ࡱ > 7 bjbj >z / [! [! [! [! [! o! o! o! o! , ! o! 61 " 1# 1# 1# 1# $ $ $ 0 0 0 0 0 0 0 3 5 B 0 [! $ $ $ $ $ 0 [! [! 1# 1# 0 i% i% i% $ [! 1# [! 1# 0 i% $ 0 i% i% r 5/ T 50 1# `l o! A% / 0 1 0 61 / 6 A% ( 6 50 6 [! 50 $ 4$ i% B$ N$ Y $ $ $ 0 0 i% $ $ $ 61 $ $ $ $ 6 $ $ $ $ $ $ $ $ $ ! : Table 1: Characteristics of intermittent preventive treatment in infants (IPTi) trials with economic data
Study SiteStudy PeriodTransmission & (Entomological Inoculation Rate /Year)Use of Insecticide Treated Nets (%) No of infants in placebo/received at least one dose of IPTi DrugAge at drug dosingSite specific PE -Intervention time and primary outcome - used in CEA modelIfakara,Tanzania ADDIN EN.CITE Schellenberg20014417Schellenberg, DavidMenendez, ClaraKahigwa, ElizeusAponte, JohnVidal, JosepTanner, MarcelMshinda, HassanAlonso, PedroIntermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzanian infants: a randomised, placebo-controlled trialThe LancetThe Lancet1471-147735792672001http://www.sciencedirect.com/science/article/B6T1B-433NPFD-9/2/896c8f8103f518bfa531cce34b3514c0 " [13]8/1999 4/2001Perennial (29)67Placebo 351
2, 3, 9 months (at time of DPT2 c, DPT3 & measles)All episodes of clinical malaria up to 12 months of ageSP = 350Navrongo, Ghana ADDIN EN.CITE Chandramohan2005121217Chandramohan, DanielOwusu-Agyei, SethCarneiro, IlonaAwine, TimothyAmponsa-Achiano, KwameMensah, NathanJaffar, ShabbarBaiden, RitaHodgson, AbrahamBinka, FredGreenwood, BrianCluster randomised trial of intermittent preventive treatment for malaria in infants in area of high, seasonal transmission in GhanaBMJBMJ727-73333175192005October 1, 2005http://www.bmj.com/cgi/content/abstract/331/7519/727 10.1136/bmj.331.7519.727" [18]9/20006/2004Highly seasonal (418)18Placebo =1,225
3, 4, 9, 12 (at time of DPT2, DPT3, measles + extra at 12 months)All episodes of clinical malaria up to 15 months of ageManhia, Mozambique ADDIN EN.CITE Macete20062217Macete, EusebioAide, PedroAponte, JohnJSanz, SergiMandomando, InacioEspasa, MateuSigauque, BetuelDobano, CarlotaMabunda, SamuelDgeDge, MartinhoAlonso, PedroMenendez, ClaraIntermittent Preventive Treatment for Malaria Control Administered at the Time of Routine Vaccinations in Mozambican Infants: A Randomized, Placebo Controlled TrialJIDJID276-28519432006http://www.journals.uchicago.edu/doi/abs/10.1086/505431 doi:10.1086/505431" [14]9/2002 2/2004Perennial with seasonal peaks (38)0Placebo= 755
3, 4, 9 Months (at time of DPT2, DPT3 & measles)All episodes of clinical malaria up to 12 months of ageSP = 748Kumasi, Ghana ADDIN EN.CITE Kobbe200718518517Kobbe, RobinKreuzberg, ChristinaAdjei, SamuelThompson, BenedictaLangefeld, IrisThompson, Peter ApiaAbruquah, Harry HoffmanKreuels, BennoAyim, MatildaBusch, WibkeMarks, FlorianAmoah, KwadoOpoku, ErnestMeyer, Christian G.Adjei, OheneMay, JurgenA Randomized Controlled Trial of Extended Intermittent Preventive Antimalarial Treatment in InfantsClinical Infectious DiseasesClinical Infectious Diseases16-25451200717554695http://www.journals.uchicago.edu/doi/abs/10.1086/518575 doi:10.1086/518575" [17]1/20039/2005Perennial with seasonal peaks (400)1.6Placebo= 535
