVVGNPANTNCLIAQASA-PKLQNKNWCAMTRLDHNRMVGALAAKFGVTPEKIH KVCIWGNHSNTQVPDTTHATVDLPEGT-VKVADKLPKEYLEGEFAQMIATRGGAVIKMRG ASSAASAANAALTCVKD-WLYGTAEGDFVSMAIPVPDNKPYGIKQGTIFSFPVTVSKDGE VHVVEGLELNDWVKGRLEATEKELIGEKETAWKVLGL--- >15620521HypotrichomonasacostacytMDH MSTPINVVITGAAGQIGYAIMFRIAKGDVFGCNQKINLHLLEIEPALPALNGCIMELQDC AFPNLAGVFPTANPEEAFKDADACFLIGAFPRKDGMDRSALLQKNGGIFRVQGEAIGKFA KKTVKVLVVGNPANTNCLICQHYAGASLKNENFSAMTRLDHNRMLGEIAARLNVTTDKVK KVIVWGNHSNTQVDDASHATVELADGV-KAVYGALPQADLEGEFAQKIATRGGAVIKARG ASSAASAANAAITQMRDWWC-STPEGDWVSMAIPVPDDEPYGIKKGIIYSFPVVV-KQGV VEVVKGLECNAHIQAGMKKTEDELIAEKQAAYEALNIQ-- >1054961TrichomonasvaginalisNIHC1cytMDH -MEPIHILITGAAGQIGYALTFRIAKGDLCG-DRKVVLHLLEIPFGMKALEGCVMELQDC AFPNVAGIVWTDKVEEAFKGVDVAFLVGSFPRKDGMDRSDLLAKNGGIFTVQGKALNDYA KPTVKVLVVGNPANTNCLIAQASA-PKLQNKNWCAMTRLDHNRMVGALAAKFGVTPEKIH KVCIWGNHSNTQVPDTTHATVDLPEGT-VKVADKLPKEYLEGEFAQMIATRGGAVIKMRG ASSAASAANAALTCVKD-WLYGTAEGDFVSMAIPVPDNEPYGIKQGTIFSFPVTVSKDGE VHVVEGLELNDWVKGRLEATEKELIGEKETAWKVLGL--- >9965340TrichomonastenaxcytMDH ----------------GYALTFRIAKGDLCG-DRKVVLHLLEIPFGMKALEGCVMELQDC AFPNVAGIVWTDKIEEAFKDVDVAFLVGSFPRKDGMDRSDLLAKNGGIFTVQGKALNDFA KKDVKVLVVGNPANTNCLIAQASA-PNLTKKNWCAMTRLDHNRMVGALAAKFGVTPEKVH NVCVWGNHSNTQVPDVSHATVDLPEGT-VKIADKLPKEYLEGEFAQMIATRGGAVIKMRG ASSAASAANAALTCVKD-WLYGTKEGEFVSMAIPVPDNEPYGIKQGIIYSFPVTV-KDGE VHVVENLERNDWVKTKMAATEQELIGEKETAWKVLGL--- >12044149TetratrichomonasgallinarumcytMDH ------------------ALTFRIAKGDLCG-DRKVFLHHLEIPFGMKALEGCVMELQDC AFPNVAGIVWTDKIEEAFKDVDVAFLVGSFPRKDGMDRSDLLAKNGGIFTVQGKALSDFA KKDVKVLVVGNPANTNCLIAQASA-PNLSKKNWCAMTRLDHNRMVGALAAKFGVTPEKVH NVIVWGNHSNTQVPDAYHATVDLPEGT-VKVADKLDAEYLEKEFAPMIATRGGAVIKMRG ASSAASAANAALTCVKD-WIYGTKDGEFVSMAIPVPDNEPYGVKQGIIYSFPCTC-KDGE VKVVENLERNEWVKSKMVATEQELVGEKETAWKVLGL--- >222064049HistomonasmeleagridiscytMDH2 ------------------------------G-------------RGLARLQV-------- ---------------------------------DTSGSKDLLKINGGIFKTQGEALSNNA KKTVKVIVVGNPANTNCRIALHYA-TNLGPENFSAMTRLDHNRAIGELAQKAGVSSDKVH