[Rpb1 Excavates Figures 2 & 3] [Shehre-Banoo Malik, Cynthia D. Brochu, Ivana Bilic, Jing Yuan, Michael Hess, John M. Logsdon Jr., and Jane M. Carlton] [Phylogeny of parasitic Parabasalia and free-living relatives inferred from conventional markers vs. Rpb1, a single-copy gene. PLOS One (2011) doi 10.1371/journal.pone.0020774. sbmalik@dal.ca] >HM016232Trichomitusbatrachorum ------------------------------------------------------------ ------------------ECPGHFGHIKL-ATVLYHIGYIDIVYKILQCVCPSCSRL-LV GYADP----HVQEAVLRY--KGKKRLLAIHAIATKS-----STRYCKHLEKKKSTKGVSG P----NQAQQSNPEEADYVKNDRFWKI----VTGSDDQEKWKRESQPCG--NAVPELTK- -ENDGHIK-KKDP-------ARGEPDLIESSKVLEILHNISEQDIRILGFDPQKCRPEWM MVKILPVPPPHVRPFIR-------QGG---HVTQDEVSHQLGQIIL----LNKKVQEDIT NGIPATKRQEDEFALQQCVTTYFINDKPSIDRATLK-NGR-PIKAISQRLKGKMGHIRGH LSGKRVNFSARSVISPDPSISIDQVGVPFELAKILTFPEVVNSLNIKDMQQLVYNGPDSQ DGAK-------------AVITPLG----ARFSLGDTQE--STVQHLDYGSVVERHLRDND IVIFNRQPSLHKMSMMGHYAKLIRGQSFRLNLCVTTPYNADFDGDEMNLHVVQTQQARAE VKHIMAVPYQIITPQSNKPIIGLVQDCLVGCRLLSIRDTFLTR-NELMNLMMWIMDTKP- ------------------------------------------------------------ -------------------------------------------DLVL-----PPPCIVAP ---QELWSGKQVFSLFLPQINLDKFS--SPADD-K----GADKSWNSSDDVRVI----IR DGHLLAGIIDSKTVAKSEGSLTHVVINSYSLDTAKAFLNQTQLVVNNWLENR-----GFS MGISTCVTTQEALDKVAGQLTELKAKI-ETIIEDAKHDRLEKMPGLTLTGTFEAKIMEVA NDFTEKSSAVAIQAAPFWNALLQMMQAGSKGSKVNIAQIIACVGQQSIEGERVRFGFKN- RTLPHYVK-DDFDLESRGFVEHSYIQGLTPQEFFFHSMGGRTGIIDTACKTADTGYIQRR LCKTMESHCVQYDGTVRDSMNNVVQFLYGGDGIDPVQIET-QSLSLIALSD-----QEF- -------------DSMYKMN-----------------------------------INDPV ------------------FGA-------GYLESSIISDLRKMEGTPTTTITGNFGGRSEE V-EIT--------RPSAVLQEE------------------LDTLLHFRQILREEIFPN-- -----GN-QKLYA------SVNLKRIIETAQRKYNINEYTS---L-SD----LNPVL-VV SEVKKLVSRLIIV--------QQNKDKI-GREVQDNGTLLLRILIHATLASKPLIEKNRL SQKAFRSIIGEIEDRFYRTIVSPGEMVGTIAGQSIGEPATQMTLNTF------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016223Hypotrichomonasacosta ------------------------------------------------------------ -----------------------SGHIRF-VRPLYHIGYIDIVYKILQCVCSKCGRL-LA SYSQP----ELQSAVTHY--HGRNRFLKVYEIIHGR------KAGCEHKKTKEMIKQQKA AQDQGAPAPAENAALADAAKNAEFWRR----VSNTLDESQWVRKSQPCG--SKQNELEK- -NAQGRIS-RKDV--------RGESGIITAEVAYEILRQITDQDIRILGFDPIRCHPKWM ILKVLPVPPLHVRPAVA-------MDG--VHKSQDDVTKKLSTIIM----CNNSLENNIN NGSANTVITEDLDTLQLHVTTYMVNDKPSIQRATMK-NGR-PFKAISQRLKGKSGHIRGH LSGKRVNFSSRSVISPDPSISIDQVGVPQEIARILTFPEVVTARNLTEMQRLVYNGNEAQ EGAN-------------YVITPQG----TRINLAVTQE--STAMQLDHDSIVERHLRDDD IVIFNRQPSLHKMSMMGHRARIMPGQTFRLNLCVTTPYNADFDGDEMNMHVPQSQMARAE AKHIMLVPNQIISPQSACPIIGLVQDSLLGCRLLSLRDTFLTR-NEITNLMMWIIDSN-- ------------------------------------------------------------ -------------------------------------------DIVL-----PPPCILKP ---KELWSGKQVFSLFLPKINYDGFSVGADAKE-NT---KEVNTWESPADLRVI----IR NGNLLAGILDKKTVAKSAGSLNHVVINSYSIETARQFLNQTQLIVNNWLENR-----GFS IGLSDCLAYEKTLDDVSDQIHQLKRNV-LDIIDQAKHGKLETPPGLTFMEGFESKINKLL NDLINDTGATVQKASRFWNSLMQMVAAGSKGSLINISQIIAVVGQQNVEGKRIRYGFKG- RTLPHYVK-DDYDLECRGFCEHSFIQGLTPQEFFFHAMGGRVGIIDTACKTSDTGYIQRR LCKSMESHCVMYDGTVRNSLNEIVQFIYGGDGLEPTKLET-QKCPLIELSD-----RVF- -------------DERFVME-----------------------------------INDPT ------------------FGV-------GKIQRDIIENLRS------------------- --DVR--------S-QERLQAE------------------TKRLRDFRDLMRTEIFPN-- -----GD-SVITL------SMKVQRLIDTSKTVHDINEHTN---I-SN----LHPYF-VI DEVDKLAKRLVVV--------PGD-DPI-GREAQDNATLLMRIQLYTMLASKPLILKERL SMDAFKWIIGEIEERFPETIVAPGEMVGTVAGQSIGEPSTQMTLNTF------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016233Tritrichomonasfoetus ------------------------------------------------------------ ------------------ECPGHFGHLKL-AEPLFHIGYLDVVYKLMQCICHRCGRL-KV NYAEP----EFQRIIKNY--HGKQRLIHMHEFCSSR-------KKCDH------------ -------VKVPTPETPDVVKDISFWKELGVEIENEAQLSEDLRNKTPCS--HDVPEISRD EDGNFRLK-EHSG-------GGGGIDIISASQILEIFKQMSDYDILALGLDPKRSHPEWM ICTVLPIPPPHVRPPVR-------AEG--SAPSQDDVTHKLASIIQ----ANNHLLKLKQ EGAQQVALNENIELLQWHVTTYFINDKPSIKRATTK-NGK-PIKAISQRLKGKEGHIRGH LSGKRVDFSARSVISPDPSIRIDQVGVPQEIAKILTFPEVVTPRNREELTKLVINGPEEL KGAN-------------YIITPQQ----MKIDLSHATE--RTAIHLDDLAIVERHLTDGD IVIFNRQPSLHKMSMMGHHALILPGSTFRLNLCVTTPYNADFDGDEMNLHVPQTQSARAE VKHIMLVPNQIITPQGNKPIIGLVQDSLLACRLLSLKSSFLNR-NEMMNLMMWVRSKQ-- ------------------------------------------------------------ -------------------------------------------NLVL-----PPPCIIHP GNKVFLWSGKQVFSLFLPSINHDFVQ--KGAKE-P-------GSWIPVDDTRII----IR DGQLLAGILDKDTVAKSEKSLAHVVINSWDKNLARDFLSETQMVVNSWLESR-----GFS IGLIDAVATDKTNETVDQQIRDLESDV-KEIISRTQKGQLTIQPGMTLIESFEREVNTKL NKAIDACGSTVQKSSRFWNSLVQMVKAGSKGSLLNISQIIATVGQQNIEGKRIRFGFKN- RTLPHFTK-DDFGLESRGFCRHCFLEGLNPPEFFFHAMAGREGIIDTACKTSDTGYIQRR LCKSMESHCVMYDGTVRNSLNEVIQFIYGGDGLDPVGLET-QNLTFMGDSD-----EDF- -------------DRKFRFD-----------------------------------LTQAA ------------------FGQ-------GIMDQEIVDELMS------------------- --NPN--------HTKNRLDHE------------------INRLLKFRQILREEIFTD-- -----AS-NKVWL------PVNIRRLIESAQQSHHINPHSD---K-SN----LNPLT-VI QKVEELVDQLVIV--------KGE-DAL-SREAQDNATLLLRIHIFSNLASKPVIFQHRL TEQALIFVLGEIKTRFVQTIVSPGEMVGTIAGQSIGEPSTQMTLNTFHFAGVSAKNVTLG VPRLNEVMNLARVMKTPQVTVYLEPDSRGDKDKAKDIQAELESSLKKLVARSEIYYDPSD MNSMIEEDEWARYQGREDSSNLSPWVLRLVLNQAALVDKNINPIE--------------- ------------------------------------------------------------ ----------------------------------------------IVEKINILYANVYY AITNEGSSGDPIIRIRGLMNDKSFEDKDGRALQFAEQHLYDSLSLKGIEGINRAVMEETT RYEVDPES---------------NAFNTERKECKHKEWVLYTEGSALREVL-------NH PRVDCRRSVSNNILETLEILGIEAARQSILI----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016222Dientamoebafragilis ------------------------------------------------------------ ------------------ECPGH-GHINL-AYPLFHFGYIDVVYKILNCVCHSCGRL-LL SYGNP----AVQRIVKNY--QGKKRFDKIVEICRLS--------SCEH------------ ------EKRANDGAYDDIVKDKAFWDAIGI-VPEDGDYSKDLRNIPTCG--TIHYNVAR- -EQDGTIR-YK---------GKGNNEEFSAAAALDVFKLMKDCDIRVLGLDPERSHPKWM ILTILPVPPPHVRPPVR-------VEG--LNPSPDDVTQHLGTILR----CNNNLKKDKK GSNSQTTIKDSLGLLQWNVTTYFVNDKPSIKRAVTR-NNK-PIKSISQRLKGKEGHIRGH LNGKRVDFSARSVISPDPSIRIDQVGVPKHVAKILTFPEVVNPRNRDELYRLVQNGPDEL QGAN-------------FVINPQG----IRFSLSRTTE--RTTTHLDDGSIVERHLQDND IVIFNRQPSLHKMSMMGHHAVIMRGSTFRLNLSVTTPYNADFDGDEMNLHVPQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016225MonocercomonasspNs1PRR ------------------------------------------------------------ ------------------------GHIEL-AEPVFHIGYIDIVYKILQCVCHNCGRL-LV SYAEP----ELQHIVLNY--HGKQRLIKIHELLKSR-------KSCCP------------ -----SKGQNIDESCPDKVKDPAFWNELGV-FKDDDDYDEDFRNVQPCG--QTVPEISK- -ESDFTLK-MKTP-------SKSSSDILSAKSVLEILKHMNIYDIRVLGFNTERARPEWM ISTILPVPPPHVRPAIV-------MDS--SRPSQDDVTHKLATILQ----TNNHLKKLIQ DNAQQVAQQDAIEMLQYHISTYLINDKPALQRATTK-NGR-PIKAISQRLKGKEGHIRGH LSGKRVNFSARSVISPDPSISIDQVGVPLEIAKVLTFPEVVTPRNREYLQQLVYNGPDAQ QGAN-------------YIITPQG----IRINLAVTEE--RSALHLNDNAIVERHLRDDD IVIFNRQPSLHKMSMMGHRAYLMPGSTFRLNLCDTTPYNADFDGDEMNLHVPQSQTARAE