A] 1) Degree hubs in M. tuberculosis R00259 Acetyl-CoA + L-Glutamate <=> CoA + N-Acetyl-L-Glutamate R00355B L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate R00986 Chorismate + L-Glutamine <=> Anthranilate + Pyruvate + L- Glutamate R01339F 2-Oxo-acid + L-Glutamate <=> alpha-Amino-acid + 2-Oxoglutarate R00209 Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH R00210F Pyruvate + CoA + NADP+ <=> Acetyl-CoA + CO2 + NADPH R01214B L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic-acid + L-Glutamate R00942F ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + Tetrahydrofolyl-[Glu](2) R04173B O-Phospho-L-serine + 2-Oxoglutarate <=> 3-Phosphonooxypyruvate + L-Glutamate R06844 N2-Acetyl-L-aminoadipate-semialdehyde + L-Glutamate <=> N2- Acetyl-L-lysine + 2-Oxoglutarate R00457B L-Lysine + 2-Oxoglutarate <=> L-2-Aminoadipate-6-semialdehyde + L-Glutamate R02283B N-Acetylornithine + 2-Oxoglutarate <=> N-Acetyl-L-Glutamate-5-semialdehyde + L-Glutamate R00694B L-Phenylalanine + 2-Oxoglutarate <=> Phenylpyruvate + L-Glutamate R04475B N-Succinyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate <=> N-Succinyl-2-L-amino-6-oxoheptanedioate + L-Glutamate R05085B O-Phospho-4-hydroxy-L-threonine + 2-Oxoglutarate <=> 2-Oxo-3-hydroxy-4-phosphobutanoate + L-Glutamate R00734B L-Tyrosine + 2-Oxoglutarate <=> 3-(4-Hydroxyphenyl)pyruvate + L-Glutamate R04467 N-Acetyl-L-2-amino-6-oxopimelate + L-Glutamate <=> N6-Acetyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate R03243B L-Histidinol-phosphate + 2-Oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl-phosphate + L-Glutamate R01090B L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate R04217B N2-Succinyl-L-ornithine + 2-Oxoglutarate <=> N2-Succinyl-L- Glutamate-5-semialdehyde + L-Glutamate A] 2) GS hubs in M. tuberculosis R00259 Acetyl-CoA + L-Glutamate <=> CoA + N-Acetyl-L-Glutamate R00355B L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate R00986 Chorismate + L-Glutamine <=> Anthranilate + Pyruvate + L-Glutamate R01339F 2-Oxo-acid + L-Glutamate <=> alpha-Amino-acid + 2-Oxoglutarate R06844 N2-Acetyl-L-aminoadipate-semialdehyde + L-Glutamate <=> N2-Acetyl-L-lysine + 2-Oxoglutarate R04173B O-Phospho-L-serine + 2-Oxoglutarate <=> 3-Phosphonooxypyruvate + L-Glutamate R01214B L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic-acid + L-Glutamate R04475B N-Succinyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate <=> N-Succinyl-2-L-amino-6-oxoheptanedioate + L-Glutamate R05085B O-Phospho-4-hydroxy-L-threonine + 2-Oxoglutarate <=> 2-Oxo-3-hydroxy-4-phosphobutanoate + L-Glutamate R00734B L-Tyrosine + 2-Oxoglutarate <=> 3-(4-Hydroxyphenyl)pyruvate + L-Glutamate R00694B L-Phenylalanine + 2-Oxoglutarate <=> Phenylpyruvate + L-Glutamate R00457B L-Lysine + 2-Oxoglutarate <=> L-2-Aminoadipate-6-semialdehyde + L-Glutamate R04467 N-Acetyl-L-2-amino-6-oxopimelate + L-Glutamate <=> N6-Acetyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate R02283B N-Acetylornithine + 2-Oxoglutarate <=> N-Acetyl-L-Glutamate-5-semialdehyde + L-Glutamate R01090B L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate R03243B L-Histidinol-phosphate + 2-Oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl-phosphate + L-Glutamate R04217B N2-Succinyl-L-ornithine + 2-Oxoglutarate <=> N2-Succinyl-L-Glutamate-5-semialdehyde + L-Glutamate R00243F L-Glutamate + NAD+ + H2O <=> 2-Oxoglutarate + NH3 + NADH + H+ R00942F ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + Tetrahydrofolyl-[Glu](2) R04051F 3-Phosphonopyruvate + L-Glutamate <=> 2-Amino-3-phosphonopropanoate + 2-Oxoglutarate B] 1) Degree hubs in M. leprae R00259 Acetyl-CoA + L-Glutamate <=> CoA + N-Acetyl-L-Glutamate R00986 Chorismate + L-Glutamine <=> Anthranilate + Pyruvate + L- Glutamate R00209 Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 +NADH R00210F Pyruvate + CoA + NADP+ <=> Acetyl-CoA + CO2 +NADPH R01214B L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic-acid + L-Glutamate R00942 ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + Tetrahydrofolyl-[Glu](2) R01339 2-Oxo-acid + L-Glutamate <=> alpha-Amino-acid + 2-Oxoglutarate R00355 L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate R00908B beta-Alanine + 2-Oxoglutarate <=> 3-Oxopropanoate + L-Glutamate R00694B L-Phenylalanine + 2-Oxoglutarate <=> Phenylpyruvate + L-Glutamate R04173B O-Phospho-L-serine + 2-Oxoglutarate <=> 3-Phosphonooxypyruvate + L-Glutamate R02199B L-Isoleucine + 2-Oxoglutarate <=> (3R)-3-Methyl-2-oxopentanoic- acid + L-Glutamate R00734B L-Tyrosine + 2-Oxoglutarate <=> 3-(4-Hydroxyphenyl)pyruvate + L-Glutamate R04467 N-Acetyl-L-2-amino-6-oxopimelate + L-Glutamate <=> N6-Acetyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate R06844 N2-Acetyl-L-aminoadipate-semialdehyde + L-Glutamate <=> N2-Acetyl-L-lysine + 2-Oxoglutarate R01072F L-Glutamine + 5-Phospho-alpha-D-ribose-1-diphosphate + H2O <=> 5-Phosphoribosylamine + Pyrophosphate + L-Glutamate R00430F GTP + Pyruvate <=> GDP + Phosphoenolpyruvate R05052B L-erythro-4-Hydroxyglutamate + 2-Oxoglutarate <=> D-4-Hydroxy-2-oxoglutarate + L-Glutamate R04051F 3-Phosphonopyruvate + L-Glutamate <=> 2-Amino-3-phosphonopropanoate + 2-Oxoglutarate R02237 ATP + Dihydropteroate + L-Glutamate <=> ADP + Orthophosphate + Dihydrofolate B] 2) GS hubs in M. leprae R00259 Acetyl-CoA + L-Glutamate <=> CoA + N-Acetyl-L-Glutamate R00986 Chorismate + L-Glutamine <=> Anthranilate + Pyruvate + L-Glutamate R01214B L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic-acid + L-Glutamate R01339 2-Oxo-acid + L-Glutamate <=> alpha-Amino-acid + 2-Oxoglutarate R00355 L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate R00908B beta-Alanine + 2-Oxoglutarate <=> 3-Oxopropanoate + L-Glutamate R00942 ATP + Tetrahydrofolate + L-Glutamate <=> ADP + Orthophosphate + Tetrahydrofolyl-[Glu](2) R00694B L-Phenylalanine + 2-Oxoglutarate <=> Phenylpyruvate + L-Glutamate R04173B O-Phospho-L-serine + 2-Oxoglutarate <=> 3-Phosphonooxypyruvate + L-Glutamate R02199B L-Isoleucine + 2-Oxoglutarate <=> (3R)-3-Methyl-2-oxopentanoic-acid + L-Glutamate R00734B L-Tyrosine + 2-Oxoglutarate <=> 3-(4-Hydroxyphenyl)pyruvate + L-Glutamate R04467 N-Acetyl-L-2-amino-6-oxopimelate + L-Glutamate <=> N6-Acetyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate R06844 N2-Acetyl-L-aminoadipate-semialdehyde + L-Glutamate <=> N2-Acetyl-L-lysine + 2-Oxoglutarate R05052B L-erythro-4-Hydroxyglutamate + 2-Oxoglutarate <=> D-4-Hydroxy-2-oxoglutarate + L-Glutamate R04051F 3-Phosphonopyruvate + L-Glutamate <=> 2-Amino-3-phosphonopropanoate + 2-Oxoglutarate