Conceived and designed the experiments: BR. Performed the experiments: AI YG. Analyzed the data: YG. Wrote the paper: AI BR YG.
BR has a financial interest in Excellin Life Sciences and in Oncobionic which are companies in the fields of electroporation and he may gain financial benefit from this paper
According to World Health Organization reports, some three quarters of the world population does not have access to medical imaging. In addition, in developing countries over 50% of medical equipment that is available is not being used because it is too sophisticated or in disrepair or because the health personnel are not trained to use it. The goal of this study is to introduce and demonstrate the feasibility of a new concept in medical imaging that is centered on cellular phone technology and which may provide a solution to medical imaging in underserved areas. The new system replaces the conventional stand-alone medical imaging device with a new medical imaging system made of two independent components connected through cellular phone technology. The independent units are: a) a data acquisition device (DAD) at a remote patient site that is simple, with limited controls and no image display capability and b) an advanced image reconstruction and hardware control multiserver unit at a central site. The cellular phone technology transmits unprocessed raw data from the patient site DAD and receives and displays the processed image from the central site. (This is different from conventional telemedicine where the image reconstruction and control is at the patient site and telecommunication is used to transmit processed images from the patient site). The primary goal of this study is to demonstrate that the cellular phone technology can function in the proposed mode. The feasibility of the concept is demonstrated using a new frequency division multiplexing electrical impedance tomography system, which we have developed for dynamic medical imaging, as the medical imaging modality. The system is used to image through a cellular phone a simulation of breast cancer tumors in a medical imaging diagnostic mode and to image minimally invasive tissue ablation with irreversible electroporation in a medical imaging interventional mode.
This study was motivated by several reports on health care and health care technology published by the World Health Organization (WHO)
While the WHO reports focus only on the use of medical imaging for diagnostics, in technologically advanced countries medical imaging is being used effectively in minimally invasive or non-invasive imaging monitored and controlled surgical interventions since the early 1980s e.g.
A possible solution to the medical imaging problems detailed in the WHO reports is to develop a different modality for medical imaging. Conventional medical imaging systems are self contained units that combine data acquisition hardware with software processing hardware and imaging display in one device. This causes substantial duplication in expensive components and increases cost. Furthermore, it increases the sensitivity of the devices to user handling and maintenance and places increased demands on users training. Most medical devices have three main components: a) the data acquisition hardware which is in contact with the patient, b) the image display unit and c) the imaging processing hardware. We propose that physically separating these three units could yield a medical imaging technology that is robust, less expensive and can be used by less rigorously trained personnel. The proposed system is illustrated in
Outlined arrows indicate optional reporting of results to the patient.
This design simplifies the apparatus at the patient site and removes the need for advanced imaging training of the personnel at the patient site. It reduces the cost of medical imaging devices in general since the patient site device is only for data acquisition. It also reduces the complexity of operating the hardware at the patient site. The medical imaging display is on a conventional and portable cellular phone and the image is reconstructed at a technologically advanced distant site. This means that there is no need to manipulate the imaging software at the patient site and furthermore, an optimal quality of imaging can be obtained. In addition, because the cellular phone is portable and replaceable its maintenance is minimal. From an economical point of view, the proposed system removes duplications which exist in all the self contained medical imaging devices and should reduce cost. The fact that the image itself is produced in a centralized location and not on the measurement device has additional advantages. Employing a centralized location for image reconstruction would also make technological advances in medical imaging processing continuously available to remote areas of the world. Experts affiliated with the centralized location can analyze the data and the software in the centralized location can be continuously upgraded. Furthermore, control inputs to the remote location (patient site) device as well as advice to the operator at the patient site can be continuously given from the centralized location.
The goal of this study is a first order proof of the feasibility of the medical imaging concept proposed above. We primarily intend to show that the conventional cellular phone can serve the proposed functions. The concept could be developed with various medical imaging modalities, such as ultrasound or even x-ray. It would be most economical with medical imaging systems in which the data acquisition hardware is relatively inexpensive and which requires substantial computation for image reconstruction.
Electrical impedance tomography (EIT) is one of several medical imaging modalities that have attributes compatible with the economical use of the concept
The primary goal of this study is to demonstrate that the cellular phone technology can function in the proposed mode. The feasibility of the concept is demonstrated using a new frequency division multiplexing electrical impedance tomography system, which we have developed for dynamic medical imaging, as the medical imaging modality. The system is used to image through a cellular phone a simulation of breast cancer tumors in a medical imaging diagnostic mode and to image minimally invasive tissue ablation with irreversible electroporation in a medical imaging interventional mode.