VKHIMFVPNQIISPQANKPIIGLVQDALLACRLMTLRDTFLNR-NQVMNLMMWIKKR--- ------------------------------------------------------------ -------------------------------------------DVVL-----PPPCILKP ---QQLWSGKQVFSLFLPEINHDAFS--ADNKD---------DSWLPVDDKRVI----IR DGKLLAGILDLKTVAKSEKSLVHVVINSWDKDIARDFLNQTQLVVNNWLELR-----GFS IGIIDCIASPRTLEKVSEQLGDLKKSV-DEITHSALNGTLKIQPGMTLKETFESEVNTRS NDFINKSGDVVKNDSRFWNSLMQMVAAGSKGSKINISQILACVGQQNVEGKRVPNGFKN- RTLPHYFK-DDVGLEAKGFCEHSYIQGLTPPEFFFHSMGGRTGIIDTACKTSDTGYIQRR LCKFMESHCVQYDGTIRNSLNEVIQFLYGTDGMDPICLET-QKIRLLSMDD-----NQF- -------------RNEYEFD-----------------------------------LSLPT ------------------FGQ-------GIMNADTIDEMNE------------------- --NIS--------ATRTILNRE------------------TERLLHFRKLLREEIFPS-- -----GE-GSVYL------PVNITRLLETAQQTHGINPHSD---K-SD----LHPIN-VI ESVENVINKLVVV--------PGD-DYI-SKEAQDNATLLLRILLYSNLAAKTLIFKYRL NEIAFKYVLGEVEVAFVKSIVSPGEMVGAIAGQSIGEPATQMTLNTF------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016224Monocercomonascolubrorum ------------------------------------------------------------ -------------------------HIEL-AEPVFHIGYVDVVYKLLQCVCHNCGRL-LV SYSEP----ELQKIVLNY--HGKQRLVRILELTKSR-------HQCSH------------ -----SKTPNGEDVHPDIVKNPAFWKELGV-VDEDGNYDQDFRKMDPCG--QMIPEITK- -DGDFTIK-MKDP-------SRNAQDALSAKKVLEILKHLSPLDTKILGFDEEKAKPEWM ICTILPVPPPHVRPAIL-------MDG--SNMCQDDVTHKLASIVQ----VNNHLKKLIA DNVQLVAKKEYIDLLQYHISTYFINDKPSLQRATTK-NGR-PIKAISQRLKGKEGHIRGH LSGKRVNFSARSVISPDPSISIDQVGVPLEIAKVLTFPEVVTARNRDYLQKLVHNGPDHQ DGAN-------------YIITPTG----IRINLAVTEE--RSALHLADNAIVERHLREDD IVIFNRQPSLHKMSMMGHRAHLMPGSTFRLNLCVTTPYNADFDGDEMNLHVPQSQSARAE VKHIMLVPNQIITPQSNKPIIGLVQDALLACRLMTLRDTFLTR-NQVMNLMMWIKKR--- ------------------------------------------------------------ -------------------------------------------DVIL-----PPPCILKP ---QQLWSGKQVFSLFLPEINHDGYS--SDVKD---------KSWLSYDDKRVI----IR NGKLLAGILDSRTVARSEKSLVHVIINSWDKDIARDFLNQTQLVVNNWLESR-----GFS IGIIDCIASEKTLIKVSEILDNLKEKV-DNITRSALSGTMTIQPGMTLKESFEQEVNSNS NDFINKSGAIVQNDARFWNSLMQMVAAGSKGSKINISQILACVGQQNVEGKRVPNGFKN- RTLPHFFK-DDMGLEAKGFCEHSYIQGLTPPEFFFHSMGGRTGIIDTACKTSDTGYIQRR LCKFMESHCVQYDGTVRNSLNEIIQFVYGCDGMDPICLET-QSIPLLEMDD-----NEF- -------------DREYEFD-----------------------------------LSLPT ------------------FGQ-------GIMRQEVIDGMND------------------- --NIS--------ATKDVLQKE------------------IARLKHFRRILREEVFPT-- -----AT-GSVYL------PVNIGRLIQTAQQIHNINPHSD---R-SD----LHPIH-VI DSVEKLVSKLIVV--------KGD-DYI-QKEAQDNATLLLRVLLYSSLAAKCLIFKHRL SEDAFRYILGEGEHAFIGSIVSPGEMVGTIAGQSIGEPATQMTLNTF------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016226Monotrichomonascarabina ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------NMHLPQSQAARAE IQHIMSVPYQIISPQGNSPIIGLVQDSLLGCRLMTFRDTFLER-EEVMNLMMWIEGQE-- ------------------------------------------------------------ -------------------------------------------DRPL-----PPPAILKP ---KMLWTGKQIFSLFLPKINYDGWSVTALDEE-K-----KQNCWMSFNDTRVI----IR EGHLLAGILDKNTVARSEKSLVHIVINSYSTLIARDFLNVTQKVVNNWLESR-----GFS IGLSDCVTKKESLDQVHTTLSELKQSLEDEEIADAVSGRMEAEPGMTLKETFEFKVNAKL NKVLETAAGIVKKSISRENSLIQMVNAGSKGSNINISQILACVGQQNVEGKRIKYGFRG- RTLPHYTK-DDLGSESRGFVMNSYLIGLTPAEFFFHAMGGREGITDTACKTSDTGYIQRR LIKAMESHQVAYDGTVRNSLNQIVQFIYGADGYDATSLET-QNVRLVNMND-----KAF- -------------RQNYELD-----------------------------------IDNAD ------------------FGI-------GFMEQHSIEELRN------------------- --DPL--------A-RDILNSE------------------ISNLSALRKKLREEVFTD-- -----AK-NRVAL------PINISRLLETARMNYNINEYVS---I-SD----LRPLD-VI KRVEEKIQSLIVV--------QGN-DRI-SRKAQENATLMLRAMLYSNLSAKQLIFRHRL NSDAFEFVLGEITHLFKRSIVAPGEMVGTLAGQSI------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016228PseudotrichomonaskeiliniNY0170 ------------------------------------------------------------ -------------------------------TPLFHVGFADKVYKLLQIVCHKCGRL-LC DYGEI----EIQKIVKHC--QGKQRFLKIFEHIKSS------NHECKH------------ -----KEST-KNKENPDFVEDKKFWRI----INGDSPHQECVRTKKPCN--EKVPEVVQ- -AKDFLVA-YKDS-------RNYDGDTISADHVFSIFENMSDQDIRILGFNPIRSHPKWL ILKVLPVPPLAVRPQVE-------APGQ-SSPSQDDVTHKLIDIIR----INNSIADHTR NKGTETAIKQEKMLLQYHVTTYLINDKPSIARATTK-NGR-PLKVISMRLKGKEGHIRGH LSGKRVDFSARSVISPDPSISIDQVGVPKDLSKVLTFPEIVTKLNQKWLQGLVDLGPNEE GGAN-------------VIITDQG----IKTDLEICKE--TCAQTISPGYIVERHIRDND IVIFNRQPSLHKMSMMGHRAVLMSGKTFRLNLCVTTPYNADFDGDEMNLHVPQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016227Pentatrichomonashominis -------MKGIADDSSLIGSIDFGLFDPEEVKKFAACEITKPQNYENGKIVTGGLSDLRM GTQSP-EYRCRTCGQDLQNCPGHFGYINL-AEPFFHIGFSDKVYKILQMVCHKCGRL-LV SYSDP----EVQYIVTHF--KGKDRFTRIFEKISGK------THKCAH------------ -----PTEKNKDPSQADEVVDEEFWNR----VNGGL-NGEHHRVKEPCN--EAVPEVAM- -GKDFLVI-YKDG-------SKTDEDYIPAERVLNIFENISDQDLRIMGFDPKRSHPKWM ILTVLPVPPLSVRPQVS-------SPGQ-AAPSQDDVTHKLHSLLQ----TNEHLKLQLA NGAPDTALAEDRQLLQWHISTYFINDKPSMDRAENK-SHR-PLKVISQRLKGKEGHIRGH LSGKRVNFSARSVISPDPSIEIDQVGVPKELAKILTFPEVVTTLNQKWLEGIVAKGPDAE GGAN-------------FIISDTG----TKTDLQFCQK--INTQNLSPGYTVERHLRDND IVIFNRQPSLHKMSMMGHRAFLMSGKTFRLNLCVTTPYNADFDGDEMNLHVPQSQTARAE VRHIMAVPYQIISPQANKPIIGLVQDALLGSRLLSMKDTFLTR-NQVMNLMMWLPNEK-- ------------------------------------------------------------ -------------------------------------------DNIL-----PPPCILKP ---VQLWSGKQIFSLFMPRINLDAYS--ANVDE-KR---GDKKTMIPDNDCKVI----IR NGELLAGIIDKKTVARGEQSLIHVVINSYDIKTAKDFLSQTQLIVNNWLEHR-----GFS IGLIDCVVPKFVTEEVDRALEELDRDV-NKEIRGAMSGQLEPAPGMTFMQTFEFNVNSKL NGFLGKSSDIVKAHIRRDNSLIEMNMAGSKGADSNISQIIASVAQQNMEGKRVRFGFRM- RTLPHYQK-GMYGLIERGFCKHSYVEGLEPPEFIFHAMAGRTGIIDTACKTSDTGYIQRR LCKSMESHHVAYDGTVRNSMNEVVQFIYGGDGLDATGLET-QNLRLSVMGD-----REF- -------------SEEYEME-----------------------------------VDDAT ------------------FGQ-------NVMEQRIIDDVQN------------------- --MQN--------R-HDVLNSE------------------IKRLQDFRQLLQTEIFLK-- -----GE-SKVVL------PVNITRIIQTSQQMQGINVHSS---K-SD----LNPID-VI RRVDEKIRSLIVV--------KGT-DAI-AVTAQENATLLLRIMLYSNLSAKQIIFKHRL DEKAFEYVLGSISERFYRSIVSPGEMVGTIAGQSIGEPSTQMTLNTFHYAGISAKDVTLG VPRLNEIMNLAKQIKTPCVTVILDYNSNNQDDDGSDMDDEEDRSVRQRQNKQELDAALAK DVRANVECAAFKKFVTKSEIFYDPEPADNTTIDEDREWIGIYINNQLDFNIDNYSPWVLR FELDVKSLLASNVSLPEI------------------------------------------ ------------------------------------------QRAIENSYSSELFVSIFE GNMANAASSFPPVIRIRPTKSLVQKNGKTDESEFFLREIEQQLYDERAISIKGIPGIRRV KIDQKAKR---------------KVLEEDHHWVEKSDPQLITEGTALKAIL-------GL DHIDKKLTYTNDINEIYDVLGIEAARNSLCNEMMMIMDNAGASLNRRHLDLLADTMTQYG RLYPVSRHGINRTGT-GTLARASYEQTIDVFFDACSFAETDPMEDVSSNIIVGKPSHAGT GIVECFIN-----------PKLLPTRQGTIIQ-N-------------------------- ---DEEGKLQGVATPVQTMSPGPENMSSLYGDDGGDYTMSPFMTSPFPASPGIGGQMSPF SPGGGLASPMSPMSPMSPVGEAYSPMVTEGVASPLVGYGGGYIATALSPSVTTQSYENTA SPMLTHAYSPLTQSSMSPLAAQQYSPASPLAATSDYSDSSPNGYSPARYNPLSPNVNMGG AGPYSYSPNQSPQSPGSPLMYNPKAKKDGKK-------------------- >HM071003TetratrichomonasgallinarumturkeyGermany4114C52005 ------------------------------------------------------------ -------------------------------------GFHDKVYKLLQMVCHHCGRL-NC NYSDP----QLQQIVKNC--KGKDRFNRVYELIGKK-----TGAKCKY-----------A