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Research Article

Age-Dependent Decrease and Alternative Splicing of Methionine Synthase mRNA in Human Cerebral Cortex and an Accelerated Decrease in Autism

  • Christina R. Muratore,

    Affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts, United States of America

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  • Nathaniel W. Hodgson,

    Affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts, United States of America

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  • Malav S. Trivedi,

    Affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts, United States of America

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  • Hamid M. Abdolmaleky,

    Affiliation: Genetics Program, School of Medicine, Boston University, Boston, Massachusetts, United States of America

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  • Antonio M. Persico,

    Affiliation: Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio-Medico, Rome, Italy

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  • Carla Lintas,

    Affiliation: Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio-Medico, Rome, Italy

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  • Suzanne De La Monte,

    Affiliation: Department of Medicine and Pathology, Rhode Island Hospital and Warren Alpert School of Medicine at Brown University, Providence, Rhode Island, United States of America

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  • Richard C. Deth mail

    r.deth@neu.edu

    Affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts, United States of America

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  • Published: February 20, 2013
  • DOI: 10.1371/journal.pone.0056927

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