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Research Article

Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers

  • Nicolas Mercado,

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Yasuo Kizawa,

    Affiliation: Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

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  • Keitaro Ueda,

    Affiliation: Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

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  • Yeping Xiong,

    Affiliation: Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

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  • Genki Kimura,

    Affiliation: Department of Physiology and Anatomy, Nihon University School of Pharmacy, Funabashi, Chiba, Japan

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  • Audric Moses,

    Affiliation: Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

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  • Jonathan M. Curtis,

    Affiliation: Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada

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  • Kazuhiro Ito,

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Peter J. Barnes mail

    p.j.barnes@imperial.ac.uk

    Affiliation: Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom

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  • Published: February 05, 2014
  • DOI: 10.1371/journal.pone.0088168

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