3, 9, 15 (at time of DPT3 & measles + extra at 15 months)All episodes of clinical malaria (>500 parasites/ul) up to 18 months of ageSP =535Tamale, Ghana ADDIN EN.CITE Mockenhaupt20078817Mockenhaupt, Frank P.Reither, KlausZanger, PhilippRoepcke, FelixDanquah, InaSaad, EimanZiniel, PeterDzisi, Stephen Y.Frempong, MarcAgana-Nsiire, PatrickAmoo-Sakyi, FeliciaOtchwemah, RowlandCramer, Jakob P.Anemana, Sylvester D.Dietz, EkkehartBienzle, UlrichIntermittent Preventive Treatment in Infants as a Means of Malaria Control: a Randomized, Double-Blind, Placebo-Controlled Trial in Northern GhanaAntimicrobial Agents and ChemotherepyAntimicrobial Agents and Chemotherepy3273-32815192007September 1, 2007http://aac.asm.org/cgi/content/abstract/51/9/3273 10.1128/aac.00513-07" [16]3/20037/2005Perennial with seasonal peaks (NA)3Placebo= 600
3, 9, 15 (at time of DPT3 & measles + extra at 15 months)All episodes of clinical malaria up to 18 months of ageSP =600Lambarn, Gabon ADDIN EN.CITE Grobusch20077717Grobusch, M. P.Lell, B.Schwarz, N. G.Gabor, J.Dornemann, J.Potschke, M.Oyakhirome, S.Kiessling, G. C.Necek, M.Langin, M. U.Klouwenberg, P. K.Klopfer, A.Naumann, B.Altun, H.Agnandji, S. T.Goesch, J.Decker, M.Salazar, C. L. O.Supan, ChristianKombila, Davy U.Borchert, LeaKoster, Kai B.Pongratz, PeterAdegnika, Akim A.Glasenapp, Isabelle vonIssifou, SaadouKremsner, Peter G.Intermittent Preventive Treatment against Malaria in Infants in Gabon--A Randomized, Double-Blind, Placebo-Controlled TrialJIDJID1595196112007The University of Chicago Presshttp://www.journals.uchicago.edu/doi/full/10.1086/522160 " [15]12/2002 8/2006Perennial with seasonal peaks (50)5Placebo=504
3, 9, 15 months (at time of DPT3 & measles + extra visit at 15 months)All episodes of clinical malaria up to 18 months of ageSP = 507Western Kenya ADDIN EN.CITE OdhiamboSubmitted383817Odhiambo, F., Hamel, M. Williamson, J.Lindblade, K.O ter Kuile, F. Peterson, E. Otieno, P.Kariuki, S.Vulule, JSlutsker, L.Newman, R.D.Intermittent preventive treatment in infants using long and short-acting drug combinations for the prevention of malaria and anaemia in rural western Kenya: a randomized, double-blind placebo-controlled trial Submitted" [6]3/2004 3/2007Perennial (7)57 a Placebo = 337
2, 3, 9 months (at time of DPT2, DPT3 & measles)All episodes of clinical malaria up to 12 months of ageSP-AS3 = 339AQ3-AS3 = 347 CD3 = 342Korogwe (K) & Same (S), Tanzania ADDIN EN.CITE Gosling200923823823817Gosling, R.Gesase, S. Mosha,J.Carneiro, I.Hashim, R., Lemnge, M, Mosha3, F.Greenwood, B, Chandramohan, D.Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, placebo-controlled trial The LancetThe Lancet1521 - 153237497002009[5]2004-2008K: Perennial with seasonal peak
K: 88 b
K / S
2, 3, 9 months (at time of DPT2, DPT3 & measles)All episodes of clinical malaria up to 11 months of agePlacebo= 320 / 284S: Low (NA)S: 88SP = 319 / 283CD3= 317 / 285MQ = 320 / 284
Table adapted from ADDIN EN.CITE ADDIN EN.CITE.DATA [4], Grobusch M, Egan A, Gosling RD, Newman R (2007) Intermittent preventive therapy for malaria: progress and future directions. Current Opinion in Infectious Diseases 20: 613-620 and site specific publications, (a) 2003 Kenyan Demographic Health Survey (b) JF Mosha (Unpublished) (c) diphtheria-tetanus toxoidpertussis vaccine
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