GVCIWGNHSNTQVPDASNCVIETKDGE-KTATELFGEEFLHGEFVQKISTRGGAVIKARG ASSAASAANAAIDQMRD-WVLGTKSGKIVSMAIPVPDNEPYGIKKGTVFSFPCEVTPEGK VKVVEGLPVSEWLQEKLNTTEQELINERNAAFQLLGI--- >123491614TrichomonasvaginalisG3MDH MTQPLHVLVTGAAGQIGYVLAFRIANGDLFG-ERDVVLHLLEISPAMKALEAVVMELHDC TFPHLLHVIGTSDLEEAFRDVDVAFLVGSFPKKPSTKLVDYFQRNASIYSEHGRALSDFA KPTVKVLVIGMPTNTNALVAMTAA-VNLSPKNFCAMTRLDHNRAVYSIAQKLGVHHSKVY KVVIWGNRSSSQIPDVSNAEYQDETGR-HHILEKVSEEYVNTEFSSDLAQRGNKVTMMRG ASSAASAATAAIQCMRD-WLYGTPADNFVSMSVPVPESSPYGVKPGIFFSFPCTVDKEGN IHVVEGLPVDEATAKKIKQQEEEILNE----LKILATPEE >123407394TrichomonasvaginalisG3LDHisoz2 MSDPAHVLITGAAGQIGYILSHWIAGGELYG-DRPVVLHLFDIPPAMNRLTALTMELEDC AFPHLAGYVATTEPEAAFKDIDCAFLVASMPLKPGQVRADLISSNSVIFKNTGEYLSKWA KPTVKVLVIGNPDNTNCEIAMLHA-KNLKPENFSFLSMLDHNRAYYEVASKLGVHVHDVH DIIVWGNHGESMVADLTQATFTKDGKT-QKVVDVLDHDYVFGTFFKKIGHRAWDILEHRG FTSAASPTKAAIQHMKA-WLFGTAPGEVLSMGIPVPEDNPYGIKPGVVFSFPCNVDKEGK IHVVDGFKVNDWLREKLDFTMNDLFHEKEIALEHLAQ--- >4193365TrichomonasvaginalisLDHisoz2 MSDPAHVLITGAAGQIGYILSHWIAGGELYG-DRPVVLHLFDIPPAMNRLTALTMELEDC AFPHLAGYVATTEPEAAFKDIDCAFLVASMPLKPGQVRADLISSNSVIFKNTGEYLSKWA KPTVKVLVTGNPDNTNCEIAMLHA-KNLKPENFSFLSMLDHNRAYYEVASKLGVHVHDVH DIIVWGNHGESMVADLTQATFTKDGKT-QKVVDVLDHDYVFGTFFKKIGHRAWDILEHRG FTSAASPTKAAIQHMKA-WLFGTAPGEVLSMGIPVPEDNPYGIKPGVVFSFPCNVDKEGK IHVVDGFKVNDWLREKLDFTMNDLFHEKEIALEHLAQ--- >123431388TrichomonasvaginalisG3L-LDH MSEAAHVLITGAAGQIGYILSHWIASGELYG-ERKVYLHLFDIPPAINRLTALTMELEDC AFPRLAGFVATTEPEQAFKDIDCAFLVASMPLKPGQVRADLISSNSVIFKNTGEYLSKWA KPTVKVLVIGNPDNTNCEIAMLHA-KNLKPENFSSLSLLDHNRAYYEIASKLGVSINDIH DIIVWGNHGESMVSDLTQATFTKDGKT-QKVVDVLDKEYVFDAFFKKIGHRVWDILEHRG FTSAASPTKAAIQHMKA-WLFGTAPGEVLSMGIPVPEGNPYGIKPGVVFSFPCSVDKEGH VHVVDGFKINDWLKEKLEFTEKDLFHEKEIALQHLAKQ-- >123500184TrichomonasvaginalisG3L-LDH MSEAAHVLITGAAGQIGYILSHWIASGELYG-DRQVYLHLLDIPPAMNRLTALTMELEDC AFPHLAGFVATTDPKAAFKDIDCAFLVASMPLKPGQVRADLISSNSVIFKNTGEYLSKWA KPSVKVLVIGNPDNTNCEIAMLHA-KNLKPENFSSLSMLDQNRAYYEVASKLGVDVKDVH DIIVWGNHGESMVADLTQATFTKEGKT-QKVVDVLDHDYVFDTFFKKIGHRAWDILEHRG FTSAASPTKAAIQHMKA-WLFGTAPGEVLSMGIPVPEGNPYGIKPGVVFSFPCNVDKEGK