QKGEKNPQEAQDEATYDMVSDDRFWEI----VNGGP-DGPHERLNRPCG--KEIPGVEM- -GKDLMVK-YKED--------QSGVDYPSAETVLRIFSSMTDQDVRILGFNVERSHPKWM ILEVLPVPPLTVRPQVE-------APGQ-SRPSQDDVTHKLVTIIQ----FNNRLAELKR QSATDTALKETRQFMQYHLTTYMINDKPSILRATTK-NGR-PLKVISQRLKGKEGHIRGH LSGKRDDFSARSVISPDPSISIDQVGVPMELAKILTFPEIVTTTNQKWLESIVMKGPEDI GGAN-------------FVTSDHG----VKTNLAMVND--LTSQTLSPGYIVERHIRDDD IVIFNRQPSLHKMSMMGHRAFLISGRTFRLNLCDTT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016234Trichomonastenax ------------------------------------------------------------ -------------------CPGHFGYIKL-AEPFFHVGFLKHVYKILQMVCHKCGRL-NC SYGDP----EIQYIATHY--KGKQRFEKLFDYVADK------NKDCCD------------ -----SPNA-KDQTNPDFVSDERFWEI----VNGDE-ISEHRRIKVPCK--SKSVAIEQ- -GKDFLIK-YKDT-------SKTEEDYLSAEYVLRIFENISDQDVRLMGFNVKRSHPKWM ILKVLPVPPLAVRPQVV-------SPGQ-SVPSQDDITHKLSDIIK----NNNHLAALRN DSSTDTAMNETRALLQYHITTYFINDKPSILRATTK-NGR-PLKVISQRLKGKEGHLRGH LSGKRDDFSARSVISPDPSISIDQVGVPEDLAKILTFPEIVTTTNQKWLESIVMKGHDDI GGAN-------------YVTNDHG----TKTDLAFCND--LSTIALSPGYVVDRHIRDND IVIFNRQPSLHKMSMMGHRALLMPARTFRLNLCDTTPYNADFDGDEMNLHVPQSQTARAE VRHIMAVPKQIISPQANRPVIGLVQDALLGCRLLSKRDTFLTR-NQVMNLMMWLPTNK-- ------------------------------------------------------------ -------------------------------------------DTIL-----PPPCILKP ---VQLWSGKQVFSLFLPKISYDSYS--NGATD-K-----D-KNWIPKNDSRVI----IR DGNLLAGILDKRSCARSEGSLTHVVINSYNTNIAKDFLNQTQLIVNNWLEYR-----GFS ISLIDCVVPHFVLDKVEEGIMQVEENV-RETIRTAQSGKLDRRPGMTYIQSFEAEVNSQL NKVLSIAYKTITENIRPDNSFVEMLTAGSKGADFNITQVIGVVAQQNIEGKRVKFGFNG- RTLPHYQK-HEYGLVPRGFCKHSYIEGLTPPEFLFHAMGGRTGIIDTACKTSDTGYIQRR LVKSMESHHVAYDGTVRNSLNEVVQFIYGGDGLDATGLET-QFLNLVDLDD-----KKF- -------------DQTYHMN-----------------------------------VDDPT ------------------FGS-------EAMDANILEEFLN------------------- --TPG--------K-EKKLQDE------------------ETRLKEFREILQTEIFPT-- -----GN-KKVVL------PINISRIIESSQRQFGINPHAS---T-SD----LNPLD-VI AKVQDCVNSLTIV--------KGN-DSI-SLRAQENATLILKIMLYSNLASKQVIFTHRL NEQAFNWILGSIRDRFYRSIVAPGEMVGTIAGQSIGEPT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016230TrichomonasgallinaeCoopershawk4 ------------------------------------------------------------ ------------------ECPGHFGYIKL-AEPFFHVGFLKHVYKILQMVCHKCGRL-NC SYGDP----EIQYIATHF--KGKQRFDAIFNYIASS------TRDCSD------------ -----SPAA-KDKESPDVVADERFWEI----VNGDA-ISEHRRMKVPCK--SKPVAIEQ- -GQDFLIK-YKDT-------SKTEEDYLSAEYVLRIFENISDQDVRLMGFNVKRSHPKWM ILKVLPVPPLAVRPQVV-------SPGQ-SVPSQDDITHKLVDIIK----INNNLIALRN DSSTDTAMNDTRKLLQYHITTYFINDKPSILRATTK-NGR-PLKVISQRLKGKEGHLRGH LSGKRDDFSARSVISPDPSISIDQVGVPEDLAKILTFPEIVTTTNQKWLESIVMKGHDDI GGAN-------------YVTNDHG----TKTDLAFCND--LSTIALSPGYIVDRHIRDND IVIFNRQPSLHKMSMMGHRALLMPARTFRLNLCDTTPYNADFDGDEMNLHVPQSQAARAE VRHIMAVPKQIISPQANRPVIGLVQDALLGCRLLSKRDTFLTR-NQVMNLMMWLPTNK-- ------------------------------------------------------------ -------------------------------------------DTIL-----PPPCILKP ---VQLWSGKQVFSLFLPKINYDHFS--NGASD-D-----DKKSWMPANDTRVI----IR DGHLLAGLLDKTSCARSEGSLTHVVINSYNTDIAKDFLNQTQLIVNNWLEHR-----GFS IGLIDCVVPQSVLDQVEEKINEVEDNV-KGVIRTAQSGKLERRPGMTYIQSFEAEVNSAL NQILGDAYKLIQKDIRRDNSFIEMLTAGSKGANFNVTQVIGVVAQQNIEGKRVKFGFNG- RTLPHYQK-HEYGLIPRGFCRHSYIEGLTPPEFLFHAMGGRTGIIDTACKTSDTGYIQRR LVKSMESHHVAYDGTVRNSLNEVVQFVYGGDGLDATGLET-QRLTLVDCDD-----KTF- -------------DKTYHLS-----------------------------------PEDPL ------------------FGT-------DCMDSNVLDEFLN------------------- --TPG--------K-ENRLMHE------------------ENRLREFREILQTDIFPT-- -----GT-TKVVL------PVNIHRLIETSQRQCGINPRAS---I-SD----LNPLD-VI SRVEECANSLTIV--------KGN-DSI-SRTAQENATLLLKIMLFSNLSAKQVIFEHRL NESAFSWILGAIHDRFYRSIVAPGEMVGTIAGQSIGEPTTQMTL---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016240TrichomonasgallinaeAustriaracingpigeon8855C32006 ------------------------------------------------------------ -------------------------YIKL-AEPFFHVGFLKHVYKILQMVCHKCGRL-NC SYGDP----EIQYIATHY--KGKQRFDAIFNYIASS------TRDCSD------------ -----SPAA-KDKESPDVVADERFWEI----VNGDA-ISEHRRMKVPCK--SKPVAIEQ- -GQDFLIK-YKDT-------SKTEEDYLSAEYVLRIFENISDQDVRLMGFNVKRSHPKWM ILKVLPVPPLAVRPQVV-------SPGQ-SVPSQDDITHKLVDIIK----INNNLIALRN DSSTDTAMNDTRKLLQYHITTYFINDKPSILRATTK-NGR-PLKVISQRLKGKEGHLRGH LSGKRDDFSARSVISPDPSISIDQVGVPEDLAKILTFPEIVTTTNQKWLESIVMKGHDDI GGAN-------------YVTNDHG----TKTDLAFCND--LSTIALSPGYIVDRHIRDND IVIFNRQPSLHKMSMMGHRALLMPARTFRLNLCDTTPYNADFDGDEMNLHVPQSQAARAE VRHIMAVPKQIISPQANRPVIGLVQDALLGCRLLSKRDTFLTR-NQVMNLMMWLPTNK-- ------------------------------------------------------------ -------------------------------------------DTIL-----PPPCILKP ---VQLWSGKQVFSLFLPKINYDHFS--NGARD-D-----DKKSWMPANDTRVI----IR DGHLLAGLLDKTSCARSEGSLTHVVINSYNTDIAKDFLNQTQLIVNNWLEHR-----GFS IGLIDCVVPQSVLDQVEEKINEVEDNV-KGVIRTAQSGKLERRPGMTYIQSFEAEVNSAL NQVLGDAYKLIQKDIRRDNSFIEMLTAGSKGANFNVTQVIGVVAQQNIEGKRVKFGFNG- RTLPHYQK-HEYGLIPRGFCRHSYIEGLTPPEFLFHAMGGRTGIIDTACKTSDTGYIQRR LVKSMESHHVAYDGTVRNSLNEVVQFVYGGDGLDATGLET-QRLTLVDCDD-----KTF- -------------DKTYHLS-----------------------------------PEDPL ------------------FGT-------DCMDSNVLDEFLN------------------- --TPG--------K-ENRLMHE------------------ENRLREFREILQTDIFPT-- -----GS-TKVVL------PVNIHRLIETSQRQCGINPRAS---I-SD----LNPLD-VI SRVEECANALTIV--------KGN-DSI-SRTAQENATLLLKIMLFSNLSAKQVIFEHRL NESAFSWILGAIHDRFYRSIVAPGEMVGTIAGQSIGEPTTQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016229TrichomonasspRWG20071commongrounddove1 ------------------------------------------------------------ ---------------------------------------------LLQMVCHSCGRV-LC NYSDP----EIQFIVRHY--KGKNRFLKLFEKISNK-----QCQKCSS------------ -----GEDK-NSNKDMDCVSDDRFWEI----VNGDA-HSDHVRIKKPCE--STVPAVEQ- -GKHFLIK-YKDS-------SANEDDYIPAEKVLRIFENISDQDVRLLGFNVKRSHPKWL IIKILPVPPLAVRPQVV-------SPGQ-SVPSQDDVTHKLSDIIQ----VNNKLTQLKN ESSTDTAMKEVRQLLQYHITTYLCNDKPSIDRAQTK-NGR-PLKVISQRLKGKEGHLRGH LSGKRDDFSARSVISPDPSISIDQVGVPEQLAKILTFPEVVTPINQKWLESIVQKGADSI GGAN-------------YVINDRG----TRTDLSLCHD--IMQVTLSNGYIVERHLRDDD IVIFNRQPSLHKMSMMGHRALIMSGRTFRLNLCDTTPYNADFDGDEMNLHVPQSQTARTE VRHIMAVPKQIISPQANKPVIGLVQDALLGCRLLSKRDTFLTR-NQVMNLMMWLPSTK-- ------------------------------------------------------------ -------------------------------------------DTNL-----PPPCILKP ---VQLWSGKQVFSLFLPKISHDSLS--QDATD-A-----D-KNSLPLNDRHVI----IR DGNLLAGILDKRTVARSEGSLIHVVINSYNTNIAKDFLNQTQLIVNNWLEHR-----GFS IGLIDCVVPSFVLEKVQDEITKVDNAV-KDTILKAKQGKLERMPGMSYMQSFETEVNNYL NEILNTTYKVINEKIRPDNSLKEMLSAGSKGADSNISQIIGVVGQQNMEGKRVKFGFSG- RTLPHYQK-HEYGLVPRGFCVNSYIAGLTPPEFLFHAMGGRTGIIDTACKTSDTGYIQRR LCKSMESHHVAYDGTVRNSQNEVVQFIYGGDGLDATGLET-QRLGLVGLDD-----KAF- -------------NKLYHLN-----------------------------------VDDPT ------------------FGQ-------DAMDANVLEDFLR------------------- --SMD--------K-DKKLQEE------------------EHRLKEFREILQHEIFPD-- -----GS-DTVVL------PVNIARIIESSQRQFDINVHVS---K-SD----LNPLD-II ARVEDCVNSLIIV--------KGN-DTI-SRRAQDNATLLLRIMLFSHLSAKQCIFKYRL NEQAFKYILGSVKDRFYRSICAPGEMVGTIAGQSIGEPS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016231TrichomonasspRWG20072whitewingeddove1200 ------------------------------------------------------------ ------------------------GYIRL-AEPFFHVGFLPHCYKLLQMVCHKCGRV-LC SYSDP----EIQYIVTHY--KGKNRFLKLFEKIASK------SGKCQH------------ -----SPDL-KNPNEPDVCLDERFWEL----VNGDS-HSEHVRVKKPCN--ATVPAIEQ- -GKDFLIK-LKDV-------SKTEEDYLSAEVVLRIFENISDQDVRLLGFNPKRSHPKWM ILKILPVPPLAVRPQVV-------SPGQ-SAPSQDDITHKLSDIII----CNKRLRAQRS ESSTDTAMKETRTLLQYHITTYMINDKPSIERAVTK-SGR-PLKVISQRLKGKEGHLRGH LSGKRDDYSARSVISPDPSISIDQVGVPEQLAKILTFPEVVTPTNQKWLESIVMKGHDDL GGAN-------------FVINDHG----TRTDLSCCTD--LSTITLSPGYIVERHLRDDD IVIFNRQPSLHKMSMMGHRALIMSGRTFRLNLCDTTPYNADFDGDEMNLHVPQSQTARTE VRHIMAVPKQIISPQANKPVIGLVQDALLGCRLLSKRDTFLTR-NQVMNLMMWLPTTK-- ------------------------------------------------------------ -------------------------------------------DTIL-----PPPCILKP ---VQLWSGKQVFSLFLPKISHDSYS--QDANK-M-----D-QNSIPLADRHVI----IR DGNLLAGILDKKTVARSEGSLIHVVINSYNTNIAKDFLNQTQLIVNNWLEHR-----GFS IGLIDCVVPDFVLQEVKHEIDEVESKV-QATIIKAQDGQLERMPGMSYMQSFETEVNNLT NEILSKTYKVINAKIRRDNSLSEMLSAGSKGADTNMSQIIGVVGQQNMEGKRVKFGFNG- RTLPHFQK-HEYGLVERGFCKNSYIAGLTPPEFLFHAMGGRTGIIDTACKTSDTGYIQRR LVKSMESHHVAYDGTVRNSQNEIVQFIYGGDGLDATGLET-QKLALVTLND-----KEF- -------------MKKYHLA-----------------------------------SEDPT ------------------FGQ-------VEMDDFVLDEFLK------------------- --TPN--------K-DKFLKEE------------------ENRLREYREILQKEIFPN-- -----GS-NTVVL------PVNIARIIESSQRQFDINVHVS---K-SD----LNPLD-II SRVDECVNSLIVV--------KGN-DNI-SRTEQENATLLLRIMLYSHLSAKQCIFEYRL NEQAFKYILGSIKDRFYRSIVAPGEMVGTIAGQSIGEPSTQMTLNTFH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016236TrichomonasvaginalisT1 ------------------------------------------------------------ -------------------------------------GFLPHCYKLLQMVCHKCGRV-LC SYSDP----EIQYIVTHY--KGKNRFLKLFEKIASK------SGKCQH------------ -----SPDL-KNPNEPDVCLDERFWEL----VNGDS-HSEHVRVKKPCN--AAVPAIEQ- -GKDFLIK-LKDV-------SKTEEDYLSAEVVLRIFENISDQDVRLLGFNPKRSHPKWM ILKILPVPPLAVRPQVV-------SPGQ-SAPSQDDITHKLSDIII----CNKRLRAQRS ESSTDTAMKETRTLLQYHITTYMINDKPSIERAVTK-SGR-PLKVISQRLKGKEGHLRGH LSGKRDDYSARSVISPDPSISIDQVGVPEQLAKILTFPEVVTPTNQKWLESIVMKGHDDL GGAN-------------FVINDHG----TRTDLSCCTD--LSTITLSPGYIVERHLRDDD IVIFNRQPSLHKMSMMGHRALIMSGRTFRLNLCDTTPYNADFDGDEMNLHVPQSQTARTE VRHIMAVPKQIISPQANKPVIGLVQDALLGCRLLSKRDTFLTR-NQVMNLMMWLPTTK-- ------------------------------------------------------------ -------------------------------------------DTIL-----PPPCILKP ---VQLWSGKQVFSLFLPKISHNSYS--QDANK-M-----D-QNSIPLADRHVI----IR DGNLLAGILDKKTVARSEGSLIHVVINSYNTNIAKDFLNQTQLIVNNWLEHR-----GFS IGLIDCVVPDFVLQEVKHEIDDVESKV-QATIIKAQDGQLERMPGMSYMQSFETEVNNLT NEILSKTYKVINAKIRRDNSLSEMLSAGSKGADTNMSQIIGVVGQQNMEGKRVKFGFNG- RTLPHFQK-HEYGLVERGFCKNSYIAGLTPPEFLFHAMGGRTGIIDTACKTSDTGYIQRR LVKSMESHHVAYDGTVRNSQNEIVQFIYGGDGLDATGLET-QRLALVTLND-----EDF- -------------MKKYHLA-----------------------------------TEDPT ------------------FGQ-------VEMDDFVLDEFLK------------------- --TPN--------K-DKFLKEE------------------ENRLREYREILQKEIFPN-- -----GS-NTVVV------PVNIARIIESSQRQFDINVHVS---K-SD----LNPLD-II SRVDECVNSLIVV--------KGN-DNI-SRTEQENATLLLRIMLYSHLSAKQCIFEYRL NEQAFKYILGSIKDRFYRSIVAPGEMVGTIAGQSIGEPST-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016235TrichomonasvaginalisB7RC2 ------------------------------------------------------------ ------------------ECPGHFGYIRL-AEPFFHVGFLPHCYKLLQMVCHKCGRV-LC SYSDP----EIQYIVTHY--KGKNRFLKLFEKIASK------SGKCQH------------ -----SPDL-KNPNEPDVCLDERFWEL----VNGDS-HSEHVRVKKPCN--ATVPAIEQ- -GKDFLIK-LKDV-------SKTEEDYLSAEVVLRIFENISDQDVRLLGFNPKRSHPKWM ILKILPVPPLAVRPQVV-------SPGQ-SAPSQDDITHKLSDIII----CNKRLRAQRS ESSTDTAMKETRTLLQYHITTYMINDKPSIERAVTK-SGR-PLKVISQRLKGKEGHLRGH LSGKRDDYSARSVISPDPSISIDQVGVPEQLAKILTFPEVVTPTNQKWLESIVMKGHDDL GGAN-------------FVINDHG----TRTDLSCCTD--LSTITLSPGYIVERHLRDDD IVIFNRQPSLHKMSMMGHRALIMSGRTFRLNLCDTTPYNADFDGDEMNLHVPQSQTARTE VRHIMAVPKQIISPQANKPVIGLVQDALLGCRLLSKRDTFLTR-NQVMNLMMWLPTTK-- ------------------------------------------------------------ -------------------------------------------DTIL-----PPPCILKP ---VQLWSGKQVFSLFLPKISHNSYS--QDANK-M-----D-QNSIPLADRHVI----IR DGNLLAGILDKKTVARSEGSLIHVVINSYNTNIAKDFLNQTQLIVNNWLEHR-----GFS IGLIDCVVPDFVLQEVKHEIDDVESKV-QATIIKAQDGQLERMPGMSYMQSFETEVNNLT NEILSKTYKVINAKIRRDNSLSEMLSAGSKGADTNMSQIIGVVGQQNMEGKRVKFGFNG- RTLPHFQK-HEYGLVERGFCKNSYIAGLTPPEFLFHAMGGRTGIIDTACKTSDTGYIQRR LVKSMESHHVAYDGTVRNSQNEIVQFIYGGDGLDATGLET-QRLALVTLND-----EDF- -------------MKKYHLA-----------------------------------TEDPT ------------------FGQ-------VEMDDFVLDEFLK------------------- --TPN--------K-DKFLKEE------------------ENRLREYREILQKEIFPN-- -----GS-NTVVV------PVNIARIIESSQRQFDINVHVS---K-SD----LNPLD-II SRVDECVNSLIVV--------KGN-DNI-SRTEQENATLLLRIMLYSHLSAKQCIFEYRL NEQAFKYILGSIKDRFYRSIVAPGEMVGTIAGQSIGEPSTQMTLNTFH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HM016237TrichomonasvaginalisBiomedCI6 ------------------------------------------------------------ -------------------CPGHFGYIRL-AEPFFHVGFLPHCYKLLQMVCHKCGRV-LC SYSDP----EIQYIVTHY--KGKNRFLKLFEKIASK------SGKCQH------------ -----SPDL-KNPNEPDVCLDERFWEL----VNGDS-HSEHVRVKKPCN--ATVPAIEQ- -GKDFLIK-LKDV-------SKTEEDYLSAEVVLRIFENISDQDVRLLGFNPKRSHPKWM ILKILPVPPLAVRPQVV-------SPGQ-SAPSQDDITHKLSDIII----CNKRLRAQRS ESSTDTAMKETRTLLQYHITTYMINDKPSIERAVTK-SGR-PLKVISQRLKGKEGHLRGH LSGKRDDYSARSVISPDPSISIDQVGVPEQLAKILTFPEVVTPTNQKWLESIVMKGHDDL GGAN-------------FVINDHG----TRTDLSCCTD--LSTITLSPGYIVERHLRDDD IVIFNRQPSLHKMSMMGHRALIMSGRTFRLNLCDTTPYNADFDGDEMNLHVPQSQTARTE VRHIMAVPKQIISPQANKPVIGLVQDALLGCRLLSKRDTFLTR-NQVMNLMMWLPTTK-- ------------------------------------------------------------ -------------------------------------------DTIL-----PPPCILKP ---VQLWSGKQVFSLFLPKISHNSYS--QDANK-M-----D-QNSIPLADRHVI----IR DGNLLAGILDKKTVARSEGSLIHVVINSYNTNIAKDFLNQTQLIVNNWLEHR-----GFS IGLIDCVVPDFVLQEVKHEIDDVESKV-QATIIKAQDGQLERMPGMSYMQSFETEVNNLT NEILSKTYKVINAKIRRDNSLSEMLSAGSKGADTNMSQIIGVVGQQNMEGKRVKFGFNG- RTLPHFQK-HEYGLVERGFCKNSYIAGLTPPEFLFHAMGGRTGIIDTACKTSDTGYIQRR LVKSMESHHVAYDGTVRNSQNEIVQFIYGGDGLDATGLET-QRLALVTLND-----EDF- -------------MKKYHLA-----------------------------------TEDPT ------------------FGQ-------VEMDDFVLDEFLK------------------- --TPN--------K-DKFLKEE------------------ENRLREYREILQKEIFPN-- -----GS-NTVVV------PVNIARIIESSQRQFDINVHVS---K-SD----LNPLD-II SRVDECVNSLIVV--------KGN-DNI-SRTEQENATLLLRIMLYSHLSAKQCIFEYRL NEQAFKYILGSIKDRFYRSIVAPGEMVGTIAGQSIGEPSTQMTLNTF------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >154414043TrichomonasvaginalisG3 ----MANVRQNAIESCLVGSIDFGLFDPEKIEMFGACEITENQMMDKGEYVKGGLSDLRM GTQTR-ERLCDTCGRNQEDCPGHFGYIRL-AEPFFHVGFLPHCYKLLQMVCHKCGRV-LC SYSDP----EIQYIVTHY--KGKNRFLKLFEKIASK------SGKCQH------------ -----SPDL-KNPNEPDVCLDERFWEL----VNGDS-HSEHVRVKKPCN--AAVPAIEQ- -GKDFLIK-LKDV-------SKTEEDYLSAEVVLRIFENISDQDVRLLGFNPKRSHPKWM ILKILPVPPLAVRPQVV-------SPGQ-SAPSQDDITHKLSDIII----CNKRLRAQRS ESSTDTAMKETRTLLQYHITTYMINDKPSIERAVTK-SGR-PLKVISQRLKGKEGHLRGH