The key aspect of the new medical imaging concept is the availability of ubiquitous cellular phones and their ability to serve as a conduit of information between remote sites and for imaging display. As a first step in developing this new medical imaging technology the goal of the technical part of this study is limited to a demonstration of the ability of a conventional cellular phone to operate in the proposed mode. Therefore, we did not try to design a simplified and dedicated DAD or an advanced multiprocessors reconstruction system. Instead we used off-the-shelf generic electronic devices and components. Consistent with the mode of operation of the new medical imaging concept, the proof-of-concept system has three components: a) an EIT DAD, b) a cell phone (Palm Treo 700W) (there are a variety of cell phones that could have served equally well) with conventional phone services (Verizon) (other phone services would have served equally well) and c) a processing unit PC (Dell Precision 690, Dual Core Xeon 3.7 GHz, 8 GB SDRAM) completely independent from the DAD.
EIT is based on the measurement of external voltages by means of electrodes placed at specific locations on the body surface. The voltages are induced by different independent currents injected into the body, also through external electrodes. The main role of the DAD is to generate the independent currents and to measure the resulting voltages. The EIT architecture chosen for this study is based on the Frequency-Division Multiplexing EIT (FDM EIT) technique that we have reported previously
Seven AC currents (at different frequencies) are injected simultaneously. Signals from voltage electrodes (V1 to V8) are connected to an analogue multiplexer (see
The gray shaded area contains the elements that were implemented on a single printed circuit board: a microcontroller (not shown) reads incoming commands from the computer (through the RS-232 connection) and, according to these commands, manages the digital control lines of the analog multiplexers (MUX 1∶15 and MUX 2∶16).
The injected AC currents are obtained from square signals generated by a set of low cost micro-controllers (PIC16F76 by Microchip Technology, Inc.) that are filtered by second-order low-pass filters (LPFs) with a quality factor (Q) of 4 and centered at the frequency of interest.
A differential amplifier (AD830 by Analog Devices, Inc.) is connected sequentially to different voltage electrode pairs by means of an analogue multiplexer (MUX 2∶16). The signal is then acquired by a digital oscilloscope (LeCroy, WaveRunner 44Xi). The same oscilloscope also records the voltages from the current injectors through another analogue multiplexer (MUX 1∶15). All the recorded signals are acquired by a laptop computer (IBM ThinkPad T43) with a LAN connection to the oscilloscope.
The whole process is performed through custom developed LabVIEW routines (National Instruments Corporation, Austin, TX).
In FDM EIT the voltage measurements are separated according to frequency. The different current patterns that were injected simultaneously are correlated with the voltage measurements. The signal processing routines that extract the voltage data are based on the Fourier transform and are implemented in Matlab (
The DAD is connected to the cell phone, via a standard USB cable. The cell phone connects to the data processing computer via a modem by dialing directly to the data processing computer using a Telnet application. The cell phone is used for several tasks – as a display, as a communication link to the processing center, and as a graphical user interface that connects to the DAD and allows the user to initiate a test, or modify settings and other local control functions.
The measurement process begins by powering the DAD and connecting the electrodes. Then the cell phone connects to the DAD via the USB data cable interface. The controller runs the process of injecting current and measuring voltages, collecting the demodulated results into a matrix. There are various ways to generate EIT data
The measurements are arranged in a matrix to be transmitted to the processing center. Every measurement is written in a row of the matrix. The columns describe the injected signal's frequency, the injecting electrode number, the positive voltage electrode number, the negative voltage electrode number, the measured voltage amplitude and the phase. For predefined patterns, it is sufficient to report only the last two columns. In our example this matrix is 225×6 and its size is 4 kB. This matrix is uploaded to the cell phone, which dials to the processing center and uploads the matrix though standard data links such as HyperTerminal.
In the data processing computer we have used a Matlab program based on EIDORS
In order to reconstruct the image from the voltage measurements that were sent from the cell phone we solve the Laplace equation over the entire tissue:
The feasibility of the cellular phone enabled imaging system was tested by imaging a simulation of breast cancer tumors in a medical imaging diagnostic mode and by imaging image a simulation of minimally invasive tissue ablation with irreversible electroporation in a medical imaging interventional mode.