IHVVEGFKVNDWLREKLDFTEKDLFHEKEIALNHLAQ--- >15620523HypotrichomonasacostaLDH -------------------MAFRIANGDLLG-NRRVCLHLLELPVALKACEGLALELEDC AFQNLEKTIVTDKLEEACKDIDIAFLVASVPLKPGEHRVNLLTKNTPIFKAIGEALSEYA KPTVRALVVGNPVNSNCLVAMLNA-PKLSAENFSCMCTLDHNRSVSRIASHLKVPIDHVY HVAVWGNHAETQVPDITHVEVTDENGTHRKAFDELCRIEPEPDFIEVIAQRAWKVLEMRG KTSAGSAVNAALCHMRA-WLFGTRPNDWISLGIPVPEGNSYGIKPGIIFSFPCTVDEKGK VHIVENLELNPEIKTKIAQTEKDLFEERETALKALAELSK >123475368TrichomonasvaginalisG3LDHisoz2 MSEPAHVLITGAAGQIGYILSHWIAGGELYG-DRPVVLHLFDIPPAMNRLTALTMELEDC AFPHLAGYIATTEPEAAFKDIDCAFLVASMPLKPGQVRADLISSNSVIFKNTGEYLSKWA KPTVKVLVIGNPDNTNCEIAMLHA-KNLKPENFSSLSMLDHNRAYYEVASKLGVDIHDVH DIIVWGNHGESMVADLTQATFTKDGKT-QKVIDVLDHDYVFDTFFKKIGHRAWDILEHRG FTSAASPTKASIQHMKA-WLFGTAPGEVLSMGIPVPEDNPYGIKPGVVFSFPCNVDKEGK IHVVEGFKVNDWLREKLNFTENDLFHEKEIALQHLSE--- >123431390TrichomonasvaginalisG3L-LDH MSEAAHVLITGAAGQIGYILSHWIASGELYG-ERKVYLHLFDIPPAINRLTALTMELEDC AFPRLAGFVATTEPEQAFKDIDCAFLVASMPLKPGQVRADLISSNSVIFKNTGEYLSKWA KPTVKVLVIGNPDNTNCEIAMLHA-KNLKPENFSSLSLLDHNRAYYEIASKLGVSINDIH DIIVWGNHGESMVSDLTQATFTKDGKT-QKVVDVLDKEYVFDAFFKKIGHRVWDILEHRG FTSAASPTKAAIQHMKA-WLFGTAPGEVLSMGIPVPEGNPYGIKPGVVFSFPCSVDKEGH VHVVDGFKINDWLKEKLEFTEEDLFHEKEIALQHLAKQ-- >123404233TrichomonasvaginalisG3LDHisoz2 MSEPAHVLITGAAGQIGYILSHWIAGGELYG-DRPVVLHLFDIPPAMNRLTALTMELEDC AFPRLAGYVATTEPEAAFKDIECAFLVASMPLKPGQVRADLISSNSVIFKNTGEYLSKWA KPTVKVLVIGNPDNTNCEIAMLHA-KNLKPENFSSLSMLDHNRAYYEVASKLGVDIHDVH DIIVWGNHGESMVADLTQATFTKDGKT-QKVVDVLDHDYVFDTFFKKIGHRAWDILEHRG FTSAASPTKASIQHMKA-WLFGTAPGEVLSMGIPVPEDNPYGIKPGVVFSFPCNVDKEGK IHVVEGFKVNDWLREKLNFTENDLFHEKEIALQHLGE--- >9965354TetratrichomonasgallinarumLDH ----------------GYILSHWIAGGELYG-ERPVFLHLFDIPPAMNRLTALTMELEDC AFPHLAGYVATTNPEEAFKDIDCAFLVASMPLKPGQVRADLISSNSVIFKNTGEYLSQWA KPTVKVLVIGNPDNTNCEIAMLHA-KNLKPENFSSLLMLDQNRAYYEIASKLNVDVKDIH NIVVWGNHGESMVAGLTQATFTKGGKE-QKVIDALDKDYVFDTFFKKISHRAWDILEHRG FTSAASPTKASIQHMKA-WLFGTKPGEVLSMGIPVPEDNPYGIKPGVVFSFPCTVDTDGK IHVVEGFKVNDWLRQKLNFTENDLINEKRIALEHLSQx--