Advertisement
Research Article

Inhibition of Ceramide Metabolism Sensitizes Human Leukemia Cells to Inhibition of BCL2-Like Proteins

  • Lavona Casson,

    Affiliation: Division of Hematology and Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America

    X
  • Lauren Howell,

    Affiliation: Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy at the Medical School of South Carolina, Charleston, South Carolina, United States of America

    X
  • Lesley A. Mathews,

    Affiliation: Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Marc Ferrer,

    Affiliation: Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Noel Southall,

    Affiliation: Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Rajarshi Guha,

    Affiliation: Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Jonathan M. Keller,

    Affiliation: Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Craig Thomas,

    Affiliation: Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Leah J. Siskind equal contributor mail,

    equal contributor Contributed equally to this work with: Leah J. Siskind, Levi J. Beverly

    Levi.Beverly@Louisville.edu (LJB); Siskind@MUSC.edu (LJS)

    Affiliations: Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy at the Medical School of South Carolina, Charleston, South Carolina, United States of America, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina, United States of America

    X
  • Levi J. Beverly equal contributor mail

    equal contributor Contributed equally to this work with: Leah J. Siskind, Levi J. Beverly

    Levi.Beverly@Louisville.edu (LJB); Siskind@MUSC.edu (LJS)

    Affiliation: Division of Hematology and Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America

    Previous address: Cancer Biology and Genetics Section, Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Published: January 16, 2013
  • DOI: 10.1371/journal.pone.0054525

Reader Comments (0)

Post a new comment on this article