LSGKRDDYSARSVISPDPSISIDQVGVPEQLAKILTFPEVVTPTNQKWLESIVMKGHDDL GGAN-------------FVINDHG----TRTDLSCCTD--LSTITLSPGYIVERHLRDDD IVIFNRQPSLHKMSMMGHRALIMSGRTFRLNLCDTTPYNADFDGDEMNLHVPQSQTARTE VRHIMAVPKQIISPQANKPVIGLVQDALLGCRLLSKRDTFLTR-NQVMNLMMWLPTTK-- ------------------------------------------------------------ -------------------------------------------DTIL-----PPPCILKP ---VQLWSGKQVFSLFLPKISHNSYS--QDANK-M-----D-QNSIPLADRHVI----IR DGNLLAGILDKKTVARSEGSLIHVVINSYNTNIAKDFLNQTQLIVNNWLEHR-----GFS IGLIDCVVPDFVLQEVKHEIDDVESKV-QATIIKAQDGQLERMPGMSYMQSFETEVNNLT NEILSKTYKVINAKIRRDNSLSEMLSAGSKGADTNMSQIIGVVGQQNMEGKRVKFGFNG- RTLPHFQK-HEYGLVERGFCKNSYIAGLTPPEFLFHAMGGRTGIIDTACKTSDTGYIQRR LVKSMESHHVAYDGTVRNSQNEIVQFIYGGDGLDATGLET-QRLALVTLND-----EDF- -------------MKKYHLA-----------------------------------TEDPT ------------------FGQ-------VEMDDFVLDEFLK------------------- --TPN--------K-DKFLKEE------------------ENRLREYREILQKEIFPN-- -----GS-NTVVV------PVNIARIIESSQRQFDINVHVS---K-SD----LNPLD-II SRVDECVNSLIVV--------KGN-DNI-SRTEQENATLLLRIMLYSHLSAKQCIFEYRL NEQAFKYILGSIKDRFYRSIVAPGEMVGTIAGQSIGEPSTQMTLNTFHFAGISAHDVTLG VPRLNELMNLAKHIRTPSVTVEFE-----------------------------------R DVAKDEEIVKAVRAQIESASFKKFVIKAEIYYDPNPEETIIEPDTKWINTRIRYGGVEDR ELQDLAPWVLRFEINREE------------------------------------------ ------------------------------------------MIASNIESISDIVQKIKG MYGDKFFVIGDDDARIIRMQARLKDEQAEFAMDVKFLRETEQQMYKSFTLKGIPGISRVK INSAAEKM---------------FLNPETHGFDKEKVSCLYTEGTAFREIL-------SL DHVDTVHTITNDIYQVCDVLGIEAARHSLSYEMMLIMENAGAALNRRHLDLLADTMTQYG VLYPVSRHGINKTPT-GTLMRASYEMTNDVFFDAAVFSEIDYMRDVSSNIIAGKPSRAGT GIVEVLIN-----------EDLLPMTKGNNGG-E-------------------------- ---DLIGP-----------ATPSMMISPVPQGYVSQDNIVTSPFQDMPTNDIVQSPMSPV SPIESPLNGGALSPMLMDAQSPYLYGAENAASPIMTYKQNYSITMPSPSYQGNAQLLNTT ITDHAYSPIAAASPLSPQAMGQSMSPLSPAQQYDPTNFSPAGGFSNTRYNPLSPQTRPMT YSPNNDTPYSPTYEPKKK--------------------------------- >1143740TrichomonasvaginalisNIHC1 ----MANVRQNAIESCLVGSIDFGLFDPEKIEMFGACEITENQMMDKGEYVKGGLSDLRM GTQTR-ERLCDTCGRNQEDCPGHFGYIRL-AEPFFHVGFLPHCYKLLQMVCHKCGRV-LC SYSDP----EIQYIVTHY--KGKNRFLKLFEKIASK------SGKCQH------------ -----SPDL-KNPNEPDVCLDERFWEL----VNGDS-HSEHVRVKKPCN--AAVPAIEQ- -GKDFLIK-LKDV-------SKTEEDYLSAEVVLRIFENISDQDVRLLGFNPKRSHPKWM ILKILPVPPLAVRPQVV-------SPGQ-SAPSQDDITHKLSDIII----CNKRLRAQRS ESSTDTAMKETRTLLQYHITTYMINDKPSIERAVTK-SGR-PLKVISQRLKGKEGHLRGH LSGKRDDYSARSVISPDTSISIDQVGVPEQLAKILTFPEVVTPTNQKWLESIVMKGHDDL GGAN-------------FVINDHG----TRTDLSCCTD--LSTITLSPGYIVERHLRDDD IVIFNRQPSLHKMSMMGHRALIMSGRTFRLNPCDTTPYNADFDGDEMNLHVPQSQTARTE VRHIMAVPKQIISPQANKPVIGLVQDALLGCRLLSKRDTFLTR-NQVMNLMMWLPTTK-- ------------------------------------------------------------ -------------------------------------------DTIL-----PPPCILKP ---VQLWSGKQVFSLFLPKISHNSYS--QDANK-M-----D-QNSIPLADRHVI----IR DGNLLAGILGKKTVARSEGSLIHVVINSYNTNIAKDFLNQTQLIVNNWLEHR-----GFS IGLIDCVVPDFVLQEVKHEIDDVESKV-QATIIKAQDGQLERMPGMSYMQSFETEVNNLT NEILSKTYKVINAKIRGDNSLSEMLSAGSKGADTNMSQIIGVVGQQNMEGKRVKFGFNG- RTLPHFQK-HEYGLVERGFCKNSYIAGLTPPEFLFHAMGGRTGIIDTACKTSDTGYIQRR LVKSMESHHVAYDGTVRNSQNEIVQFIYGGDGLDATGLET-QRLALVTLND-----EDF- -------------MKKYHLA-----------------------------------TEDPT ------------------FGQ-------VEMDDFVLDEFLK------------------- --TPN--------K-DKFLKEE------------------ENRLREYREILQKEIFPN-- -----GS-NTVVV------PVNIARIIESSQRQFDINVHVS---K-SD----LNPLD-II SRVDECVNSLIVV--------KGN-DNI-SRTEQENATLLLRIMLYSHLSAKQCIFEYRL NEQAFKYILGSIKDRFYRSIVAPGEMVGTIAGQSIGEPSTQMTLNTFHFAGISAHDVTLG VPRLNELMNLAKHIRTPSVTVEFE-----------------------------------R DVAKDEEIVKAVRAQIESASFKKFVIKAEIYYDPNPEETIIEPDTKWINTRIRYGGVEDR ELQDLAPWVLRFEINREE------------------------------------------ ------------------------------------------MIASNIESISDIVQKIKG MYGDKFFVIGDDDARIIRMQARLKDEQAEFAMDVKFLRETEQQMYKSFTLKGIPGISRVK INSAAEKM---------------FLNPETHGFDKEKVSCLYTEGTAFREIL-------SL DHVDTVHTITNDIYQVCDVLGIEAARHSLSYEMMLIMEKAGAALNRRHLDLLADTMTQYG VLYPVSRHGINKTPT-GTLMRASYEMTNDVFFDAAVFSEIDYMRDVSSNIIAGKPSRAGT GIVEVLIN-----------EDLLPMTKGNNGG-E-------------------------- ---DLIGP-----------ATPSMMISPVPQGYVSQDNIVTSPFQDMLTNDIVQSPMSPV SPIESPLNGGALSPMLMDAQSPYLYGAENAASPIMTYKQNYSITMPSPSYQGNAQLLNTT ITDHAYSPIAAASPLSPQAMGQSMSPLSPAQQYDPTNFSPAGGFFNTRYNPLSPQTRPMT YSPNNDTPYSPTYEPKKK--------------------------------- >Spironucleusvortens_JGI_Scaf14.195603.201146 ----MRKDSIFYIPFGTPKSVFSVMNKQLMQSFYQVVAGANSQKIDEELDVKQMGVVFRE DGECKRCFGTSGDNIGEMPCPGHFGAVKLINEKVFHPMLVDKLAMIMNMFCPECRRLKAL KYFQQLGYGKAENTASSTPQDQVRRFLAQFPQFKR------------------------- -----LPEL-HELTAPVICCDKR--------VRFDN---------------GTFGLVKTE EIKDGRVS------------TETSTQAVTPYEAFNIMERYLQEDIDLIGL--KKSHPINM IMDSFPIAPRCIRPTIV-------MDGQ-S--SRDQLTDMYSTLCK----AIQNYDSSQE ANQLETKLKQEAVSKSF---ARVCKSSKGQEESAEK-----TQKGIMERLRGKYGRLRNN CMGKRVNFCSRSVISGDPTISIDQLGVPKSTAKRLSFPERVTARNREYLQKLVDN-PSQY PGAN--------------VIEKDG----SLQRLDQGKN--MQQIRLEIGDVVHRHLVDGD YVMFNRQPSLHKMSFMAHRAKILPYSTFRLNLCATKPYNADFDGDEMNMHEPQHLQAISE MAEIMLVSKQVVSCKSNGPLMSIVQDSLVGCQLMTQRDVFIDC-ANFQKYQMVVSYPDNH YRPDSTDEINKATSNDNDHNYNNSSSALSGTRSEIESSKSSDADADVYEMLKRNFYASVQ DL-----------------------------------------DKPQFVSMKTPPSVVFP ---QPRWTGK-LFSLSLP----SQFSLTIGGNP-------KVTADNNPIVKDAI----IF DGELVTGICNNQIIGQAQCGLIHVLWKDYSPDACRTFMDNCRIV--TFMADN-----SFS VGFGDMVISKKAKVECKTLADGLLQV--NAIIDRSVNGKI-LKPGFTHEMSFEGELNIAI K--CSEMEKVVKGDLPKRNALLHMVTSGSKGKFFNVLQIASGLGQQYLQSNRMKYKYLTF RTLPHFP--FDYFIDSRGYVRSSFI-GLTPTEFLFHMTGGREGVCDTAIKTADSGYVERK MMKNMESLGLTYDGSVRDDRGQVV-IRYGEDSSDPHLTER-KDYDIILQND-----ETF- -------------NKNCFLDYNFILKDVAKNTGDLFFASEAQPQEMAHVLSIEGFSQITE SLNDTYDRQLGYTLKSPDFKDFNVNVDPDIIDPHVLAEYVSNHIVFVSEPRQQQYKNKDV SWNIHSWMNETVINELNNVESQ------------------KMLMLEYISLLVERCWLIYC QSYLLTSTNSTKVEASKNTSCDIQRVININRFNNEIGHTPI---YLADLLKQIQQQSVGY DQMKTDLSPIYVI--------STVNHLLSEIQCRDQESKLFRVLIRQLLSSKLVCY-YRI T-KAFDKIIATIRKKFIKS-CSPGEGVGPLASHSISEPATQLTLNTFHTAGTSALG-NLG LPRLKELIDFRDTKVPIMTIHLNYKPGEMFIFNADGYRKRAQHSKALMKLGSKLENTFFR DFVEKYEVLFEPSIQDCYQNDDSWWLKLNELETNNSGRETSPFVIRYNILLKKLIEKFDN DITIDVICDKIQNSMKND------------------------------------------ -------------------------------------------------IGESKIDVKYY SGIGDIVVRVRPFISKAESFLFATDLDVINQDILNVHISGIKIKKVFDNNTPIILYGIDR FTPKLEEIEKDDRTSFLKKYGGIMKGGQSYSKGSKSGSTAEVEELFIKTEGSDLRTVLNM EEIDATRTYCNDLPELYRVLGVEACRNLLVNEMAKTLGDNSINKRHYIMLADIMTYHPVQ QKLIGINRHGMSATETGVLA-ASFEQPGDVFMKAAAFGLNDPCTAISSAVLLGREISHGT GSFDLLLD---------------------------------------------------- ---------------------------------TNKSRLPQEPDEGAAHPRSLVKRQNDA LSLAQTERNNASEQTAFTQRSMSNFSMATTGNPVQSIFGNSNRNSHRSQRTALQSNVLMG STTMRSANVNSVYSRTSNVSSTQKSALNPYIENDVFGEGTARSVDANSRSAATQNSRNSG LSHLSRLSSAASKMS------------------------------------ >159107886GiardiaintestinalisWBc6ATCC50803 MDKEFALRIPYGVPKRVRFTLFSENEKNSLIPIVPRESSSDQMSMFSELNSTRLGVIFQE ENECPTCSGKAGDQDPSVLCPGHLGVVKF-GYDIFHPMIIDDLATLMNCFCPNCYHLKFF RLFKE---------------TDRELAINALNRLRDT------TPTLNF------------ -----LPKLAELSATIACCERNILYRKK---ASGTS------RNGVAPQ--PLILAVSKS