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Research Article

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

  • Amanda L. Wright,

    Affiliations: Neurodegenerative Disorders, Garvan Institute of Medical Research, Neuroscience Department, Sydney, Australia, Faculty of Medicine, University of New South Wales, Sydney, Australia

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  • Raphael Zinn,

    Affiliations: Neurodegenerative Disorders, Garvan Institute of Medical Research, Neuroscience Department, Sydney, Australia, Faculty of Medicine, University of New South Wales, Sydney, Australia

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  • Barbara Hohensinn,

    Affiliations: Neurodegenerative Disorders, Garvan Institute of Medical Research, Neuroscience Department, Sydney, Australia, Faculty of Medicine, University of New South Wales, Sydney, Australia

    Current address: Institute of Molecular Biosciences, University of Graz, Graz, Austria

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  • Lyndsey M. Konen,

    Affiliation: Neurodegenerative Disorders, Garvan Institute of Medical Research, Neuroscience Department, Sydney, Australia

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  • Sarah B. Beynon,

    Affiliation: Neurodegenerative Disorders, Garvan Institute of Medical Research, Neuroscience Department, Sydney, Australia

    Current address: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia

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  • Richard P. Tan,

    Affiliation: Neurodegenerative Disorders, Garvan Institute of Medical Research, Neuroscience Department, Sydney, Australia

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  • Ian A. Clark,

    Affiliation: Research School of Biology, Australian National University, Canberra, Australia

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  • Andrea Abdipranoto,

    Affiliation: Neurodegenerative Disorders, Garvan Institute of Medical Research, Neuroscience Department, Sydney, Australia

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  • Bryce Vissel mail

    b.vissel@garvan.org.au

    Affiliations: Neurodegenerative Disorders, Garvan Institute of Medical Research, Neuroscience Department, Sydney, Australia, Faculty of Medicine, University of New South Wales, Sydney, Australia

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  • Published: April 01, 2013
  • DOI: 10.1371/journal.pone.0059586

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