Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers

• Nicolas Mercado,

  Affiliation Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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• Yasuo Kizawa,

  Affiliation Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

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• Keitaro Ueda,

  Affiliation Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

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• Yeping Xiong,

  Affiliation Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

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• Genki Kimura,

  Affiliation Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

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• Audric Moses,

  Affiliation Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

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• Jonathan M. Curtis,

  Affiliation Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

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• Kazuhiro Ito,

  Affiliation Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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• Peter J. Barnes

  * E-mail: p.j.barnes@imperial.ac.uk

  Affiliation Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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