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Research Article

Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint

  • James J. Burston equal contributor,

    equal contributor Contributed equally to this work with: James J. Burston, Devi Rani Sagar

    Affiliations: Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Devi Rani Sagar equal contributor,

    equal contributor Contributed equally to this work with: James J. Burston, Devi Rani Sagar

    Affiliations: Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Pin Shao,

    Affiliation: Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

    X
  • Mingfeng Bai,

    Affiliations: Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America

    X
  • Emma King,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Louis Brailsford,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Jenna M. Turner,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Gareth J. Hathway,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Andrew J. Bennett,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • David A. Walsh,

    Affiliation: Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom

    X
  • David A. Kendall,

    Affiliation: School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

    X
  • Aron Lichtman,

    Affiliation: Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, United States of America

    X
  • Victoria Chapman mail

    victoria.chapman@nottingham.ac.uk

    Affiliation: Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom

    X
  • Published: November 25, 2013
  • DOI: 10.1371/journal.pone.0080440

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