R01648 4-Aminobutanoate + 2-Oxoglutarate <=> Succinate-semialdehyde + L-Glutamate R01072F L-Glutamine + 5-Phospho-alpha-D-ribose-1-diphosphate + H2O <=> 5-Phosphoribosylamine + Pyrophosphate + L-Glutamate R00573 ATP + UTP + L-Glutamine + H2O <=> ADP + Orthophosphate + CTP + L-Glutamate R00768 L-Glutamine + D-Fructose-6-phosphate <=> L-Glutamate + D-Glucosamine-6-phosphate R02237 ATP + Dihydropteroate + L-Glutamate <=> ADP + Orthophosphate + Dihydrofolate C] 1) Degree hubs in E. coli R00210 Pyruvate + CoA + NADP+ <=> Acetyl-CoA + CO2 + NADPH R00209F Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH R00355B L-Aspartate + 2-Oxoglutarate <=> Oxaloacetate + L-Glutamate R00986 Chorismate + L-Glutamine <=> Anthranilate + Pyruvate + L-Glutamate R00259B Acetyl-CoA + L-Glutamate <=> CoA + N-Acetyl-L-Glutamate R00430 GTP + Pyruvate <=> GDP + PhosphoenolPyruvate R00259F Acetyl-CoA + L-Glutamate <=> CoA + N-Acetyl-L-Glutamate R00494B Glutathione + H2O <=> Cys-Gly + L-Glutamate R00409B (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate <=> Pyruvate + Succinate R00212 Acetyl-CoA + Formate <=> CoA + Pyruvate R03145F Ferricytochrome b1 + Pyruvate + H2O <=> Ferrocytochrome b1 + Acetate + CO2 R02628B PhosphoenolPyruvate + Protein histidine <=> Pyruvate + Protein N(pai)-phosphohistidine R01138 dATP + Pyruvate <=> dADP + PhosphoenolPyruvate R00750B 4-Hydroxy-2-oxopentanoate <=> Acetaldehyde + Pyruvate R05636F Pyruvate + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal <=> 1-Deoxy-D-xylulose 5-phosphate + CO2 R00199 ATP + Pyruvate + H2O <=> AMP + PhosphoenolPyruvate + Orthophosphate R00782B L-Cysteine + H2O <=> Hydrogen sulfide + Pyruvate + NH3 R01215F L-Valine + Pyruvate <=> 3-Methyl-2-oxobutanoic acid + L-Alanine R00659B UDP + PhosphoenolPyruvate <=> UTP + Pyruvate R00393 Acyl-CoA + Acetate <=> Fatty acid anion + Acetyl-CoA C] 2) GS hubs in E. coli R00210 Pyruvate + CoA + NADP+ <=> Acetyl-CoA + CO2 + NADPH R00209F Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH R00986 Chorismate + L-Glutamine <=> Anthranilate + Pyruvate + L-Glutamate R00212 Acetyl-CoA + Formate <=> CoA + Pyruvate R00430 GTP + Pyruvate <=> GDP + PhosphoenolPyruvate R00409B (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate <=> Pyruvate + Succinate R02628B PhosphoenolPyruvate + Protein histidine <=> Pyruvate + Protein N(pai)-phosphohistidine R03145F Ferricytochrome b1 + Pyruvate + H2O <=> Ferrocytochrome b1 + Acetate + CO2 R01138 dATP + Pyruvate <=> dADP + PhosphoenolPyruvate R00750B 4-Hydroxy-2-oxopentanoate <=> Acetaldehyde + Pyruvate R00199 ATP + Pyruvate + H2O <=> AMP + PhosphoenolPyruvate + Orthophosphate R05636F Pyruvate + (2R)-2-Hydroxy-3-(phosphonooxy)-propanal <=> 1-Deoxy-D-xylulose 5-phosphate + CO2 R01215F L-Valine + Pyruvate <=> 3-Methyl-2-oxobutanoic acid + L-Alanine R00782B L-Cysteine + H2O <=> Hydrogen sulfide + Pyruvate + NH3 R00209B Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH R00200B ADP + PhosphoenolPyruvate <=> ATP + Pyruvate R00659B UDP + PhosphoenolPyruvate <=> UTP + Pyruvate R06860 2-Oxoglutarate + Isochorismate <=> 2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + Pyruvate + CO2 R03277 2-Hydroxy-3-oxopropanoate + Pyruvate <=> 2-Dehydro-3-deoxy-D-glucarate R00214B (S)-Malate + NAD+ <=> Pyruvate + CO2 + NADH