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Research Article

Combinatorial PD-1 Blockade and CD137 Activation Has Therapeutic Efficacy in Murine Cancer Models and Synergizes with Cisplatin

  • Huafeng Wei equal contributor,

    equal contributor Contributed equally to this work with: Huafeng Wei, Likun Zhao

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Likun Zhao equal contributor,

    equal contributor Contributed equally to this work with: Huafeng Wei, Likun Zhao

    Affiliation: School of Bioscience and Bioengneering, South China University of Technology, Guangzhou, China

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  • Wei Li,

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Kexing Fan,

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Weizhu Qian,

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Sheng Hou,

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Hao Wang,

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Min Dai,

    Affiliation: Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington, United States of America

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  • Ingegerd Hellstrom,

    Affiliation: Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington, United States of America

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  • Karl Erik Hellstrom,

    Affiliation: Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington, United States of America

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  • Yajun Guo mail

    yguo_smmu@163.com

    Affiliations: International Joint Cancer Institute, Second Military Medical University, Shanghai, China, School of Bioscience and Bioengneering, South China University of Technology, Guangzhou, China, School of Pharmacy, Liaocheng University, Liaocheng, China

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  • Published: December 19, 2013
  • DOI: 10.1371/journal.pone.0084927

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