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Open Access
Peer-reviewed
Research Article
A Single Cell Level Based Method for Copy Number Variation Analysis by Low Coverage Massively Parallel Sequencing
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Chunlei Zhang ,
Contributed equally to this work with: Chunlei Zhang, Chunsheng Zhang, Shengpei Chen, Xuyang Yin
Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China
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Chunsheng Zhang ,
Contributed equally to this work with: Chunlei Zhang, Chunsheng Zhang, Shengpei Chen, Xuyang Yin
Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China
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Shengpei Chen ,
Contributed equally to this work with: Chunlei Zhang, Chunsheng Zhang, Shengpei Chen, Xuyang Yin
Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China, State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China
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Xuyang Yin ,
Contributed equally to this work with: Chunlei Zhang, Chunsheng Zhang, Shengpei Chen, Xuyang Yin
Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China
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Xiaoyu Pan,
Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China, School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China
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Ge Lin,
Affiliations Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China, Key laboratory of Stem Cell and Reproductive Engineering, Ministry of Health, Changsha, China
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Yueqiu Tan,
Affiliations Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China, Key laboratory of Stem Cell and Reproductive Engineering, Ministry of Health, Changsha, China
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Ke Tan,
Affiliation Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China
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Zhengfeng Xu,
Affiliation Center of Prenatal Diagnosis, Nanjing Maternal and Child Health Hospital, Nanjing Medical University, Nanjing, China
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Ping Hu,
Affiliation Center of Prenatal Diagnosis, Nanjing Maternal and Child Health Hospital, Nanjing Medical University, Nanjing, China
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Xuchao Li,
Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China
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Fang Chen,
Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Xun Xu,
Affiliation Science and Technology, BGI-Shenzhen, Shenzhen, China
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Yingrui Li,
Affiliation Science and Technology, BGI-Shenzhen, Shenzhen, China
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Xiuqing Zhang,
Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China
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Hui Jiang ,
* E-mail: jianghui@genomics.cn (HJ); wangw@genomics.cn (WW)
Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China, Guangdong Provincial Key Laboratory of Human Diseases Genome, BGI-Shenzhen, Guangdong, China, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Wei Wang
* E-mail: jianghui@genomics.cn (HJ); wangw@genomics.cn (WW)
Affiliations Science and Technology, BGI-Shenzhen, Shenzhen, China, Shenzhen Municipal Key Laboratory of Birth Defects Screening and Engineering, BGI-Shenzhen, Shenzhen, China
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A Single Cell Level Based Method for Copy Number Variation Analysis by Low Coverage Massively Parallel Sequencing
- Chunlei Zhang,
- Chunsheng Zhang,
- Shengpei Chen,
- Xuyang Yin,
- Xiaoyu Pan,
- Ge Lin,
- Yueqiu Tan,
- Ke Tan,
- Zhengfeng Xu,
- Ping Hu
- Published: January 23, 2013
- https://doi.org/10.1371/journal.pone.0054236