MicroRNA-145 Is Downregulated in Glial Tumors and Regulates Glioma Cell Migration by Targeting Connective Tissue Growth Factor

Hae Kyung Lee; Ariel Bier; Simona Cazacu; Susan Finniss; Cunli Xiang; Hodaya Twito; Laila M. Poisson; Tom Mikkelsen; Shimon Slavin; Elad Jacoby; Michal Yalon; Amos Toren; Sandra A. Rempel; Chaya Brodie

doi:10.1371/journal.pone.0054652

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Open Access

Peer-reviewed

Research Article

MicroRNA-145 Is Downregulated in Glial Tumors and Regulates Glioma Cell Migration by Targeting Connective Tissue Growth Factor

Hae Kyung Lee ,

Contributed equally to this work with: Hae Kyung Lee, Ariel Bier

Affiliation Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Ariel Bier ,

Contributed equally to this work with: Hae Kyung Lee, Ariel Bier

Affiliation Everard and Mina Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
⨯
Simona Cazacu,

Affiliation Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Susan Finniss,

Affiliation Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Cunli Xiang,

Affiliation Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Hodaya Twito,

Affiliation Everard and Mina Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
⨯
Laila M. Poisson,

Affiliation Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Tom Mikkelsen,

Affiliation Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Shimon Slavin,

Affiliation International Center for Cell Therapy and Cancer Immunotherapy (CTCI), Tel-Aviv, Israel
⨯
Elad Jacoby,

Affiliation Pediatric Hemato-Oncology, The Edmond and Lilly Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer and The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Michal Yalon,

Affiliation Pediatric Hemato-Oncology, The Edmond and Lilly Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer and The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Amos Toren,

Affiliation Pediatric Hemato-Oncology, The Edmond and Lilly Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer and The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯
Sandra A. Rempel,

Affiliation Barbara Jane Levy Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Chaya Brodie

* E-mail: nscha@neuro.hfh.edu

Affiliations Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, United States of America, Everard and Mina Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
⨯

MicroRNA-145 Is Downregulated in Glial Tumors and Regulates Glioma Cell Migration by Targeting Connective Tissue Growth Factor

Hae Kyung Lee,
Ariel Bier,
Simona Cazacu,
Susan Finniss,
Cunli Xiang,
Hodaya Twito,
Laila M. Poisson,
Tom Mikkelsen,
Shimon Slavin,
Elad Jacoby

Published: February 4, 2013
https://doi.org/10.1371/journal.pone.0054652

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19 Dec 2023
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Note from PLOS ONE Editors Posted by PLOS_ONE_Group on 19 Dec 2023 at 00:04 GMT
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19 Nov 2013
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gliomas Posted by finocchiaro on 19 Nov 2013 at 12:53 GMT

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