TRGSTARQ------------AKDQDQLMDAHTCKLLITRYNKDDIVLLGL--KRDHIENF IISSIQVGSRAVRPSIR-------TDG---TTAEDQLTEMYVSLFRNIRDCNNN--SLNA GGGATGAKSQIGPNDIYNAYKTLISAK-----GLNADGGSVPTKGIFERLSGKYGRMRSN LMGKRVNYCSRSVITGDPTISINELGVPRSVASRLTFPEVVTARNRDFLMKLVSNGNRYP GAVSKTLPSGTVQLIDTQVINSTGWGSSTDADGRLGGE--TTNDPLPLGTIVNRHLLDGD YVLFNRQPTLHKSSFMGHRVKVLPYSTYRLNLSATSSYNADFDGDEMNLHALQSLEAVAE ISELCMVSNQVVSVKDNRPIVYIVQDVLLGCYLFTGKDVTIPF-ARVCEYIMWMGFSRTS DPTYAHKLQRYDKGSVNQRGHSSASMSYDFSDHTSGSYNPAEYDSSSYLVGNSATGSVVD GRGSYLSTGNYGASSASRKAYEDNINNDNGAYFKRPGSNVNTNDHVLLNV--SQPAICYP ---EARWTGKQVFSMFVPRGVFYRSG--------------DPKDISAHADKYIS----FL DGSVMCGRIASSVVGGTESALIHILFRDYGIEPCRAFIDNCQRVVCRFMLDH-----GFS VGMGDMVSSEHTERKVAEIQTKLSKDI-SELFKLSIHYKIKLAPGQSRNDAFEQEVISKV SGTSLALEKVITDAAPHRNALLVMINAGSKGKKFNMMQISSSLGQQFLQSKRMPHRFETH RSLPCYSPFSSLNMESRGYIFNSFIRGLNPAEFYFHAVGGREGVCDTAVKTADSGYVERK LLKVMESVCYRYDNSVRNDSNEIISFRYGDDGIDPHKSES-REFKDFSISD-----MDF- -------------LRAHYID-WSQIVDFQNTEMDESTDFYATLVREKFAVIIAKLRDTPE QFAHLCDGVSFYEVCDDELRA-------KGFDNLVLDNNLVSFTELSSYLQNHYALFMDA ESSPG--------YVPENIDDSWLDIGVKSSLVLERDFAISTILVEYIVLLLERIWLQRS RITLDTDVKKFTF------GMNLDRIIQSEIQAGSINKVSRLIRE-SAWRCYLKPFE-AI EKVNKLLSR--------------------IKSFRPKESTLFRVILRQCLSSKSCCYKYRL TSEQLDRILATIEEKFVRGQVSPGEPVGPLAGHSVSEPATQLTLNTFHTAGTSALG-GLG LPRLKELIDFRNPKISVSTIYLNI---SNQDPANAGVDTRCTSHSPMLFNRPVAPRPNSY NIASAEEATGRNIRQSKAWMNLAAKIEHTTFNYYIDDYKLIFDPFDELTCVADDREWLHL ESEIGHLQQQVYGERPNEAVRFYSPFVLRYEIGLKQMQQKIEAGITIQTLVSRLILMLQQ IYTSRAGRPKSEDDDEDDEDDINIKQKAMIGREMPIINYYTGLGKTVIRVRPSLTEDEYN AVKGSAIGSGAPDMEKSRLLAERYDGVDAFLRNVHISGNESIRKVFMASSNPLVHYGYDG FTSNVDVFSQGSSDGLSMHKMSEGDLSKIGSIGKFTQPNSDISELYLQTDGSDLLWILTQ PEVDFTRTWTTNVREIYEILGIEAARALFIKQIRATLDKVDLNIHHYLILADIMSSRPQN NKMISINRYGMQATNTGVLAQATFERPGATVLKAAAFGVVDPLKSVSSCVVMGKQGDFGT GCFDLLLN-----------CAELPSINEDELFPNSYYLKVHNATTEVRPTAGAEETPVDS MGMPFSTTFISPTATAMVTPTSTYTSHSSVRSVVSAGGRVDANMNPLFSPGCNRSRQAEN ASRIFSSYTANTLTSAKSSLPTQLTITSRSRGLSNIVDGRDSRIASITSAVNSKMSAFSM TSCNSINSFRSALASKASTHSNQYDTSDLVDVKGAGRYGIFTHSTNMSYENTAASIRNSG GMFASRSGSASSVRSQSATNIDASAADSGQSGELRDNHEDDNNDYAEW--- >253743536GiardiaintestinalisGSMH7ATCC50581 MDKEFALRIPYGIPKRVRFTLFSENEKNSLIPIVPRESSSDQMSMFSELNSTRLGVIFQE ENECPTCGGKAGDQDPSVLCPGHLGVVKF-GYDIFHPMIVDDLAILMNCFCPNCYHLKFF KLFQE---------------ADRELAITALNRLRDT------TPTLNF------------ -----LPKLADISTTIVCCERNIVYKKK---ASGTS------KNGVAAQ--PTILAISKS TRGSSMKQ------------SKDQDQLMDAHACKLLISRYNKDDITLLGL--KKDHVESF IISSIQVGSRAVRPSIR-------TDG---TTAEDQLTEMYVSLFRNIRDCNSN--SLSA GGGSTGIKSQIGPNDIYNAYKNLISAK-----GLNTDGGSVPTKGIFERLSGKYGRMRSN LMGKRVNYCSRSVITGDPTISINELGVPRSVASRLTFPEVVTARNRDFLMKLVSNGNRYP GAVSKTLPSGTVQLIDTQVINSTGWGSSTDADGRLGGE--ATNDPLPLGTIVNRHLLDGD YVLFNRQPTLHKSSFMGHRVRVLPYSTYRLNLSATSSYNADFDGDEMNLHALQSLEAVAE ISELCMVSNQVVSVKDNRPIVYIVQDVLLGCYLFTGKDVTIPF-ARVCEYVMWMGFSRTS DPTYAHKLQRYDKGSVHQRAHSSSSTPYDSSDHTSGSYNPAEYDSSSYLIGNSATGSVFD GRGSYLSTGNH-SSNISRKAYEDNINNDNGAYFKRLGSNVNTNDHVLLSI--SQPAICYP ---QARWTGKQVFSMFVPKGIFYRSG--------------DPKDISAHADKYVA----FL DGSVMCGRIASSVVGGTESALIHILFRDYGVEPCRAFIDNCQRVICRFMLDH-----GFS VGMGDMVSSQHTEKKVAEIQTKLSKDI-AELFKLSVHYKIKLAPGQSRNDAFEQEVISKV SGTSLALEKVITDAVPHRNALLVMINAGSKGKKFNMMQISSSLGQQFLQSKRMPHRFETH RALPCYSPFSSLNMESRGYIFNSFIRGLNPAEFYFHAVGGREGVCDTAVKTADSGYVERK LLKVMESVCYRYDNSVRNDSNEIISFRYGDDGIDPHKSES-HEFTDFSISD-----MDF- -------------LRAHYID-WSQIIDFQNVEGDEETDFYATLVREKFSLIAAKLRDTPE QFSHLCDGVSFYEVCDDELKA-------KGFDNLVLDNNLVSFTELSSYLQNHYSLFMDA ENSPG--------YVRENIDDSWLDIGVKSSLVLERDFAISTILVEYIVLLLERVWLQRS RINLDTDVKKFTF------GMNLDRIIQSEILAGSINKVSRLIHG-SAWKCYLKPFE-AI EKVNKLLSR--------------------IRSFRPKESTLFRVILRQCLSSKSCCYKYRF TGEQLDRVLAIIEEKFVRGQAAPGEPVGPLAGHSVSEPATQLTLNTFHTAGTSALG-GLG LPRLKELIDFRDPKISVSTIYLNIPDQEHGRAGGDGIDDRHNNQFSMLFNRSPVPHPNSY NVSSAEEATGRNIRQSKAWMNLAAKIEYTTFNYYIDNYKLIFDPFDEITSVAADRDWLTL ESEIGHLQQQAYGERPNDIVRFYSPFVLRYEIGLKQMQQKIEAGITIQTLVSRLMLALQK IYTSRAGHAKVDDDDDDDEDDINTKQKSMIGREMPIINYYTGLGKTIIRVRPSLTEDEYT AIKGSTIGGGAPDIEKGRLSVERYDGIDTFLRDIHISGNESIRKVFMASSNPLVHYGYDS FTSNVDAFSQSSCDELSTHKLTEADLGKIGSIGRFTQANNDISELYLQTDGSDLLWILTQ PEVDFTRTWTTNVREVYETLGIEAARTLFIKQIRATLDKVDLNIHHYLILADIMSSRPQN NKMISINRYGMQATNTGVLAQATFERPGATVLKAAAFGVVDPLKSVSSCVVMGKQGDFGT GCFDLLLN-----------CAELPSVNEDELFPNSYYLKIHTATTEIRPSTGAEETPVDS MGMPFSTTFISPTATAMVTPTSAYTASSV-RSVVSAGGRVDANMNPMFSPGCNRSRQAEN VSRIFSSYTANTLTSAKSSLPTQLTLTSRSRGLSNIVDGRDSRIASITSAINSKMSAFSM TSCNSINSFRSALASKASTHSNQYDTSDLVDVKGAGRYGIFTHSTNMSYENTAASIRNSG GMFASRSGSASSVRSQSATNIDASAADSGQSGELRDNNEDDNNDYAEW--- >110142366Trimastixpyriformis ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------GN LSGKRVDFSGRTVISPDPNLQIDEVAVPRLIAMNMTYPERVHPANIERLRKLVINGPTVH PGAN-------------FIELRDG----SKRFLKYGDRQ-KMAEQLRVGDIVERHLEDGD IVLFNRQPSLHKMSIMCHRAKIMPWRTLRFNVCDCTPYNADFDGDEMNLHLPQTEEARAE AAVLMAVHQNLCTPRHGAPLIAPTQDFLTGGYLM-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HQ436411Jakobalibera ------------------------------------------------------------ -------------------------HIEL-AKPMYHVGYMNVVRKVLDCVCMKCSSP-LF N-------------------PVSKRLGELAKYCNSK------VRMCGD------------ ----------RSLAAAGAAGGA---------EGAEGQGQGAMDIDHGCG--FTKPKITR- -KEYFLMKEEKSPGQ-ESGSQKVSQRILTAEEAHQVLKALTNEACEMLGFNPNFARPDWL LVTVLPVPPPAVRPSID-------MGGS-GRAAQDDLTFKLGDILS----TNQLLRRQEE HGVNPQTLRNTEEMLQFHLFTFVDNELAGK-------SGK-VLKSISQRLKGKSGRIRNN LMGKRVDFSARSVITADPILEIDQVGVPVDIAKIMTVPR---------LQELVNHGPSVH PGAR-------------FVFMEDG----TRQDLEFSPN-----FPLAYGYTVERHLQDND VVLFNRQPTLHRMGMMGHRVKTMKFKTFRLNLSVTSPYNADFDGDEMNLHAPQSLLTKAE LLELVMIPKNMISPKSNSPVMGLVQDSLLACRRITLRDVFLERQDHFMNCLMWVDDF--- ------------------------------------------------------------ -------------------------------------------DGQL-----PMPAILKP ---KPLWTGKQLFSQILPKVNLRLRS--KDHPR-------SENTLVSPGDTQVI----IE QGELLAGKCCKNTMGTSQGSLVHVVYTEQGPEVCARMMGQVQRLVNYWLLTVSELSLGFS IGIGDCVPDEITMRTITEAITDDKKQV-TGVIKELHKRKLEKKPGLTLLESFEAVVNDKL NQARDKAGNAALESLSERNNFKNMVTAGSKGNELNISQVIACVGQQNVEGRRIPFGFRN- RTLPHFRQ-ENYGPESKGFVSNSYLSGLTPQEFFFHSMGGREGIIDTAVKTSETGYIQRR LVKAMEDIMVRYDGTVRDARGKVLQPPHNHPLLSSSQSSFTVLLACIMVSR--------- ------------------------------------------------------------ --------------------------------AQVIESLRN------------------- --DPT--------KVDELVDE-------------------VEQLREDRRAL--AIFTS-- -----GE-GRSPM------PVNVDRLIVNAQKTFTIDMYSKSDLHPNDVPPVPSPWQ-VL RAVKKLCSDVMVT-------------NIPDSEGSRNATYLFEIYLRTKLASKRVIQKYHL DKQSFEWLISEIRTRFFQALITPGECVGVIAAQSVGEPATQMTLNTFHFAGVSAKNVT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >284088088Naegleriagruberi ---------------------------------MSVCEVLHAETQEKGKPKESGLMDLRM GTIDH-HLSCLTCGGNATECPGHFGHVRI--HPVFNVLFINTVVKVLQSVCIHCGKL-LA DKSSL----QFKKASKFV--NRRKRFKEMIDLCRKD--------KCII------------ -----ETGNKENEQNQEANIDPTF------------------QPRNGCG--GLQPKISR- DGLKIFAE-YKKDTS-AEAKQELTKQELTAERALQIFKRIPAEDLELLGFDKDNARPEWM ILTCLPIPPPQVRPSV--------HHGS-ADRSEDDLTHKLADIIK----ANAAIQKNEK SGTPLHQMEEMVRMLQYHCATYVNNEYPGVPTATTK-SGR-PLKSIRQRLKGKEGRVRGN