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Research Article

Pharmacokinetics, Brain Delivery, and Efficacy in Brain Tumor-Bearing Mice of Glutathione Pegylated Liposomal Doxorubicin (2B3-101)

  • Pieter J. Gaillard mail,

    PieterGaillard@toBBB.com

    Affiliation: to-BBB technologies BV, Leiden, The Netherlands

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  • Chantal C. M. Appeldoorn,

    Affiliation: to-BBB technologies BV, Leiden, The Netherlands

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  • Rick Dorland,

    Affiliation: to-BBB technologies BV, Leiden, The Netherlands

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  • Joan van Kregten,

    Affiliation: to-BBB technologies BV, Leiden, The Netherlands

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  • Francesca Manca,

    Affiliation: to-BBB technologies BV, Leiden, The Netherlands

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  • Danielle J. Vugts,

    Affiliation: Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

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  • Bert Windhorst,

    Affiliation: Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

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  • Guus A. M. S. van Dongen,

    Affiliation: Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

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  • Helga E. de Vries,

    Affiliation: Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands

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  • David Maussang,

    Affiliation: to-BBB technologies BV, Leiden, The Netherlands

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  • Olaf van Tellingen

    Affiliation: The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AvL), Amsterdam, The Netherlands

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  • Published: January 08, 2014
  • DOI: 10.1371/journal.pone.0082331

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