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Research Article

Bruton’s Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin

  • Elaine F. Kenny mail,

    kennyef@tcd.ie

    Affiliation: Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

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  • Susan R. Quinn,

    Affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

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  • Sarah L. Doyle,

    Affiliation: Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

    Current address: Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2, Ireland

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  • Paul M. Vink,

    Affiliation: Janssen Infectious Diseases BVBA, Beerse, Belgium

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  • Hans van Eenennaam,

    Affiliation: BioNovion B.V., Oss, The Netherlands

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  • Luke A. J. O’Neill

    Affiliation: Immunology Research Centre, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

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  • Published: August 14, 2013
  • DOI: 10.1371/journal.pone.0074103

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