LMGKRVDFSARTVITADPNIDIDQVGVPRTVASNMTVPEIVTPFNFERLNELVTNGPLTY PGAK-------------YVIREDG----TRIDLRFASGKANDQIQLEYGYKVERHLQDGD VILFNRQPSLHKMSMMGHRIKVMPYSTFRMNLSVTTPYNADFDGDEMNLHVPQSLQTKAE LLELMMVPRNIITPQSNRPVIALVQDTLLAASKLTRRDVFIAK-DLMMNCLMHLIDF--- ------------------------------------------------------------ -------------------------------------------DGKL-----PVPAILKP ---KPLWTGKQLFTFLLPKVNLENTS--STHED-LTDKKDHLDHDIPEFDTKVL----ID RGELVSGVLDKKSLGSSHGSLIHIIVNEKGVNEGKKFLGQCQRVINHWLINR-----GFS IGIGDTIADKATMEQIEETIRKAEKDV-KLIVKDAQEGKLRAEAGRTIQQSFENQVNKVL NKAREDAGNKAKKSLKDDNNIKSMVTAGSKGSYINISQIIACVGQQNVEGKRIPYGFRN- RTLPHFAQ-DDHGPESRGFVANSYLRGLTPQEFFFHTMGGREGLIDTAVKTSETGYIQRR LIKAMEDIMVKYDGTVRDAQGNVVQFLYGEDGMDAHKVES-QSIDIMNLSD-----AKF- -------------QDKYWYN----------------------------SLGSSPSFTNPT -------ESSVSMPSGGILKE-------SFISTKVYDEILK------------------- --DPA--------TYLSKVREE------------------YKTLMEDRHILRTEIFPN-- -----AE-NKIVM------PVNLKRIIKNAQKEYGIHPSIG---KPSD----MNPIY-VI EKIKKLCDDLVVI--------KGT-DEL-STEAQTNATLLFSMFLRSTFSSKVVLKELCL TQEAFDFLVGEIRMRFHNCLAQPGEMVGSVAAQSIGEPATQMTLNTFHFAGVSSKNVTLG VPRLKELLNVAKNIKTPGLTIYLNNEYIGDFEKAKMVKEDLEYTTLGHVTAATSIVYDPE PANSVIEEDREFIEELLEELKDTAVLDSTTLNPWSLRFELDKMMMSDTLTMAQVAKKIQE EFQNDITCFYS------------------------------------------------- ------------------------------------------------------------ ----------DDNADKLILVVRIHKDDKEKEKDAQVAKDPSDEVLRKLEEEDIENSTVEF LRRLESNMLNELALKGYKDLKKVFLREENDKKVFSSSGVATVKQWVLDTEGCNLLAVLSH PYVDHTITTSNDVNEILDVLGIEACRNALMREMRKVIEFDGSYVNYRHLAILCDVMTHRG GLMAITRHGINRSDT-GPLMRCSFEETVEILIEAATFADTDTLKGVSANVMVGQLAPIGT GCFGLYLDEELLKQAVAVKPSFVTETKSMYGSLGATTPYHTSGLATPYHGGVATPYHGGA SSPWTQGAMTPLGRTPSPEYQGGFSPSPYNSAFSPVASSPTSPGHQGGYSPSSPGNYSPT SPAYSPSSPNYSPTSPAYSPTSPNYSPTSPAYSPTSPNYSPTSPAYSPTSPAYSPTSPNY SPSSPAYSPTSPRATSPGAGYSPSSPAYSPTSPSYSPSSPNYSPSSPAYSPSSPNYSPSS PAYSPSSPSYNPGGGYSPSSPAYSPTSPSYSPTSPSYSPSSPAYSPGREDK >HQ436410Percolomonascosmopolitus ------------------------------------------------------------ -------------------------HINL-AQDVFHISYVTTVAKILRCICYKCSKL-LV DIDS-------GDGLNQAGDENRKRIYERYQSLKNI------VPKSKR------------ -----FEKMVQLSREVHRCKND------------------------GCT--EEQPKSYKT DGLKIEAI-LRNN----------NRENITPEAAKLKLERISDEHARDLGFEPEHIRPHWM ILSKLPVVPPCVRPSI--------EHGT-AGAGQDDLTYKLSDIVK----TNNRLREKEK NGETDFNISETRDLLMLYVAQMMDNTNPKLTQAIQK-SGR-VLKCISSKLKGKERRLRNN LMGKRVDFSARTVITPDPNLEIDQVGVPISIASNMTFPERVTLYNMERLKEKVENG-SEY PGAK-------------FIIHKDG----TSVDVELASD---EYKQLQPGYIVERHVEDDD LILFNRQPTLHKMSMMGHRVKVLPYSTFRLNVSVTSPYNADFDGDEMNLHLPQSLGAKAE LQEMMMVSKNIVSTQGNAPVIAIVQDALLGSVLMTKRDVFLEK-DIMMNCCMRLKENF-- ------------------------------------------------------------ -------------------------------------------NGEL-----PQPCILKP ---KQLWSGKQLFSLVLKGCEVNLFREANQYDDVKKIMGKEFDEDICPMDTKVV----IS RGELISGVADKRTLGKGGGSLIHTIFNEYSFIEASNFLNTLQWVVNYWMLQH-----GYS IGVEDTIADENTADQVQQTLSKAHEEV-SKYIKEAQEGKLKSKPGMSLQESFEAAVNKTL NDSMSSAGKNSASSLSKRNRIKTMVVGGSKGSNTNISQIIACVGQQNIEGKRITFGFRK- RTLPHFEQ-NDHRPISRGFVQNSYLRGLLPQEFFFHTMGGREGLIDTAVKTAKTGYIQRR LIKSMEDFQVKYDGTVRDSAGNILQFLYGEDGMDGVKLES-QYFGMYKMSD-----KKF- -------------SETYQYE-------------------------------TKNGSLSPE ------------------FGS-------KYLSQKIHEEFVT------------------- --TPS--------R-IHILEAE------------------YQQLLRDRELLRDSIFSN-- -----PTIKKLCQ------PVNIKRLLLNASKKYLNRGK-------SD----LDPIV-II QKVEELSKKLVVI--------SGD-DYL-AREAQQNATILVNILIRFNLASKVVITKHKL NANGFEWILGEIETTFKRAFVQPGEMVGALAAQSIGEPATQMTLNTFHFAGVSAKNVTLG VP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HQ436409Diplonemasp2 ------------------------------------------------------------ -------------------------NITL-AKPMLHFGYLRTMVNLLKCVCFHCSLI-KL DPDDP----KYREAAAKR--LPEHRLRMFAKACAGK-------SICEA------------ -------------------------------KHGSDELDEAHGAMSGCG--KPQPKIYH- EPHSFNLWIEYTSQS-VDAEGADRKQRLQPEDARKILCKIRESQLHDLGFSAQ-SRPEWM LLTEFPISPPAVRPAIT-------MDA--VTKTEDHTTYMYNKILI----YNNKLKKAVA QQAADSVIQDYSNLVQYHIVTLMDNEKNGIPKCKVR-SGQ-PIKSIRERIKGKGGRVRSN LMGKRVDFSARTVIGGDSQIGMDEVGVPLSIAANMTFPERVTSYNQDILKVLVANGPDKY PGAK-------------FIIREDG----TRINLAFRRK--DSELFLQPGYIVERHVLTND VVLFNRQPTLHRMSMMGHRARVMPFCTFRLNLSATSPYNADFDGDEMNLHVPQSVLSKSE LQEFMMVPKNIISPKSNSPVMGIVQDSLLGIHLLTKRSTFLDK-QFMMNAVMHIPTM--- ------------------------------------------------------------ -------------------------------------------PAQI-----PIPAILKP ---EMLWTGKQLFSLVLPPVNFTATS--NEDIS-------EPDRFLPLADTKVR----IE KGNLHTGIIDKKSVGSSENSLVHVIHNEFSPDWARDLINGIQRITAFYLINK-----GFS VGVQDTVADVNTKKMIQEIIRRSYDSV-DELCNKAQEG-LKRQPGKTVKETFEANINKIL NKTREDAGKRAQQSLTRSNSFKVMVSAGSKGSYLNISQITAVVGQQNVGGKRIPYGFRK- RTLPHFTQ-DDYGPESRGFVQNSYLEGLTPSEFFFHMSGGREGLIDTACKTAETGYIQRK LVKALEDLYVGYDATVRDAQGRVVQFLYGEEGYDSTKMESLRPLPLINLDN-----AAR- -------------DKTYKHT---------------------------------WEEEGPE ------------------WGR-------EFLEPRVREMLLQ------------------- --DPN--------A-ATKLQEE------------------YEAVKDNREWLRKVFQPA-- -----GEIPFVHPMDGIKVPINLVRLLDNAKINFDINPKGL-----SD----LSPLE-VI DGLDQLKKDLVVC--------RGF-NSI-HEERQFNGTRLWNVILQAFFASKRVICEYRL NAKAFQWLLGEVRQRYNSAQVPPGEMVGCIAAQSMGEPATQMTLNTF------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >HQ436408Parabodocaudatus ------------------------------------------------------------ -------------------------YADL-AEPMFNIGFFDTVLATLRCVCQNCGKLLLS NEKEA----ERRKLERTFLLKGNARLREISKISPKG-------GKCPS------------ -----------------------------------------------CQ--YQQARLGR- ----FMTL-YPGLVI-----KADKDTVWYGTDAYRVLDKISVEDAIMLGFDPRRAHPRDL LIKALPIPPPAVRPAVS-------FGS---GVSENELTAKLTSIIR----LNERLGREIA DNSPSDMVASTRRLLQADLATYFNNASTYYKPAKVSQTSKMQLKSIYERLKGKQGRLRGN LMGKRVNFSARTVITGDPNIDVDEVGVPFSVAMTLTFPERVNHLNRHRLTQIVRSS--QY PSAN-------------AIVSNSG----TVWRLNGMKPERRQQLTLEIGDIVERQVLNGD VVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAE LIEMMMVPKNFVSPNKSAPCMGIVQDSLLGSWRITDKEVFLDK-YFVQNVFMWLS----- ------------------------------------------------------------ -------------------------------------------DLIPSLTELPIPAILKP ---RPLWTGKQMFSLILRETNITREN---------------LKKSFPHDDAGTL----IR NGDVLVGQVDKGLIGASPGSFIHVIFNDRGSDAVAQFINGVQRLTTHYLYHF-----SFS VGVQDTLGDENTLRSVKEMIADARKQV-RNRGSAANEKRLTRRAGMTLMGSFEFEVNSIL NNVREKASPMVKNGVHRRNSFRVMVDAGSKGSPLNIYQIVAAVGQQNIFGARIPFYFRR- RTLPHFML-DDYGDASKGHVSRGYVEGLKPYEFFFHTMGGREGLIDTAVKTAETGYFQRK LVKAMEDLHVAYDGTVRNADQEVVQFTYGEDGLDGARIESNEKIDMVYYSN-----NKM- -------------KETFKFE----------------------------------YQEDGT --------------FAANFGG-------VNMAPSVQAALKR------------------- --DPR--------N-LDILESE------------------FKALMKSREAFRSWLIAP-- -----GA-PAQSL------PVNLTRVIRNAQIEGRRSTELT---R-SN----LNPIN-II QDVRRLLDDLSKCHPCVGRGPNGTYTNPHSQERVENALRIFSVHVQSMLASKRVINEHKL DSKSFELVLKQIRLKYLQSVLVAGEMIGAMTAQSCGEPATQMTLNTFHNAGISSKNVTLG VPRLLELLSVSKQQRISSMAIHFIAIEV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------- >13183799Leptomonas -MSGGAPLPPSQMPLQKVHDVQFEVFKERQIKAYATCRIEHAKSYEHGQPVRGGINDLRM GTTDF-DYSCETCGLKHPECPGHFGYIEL-AEPIFNINVFDVVLIALKCVCKYCGAL-LM