The diagnostic mode study is also one of the most widely studied uses of EIT and electrical impedance spectroscopy (EIS)
The objective of the tests was to verify that a standard commercial cell phone can be used in two phases of producing the image – connecting the data collection device with the reconstruction center and display of results. We have collected data from an actual EIT system, as described above, and used a cell phone to transmit the measurements. The reconstructed image was sent back to the cellular phone in the form of a standard multimedia message (MMS) and was displayed on the cell phone screen. These tests prove first that the DAD can be separate and independent from the reconstruction process and second that a cell phone can be an effective means of connecting these two parts.
a) The DAD of the system with two types of gel representing an area treated with irreversible electroporation, marked in red, surrounded by normal tissue. b) Reconstructed result as it was displayed on the screen of a commercial cellular phone. Warm colors represent higher conductivity regions that denote an electroporated area.
The conductivity of the gel is 0.65 mS/cm which is similar to that of a normal liver tissue
In
a) The DAD of the system with two types of gel representing a breast cancer tumor surrounded by normal breast tissue. b) Reconstructed result as it was displayed on the screen of a commercial cellular phone. Warm colors represent higher conductivity regions that are typical of breast cancer lesions.
Another important result of this research is the ease of use of cellular phones in the manner described. This system is easily scalable and could be used in a very similar manner for 3D EIT for example. With the increase in number of electrodes, or the number of current patterns that are used, the size of the measurement matrix increases slightly and in a linear fashion while the requirements from the processing center in terms of memory and processing power increase significantly, usually in a quadratic fashion. This makes the system scalable with only small changes at the DAD, which is typically the hardest place to implement changes in terms of logistics and cost.
The goal of this study was to first and foremost demonstrate that the conventional cellular phone can be used as a central component in the new concept of medical imaging. While in this study we have used the cellular phone as a wireless device with a PC interface there are several options for the use of the cell phone as a communication channel. First is the use as a simple modem. Depending on the cell phone model, many phones on the market today have either a built-in option or a possible add-on to enable them to function as a modem. This usually works with a PC, but a modem interface can be also included in the DAD. The configuration may be complex for this case, depending on the cell phone model and on the DAD hardware that is chosen. The more the DAD resembles a PC interface, the easier the connection will be, but this will also increase the cost and size of the DAD. A second option is to upload the data to the cell phone and to send it using the cell phone's links such as Email, texting / MMS options or Telnet. This depends on the types of service that the cellular provider supports, but at least text messages are a widely available option today, even in the simplest cellular networks. The third option is a customized modem. To be completely independent of the cell phone model, it is possible to implement the modem on the DAD with a suitable speaker that would match an ordinary cell phone microphone. In this case, the cell phone uses the voice channel to transmit an analog signal (much like a fax). This has the disadvantages of possible lost bits due to line quality and other problems that are characteristic of analog communications, but it is probably the best option in terms of cell phone compatibility.
Indeed, an important issue to consider is the requirements for cell phone compatibility. If it is required that the DAD connects to every type of cell phone available the design will have to consider numerous constraints. On the other hand, if the DAD will only be compatible with cell phones that also function as Personal Digital Assistants (PDAs) and run an operating system such as Windows, the design could be very flexible and there are still enough available options on the market for this. Almost every cellular provider, whether it is using GSM, CDMA or other protocols supports a few PDA-like cell phone models that are relatively easy to work with and connect to. An intermediate option, is to limit the compatibility of the DAD to those cells phones that support some minimum features such as USB connection, color display and perhaps a few other things that will be required.
If the cell phone is at least an intermediate option, it may be used as a display/graphical user interface (GUI) for the DAD. Creating the cell phone GUI application depends on the cell phone model and its support of Java or a similar technology. This will make the DAD a little bit simpler since it will not require a built-in display and/or keyboard and the user will not need a PC to use the device (although that is also an option as laptops are widely available). Using the cell phone's keypad, the user can also configure the DAD, run built-in test functions and operate the device.
The phone can be also used for some data processing. This will be limited to the case of using a PDA like model. These cell phones have relatively powerful processing units which may be used to simplify the DAD and move some of the signal processing to the cell phone.
In summary, this study demonstrates the feasibility of using a cellular phone as an integrated part of a medical imaging system in which a robust and independent DAD is connected to the imaging processing site through the cell phone. We believe that this concept has the potential for decreasing the complexity of operating the imaging system at the patient site and make state of the art diagnostic imaging as well as interventional imaging available to people and places that do not have adequate medical imaging now.