DTNDP----TEMKKITHV--QGLNRLRLVAKLCGSV---------CKR------------ -----SKDI------------------------------------QGCEGKGRQPRIGRF LGIYPGLQ-IKVT-------QEEQDYVWHADNARQVLDRVSDSDATIMGFDPRFCHPRDL ILTVVPIPPPQVRPAVA-------FGS---AKSDDELTHQIMSIVK----REHQL-RKDK ESGVKAAVDRSRALLQEHVATFFNNASTFYKPAKVG-DTK-KLKSLTERLKGKYGRLRGN LMGKRVDFSARTVITGDPNIDVDEVGVPFSIAMTLTFPERVNVINKKRLTEFVQR--STY PSAN-------------YIMRPNG----NVTKLALVKD--RSAVHLDVGDVVERHVIDGD VVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAE LIEMMMVPKNFVSPNKSAPCMGIVQDSLLGSYRLTDKDTFVDK-YFIQSVALWL------ ------------------------------------------------------------ -------------------------------------------DLWEL----PIPAILKP ---RPLWTGKQIFSLILPEVNHPASP--------------YGKPPFPHNDKKII----QR -GLLLVGAITKGVVGAAPGSLIHVIFNERGSDEVAKFINGVQRITTYFNYCF-----AFS VGVQDTVADASTLKEMNNVLHKTRQSV-EKIGAAANNGKLTRKAGMSLLQSFEADVNSAL NKCREEAAKKALSNVRRTNSFKVMIEAGSKGSDLNICQIAVFVGQQNVAGSRIPFGFRR- RTLPHFML-DDYGETSRGMATRGYVEGLQPHEFYFHTMAGREGLIDTAVKTSDTGYLQRK LIKALEDVHAAYDGTVRNANQELIQLAYGEDGLDGARIEGNQAFPIPHMAN-----NEM- -------------IDKYRYE----------------------------------YNEEGS --------------FSENMGG-------SYMDPFVRDSLLR------------------- --DPQ--------S-VSKLQEE------------------FDQLVKDRDMSRLIIDME-- ---EKNK-LKMNL------PVNVARLIQNATTTMGQAHQV------SN----LNPIT-VI QRVRDCRKTLVQLFPSYHKDYSGRFLNVLSQQRVKRALTLFDIHLRQILGSKRVLKEYKL NDKAFEYLLKEIRTKYQQSLITPGEIIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLG VPRLLELLNVSKNQRNASVAVCLTREYQQR-----------------------------Q KAQEAQQYIEYCTLANITTTVPRPLNTVVVEDVNILEWEQAVMNEDEGLDAAQPSPFIAR LILNTELFNNKQLNMKDV------------------------------------------ -------------------------------------------------------KSAIQ QMDDSYLMQANLKNNIRHRVVRLRPRKCAGADSVPELTKAVAQLLQSVHLLGIPGIKKTL LKEGTTF----------------NVDPATGGITKESSWMVDTEGTALQRIFVGVVNQHGV NIVDFAKTSSNKIPEIVTVLGIEAARPKLLFELCQAYLAYGLNINYRHYTILVDTMCQRG YLMAVSRTGINRSETSGPLMRCSFEETVKVLMTAAAFGEKDPVRGVSANLVMGNQARIGT GLFDLMLD-------MGNCSNVVPLDKADGGRTS-------------------------- ---NVYHTEASVVAGSSVQGLHGELPSSAMHENSSVGIGASSVYPRHGGGAAGAGLYAGM AIEASQVQFSSALHPSTGSALAASNTSDYQSSLRFSGASTYVASPNMASMSALDAELSSY HLQSVAPSYQGGGYGPLQGRIPMLGVPSTGGSGQPYLFEASNGGAGSVADAKSGAASSRA SAPYDPNQPSQDFSPTEEQEEQ----------------------------- >22002086Trycruzi -MSGGAPLPPSQMDLQKVVEVQFEMFKEKQIKDYAVCLVEHAKSYERGQPVRGGINDLRM GTTDF-EFACETCHRKHPECPGHFGYIDL-AEPVFNIGVFDIVLQVLKCVCKSCGAL-LM DTNDP----QVHKKLQHL--TGVNRLRQVVKMCGMK---------CR------------- -------------------------------MSTDATTPEEAVVARGCG--ATQPRIGRY LGIYPTLI-IKAT-------LEEQDMVWHADTARQVLDRVSDEDARVMGFDALRCHPRDL VLTVLPVPPPQVRPAIS-------FGS---LKSDDELTHQIMSIVK----RNNQL-RKDK ESDVQVAVDRSRALLQEHVAAYFNNASMYYKPTKVN-DTK-KLKSLTERLKGKYGRLRGN LMGKRVDFSARTVITGDPNIDVDEVGVPFSIAMTLTFPERVSAVNKKRLTEFVRRP--VY PSAN-------------YIHHPNG----TTTKLALRRD--RSKVTLNIGDVVERHVINGD VVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAE LIEMMMVPKNFVSPNKSAPCMGIVQDSLLGSYRLTDKDTFLDK-YFVQSVALWLDLWQ-- ------------------------------------------------------------ ----------------------------------------------L-----PVPAVLKP ---RPLWTGKQVFSLILPEVNHPATP--------------QERPPFPHNDSSIM----IR RGQLLCGPITKGIVGAAPGSLIHVIFNERGSDEVARFINGVQRITTFFLINF-----GFS VGVQDTVADADTLRQMNEVLVKTRENV-EKIGAAANNRTLNRKAGMTLLQSFEADVNSAL NKCREEAAKKALSNVRRTNSFKVMIEAGSKGTDLNICQIAVFVGQQNVAGSRIPFGFRR- RTLPHFML-DDYGETSRGMANRGYVEGLKPHEFFFHTMAGREGLIDTAVKTSDTGYLQRK LIKALEDVHAAYDGTVRNANQELIQFMYGEDGLDGARIEGGQLFPLPFRDN-----KEM- -------------ESTYKYE-----------------------------------YDETG -------------AFNEKVGG-------AYMDPHVKKMLRA------------------- --DPE--------N-VRKLQSE------------------FDQLMADRDWARRMMDLE-- ----EREKLKLNL------PVNIGRLIQNARSTMGKRSQV------SN----LSPVT-II DHVRKLQEDMLKLFPCYHKGVDGRIHNLLSRQRIENALTLFSVHLRQLLASKRVLREYKL NDKAFEYLLKEIRTKYLQSLVSPGENIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLG VPRLLELLNVSRHQKHASMNVSLYPPWDKK--------------------RTAQQAQHLI EYCTLESVTKRIQFIYDPDPRETVVEADRAILELEWSVMDESDERARLQEVENGSPWIAR LELDADMFVDKALNMKDV------------------------------------------ --------------------------------------------------------KQAI LRVDDGYVIETGMANDTKERTIRMRPKKNDGVDSIPRLKHAIPELLARVHLRGIPGVRKA LLKDRTTF---------------TVDPATGKMTGEKTWLIDTDGTALRRAFIGIVDEKGN NIINATRTSSNKVPEVCSLLGIEAARYKMLHELREAYLAYGLNINYRHYTILVDTICQRG YLMAVSRVGINRSEMSGPLMRCSFEETVKVLMAAAAFGERDPVRGVSANLVLGNQARIGT GLFDLVLN-------MAALQQAVPQEDAVAPGKEVNVYHGLASTQNLPSSMPYRAKDHEA TPFVNDASLFFREGVGGSSSAAPLTASTLYGGMHEASAVHFSQAYPAMGMSDQRVRASSV SQPYSVMSSASVYNPASMQVPSALPSSVDYSEASSFHIQSSMAMPSVPSSPQFEAPQAFG GGRFGGLSPAYVPSVMSSVATQPYQCVGDSESQHSASYVPTLSPAYSAYTARRSVVASRA SASRVDQQSQQQEDDSASYLPKSPGLHGLPPPVGEFSLTEDPEEEEEGHQ- >5263288Leishmaniamajor -MSGGAALPPSQMPLQKVHEVQFEVFKEAQIKAYAKCIIEHAKSYASTASRCGAASTTCA WARQTSSIACETCGLRHPECPGHFGYVEL-AEPIFNINVFDVVLIALKCVCKYCGAL-LM DTNDP----SEMKKIAHL--QGLNRLRMVAKLCGSV---------CKR------------ -----SKDIQGCEGGPPA---------------------------------AHRPFV--- -GIYPGLQ-IKVT-------QEEQDYVWHAENARQVLDRVSDSDALIMGFDRRFCHPRDL DLTVLPIPPPQVRSSIY-------LGG---LMQVDDLTHQIMSIVK----RNIQL-RKDK ESGVKAAVDRSRALLQEHVATFFNNASTYYKPAKVG-DTK-KLKSLTERLKGKYGRLRGN LMGKRVDFSARTVITGDPNIDVDEVGVPFSVAMTLTFPERVNVINKKRLTEFVQR--TTY PSAN-------------YIIRPNG----NVTKLALVKD--RSAVHLDVGDVVERHVIDGD VVLFNRQPTLHRMSMMGHRVRVLNYNTFRLNLSCTTPYNADFDGDEMNLHVPQSLLTKAE LIEMMMVPKNFVSPNKSAPCMGIVQDSVLGSYKLTEKDTFLDK-YFIAERPLWLDLWQ-- ------------------------------------------------------------ ----------------------------------------------L-----PIPTILKP ---RPLWTGKQIFSLILPEVNHPASP--------------HDKPPFPHNDSKIM----IQ RGQLLGGAITKGVVGAAPGSLIHVIFNERGSDEVAKFINGVQRITTYFNYCF-----AFS VGVQDTVADATTLKEMNNVLHKTRQSV-EKIGAAANNGKLTRKAGMSLLQSFEADVNSAL NKCREEAAKKALSNVRRTNSFKVMIEAGSKGSDLNICQIAVFVGQQNVAGSRIPFGFRR- RTLPHFML-DDYGETSRGMATRGYVEGLQPHEFYFHTMAGREGLIDTAVKTSDTGYLQRK LVKALEDVHASYDGTVRNANQELIQLAYGEDGLDGARIEGNQAFPIPHMTN-----SEM- -------------ADKYRYE-----------------------------------YNDEG -------------SFSENMGG-------HYMDPFVRDSLLR------------------- --DPQ--------S-VLKLQEE------------------FEQLMKDRAMSRLVIDME-- ----DKNKLKMNL------PVNVARLIQNARTTMGKRSQV------SN----LNPIT-VI NRVRELQEDLVQLFPSYHKDYNGRFVNVLSQQRVERALTLFGIHLRQILGSKRVLKEYKL NDKAFEYLLKEIRTKYQQSLITPGEIIGAIAAQSCGEPATQMTLNTFHNAGISSKNVTLG VPRLLELLNVSKNQRNASVAVCLIREYQKRNKAQEAQQFIEYCTLANITTTVQIIYDPDP RNTVVAEDEEMIRWEQAVMNAEDEEPDAEQPPSPFIARLILDNDLFNDKRLNMKDVKSAI RQVDDTYMVQANMENDGQ------------------------------------------ ------------------------------------------------------------ --------------RIVRLRPRKCTGADSPALTKAVAQLLQSVHLRGIPGIKKTLLKEGN TF---------------------RVDPEAGGIKNESSWMVDTEGTALQRIFVGVVNSEGK NIIDFSKTSSNKIPEVVTVLGIEAARRKMLSELREAYLAYGLNINYRHYTILVDTMCQRG YLMAVSRTGINRSETSGPLMRCSFEETVKVLMTAAAFGEKDPVRGVSASLVLGNQARIGT GLFDLLLD-------MSKLQHVVPLDKATEARTS-------------------------- ---NVYHTDASVAPGSSTLQGSHGELPPSTVHENSSLAAGASSVYPRHERAGMYGGIPIE ASEVQFSSALPTVMRTALACLEHDRVPQQPPPLWCFHVLGVVGAAERESLDTELSSYHLQ SVAPSTAYGYAPMAASGMPMPGATQLSVGEGGSLPYPYEASNGERFGSLGGAASSRASAP YDPTQQPSQEFSQTEEQEEP-------------------------------